-
1
-
-
0028968949
-
Tyrosine kinase inhibition: An approach to drug development
-
Levitzki A, Gazit A. 1995. Tyrosine kinase inhibition: an approach to drug development. Science 267:1782-88
-
(1995)
Science
, vol.267
, pp. 1782-1788
-
-
Levitzki, A.1
Gazit, A.2
-
2
-
-
0028097472
-
Pharmaceutical research in molecular oncology
-
Gibbs JB, Oliff A. 1994. Pharmaceutical research in molecular oncology. Cell 79:193-98
-
(1994)
Cell
, vol.79
, pp. 193-198
-
-
Gibbs, J.B.1
Oliff, A.2
-
3
-
-
0002457485
-
ras protooncogene activation in human malignancy
-
ed. CT Garrett, S Sell. Totowa, NJ: Humana
-
Clark GJ, Der CJ. 1995. ras protooncogene activation in human malignancy. In Cellular Cancer Markers, ed. CT Garrett, S Sell, pp. 17-52. Totowa, NJ: Humana
-
(1995)
Cellular Cancer Markers
, pp. 17-52
-
-
Clark, G.J.1
Der, C.J.2
-
6
-
-
0029126877
-
Neurofibromatosis type 1 and Ras-mediated signaling: Filling in the GAPs
-
Bernards A. 1995. Neurofibromatosis type 1 and Ras-mediated signaling: filling in the GAPs. Biochim. Biophys. Acta 1242:43-59
-
(1995)
Biochim. Biophys. Acta
, vol.1242
, pp. 43-59
-
-
Bernards, A.1
-
7
-
-
0003132267
-
ras gene mutations and human cancer
-
ed. J Cossman. Amsterdam, Netherlands: Elsevier Sci.
-
Bos JL. 1990. ras gene mutations and human cancer. In Molecular Genetics in Cancer Diagnosis, ed. J Cossman, pp. 273-87. Amsterdam, Netherlands: Elsevier Sci.
-
(1990)
Molecular Genetics in Cancer Diagnosis
, pp. 273-287
-
-
Bos, J.L.1
-
8
-
-
9044251606
-
Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells
-
Bollag G, Clapp DW, Shih S, Adler F, Zhang YY, et al. 1996. Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells. Nat. Genet. 12:144-48
-
(1996)
Nat. Genet.
, vol.12
, pp. 144-148
-
-
Bollag, G.1
Clapp, D.W.2
Shih, S.3
Adler, F.4
Zhang, Y.Y.5
-
9
-
-
0030045594
-
Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia
-
Largaespada DA, Brannan CI, Jenkins NA, Copeland NG. 1996. Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia. Nat. Genet. 12:137-43
-
(1996)
Nat. Genet.
, vol.12
, pp. 137-143
-
-
Largaespada, D.A.1
Brannan, C.I.2
Jenkins, N.A.3
Copeland, N.G.4
-
10
-
-
0027024351
-
Pharmacological probes of Ras function
-
Gibbs JB. 1992. Pharmacological probes of Ras function. Semin. Cancer Biol. 3:383-90
-
(1992)
Semin. Cancer Biol.
, vol.3
, pp. 383-390
-
-
Gibbs, J.B.1
-
11
-
-
0025877861
-
Ras C-terminal processing enzymes - New drug targets?
-
Gibbs JB. 1991. Ras C-terminal processing enzymes - new drug targets? Cell 65:1-4
-
(1991)
Cell
, vol.65
, pp. 1-4
-
-
Gibbs, J.B.1
-
12
-
-
0028388748
-
Regulatory interactions in Ras signal transduction: New targets for anti-cancer intervention?
-
Prendergast GC, Gibbs JB. 1994. Regulatory interactions in Ras signal transduction: new targets for anti-cancer intervention? BioEssays 16:187-91
-
(1994)
BioEssays
, vol.16
, pp. 187-191
-
-
Prendergast, G.C.1
Gibbs, J.B.2
-
13
-
-
0028797652
-
Signal transduction by Ras-like GTPases: A potential target for anticancer drugs
-
Spaargaren M, Bischoff JR, McCormick F. 1995. Signal transduction by Ras-like GTPases: a potential target for anticancer drugs. Gene Expr. 4:345-56
-
(1995)
Gene Expr.
, vol.4
, pp. 345-356
-
-
Spaargaren, M.1
Bischoff, J.R.2
McCormick, F.3
-
14
-
-
0002857679
-
Prenylation of Ras and inhibitors of prenyltransferases
-
ed. H Maruta. Austin, TX: RG Landes. In press
-
Sattler I, Tamanoi F. 1996. Prenylation of Ras and inhibitors of prenyltransferases. In Molecular Biology Intelligence Unit Ser., ed. H Maruta. Austin, TX: RG Landes. In press
-
(1996)
Molecular Biology Intelligence Unit Ser.
-
-
Sattler, I.1
Tamanoi, F.2
-
15
-
-
0028024877
-
Farnesylprotein transferase inhibitors
-
Omura S, Takeshima H. 1994. Farnesylprotein transferase inhibitors. Drugs Future 19:751-55
-
(1994)
Drugs Future
, vol.19
, pp. 751-755
-
-
Omura, S.1
Takeshima, H.2
-
16
-
-
0029022361
-
Inhibitors of Ras farnesyltransferase as novel antitumor agents
-
Hamilton AD, Sebti SM. 1995. Inhibitors of Ras farnesyltransferase as novel antitumor agents. DN&P 8:138-45
-
(1995)
DN&P
, vol.8
, pp. 138-145
-
-
Hamilton, A.D.1
Sebti, S.M.2
-
17
-
-
0028784266
-
Inhibitors of protein farnesylation: A new approach to cancer chemotherapy
-
Graham SL. 1995. Inhibitors of protein farnesylation: a new approach to cancer chemotherapy. Exp. Opin. Ther. Patents 5:1269-85
-
(1995)
Exp. Opin. Ther. Patents
, vol.5
, pp. 1269-1285
-
-
Graham, S.L.1
-
18
-
-
0028331587
-
Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic
-
Gibbs JB, Oliff A, Kohl NE. 1994. Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic. Cell 77:175-78
-
(1994)
Cell
, vol.77
, pp. 175-178
-
-
Gibbs, J.B.1
Oliff, A.2
Kohl, N.E.3
-
19
-
-
0028967646
-
Ras farnesylation as a target for novel antitumor agents: Potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase
-
Manne V, Ricca CS, Brown JG, Tuomari AV, Van N, et al. 1995. Ras farnesylation as a target for novel antitumor agents: potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase. Drug Dev. Res. 34:121-37
-
(1995)
Drug Dev. Res.
