N-arlalkyl pseudopeptide inhibitors of farnesyltransferase

Journal of Medicinal Chemistry

Volumn 41, Issue 14, 1998, Pages 2651-2656

  DeSolms, S Jane ^a   Giuliani, Elizabeth A ^a   Graham, Samuel L ^a   Koblan, Kenneth S ^a   Kohl, Nancy E ^a   Mosser, Scott D ^a   Oliff, Allen I ^a   Pompliano, David L ^a   Rands, Elaine ^a   Scholz, Thomas H ^a   Wiscount, Catherine M ^a   Gibbs, Jackson B ^a   Smith, Robert L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 [2 (2 AMINO 3 MERCAPTOPROPYLAMINO) 3 METHYLPENTYL]NAPHTHALEN 1 YLMETHYLAMINO]ACETYLAMINO] 4 METHYLSULFANYLBUTYRIC ACID; FARNESYL TRANS TRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; UNCLASSIFIED DRUG; 2 AMINO 3 MERCAPTOPROPYLAMINO 3 METHYLPENTYL NAPHTHALEN 1 YL METHYLAMINO ACETYLAMINO 4 METHYLSULFANYLBUTYRIC ACID METHY ESTER; 2-AMINO-3-MERCAPTOPROPYLAMINO-3-METHYLPENTYL NAPHTHALEN-1-YL-METHYLAMINO ACETYLAMINO-4-METHYLSULFANYLBUTYRIC ACID METHY ESTER; ENZYME INHIBITOR; ESTER; NAPHTHALENE DERIVATIVE; OLIGOPEPTIDE; PRODRUG; PROTEIN P21; TRANSFERASE;

ARTICLE; CELL CULTURE; CELL GROWTH; CHEMICAL STRUCTURE; ENZYME INHIBITION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; ANIMAL; CELL DIVISION; CELL LINE; CELL STRAIN 3T3; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; MOLECULAR MIMICRY; MOUSE; PROTEIN PROCESSING; RAT; SYNTHESIS;

3T3 CELLS; ALKYL AND ARYL TRANSFERASES; ANIMALS; CELL DIVISION; CELL LINE, TRANSFORMED; ENZYME INHIBITORS; ESTERS; FARNESYLTRANSTRANSFERASE; MICE; MOLECULAR MIMICRY; NAPHTHALENES; OLIGOPEPTIDES; ONCOGENE PROTEIN P21(RAS); PRODRUGS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 7344260158     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9800907     Document Type: Article

References (21)

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21. manuscript in preparation.