Novel conformationally extended naphthalene-based inhibitors of farnesyltransferase [1]

Journal of Medicinal Chemistry

Volumn 40, Issue 12, 1997, Pages 1763-1767

  Burns, C J ^a   Guitton, J D ^a   Baudoin, B ^a   Lelievre, Y ^a   Duchesne, M ^a   Parker, F ^a   Fromage, N ^a   Commercon, A ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BMS 187912; PROTEIN FARNESYLTRANSFERASE; RPR 113829; RPR 114334; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; CARCINOMA CELL; CELL GROWTH; CELL STRAIN 3T3; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CONFORMATION; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LETTER; MOUSE; NONHUMAN; ONCOGENE RAS; PROTO ONCOGENE;

2-NAPHTHYLAMINE; ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL LINE, TRANSFORMED; CYSTEINE; DIPEPTIDES; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; GENES, RAS; METHIONINE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAPHTHALENES; PROTEIN CONFORMATION; RAS PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFERASES; TUMOR CELLS, CULTURED;

EID: 0030914577     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9701177     Document Type: Letter

References (20)