, vol.34
, pp. 121-137
-
-
Manne, V.1
Ricca, C.S.2
Brown, J.G.3
Tuomari, A.V.4
Van, N.5
-
21
-
-
0026735063
-
Protein isoprenylation and methylation at carboxyl-terminal cysteine residues
-
Clarke S. 1992. Protein isoprenylation and methylation at carboxyl-terminal cysteine residues. Annu. Rev. Biochem. 61:355-86
-
(1992)
Annu. Rev. Biochem.
, vol.61
, pp. 355-386
-
-
Clarke, S.1
-
22
-
-
0027076554
-
Protein prenylation: Genes, enzymes, targets, and functions
-
Schafer WR, Rine J. 1992. Protein prenylation: genes, enzymes, targets, and functions. Annu. Rev. Genet. 30:209-37
-
(1992)
Annu. Rev. Genet.
, vol.30
, pp. 209-237
-
-
Schafer, W.R.1
Rine, J.2
-
23
-
-
0024250829
-
Structure and expression of yeast DPR1, a gene essential for the processing and intracellular localization of ras proteins
-
Goodman LE, Perou CM, Fujiyama A, Tamanoi F. 1988. Structure and expression of yeast DPR1, a gene essential for the processing and intracellular localization of ras proteins. Yeast 4:271-81
-
(1988)
Yeast
, vol.4
, pp. 271-281
-
-
Goodman, L.E.1
Perou, C.M.2
Fujiyama, A.3
Tamanoi, F.4
-
24
-
-
0022994652
-
RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor
-
Powers S, Michaelis S, Broek D, Santa-Anna AS, Field J, et al. 1986. RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor. Cell 47:413-22
-
(1986)
Cell
, vol.47
, pp. 413-422
-
-
Powers, S.1
Michaelis, S.2
Broek, D.3
Santa-Anna, A.S.4
Field, J.5
-
25
-
-
0025838675
-
Regulators and effectors of ras proteins
-
Bollag G, McCormick F. 1991. Regulators and effectors of ras proteins. Annu. Rev. Cell Biol. 7:601-32
-
(1991)
Annu. Rev. Cell Biol.
, vol.7
, pp. 601-632
-
-
Bollag, G.1
McCormick, F.2
-
26
-
-
0028917954
-
Regulation of Ras-mediated signalling: More than one way to skin a cat
-
Burgering BMT, Bos JL. 1995. Regulation of Ras-mediated signalling: more than one way to skin a cat. Trends Biochem. Sci. 20:18-22
-
(1995)
Trends Biochem. Sci.
, vol.20
, pp. 18-22
-
-
Burgering, B.M.T.1
Bos, J.L.2
-
27
-
-
0028825531
-
Ras target proteins in eukaryotic cells
-
Marshall MS. 1995. Ras target proteins in eukaryotic cells. FASEB J. 9:1311-18
-
(1995)
FASEB J.
, vol.9
, pp. 1311-1318
-
-
Marshall, M.S.1
-
28
-
-
0026436279
-
The prenylation of proteins
-
Sinensky M, Lutz MJ. 1992. The prenylation of proteins. BioEssays 14:25-31
-
(1992)
BioEssays
, vol.14
, pp. 25-31
-
-
Sinensky, M.1
Lutz, M.J.2
-
29
-
-
0025649688
-
Posttranslational modification of proteins by isoprenoids in mammalian cells
-
Maltese WA. 1990. Posttranslational modification of proteins by isoprenoids in mammalian cells. FASEB J. 4:3319-27
-
(1990)
FASEB J.
, vol.4
, pp. 3319-3327
-
-
Maltese, W.A.1
-
30
-
-
0025277259
-
Prenyl proteins in eucaryotic cells: A new type of membrane anchor
-
Glomset JA, Gelb MH, Farnsworth CC. 1990. Prenyl proteins in eucaryotic cells: a new type of membrane anchor. Trends Biochem. Sci. 15:139-42
-
(1990)
Trends Biochem. Sci.
, vol.15
, pp. 139-142
-
-
Glomset, J.A.1
Gelb, M.H.2
Farnsworth, C.C.3
-
31
-
-
0029898894
-
Protein prenylation: Molecular mechanisms and functional consequences
-
Zhang FL, Casey PJ. 1996. Protein prenylation: molecular mechanisms and functional consequences. Annu. Rev. Biochem. 65:241-69
-
(1996)
Annu. Rev. Biochem.
, vol.65
, pp. 241-269
-
-
Zhang, F.L.1
Casey, P.J.2
-
33
-
-
0027213688
-
Inhibitors of Ras farnesyltransferases
-
Tamanoi F. 1993. Inhibitors of Ras farnesyltransferases. Trends Biochem. Sci. 18:349-53
-
(1993)
Trends Biochem. Sci.
, vol.18
, pp. 349-353
-
-
Tamanoi, F.1
-
34
-
-
0021528719
-
Harvey murine sarcoma virus p21 ras protein: Biological and biochemical significance of the cysteine nearest the carboxy terminus
-
Willumsen BM, Norris K, Papageorge AG, Hubbert NL, Lowy DR. 1984. Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus. EMBO J. 3:2581-85
-
(1984)
EMBO J.
, vol.3
, pp. 2581-2585
-
-
Willumsen, B.M.1
Norris, K.2
Papageorge, A.G.3
Hubbert, N.L.4
Lowy, D.R.5
-
35
-
-
0018584369
-
Structure of rhodotorucine A, a peptidyl factor, inducing mating tube formation in Rhodosporidium toruloides
-
Kamiya Y, Sakurai A, Tamura S, Takahashi N, Tsuchiya E, et al. 1979. Structure of rhodotorucine A, a peptidyl factor, inducing mating tube formation in Rhodosporidium toruloides. Agric. Biol. Chem. 43:363-69
-
(1979)
Agric. Biol. Chem.
