N-arylpiperazinone inhibitors of farnesyltransferase: Discovery and biological activity [1]

Journal of Medicinal Chemistry

Volumn 42, Issue 19, 1999, Pages 3779-3784

  Williams, Theresa M ^a   Bergman, Jeffrey M ^a   Brashear, Karen ^a   Breslin, Michael J ^a   Dinsmore, Christopher J ^a   Hutchinson, John H ^a   MacTough, Suzanne C ^a   Stump, Craig A ^a   Wei, Donna D ^a   Zartman, C Blair ^a   Bogusky, Michael J ^a   Culberson, J Christopher ^a   Buser Doepner, Carolyn ^a   Davide, Joseph ^a   Greenberg, Ian B ^a   Hamilton, Kelly A ^a   Koblan, Kenneth S ^a   Kohl, Nancy E ^a   Liu, Dongming ^a   Lobell, Robert B ^a   Mosser, Scott D ^a   O'Neill, Timothy J ^a   Rands, Elaine ^a   Schaber, Michael D ^a   Wilson, Francine ^a   Senderak, Edith ^a   Motzel, Sherri L ^a   Gibbs, Jackson B ^a   Graham, Samuel L ^a   Heimbrook, David C ^a   Hartman, George D ^a   Oliff, Allen I ^a,b   Huff, Joel R ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PIPERAZINE DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR;

CANCER THERAPY; DRUG ACTIVITY; DRUG POTENCY; ENZYME BINDING; ENZYME INHIBITION; LETTER;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; HUMANS; IMIDAZOLES; MICE; MICE, NUDE; MODELS, MOLECULAR; PIPERAZINES; RATS; TUMOR CELLS, CULTURED;

EID: 0033598330     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990254z     Document Type: Letter

References (30)

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