Non-peptidic prenyltransferase inhibitors: Diverse structural classes and surprising anti-cancer mechanisms

Current Medicinal Chemistry

Volumn 8, Issue 12, 2001, Pages 1437-1465

  Gibbs, Richard A ^a   Zahn, Todd J ^a   Sebolt Leopold, Judith S ^b  

^a WAYNE STATE UNIVERSITY   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[2 [[2 [(2 AMINO 3 MERCAPTOPROPYL)AMINO] 3 METHYLPENTYL]OXY] 1 OXO 3 PHENYLPROPYL]AMINO] 4 (METHYLSULFONYL)BUTANOIC ACID ISOPROPYL ESTER; ATORVASTATIN; CHAETOMELLIC ACID A; CYTOTOXIC AGENT; DIMETHYLALLYLTRANSFERASE; DIMETHYLALLYLTRANSFERASE INHIBITOR; FARNESYL DIPHOSPHATE; FTI 205; FTI 249; FTI 250; GERANYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; L 731734; L 731735; L 745631; MANUMYCIN; MEVINOLIN; N [2 [2 (2 AMINO 3 MERCAPTOPROPYLAMINO) 3 METHYLPENTYLOXY] 3 PHENYLPROPIONYL]METHIONINE SULFONE; N [2 [2 (2 AMINO 3 MERCAPTOPROPYLAMINO) 3 METHYLPENTYLOXY] 3 PHENYLPROPIONYL]METHIONINE SULFONE METHYL ESTER; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE; NATURAL PRODUCT; OREGANIC ACID; PEPTIDE DERIVATIVE; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; SEX PHEROMONE; TETRAPEPTIDE; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AMINO ACID SEQUENCE; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOCHEMISTRY; CANCER CELL; COMPETITIVE INHIBITION; CYTOSTASIS; DRUG CLASSIFICATION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG TARGETING; ENZYME MECHANISM; ENZYME SPECIFICITY; FUNGUS; GROWTH INHIBITION; HUMAN; NONHUMAN; ONCOGENE RAS; PRENYLATION; SACCHAROMYCES CEREVISIAE;

EID: 0034820134     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867013372111     Document Type: Article

References (206)