, vol.43
, pp. 363-369
-
-
Kamiya, Y.1
Sakurai, A.2
Tamura, S.3
Takahashi, N.4
Tsuchiya, E.5
-
36
-
-
0009680157
-
Structures of tremerogens A-9291-I and A-9291-VIII: Peptidyl sex hormones of tremella brasiliensis
-
Ishibashi Y, Sakagami Y, Isogai A, Suzuki A. 1984. Structures of tremerogens A-9291-I and A-9291-VIII: peptidyl sex hormones of tremella brasiliensis. Biochemistry 23:1399-404
-
(1984)
Biochemistry
, vol.23
, pp. 1399-1404
-
-
Ishibashi, Y.1
Sakagami, Y.2
Isogai, A.3
Suzuki, A.4
-
37
-
-
0024279583
-
Structure of Saccharomyces cerevisiae mating hormone a-factor
-
Anderegg RJ, Betz R, Carr SA, Crabb JW, Duntze W. 1988. Structure of Saccharomyces cerevisiae mating hormone a-factor. J. Biol. Chem. 263:18236-40
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 18236-18240
-
-
Anderegg, R.J.1
Betz, R.2
Carr, S.A.3
Crabb, J.W.4
Duntze, W.5
-
40
-
-
0024406286
-
All ras proteins are polyisoprenylated but only some are palmitoylated
-
Hancock JF, Magee AI, Childs JE, Marshall CJ. 1989. All ras proteins are polyisoprenylated but only some are palmitoylated. Cell 57:1167-77
-
(1989)
Cell
, vol.57
, pp. 1167-1177
-
-
Hancock, J.F.1
Magee, A.I.2
Childs, J.E.3
Marshall, C.J.4
-
41
-
-
0024316475
-
Genetic and pharmacological suppression of oncogenic mutations in RAS genes of yeast and humans
-
Schafer WR, Kim R, Sterne R, Thorner J, Kim S-H, et al. 1989. Genetic and pharmacological suppression of oncogenic mutations in RAS genes of yeast and humans. Science 245:379-85
-
(1989)
Science
, vol.245
, pp. 379-385
-
-
Schafer, W.R.1
Kim, R.2
Sterne, R.3
Thorner, J.4
Kim, S.-H.5
-
42
-
-
0026619185
-
The Ras/cholesterol connection: Implications for ras oncogenicity
-
Cox AD, Der CJ. 1992. The Ras/cholesterol connection: implications for ras oncogenicity. Crit. Rev. Oncog. 3:365-400
-
(1992)
Crit. Rev. Oncog.
, vol.3
, pp. 365-400
-
-
Cox, A.D.1
Der, C.J.2
-
43
-
-
0028260390
-
Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation
-
Graham SM, Cox AD, Drivas G, Rush MG, D'Eustachio P, et al. 1994. Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation. Mol. Cell. Biol. 14:4108-15
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 4108-4115
-
-
Graham, S.M.1
Cox, A.D.2
Drivas, G.3
Rush, M.G.4
D'Eustachio, P.5
-
44
-
-
0030021367
-
The TC21 oncoprotein interacts with the Ral guanosine nucleotide dissociation factor
-
Lopez-Barahona M, Bustelo XR, Barbacid M. 1996. The TC21 oncoprotein interacts with the Ral guanosine nucleotide dissociation factor. Oncogene 12:463-70
-
(1996)
Oncogene
, vol.12
, pp. 463-470
-
-
Lopez-Barahona, M.1
Bustelo, X.R.2
Barbacid, M.3
-
45
-
-
0028808638
-
The Rac and Rho pathways as a source of drug targets for Ras-mediated malignancies
-
Symons M. 1995. The Rac and Rho pathways as a source of drug targets for Ras-mediated malignancies. Curr. Opin. Biotechnol. 6:668-74
-
(1995)
Curr. Opin. Biotechnol.
, vol.6
, pp. 668-674
-
-
Symons, M.1
-
46
-
-
0028359370
-
PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth
-
Diamond RH, Cressman DE, Laz TM, Abrams CS, Taub R. 1994. PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth. Mol. Cell. Biol. 14:3752-62
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 3752-3762
-
-
Diamond, R.H.1
Cressman, D.E.2
Laz, T.M.3
Abrams, C.S.4
Taub, R.5
-
47
-
-
0343738316
-
Prenylation of novel oncogenic human PTP CAAX protein tyrosine phosphatases
-
Crowell PL, Cates CA, Burke YD, Harvey K, Crowell DN, et al. 1996. Prenylation of novel oncogenic human PTP CAAX protein tyrosine phosphatases. Proc. Am. Assoc. Cancer Res. 37:576
-
(1996)
Proc. Am. Assoc. Cancer Res.
