Novel limonene phosphonate and farnesyl diphosphate analogues: Design, synthesis, and evaluation as potential protein-farnesyl transferase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 2, 1999, Pages 241-250

  Eummer, Jeffrey T ^a   Gibbs, Barbara S ^b   Zahn, Todd J ^a   Sebolt Leopold, Judith S ^b   Gibbs, Richard A ^a  

^a 619 Shapero Hall   (United States)

^b Parke Davis Pharmaceutical R ^*  (United States)

Author keywords

Antineoplastics; Antitumor compounds; Enzyme inhibitors; Phosphonic acids and derivatives; Terpenes and terpenoids

Indexed keywords

LIMONENE; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; TERPENOID;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CYCLOHEXENES; DOSE-RESPONSE RELATIONSHIP, DRUG; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, CHEMICAL; POLYISOPRENYL PHOSPHATES; TERPENES;

EID: 0033015439     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00202-8     Document Type: Article

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