Solid-phase synthesis of novel inhibitors of Farnesyl Transferase

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 4, 1999, Pages 623-626

  Barber, Amelia Moreno ^a   Hardcastle, Ian R ^a   Rowlands, Martin G ^a   Nutley, Bernard P ^a   Marriott, Jonathan H ^a   Jarman, Michael ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FARNESYLOXY 5 HYDROXY 2,3,6 TRIFLUORO 4 NITROBENZENE; NITROBENZENE DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; COLON CARCINOMA; CYTOSOL; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; ENZYME MECHANISM; NONHUMAN; PANCREAS CARCINOMA; PROTEIN PROCESSING; RAT; SOLID PHASE EXTRACTION;

ALKYL AND ARYL TRANSFERASES; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE;

TRIFLUORO;

EID: 0033593920     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00043-8     Document Type: Article

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13. 3( 10 eq.) and the alcohol (20 eq.) in THF ( 1 ml) was added under an Ar and the slurry was cooled to -15°C. Then, DEAD (10 eq.) in THF (500 μl) was added dropwise over 30 minutes. The mixture was kept at -15°C for 1 hour, then shaken at r.t. for 24 hours.
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