, vol.37
, pp. 576
-
-
Crowell, P.L.1
Cates, C.A.2
Burke, Y.D.3
Harvey, K.4
Crowell, D.N.5
-
49
-
-
0026686468
-
Farnesylation of YDJ1p is required for function at elevated growth temperatures in Saccharomyces cerevisiae
-
Caplan AJ, Tsai J, Casey PJ, Douglas MG. 1992. Farnesylation of YDJ1p is required for function at elevated growth temperatures in Saccharomyces cerevisiae. J. Biol. Chem. 267:18890-95
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 18890-18895
-
-
Caplan, A.J.1
Tsai, J.2
Casey, P.J.3
Douglas, M.G.4
-
50
-
-
0027216523
-
Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein
-
Chellaiah A, Davis A, Mohanakumar T. 1993. Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein. Biochim. Biophys. Acta 1174:111-13
-
(1993)
Biochim. Biophys. Acta
, vol.1174
, pp. 111-113
-
-
Chellaiah, A.1
Davis, A.2
Mohanakumar, T.3
-
51
-
-
0026666233
-
Farnesylcysteine, a constituent of the a and b subunits of rabbit skeletal muscle phosphorylase kinase: Localization by conversion to S-ethylcysteine and by tandem mass spectrometry
-
Heilmeyer LMG Jr, Serwe M, Weber C, Metzger J, Hoffmann-Posorske E, et al. 1992. Farnesylcysteine, a constituent of the a and b subunits of rabbit skeletal muscle phosphorylase kinase: localization by conversion to S-ethylcysteine and by tandem mass spectrometry. Proc. Natl. Acad. Sci. USA 89:9554-58
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 9554-9558
-
-
Heilmeyer L.M.G., Jr.1
Serwe, M.2
Weber, C.3
Metzger, J.4
Hoffmann-Posorske, E.5
-
52
-
-
0028227288
-
PxF, a prenylated protein of peroxisomes
-
James GL, Goldstein JL, Pathak RK, Anderson RGW, Brown MS. 1994. PxF, a prenylated protein of peroxisomes. J. Biol. Chem. 269:14182-90
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 14182-14190
-
-
James, G.L.1
Goldstein, J.L.2
Pathak, R.K.3
Anderson, R.G.W.4
Brown, M.S.5
-
53
-
-
0029894664
-
Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation
-
Foster R, Hu K-Q, Lu Y, Nolan KM, Thissen J, et al. 1996. Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. Mol. Cell. Biol. 16:2689-99
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 2689-2699
-
-
Foster, R.1
Hu, K.-Q.2
Lu, Y.3
Nolan, K.M.4
Thissen, J.5
-
56
-
-
0025179232
-
Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase
-
Schaber MD, O'Hara MB, Garsky VM, Mosser SD, Bergstrom JD, et al. 1990. Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase. J. Biol. Chem. 265:14701-4
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 14701-14704
-
-
Schaber, M.D.1
O'Hara, M.B.2
Garsky, V.M.3
Mosser, S.D.4
Bergstrom, J.D.5
-
57
-
-
0026353346
-
Sequence dependence of protein isoprenylation
-
Moores SL, Schaber MD, Mosser SD, Rands E, O'Hara MB, et al. 1991. Sequence dependence of protein isoprenylation. J. Biol. Chem. 266:14603-10
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 14603-14610
-
-
Moores, S.L.1
Schaber, M.D.2
Mosser, S.D.3
Rands, E.4
O'Hara, M.B.5
-
58
-
-
0028958919
-
Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro
-
James GL, Goldstein JL, Brown MS. 1995. Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro. J. Biol. Chem. 270:6221-26
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 6221-6226
-
-
James, G.L.1
Goldstein, J.L.2
Brown, M.S.3
-
59
-
-
0030039165
-
Substitution of cadmium for zinc in farnesyl: Protein transferase alters its substrate specificity
-
Zhang FL, Fu H-W, Casey PJ, Bishop WR. 1996. Substitution of cadmium for zinc in farnesyl: protein transferase alters its substrate specificity. Biochemistry 35:8166-71
-
(1996)
Biochemistry
, vol.35
, pp. 8166-8171
-
-
Zhang, F.L.1
Fu, H.-W.2
Casey, P.J.3
Bishop, W.R.4
-
60
-
-
0027299926
-
Genetic evidence for in vivo cross-specificity of the CaaX-box protein prenyltransferases farnesyltransferase and geranylgeranyltransferase-I in Saccharomyces cerevisiae
-
Trueblood CE, Ohya Y, Rine J. 1993. Genetic evidence for in vivo cross-specificity of the CaaX-box protein prenyltransferases farnesyltransferase and geranylgeranyltransferase-I in Saccharomyces cerevisiae. Mol. Cell. Biol. 13:4260-75
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 4260-4275
-
-
Trueblood, C.E.1
Ohya, Y.2
Rine, J.3
-
61
-
-
0028920240
-
CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB
-
Armstrong SA, Hannah VC, Goldstein JL, Brown MS. 1995. CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB. J. Biol. Chem. 270:7864-68
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 7864-7868
-
-
Armstrong, S.A.1
Hannah, V.C.2
Goldstein, J.L.3
Brown, M.S.4
-
62
-
-
0027409561
-
Identification of Ras farnesyltransferase inhibitors by microbial screening
-
Hara M, Akasaka K, Akinaga S, Okabe M, Nakano H, et al. 1993. Identification of Ras farnesyltransferase inhibitors by microbial screening. Proc. Natl. Acad. Sci. USA 90:2281-85
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 2281-2285
-
-
Hara, M.1
Akasaka, K.2
Akinaga, S.3
Okabe, M.4
Nakano, H.5
-
63
-
-
0027413551
-
Selective inhibition of farnesyl-protein transferase blocks Ras processing in vivo
-
Gibbs JB, Pompliano DL, Mosser SD, Rands E, Lingham RB, et al. 1993. Selective inhibition of farnesyl-protein transferase blocks Ras processing in vivo. J. Biol. Chem. 268:7617-20
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 7617-7620
-
-
Gibbs, J.B.1
Pompliano, D.L.2
Mosser, S.D.3
Rands, E.4
Lingham, R.B.5
-
64
-
-
0026657881
-
Divalent cation and prenyl pyrophosphate specificities of the protein farnesyltransferase from rat brain, a zinc metalloenzyme
-
Reiss Y, Brown MS, Goldstein JL. 1992. Divalent cation and prenyl pyrophosphate specificities of the protein farnesyltransferase from rat brain, a zinc metalloenzyme. J. Biol. Chem. 267:6403-8
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 6403-6408
-
-
Reiss, Y.1
Brown, M.S.2
Goldstein, J.L.3
-
65
-
-
0026729445
-
Steady-state kinetic mechanism of Ras farnesyl: Protein transferase
-
Pompliano DL, Rands E, Schaber MD, Mosser SD, Anthony NJ, et al. 1992. Steady-state kinetic mechanism of Ras farnesyl: protein transferase. Biochemistry 31:3800-7
-
(1992)
Biochemistry
, vol.31
, pp. 3800-3807
-
-
Pompliano, D.L.1
Rands, E.2
Schaber, M.D.3
Mosser, S.D.4
Anthony, N.J.5
-
66
-
-
0029007105
-
Protein farnesyltransferase: Kinetics of farnesyl pyrophosphate binding and product release
-
Furfine ES, Leban JJ, Landavazo A, Moomaw JF, Casey PJ. 1995. Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release. Biochemistry 34:6857-62
