Kinetics of protein farnesyltransferase: Sigmoidal vs hyperbolic behavior as a function of assay conditions

Analytical Biochemistry

Volumn 243, Issue 1, 1996, Pages 80-85

  Thissen, Julia A ^a   Casey, Patrick J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AIR FILTERS; AMINO ACIDS; GLASS FIBERS; HYPERBOLIC FUNCTIONS; MAMMALS;

CYSTEINE RESIDUES; GLASS FIBER FILTERS; LOW CONCENTRATIONS; PROTEIN FARNESYLTRANSFERASE; SCINTILLATION COUNTING; STABLE COMPLEXES; SUBSTRATE SATURATION; VACUUM FILTRATION;

PROTEINS;

PROTEIN FARNESYLTRANSFERASE;

ARTICLE; BRAIN; CATALYSIS; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SUBSTRATE COMPLEX; LIVER CYTOSOL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; REACTION ANALYSIS;

BOVINAE;

EID: 0030561369     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.1996.0484     Document Type: Article

References (18)

1. 1. Zhang, F. L., and Casey, P. J. (1996) Annu. Rev. Biochem. 65, 241-269.
2. 2. Moores, S. L., Schaber, M. D., Mosser, S. D., Rands, E., O'Hara, M. B., Garsky, V. M., Marshall, M. S., Pompliano, D. L., and Gibbs, J. B. (1991) J. Biol. Chem. 266, 14603-14610.
3. 3. Reiss, Y., Goldstein, J. L., Seabra, M. C., Casey, P. J., and Brown, M. S. (1990) Cell 62, 81-88.
4. 4. Chen, W-J., Andres, D. A., Goldstein, J. L., Russel, D. W., and Brown, M. S. (1991) Cell 66, 327-334.
5. 5. Kohl, N. E., Diehl, R. E., Schaber, M. D., Rands, E., Soderman, D. D., He, B., Moores, S. L., Pompliano, D. L., Ferro-Novick, S., Powers, S., Thomas, K. A., an Gibbs, J. B. (1991) J. Biol. Chem. 266, 18884-18888.
6. 6. Chen, W-J., Moomaw, J. F., Overton, L., Kost, T. A., and Casey, P. J. (1993) J. Biol. Chem. 268, 9675-9680.
7. 7. Reiss, Y., Brown, M. S., and Goldstein, J. L. (1992) J. Biol. Chem. 267, 6403-6408.
8. 8. Moomaw, J. F., and Casey, P. J. (1992) J. Biol. Chem. 267, 17438-17443.
9. 9. Furfine, E. S., Leban, J. J., Landavazo, A., Moomaw, J. F., and Casey, P. J. (1995) Biochemistry 34, 6857-6862.
10. 10. Pompliano, D. L., Rands, E., Schaber, M. D., Mosser, S. D., Anthony, N. J., and Gibbs, J. B. (1992) Biochemistry 31, 3800-3807.
11. 11. Pompliano, D. L., Schaber, M. D., Mosser, S.D., Omer, C. A., Shafer, J. A., and Gibbs, J. B. (1993) Biochemistry 32, 8341-8347.
12. 12. James, G. L., Goldstein, J. L., and Brown, M. S. (1995) J. Biol. Chem. 270, 6221-6226.
13. 13. Schaber, M. D., O'Hara, M. B., Garsky, V. M., Mosser, S. D., Bergstrom, J. D., Moores, S. L., Marshall, M. S., Friedman, P. A., Dixon, R. A. F., and Gibbs, J. B. (1990) J. Biol. Chem. 265, 14701-14704.
14. 14. Casey, P. J., Thissen, J. A., and Moomaw, J. F. (1991) Proc. Natl. Acad. Sci. USA 88, 8631-8635.
15. 15. Laemmli, U. K. (1970) Nature 227, 680-685.
16. 16. Simon, J. R., Adam, N. A., and Salmon, E. D. (1991) Micron. Microscopica Acta 22, 405-412.
17. 17. Bradford, M. M. (1976) Anal. Biochem. 72, 248-259.
18. 18. Manne, V., Roberts, D., Tobin, A., O'Rourke, E., Virgilio, M. D., Meyers, C., Ahmed, N., Kurz, B., Resh, M., Kung, H.-F., and Barbacid, M. (1990) Proc. Natl. Acad. Sci. USA 87, 7541-7545.