The α-isoform of class II phosphoinositide 3-kinase is more effectively activated by insulin receptors than IGF receptors, and activation requires receptor NPEY motifs

FEBS Letters

Volumn 460, Issue 3, 1999, Pages 423-426

  Urso B ^a   Brown, R A ^b   O'Rahilly, S ^a   Shepherd, P R ^b   Siddle, K ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

3T3 L1 adipocyte; C2 ; Insulin; Insulin like growth factor; Phosphoinositide 3 kinase; Receptor

Indexed keywords

INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; SOMATOMEDIN RECEPTOR;

ADIPOCYTE; ARTICLE; CHIMERA; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ADIPOCYTES; AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; HUMANS; ISOENZYMES; MICE; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; RECOMBINANT FUSION PROTEINS; TYROSINE;

EID: 0032730956     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(99)01388-5     Document Type: Article

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