-
(1995)
Biochemistry
, vol.34
, pp. 6857-6862
-
-
Furfine, E.S.1
Leban, J.J.2
Landavazo, A.3
Moomaw, J.F.4
Casey, P.J.5
-
67
-
-
0027301696
-
Isoprenoid diphosphate utilization by recombinant human farnesyl-protein transferase: Interactive binding between substrates and a preferred kinetic pathway
-
Pompliano DL, Schaber MD, Mosser SD, Omer CA, Shafer JA, et al. 1993. Isoprenoid diphosphate utilization by recombinant human farnesyl-protein transferase: interactive binding between substrates and a preferred kinetic pathway. Biochemistry 32:8341-47
-
(1993)
Biochemistry
, vol.32
, pp. 8341-8347
-
-
Pompliano, D.L.1
Schaber, M.D.2
Mosser, S.D.3
Omer, C.A.4
Shafer, J.A.5
-
68
-
-
0027248872
-
Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor
-
Kohl NE, Mosser SD, deSolms SJ, Giuliani EA, Pompliano DL, et al. 1993. Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. Science 260:1934-37
-
(1993)
Science
, vol.260
, pp. 1934-1937
-
-
Kohl, N.E.1
Mosser, S.D.2
DeSolms, S.J.3
Giuliani, E.A.4
Pompliano, D.L.5
-
69
-
-
0027323459
-
Benzodiazepine peptidomimetics: Potent inhibitors of Ras farnesylation in animal cells
-
James GL, Goldstein JL, Brown MS, Rawson TE, Somers TC, et al. 1993. Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells. Science 260:1937-42
-
(1993)
Science
, vol.260
, pp. 1937-1942
-
-
James, G.L.1
Goldstein, J.L.2
Brown, M.S.3
Rawson, T.E.4
Somers, T.C.5
-
70
-
-
0027320616
-
Peptidomimetic inhibitors of Ras farnesylation and function in whole cells
-
Garcia AM, Rowell C, Ackermann K, Kowalczyk JJ, Lewis MD. 1993. Peptidomimetic inhibitors of Ras farnesylation and function in whole cells. J. Biol. Chem. 268:18415-18
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 18415-18418
-
-
Garcia, A.M.1
Rowell, C.2
Ackermann, K.3
Kowalczyk, J.J.4
Lewis, M.D.5
-
71
-
-
0029586503
-
Novel tricyclic inhibitors of farnesyl protein transferase
-
Bishop WR, Bond R, Petrin J, Wang L, Patton R, et al. 1995. Novel tricyclic inhibitors of farnesyl protein transferase. J. Biol. Chem. 270:30611-18
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 30611-30618
-
-
Bishop, W.R.1
Bond, R.2
Petrin, J.3
Wang, L.4
Patton, R.5
-
72
-
-
0029986149
-
2-Substituted piperazines as constrained amino acids. Application to the synthesis of potent, noncarboxylic acid inhibitors of farnesyltransferase
-
Williams TM, Ciccarone TM, MacTough SC, Bock RL, Conner MW, et al. 1996. 2-Substituted piperazines as constrained amino acids. Application to the synthesis of potent, noncarboxylic acid inhibitors of farnesyltransferase. J. Med. Chem. 39:1345-48
-
(1996)
J. Med. Chem.
, vol.39
, pp. 1345-1348
-
-
Williams, T.M.1
Ciccarone, T.M.2
MacTough, S.C.3
Bock, R.L.4
Conner, M.W.5
-
73
-
-
0028912593
-
A non-peptide mimetic of Ras-CAAX: Selective inhibition of farnesyltransferase and ras processing
-
Vogt A, Qian Y, Blaskovich MA, Fossum RD, Hamilton AD, et al. 1995. A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and ras processing. J. Biol. Chem. 270:660-64
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 660-664
-
-
Vogt, A.1
Qian, Y.2
Blaskovich, M.A.3
Fossum, R.D.4
Hamilton, A.D.5
-
74
-
-
0030034763
-
Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase
-
Hunt JT, Lee VG, Leftheris K, Seizinger B, Carboni J, et al. 1996. Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase. J. Med. Chem 39:353-58
-
(1996)
J. Med. Chem
, vol.39
, pp. 353-358
-
-
Hunt, J.T.1
Lee, V.G.2
Leftheris, K.3
Seizinger, B.4
Carboni, J.5
-
75
-
-
0028936976
-
NMR studies of novel inhibitors bound to farnesyl-protein transferase
-
Koblan KS, Culberson JC, deSolms SJ, Giuliani EA, Mosser SD, et al. 1995. NMR studies of novel inhibitors bound to farnesyl-protein transferase. Protein Sci. 4:681-88
-
(1995)
Protein Sci.
, vol.4
, pp. 681-688
-
-
Koblan, K.S.1
Culberson, J.C.2
DeSolms, S.J.3
Giuliani, E.A.4
Mosser, S.D.5
-
76
-
-
0027137932
-
Conformation of a heptapeptide substrate bound to protein farnesyltransferase
-
Stradley SJ, Rizo J, Gierasch LM. 1993. Conformation of a heptapeptide substrate bound to protein farnesyltransferase. Biochemistry 32:12586-90
-
(1993)
Biochemistry
, vol.32
, pp. 12586-12590
-
-
Stradley, S.J.1
Rizo, J.2
Gierasch, L.M.3
-
77
-
-
0029025272
-
Phosphinyl acid-based bisubstrate analog inhibitors of ras farnesyl protein transferase
-
Patel DV, Gordon EM, Schmidt RJ, Weller HN, Young MG, et al. 1995. Phosphinyl acid-based bisubstrate analog inhibitors of ras farnesyl protein transferase. J. Med. Chem. 38:435-42
-
(1995)
J. Med. Chem.
, vol.38
, pp. 435-442
-
-
Patel, D.V.1
Gordon, E.M.2
Schmidt, R.J.3
Weller, H.N.4
Young, M.G.5
-
78
-
-
0029000897
-
Bisubstrate inhibitors of farnesyltransferase: A novel class of specific inhibitors of ras transformed cells
-
Manne V, Yan N, Carboni JM, Tuomari AV, Ricca CS, et al. 1995. Bisubstrate inhibitors of farnesyltransferase: A novel class of specific inhibitors of ras transformed cells. Oncogene 10:1763-79
-
(1995)
Oncogene
, vol.10
, pp. 1763-1779
-
-
Manne, V.1
Yan, N.2
Carboni, J.M.3
Tuomari, A.V.4
Ricca, C.S.5
-
79
-
-
0027998986
-
The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation
-
Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD, et al. 1994. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. J. Biol. Chem. 269:19203-6
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 19203-19206
-
-
Cox, A.D.1
Garcia, A.M.2
Westwick, J.K.3
Kowalczyk, J.J.4
Lewis, M.D.5
-
80
-
-
0028973293
-
Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes
-
Lerner EC, Qian Y, Blaskovich MA, Fossum RD, Vogt A, et al. 1995. Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes. J. Biol. Chem. 270:26802-6
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 26802-26806
-
-
Lerner, E.C.1
Qian, Y.2
Blaskovich, M.A.3
Fossum, R.D.4
Vogt, A.5
-
81
-
-
0028810275
-
Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor
-
Lerner EC, Qian Y, Hamilton AD, Sebti SM. 1995. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J. Biol. Chem. 270:26770-73
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 26770-26773
-
-
Lerner, E.C.1
Qian, Y.2
Hamilton, A.D.3
Sebti, S.M.4
-
83
-
-
0028869067
-
Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956
-
Nagasu T, Yoshimatsu K, Rowell C, Lewis MD, Garcia AM. 1995. Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956. Cancer Res. 55:5310-14
-
(1995)
Cancer Res.
