NF-κB is a target of AKT in anti-apoptotic PDGF signalling

Nature

Volumn 401, Issue 6748, 1999, Pages 86-90

  Romashkova, Julia A ^a   Makarov, Sergel S ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; AKT1 PROTEIN, HUMAN; AKT1 PROTEIN, RAT; CHUK PROTEIN, HUMAN; CHUK PROTEIN, MOUSE; DNA; I KAPPA B KINASE; IKBKB PROTEIN, HUMAN; IKBKB PROTEIN, MOUSE; IKBKE PROTEIN, HUMAN; IKBKE PROTEIN, MOUSE; MITOGENIC AGENT; MYC PROTEIN; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; RAS PROTEIN; RECOMBINANT PROTEIN;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; ENZYME ACTIVATION; GENE INDUCTION; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; CATALYSIS; CELL CULTURE; CELL DIVISION; CELL STRAIN 3T3; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; MOUSE; MUTATION; PHYSIOLOGY; PROTEIN BINDING; RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ANIMALS; APOPTOSIS; CATALYSIS; CELL DIVISION; CELLS, CULTURED; DNA; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B KINASE; MICE; MITOGENS; MUTATION; NF-KAPPA B; PLATELET-DERIVED GROWTH FACTOR; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MYC; RAS PROTEINS; RATS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0033517190     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/43474     Document Type: Article

References (30)

1. Harrington, E. A., Bennett, M. R., Fanidi, A. & Evan, G. I. c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J. 13, 3286-3295 (1994).
2. Evan, G. Cancer - a matter of life and cell death. Int. J. Cancer 71, 709-711 (1997).
3. Baldwin, A. S. Jr. The NF-κB and I-κB proteins: new discoveries and insights. Annu. Rev. Immunol. 14, 649-683 (1996).
4. Yin Foo, S. & Nolan, G. P. NF-kappaB to the rescue: RELS, apoptosis and cellular transformation. Trends Genet. 15, 229-235 (1999).
5. Mercurio, F. & Manning, A. M. Multiple signals converging on NF-kappaB. Curr. Opin. Cell Biol. 11, 226-232 (1999).
6. Kauffmann-Zeh, A. et al. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature 385, 544-548 (1997).
7. Kennedy, S. G. et al. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev. 11, 701-713 (1997).
8. Evan, G. I. et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69, 119-128 (1992).
9. Olashaw, N. E., Kowalik, T. F., Huang, E. S. & Pledger, W. J. Induction of NF-κB-like activity by platelet-derived growth actor in mouse fibroblasts. Mol. Biol. Cell 3, 1131-1139 (1992).
10. Hinz, M. et al. NF-κB function in growth control: regulation of cyclin D1 expression an dG0/G1-to-S-phase transition. Mol. Cell. Biol. 19, 2690-2698 (1999).
11. Kessler, D. J., Duyao, M. P., Spicer, D. B. & Sonenshein, G. E. NF-κB-like factors mediate interleukin 1 induction of c-myc gene transcription in fibroblasts. J. Exp. Med. 176, 787-792 (1992).
12. Miagkov, A. V. et al. NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. Proc. Natl Acad. Sci. USA 95, 13859-13864 (1998).
13. Downward, J. Mechanisms and consequences of activation of protein kinase B/Akt. Curr. Opin. Cell Biol. 10, 262-267 (1998).
14. Franke, T. F. et al. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81, 727-736 (1995).
15. Mercurio, F. et al. IKK-1 and IKK-2 cytokine-activated IκB kinases essential for NF-κB activation. Science 278, 860-866 (1997).
16. Mayo, M. W. et al. Requirement of NF-κB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science 278, 1812-1815 (1997).
17. Marte, B. M., Rodriguez-Viciana, P., Wennstrom, S. Warne, P. H. & Downward, J. R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways. Curr. Biol. 7, 63-70 (1997).
18. Firestein, G. S. & Manning, A. M. Signal transduction and transcription factors in rheumatic disease. Arthritis Rheum. 42, 609-621 (1999).
19. Datta, S. R. et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241 (1997).
20. del Peso, L., Gonzalez-Garcia, M., Page, C., Herrera, R. & Nunez, G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278, 687-689 (1997).
21. Cardone, M. H. et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 282, 1318-1321 (1998).
22. Brunet, A. et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868 (1999).
23. Kops, G. J. P. L. et al. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398, 630-634 (1999).
24. Beraud, C., Henzel, W. J. & Baeuerle, P. A. Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-κB activation. Proc. Natl Acad. Sci. USA 96, 429-434 (1999).
25. Berra, E. et al. Protein kinase C-ζ isoform is critical for mitogenic signal transduction. Cell 74, 555-563 (1993).
26. 2 for platelet-derived growth factor signal transduction. Science 270, 296-299 (1995).
27. Konishi, H., Shinomura, T., Kuroda, S., Ono, Y. & Kikkawa, U. Molecular cloning of rat RAC protein kinase α and β and their association with protein kinase C ζ. Biochem. Biophys. Res. Commun. 205, 817-825 (1994).
28. Lallena, M. J., Diaz-Meco, M. T., Bren, G., Paya, C. V. & Moscat, J. Activation of κB kinase beta by protein kinase C isoforms. Mol. Cell. Biol. 19, 2180-2188 (1999).
29. Karin, M. & Delhase, M. INK or IKK, AP-1 or NF-κB, which are the targets for MEK kinase 1 action? Proc. Natl Acad. Sci. USA 95, 9067-9069 (1998).
30. Makarov, S. S. et al. Suppression of experimental arthritis by gene transfer of interteukin 1 receptor antagonist cDNA. Proc. Natl Acad. Sci. USA 93, 402-406 (1996).