CA1A2X-competitive inhibitors of farnesyltransferase as anti-cancer agents

Trends in Pharmacological Sciences

Volumn 18, Issue 11, 1997, Pages 437-445

  Omer, Charles A ^a   Kohl, Nancy E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; FARNESYL TRANS TRANSFERASE; METALLOPROTEINASE; ENZYME INHIBITOR; TRANSFERASE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; BREAST CARCINOMA; CANCER; CANCER RESEARCH; ENZYME INHIBITION; NONHUMAN; ONCOGENE H RAS; PRIORITY JOURNAL; REVIEW; ANIMAL; BINDING COMPETITION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; PROTEIN CONFORMATION;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; BINDING, COMPETITIVE; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; HUMANS; PROTEIN CONFORMATION;

EID: 0030609121     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(97)01129-2     Document Type: Article

References (76)

1. Gibbs, J. B. (1991) Cell 65, 1-4
2. Gibbs, J. B., Oliff, A. and Kohl, N. E. (1994) Cell 77, 175-178
3. Barbacid, M. (1987) Annu. Rev. Biochem. 56, 779-827
4. Bos, J. L. (1988) Mutat. Res. 195, 255-271
5. Bos, J. L. (1989) Cancer Res. 49, 4682-4689
6. Zhang, F. L. and Casey, P. J. (1996) Annu. Rev. Biochem. 65, 241-269
7. Willumsen, B. M. et al. (1984) EMBO J. 3, 2581-2585
8. Kato, K. et al. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 6403-6407
9. Jackson, J. H. et al. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 3042-3046
10. Hancock, J. F. et al. (1989) Cell 57, 1167-1177
11. Reiss, Y. et al. (1991) J. Biol. Chem. 266, 10672-10677
12. Omer, C. A. et al. (1993) Biochemistry 32, 5167-5176
13. Bukhtiyarov, Y. E., Orner, C. A. and Allen, C. M. (1995) J. Biol. Chem. 270, 19035-19040
14. Reiss, Y., Brown, M. S. and Goldstein, J. L. (1992) J. Biol. Chem. 267, 6403-6408
15. Gibbs, J. B. and Oliff, A. (1997) Annu. Rev. Pharmacol. Toxicol. 37, 143-166
16. Reiss, Y. et al. (1990) Cell 62, 81-88
17. Schaber, M. D. et al. (1990) J. Biol. Chem. 265, 14701-14704
18. James, G. L., Goldstein, J. L. and Brown, M. S. (1995) J. Biol. Chem. 270, 6221-6226
19. Moores, S. L. et al. (1991) J. Biol. Chem. 266, 14603-14610
20. James, G., Goldstein, J. L. and Brown, M. S. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 4454-4458
21. Zhang, F. L. et al. (1997) J. Biol. Chem. 272, 10232-10239
22. Rowell, C. A. et al. (1997) J. Biol. Chem. 272, 14093-14097
23. Whyte, D. B. et al. (1997) J. Biol. Chem. 272, 14459-14464
24. Graham, S. L. (1995) Expert Opin. Ther. Pat. 5, 1269-1285
25. Manne, V. et al. (1995) Drug Dev. Res. 34, 121-137
26. Ayral-Kaloustian, S. and Skotnicki, J. S. (1996) in Annual Reports in Medicinal Chemistry (Vol. 31) (Bristol, J. A., ed.), pp. 171-180, Academic Press
27. Graham, S. L. and Williams, T. M. (1996) Expert Opin. Ther. Pat. 6, 1295-1304
28. Reiss, Y. et al. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 732-736
29. Pompliano, D. L. et al. (1992) Biochemistry 31, 3800-3807