, vol.55
, pp. 5310-5314
-
-
Nagasu, T.1
Yoshimatsu, K.2
Rowell, C.3
Lewis, M.D.4
Garcia, A.M.5
-
84
-
-
0029023145
-
Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion
-
Sun J, Qian Y, Hamilton AD, Sebti SM. 1995. Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion. Cancer Res. 55:4243-47
-
(1995)
Cancer Res.
, vol.55
, pp. 4243-4247
-
-
Sun, J.1
Qian, Y.2
Hamilton, A.D.3
Sebti, S.M.4
-
85
-
-
13344276587
-
Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity
-
Leftheris K, Kline T, Vite GD, Cho YH, Bhide RS, et al. 1996. Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity. J. Med. Chem. 39:224-36
-
(1996)
J. Med. Chem.
, vol.39
, pp. 224-236
-
-
Leftheris, K.1
Kline, T.2
Vite, G.D.3
Cho, Y.H.4
Bhide, R.S.5
-
86
-
-
0028603395
-
Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice
-
Kohl NE, Wilson FR, Mosser SD, Giuliani E, DeSolms SJ, et al. 1994. Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice. Proc. Natl. Acad. Sci. USA 91:9141-45
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 9141-9145
-
-
Kohl, N.E.1
Wilson, F.R.2
Mosser, S.D.3
Giuliani, E.4
DeSolms, S.J.5
-
87
-
-
0028318136
-
Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton
-
Prendergast GC, Davide JP, deSolms SJ, Giuliani EA, Graham SL, et al. 1994. Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton. Mol. Cell. Biol. 14:4193-202
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 4193-4202
-
-
Prendergast, G.C.1
Davide, J.P.2
DeSolms, S.J.3
Giuliani, E.A.4
Graham, S.L.5
-
88
-
-
0342433200
-
Characterization of prenyl groups attached to K-Ras in DLD-1 human colon carcinoma cells treated with the FPT inhibitor SCH. 44342
-
Pai JJ-K, Bishop WR, Catino J, Kirschmeier P, Whyte D. 1996. Characterization of prenyl groups attached to K-Ras in DLD-1 human colon carcinoma cells treated with the FPT inhibitor SCH. 44342. Proc. Am. Assoc. Cancer Res. 37:503
-
(1996)
Proc. Am. Assoc. Cancer Res.
, vol.37
, pp. 503
-
-
Pai, J.J.-K.1
Bishop, W.R.2
Catino, J.3
Kirschmeier, P.4
Whyte, D.5
-
89
-
-
0028835253
-
A peptidomimetic inhibitor of farnesyl: Protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines
-
Sepp-Lorenzino L, Ma Z, Rands E, Kohl NE, Gibbs JB, et al. 1995. A peptidomimetic inhibitor of farnesyl: protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res. 55:5302-9
-
(1995)
Cancer Res.
, vol.55
, pp. 5302-5309
-
-
Sepp-Lorenzino, L.1
Ma, Z.2
Rands, E.3
Kohl, N.E.4
Gibbs, J.B.5
-
90
-
-
0029154458
-
Farnesyltransferase inhibitors block the neurofibromatosis type I (NF1) malignant phenotype
-
Van N, Ricca C, Fletcher J, Glover T, Seizinger BR, et al. 1995. Farnesyltransferase inhibitors block the neurofibromatosis type I (NF1) malignant phenotype. Cancer Res. 55:3569-75
-
(1995)
Cancer Res.
, vol.55
, pp. 3569-3575
-
-
Van, N.1
Ricca, C.2
Fletcher, J.3
Glover, T.4
Seizinger, B.R.5
-
91
-
-
0022472990
-
Requirement for c-ras proteins during viral oncogene transformation
-
Smith MR, DeGudicibus SJ, Stacey DW. 1986. Requirement for c-ras proteins during viral oncogene transformation. Nature 320:540-43
-
(1986)
Nature
, vol.320
, pp. 540-543
-
-
Smith, M.R.1
Degudicibus, S.J.2
Stacey, D.W.3
-
92
-
-
0026336517
-
Dominant inhibitory Ras mutants demonstrate the requirement for Ras activity in the action of tyrosine kinase oncogenes
-
Stacey DW, Roudebush M, Day R, Mosser SD, Gibbs JB, et al. 1991. Dominant inhibitory Ras mutants demonstrate the requirement for Ras activity in the action of tyrosine kinase oncogenes. Oncogene 6:2297-304
-
(1991)
Oncogene
, vol.6
, pp. 2297-2304
-
-
Stacey, D.W.1
Roudebush, M.2
Day, R.3
Mosser, S.D.4
Gibbs, J.B.5
-
93
-
-
0028063058
-
Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells
-
James GL, Brown MS, Cobb MH, Goldstein JL. 1994. Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells. J. Biol. Chem. 269:27705-14
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 27705-27714
-
-
James, G.L.1
Brown, M.S.2
Cobb, M.H.3
Goldstein, J.L.4
-
95
-
-
0025883047
-
Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras
-
Stacey DW, Feig LA, Gibbs JB. 1991. Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras. Mol. Cell. Biol. 11:4053-64
-
(1991)
Mol. Cell. Biol.
, vol.11
, pp. 4053-4064
-
-
Stacey, D.W.1
Feig, L.A.2
Gibbs, J.B.3
-
96
-
-
0024341930
-
Mutants of H-ras that interfere with RAS effector function in Saccharomyces cerevisiae
-
Michaeli T, Field J, Ballester R, O'Neill K, Wigler M. 1989. Mutants of H-ras that interfere with RAS effector function in Saccharomyces cerevisiae. EMBO J. 8:3039-44
-
(1989)
EMBO J.
