C-Terminal Modifications of Histidyl-JV-benzylglycinamides to Give Improved Inhibition of Ras Farnesyltransferase, Cellular Activity, and Anticancer Activity in Mice

Journal of Medicinal Chemistry

Volumn 40, Issue 21, 1997, Pages 3320-3322

  McNamara, Dennis J ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYL HISTIDYL N (2 (BENZYLOXYPHENYLMETHYL))GLYCINE N (2 METHYL 2 PHENYLPROPYL)AMIDE; BENZYLOXYCARBONYL-HISTIDYL-N-(2-(BENZYLOXYPHENYLMETHYL))GLYCINE N-(2-METHYL-2-PHENYLPROPYL)AMIDE; DIPEPTIDE; ENZYME INHIBITOR; P21(RAS) FARNESYL PROTEIN TRANSFERASE; P21(RAS) FARNESYL-PROTEIN TRANSFERASE; PD 152440; RAS PROTEIN; TRANSFERASE;

ANIMAL; ARTICLE; CELL CULTURE; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG SCREENING; EXPERIMENTAL NEOPLASM; METABOLISM; MOUSE; PROTEIN PROCESSING; RAT; SYNTHESIS;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; DIPEPTIDES; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; MICE; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; PROTEIN ISOPRENYLATION; RAS PROTEINS; RATS; TUMOR CELLS, CULTURED;

EID: 33646758912     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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