30. Goldstein, J. L. et al. (1991) J. Biol. Chem. 266, 15575-15578
31. Leftheris, K. et al. (1994) Bioorg. Med. Chem. Lett. 4, 887-892
32. Kowalczyk, J. J. et al. (1995) Bioorg. Med. Chem. Lett. 5, 3073-3078
33. Brown, M. S. et al. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 8313-8316
34. Garcia, A. M. et al. (1993) J. Biol. Chem. 268, 18415-18418
35. Graham, S. L. et al. (1994) J. Med. Chem. 37, 725-732
36. Kohl, N. E. et al. (1993) Science 260, 1934-1937
37. Kohl, N. E. et al. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 9141-9145
38. Kohl, N. E. et al. (1995) Nat. Med. 1, 792-797
39. Wai, J. S. et al. (1994) Bioorg. Med. Chem. Lett. 2, 939-947
40. Nagasu, T. et al. (1995) Cancer Res. 55, 5310-5314
41. Prendergast, G. C. et al. (1994) Mol. Cell Biol. 14, 4193-4202
42. Schafer, W. R. et al. (1990) Science 249, 1133-1139
43. Ohya, Y. et al. (1991) J. Biol. Chem. 266, 12356-12360
44. Sepp-Lorenzino, L. et al. (1995) Cancer Res. 55, 5302-5309
45. Cox, A. D. et al. (1992) Mol. Cell Biol. 12, 2606-2615
46. Sinn, E. et al. (1987) Cell 49, 465-475
47. Marsters, J. C., Jr. et al. (1994) Bioorg. Med. Chem. Lett. 2, 949-957
48. Leftheris, K. et al. (1996) J. Med. Chem. 39, 224-236
49. Byk, G. et al. (1997) Bioorg. Med. Chem. Lett. 5, 115-124
50. Hunt, J. T. et al. (1996) J. Med. Chem. 39, 353-358
51. deSolms, S. J. et al. (1995) J. Med. Chem. 38, 3967-3971
52. Williams, T. M. et al. (1996) J. Med. Chem. 39, 1345-1348
53. Stradley, S. J., Rizo, J. and Gierasch, L. M. (1993) Biochemistry 32, 12586-12590
54. Koblan, K. S. et al. (1995) Protein Science 4, 681-688
55. James, G. L. et al. (1993) Science 260, 1937-1942
56. James, G. L. et al. (1994) J. Biol. Chem. 269, 27705-27714
57. Sebti, S. M. and Hamilton, A. D. (1996) Biochem. Soc. Trans. 24, 692-699
58. Lerner, E. C. et al. (1995) J. Biol. Chem. 270, 26802-26806
59. Sun, J. et al. (1995) Cancer Res. 55, 4243-4247
60. McKenna, W. G. et al. (1990) Cancer Res. 50, 97-102
61. Bernhard, E. J. et al. (1996) Cancer Res. 56, 1727-1730
62. Bishop, W. R. et al. (1995) J. Biol. Chem. 270, 30611-30618
63. Njoroge, F. G. et al. (1996) Bioorg. Med. Chem. Lett. 6, 2977-2982
64. Mallams, A. K. et al. (1997) Bioorg. Med. Chem. Lett. 5, 93-99
65. Njoroge, F. G. et al. (1997) Bioorg. Med. Chem. Lett. 5, 101-113
66. Bhide, R. S. et al.. (1994) Bioorg. Med. Chem. Lett. 4, 2107-2112
67. Patel, D. V. et al. (1996) J. Med. Chem. 39, 4197-4210
68. Manne, V. et al. (1995) Oncogene 10, 1763-1779
69. Yan, N. et al. (1995) Cancer Res. 55, 3569-3575
70. Basu, T. N. et al. (1992) Nature 356, 713-715
71. DeClue, J. E. et al. (1992) Cell 69, 265-273
72. Shirasawa, S. et al. (1993) Science 260, 85-88
73. Plattner, R. et al. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 6665-6670
74. Murphy, C. et al. (1996) Nature 384, 427-432
75. James, G. L. et al. (1994) J. Biol. Chem. 269, 14182-14190
76. Prendergast, G. C. et al. (1996) Cancer Res. 56, 2626-2632