, vol.8
, pp. 3039-3044
-
-
Michaeli, T.1
Field, J.2
Ballester, R.3
O'Neill, K.4
Wigler, M.5
-
97
-
-
0030068062
-
Unfarnesylated transforming Ras mutant inhibits the Ras-signaling pathway by forming a stable Ras Raf complex in the cytosol
-
Miyake M, Mizutani S, Koide H, Kaziro Y. 1996. Unfarnesylated transforming Ras mutant inhibits the Ras-signaling pathway by forming a stable Ras Raf complex in the cytosol. FEBS Lett. 378:15-18
-
(1996)
FEBS Lett.
, vol.378
, pp. 15-18
-
-
Miyake, M.1
Mizutani, S.2
Koide, H.3
Kaziro, Y.4
-
98
-
-
0029921232
-
The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed Rat embryo fibroblasts
-
Bernhard EJ, Kao G, Cox AD, Sebti SM, Hamilton AD, et al. 1996. The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed Rat embryo fibroblasts. Cancer Res. 56:1727-30
-
(1996)
Cancer Res.
, vol.56
, pp. 1727-1730
-
-
Bernhard, E.J.1
Kao, G.2
Cox, A.D.3
Sebti, S.M.4
Hamilton, A.D.5
-
99
-
-
0028822834
-
Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis
-
Rak J, Mitsuhashi Y, Bayko L, Filmus J, Shirasawa S, et al. 1995. Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res. 55:4575-80
-
(1995)
Cancer Res.
, vol.55
, pp. 4575-4580
-
-
Rak, J.1
Mitsuhashi, Y.2
Bayko, L.3
Filmus, J.4
Shirasawa, S.5
-
100
-
-
0029877708
-
Suppression of human pancreatic cancer growth in BALB/c nude mice by manumycin, a farnesyl: Protein transferase inhibitor
-
Ito T, Kawata S, Tamura S, Igura T, Nagase T, et al. 1996. Suppression of human pancreatic cancer growth in BALB/c nude mice by manumycin, a farnesyl: protein transferase inhibitor. Jpn. J. Cancer Res. 87:113-16
-
(1996)
Jpn. J. Cancer Res.
, vol.87
, pp. 113-116
-
-
Ito, T.1
Kawata, S.2
Tamura, S.3
Igura, T.4
Nagase, T.5
-
101
-
-
0029150669
-
Inhibition of famesyltranserase induces regression of mammary and salivary carcinomas in ras transgenic mice
-
Kohl NE, Omer CA, Conner MW, Anthony NJ, Davide JP, et al. 1995. Inhibition of famesyltranserase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nat. Med. 1:792-97
-
(1995)
Nat. Med.
, vol.1
, pp. 792-797
-
-
Kohl, N.E.1
Omer, C.A.2
Conner, M.W.3
Anthony, N.J.4
Davide, J.P.5
-
102
-
-
0023631608
-
Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo
-
Sinn E, Muller W, Pattengale P, Tepler I, Wallace R, et al. 1987. Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo. Cell 49:465-75
-
(1987)
Cell
, vol.49
, pp. 465-475
-
-
Sinn, E.1
Muller, W.2
Pattengale, P.3
Tepler, I.4
Wallace, R.5
-
104
-
-
0029973389
-
Cell-cycle control and its watchman
-
Jacks T, Weinberg RA. 1996. Cell-cycle control and its watchman. Nature 381:643-716
-
(1996)
Nature
, vol.381
, pp. 643-716
-
-
Jacks, T.1
Weinberg, R.A.2
-
105
-
-
0028898579
-
Ras farnesyltranserase inhibitors suppress the phenotype resulting from an activated ras mutation in Caenorhabditis elegans
-
Hara M, Han M. 1995. Ras farnesyltranserase inhibitors suppress the phenotype resulting from an activated ras mutation in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 92:3333-37
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 3333-3337
-
-
Hara, M.1
Han, M.2
-
106
-
-
0028868945
-
Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors
-
Kauffmann RC, Qian Y, Vogt A, Sebti SM, Hamilton AD, et al. 1995. Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors. Proc. Natl. Acad. Sci. USA 92:10919-23
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 10919-10923
-
-
Kauffmann, R.C.1
Qian, Y.2
Vogt, A.3
Sebti, S.M.4
Hamilton, A.D.5
-
107
-
-
0026006719
-
Signal transduction during C. elegans vulval induction
-
Sternberg PW, Horvitz HR. 1991. Signal transduction during C. elegans vulval induction. Trends Genet. 7:366-71
-
(1991)
Trends Genet.
, vol.7
, pp. 366-371
-
-
Sternberg, P.W.1
Horvitz, H.R.2
-
108
-
-
0026015023
-
Signal transduction and the fate of the R7 photoreceptor in Drosophila
-
Rubin G. 1991. Signal transduction and the fate of the R7 photoreceptor in Drosophila. Trends Genet. 7:372-77
-
(1991)
Trends Genet.
, vol.7
, pp. 372-377
-
-
Rubin, G.1
-
109
-
-
0029584327
-
KSR, a novel protein kinase required for Ras signal transduction
-
Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA, et al. 1995. KSR, a novel protein kinase required for Ras signal transduction. Cell 83:879-88
-
(1995)
Cell
, vol.83
, pp. 879-888
-
-
Therrien, M.1
Chang, H.C.2
Solomon, N.M.3
Karim, F.D.4
Wassarman, D.A.5
-
110
-
-
0026037624
-
A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of Ras proteins
-
Hancock JF, Cadwallader K, Paterson H, Marshall CJ. 1991. A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of Ras proteins. EMBO J. 10:4033-39
-
(1991)
EMBO J.
