Multivariate data analysis using D-optimal designs, partial least squares, and response surface modeling: A directional approach for the analysis of farnesyltransferase inhibitors

Journal of Medicinal Chemistry

Volumn 43, Issue 9, 2000, Pages 1807-1816

  Giraud, Elie ^a,b   Luttmann, Claude ^b   Lavelle, François ^b   Riou, Jean François ^b   Mailliet, Patrick ^b   Laoui, Abdelazize ^b  

^a Synt:em   (France)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4,9,9A HEXAHYDRO 2 [2 (2 METHOXYPHENYL) 1 OXO 2 PROPENYL] 9 (4 METHYLPHENYL) 4,9 ETHANO 3AH BENZ[F]ISOINDOLE 3A CARBOXYLIC ACID; BENZO[F]PERHYDROISOINDOLE DERIVATIVE; INDOLE DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN P21; RAS PROTEIN; RPR 104213; RPR 115135; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CHEMOMETRICS; DRUG DESIGN; ENZYME INHIBITION; MOLECULAR MODEL; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATISTICAL ANALYSIS;

ALKYL AND ARYL TRANSFERASES; ARTIFICIAL INTELLIGENCE; COMPUTER SIMULATION; DATABASES; DRUG DESIGN; ENZYME INHIBITORS; LEAST-SQUARES ANALYSIS; MODELS, CHEMICAL; MULTIVARIATE ANALYSIS; RAS PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034103807     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm991166h     Document Type: Article

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