, vol.10
, pp. 4033-4039
-
-
Hancock, J.F.1
Cadwallader, K.2
Paterson, H.3
Marshall, C.J.4
-
111
-
-
0026659959
-
Specific isoprenoid modification is required for function of normal, but not oncogeneic, Ras function
-
Cox AD, Hisaka MM, Buss JE, Der CJ. 1992. Specific isoprenoid modification is required for function of normal, but not oncogeneic, Ras function. Mol. Cell. Biol. 12:2606-15
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 2606-2615
-
-
Cox, A.D.1
Hisaka, M.M.2
Buss, J.E.3
Der, C.J.4
-
112
-
-
0028211246
-
Pseudopeptide inhibitors of Ras farnesylprotein transferase
-
Graham SL, deSolms SJ, Giuliani EA, Kohl NE, Mosser SD, et al. 1994. Pseudopeptide inhibitors of Ras farnesylprotein transferase. J. Med. Chem. 37:725-32
-
(1994)
J. Med. Chem.
, vol.37
, pp. 725-732
-
-
Graham, S.L.1
DeSolms, S.J.2
Giuliani, E.A.3
Kohl, N.E.4
Mosser, S.D.5
-
113
-
-
0027163307
-
Differential prenylation of proteins and lipid synthesis as a function of mevalonate concentration in CHO cells
-
Rilling HC, Bruenger E, Leining LM, Buss JE, Epstein WW. 1993. Differential prenylation of proteins and lipid synthesis as a function of mevalonate concentration in CHO cells. Arch. Biochem. Biophys. 301:210-15
-
(1993)
Arch. Biochem. Biophys.
, vol.301
, pp. 210-215
-
-
Rilling, H.C.1
Bruenger, E.2
Leining, L.M.3
Buss, J.E.4
Epstein, W.W.5
-
114
-
-
0342433193
-
Use of the insect-baculovirus expression system to produce lipid-modified Ras protein for electrospray mass spectrometric studies
-
Page MJ, Aitken A, Cooper DJ, Magee AI, Lowe PN. 1990. Use of the insect-baculovirus expression system to produce lipid-modified Ras protein for electrospray mass spectrometric studies. Methods 1:221-30
-
(1990)
Methods
, vol.1
, pp. 221-230
-
-
Page, M.J.1
Aitken, A.2
Cooper, D.J.3
Magee, A.I.4
Lowe, P.N.5
-
115
-
-
0026063559
-
The carboxyl-terminal domain of the RAP1A KREV-1 protein is isoprenylated and supports transformation by an H-Ras RAP1A chimeric protein
-
Buss JE, Quilliam LA, Kato K, Casey PJ, Solski PA, et al. 1991. The carboxyl-terminal domain of the RAP1A KREV-1 protein is isoprenylated and supports transformation by an H-Ras RAP1A chimeric protein. Mol. Cell. Biol. 11:1523-30
-
(1991)
Mol. Cell. Biol.
, vol.11
, pp. 1523-1530
-
-
Buss, J.E.1
Quilliam, L.A.2
Kato, K.3
Casey, P.J.4
Solski, P.A.5
-
116
-
-
0028892646
-
Evidence that farneslytransferase inhibitors suppress Ras transformation by interfering with Rho activity
-
Lebowitz PF, Davide JP, Prendergast GC. 1995. Evidence that farneslytransferase inhibitors suppress Ras transformation by interfering with Rho activity. Mol. Cell. Biol. 15:6613-22
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 6613-6622
-
-
Lebowitz, P.F.1
Davide, J.P.2
Prendergast, G.C.3
-
117
-
-
0029891796
-
The molecular chaperone Ydj1 is required for the p34CDC28-dependent phosphorylation of the cyclin Cln3 that signals its degradation
-
Yaglom JA, Goldberg AL, Finley D, Sherman MY. 1996. The molecular chaperone Ydj1 is required for the p34CDC28-dependent phosphorylation of the cyclin Cln3 that signals its degradation. Mol. Cell. Biol. 16:3679-84
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 3679-3684
-
-
Yaglom, J.A.1
Goldberg, A.L.2
Finley, D.3
Sherman, M.Y.4
-
118
-
-
0029057465
-
Critical role of Rho in cell transformation by oncogenic Ras
-
Prendergast GC, Khosravi-Far R, Solski PA, Kurzawa H, Lebowitz PF, et al. 1995. Critical role of Rho in cell transformation by oncogenic Ras. Oncogene 10:2289-96
-
(1995)
Oncogene
, vol.10
, pp. 2289-2296
-
-
Prendergast, G.C.1
Khosravi-Far, R.2
Solski, P.A.3
Kurzawa, H.4
Lebowitz, P.F.5
-
120
-
-
0029983156
-
Delivery of molecular medicine to solid tumors
-
Jain RK. 1996. Delivery of molecular medicine to solid tumors. Science 271:1079-80
-
(1996)
Science
, vol.271
, pp. 1079-1080
-
-
Jain, R.K.1
-
121
-
-
0029952467
-
Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyl transferase inhibitors
-
Prendergast GC, Davide JP, Lebowitz PF, Wechsler-Reya R, Kohl NE. 1996. Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyl transferase inhibitors. Cancer Res. 56:2626-32
-
(1996)
Cancer Res.
, vol.56
, pp. 2626-2632
-
-
Prendergast, G.C.1
Davide, J.P.2
Lebowitz, P.F.3
Wechsler-Reya, R.4
Kohl, N.E.5
-
122
-
-
0028935780
-
Protein lipidation in cell signaling
-
Casey PJ. 1995. Protein lipidation in cell signaling. Science 268:221-25
-
(1995)
Science
, vol.268
, pp. 221-225
-
-
Casey, P.J.1
-
123
-
-
0028961785
-
Properties of type II inositol polyphosphate 5-phosphatase
-
Jefferson AB, Majerus PW. 1995. Properties of type II inositol polyphosphate 5-phosphatase. J. Biol. Chem. 270:9370-77
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 9370-9377
-
-
Jefferson, A.B.1
Majerus, P.W.2
-
124
-
-
0028099724
-
Isoprenylation of brain 2′, 3′-cyclic nucleotide 3′-phosphodiesterase modulates cell morphology
-
Angelis DAD, Braun PE. 1994. Isoprenylation of brain 2′, 3′-cyclic nucleotide 3′-phosphodiesterase modulates cell morphology. J. Neurosci. Res. 39:386-97
-
(1994)
J. Neurosci. Res.
, vol.39
, pp. 386-397
-
-
Angelis, D.A.D.1
Braun, P.E.2
-
125
-
-
0029880626
-
Post-translational modification of human brain type I inositol-1,4,5-triphosphate 5-phosphatase by farnesylation
-
De Smedt F, Boom A, Pesesse X, Schiffman SN, Erneux C. 1996. Post-translational modification of human brain type I inositol-1,4,5-triphosphate 5-phosphatase by farnesylation. J. Biol. Chem. 271:10419-24
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 10419-10424
-
-
De Smedt, F.1
Boom, A.2
Pesesse, X.3
Schiffman, S.N.4
Erneux, C.5
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