A mutant form of human protein farnesyltransferase exhibits increased resistance to farnesyltransferase inhibitors

Journal of Biological Chemistry

Volumn 274, Issue 38, 1999, Pages 27010-27017

  Del Villar, Keith ^a   Urano, Jun ^a   Lea, Guo ^a   Tamanoi, Fuyuhiko ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR;

AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; HUMAN; PRIORITY JOURNAL; TUMOR GROWTH;

ALKYL AND ARYL TRANSFERASES; BENZAZEPINES; BINDING SITES; COMPUTER SIMULATION; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN ISOPRENYLATION; SACCHAROMYCES CEREVISIAE; TEMPERATURE; ZINC;

EID: 0033578751     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.38.27010     Document Type: Article

References (41)

1. Sattler, I., and Tamanoi, F. (1996) in Regulation of the RAS Signaling Network (Maruta, H., and Burgess, A. W., eds) pp. 95-137, R. G. Landes, Austin, TX
2. Gibbs, J. B., and Oliff, A. (1997) Annu. Rev. Pharmacol. Toxicol. 37, 143-166
3. Zhang, F. L., and Casey, P. J. (1996) Annu. Rev. Biochem. 65, 241-269
4. Cox, A. D., and Der, C. J. (1997) Biochim. Biophys. Acta 1333, F51-F71
5. Park, H. W., Boduluri, S. R., Moomaw, J. F., Casey, P. J., and Beese, L. S. (1997) Science 275, 1800-1804
6. Dunten, P., Kammlott, U., Crowther, R., Weber, D., Palermo, R., and Birktoft, J. (1998) Biochemistry 37, 7907-7912
7. Long, S. B., Casey, P. J., and Beese, L. S. (1998) Biochemistry 37, 9612-9618
8. Strickland, C. L., Windsor, W. T., Syto, R., Wang, L., Bond, R., Wu, Z., Schwarte, J., Le, H. V., Beese, L. S., and Weber, P. C. (1998) Biochemistry 37, 16601-16611
9. Huang, C.-C., Casey, P. J., and Fierke, C. A. (1997) J. Biol. Chem. 272, 20-23
10. Kral, A. M., Diehl, R. E., deSolms, S. J., Williams, T. M., Kohl, N. E., and Omer, C. A. (1997) J. Biol. Chem. 272 27319-27323
11. Kurth, D. D., Farh, L., and Besehenes, R. J. (1997) Biochemistry 36 15932-15939
12. Dolence, J. M., Rozema, D. B., and Poulter, C. D. (1997) Biochemistry 36 9246-9252
13. Caplin, B. E., Ohya, Y., and Marshall, M. S. (1998) J. Biol. Chem. 273 9472-9479
14. Mitsuzawa, H., Esson, K., and Tamanoi, F. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 1704-1708
15. Del Villar, K., Mitsuzawa, H., Yang, W., Sattler, I., and Tamanoi, F. (1997) J. Biol. Chem. 272, 680-687
16. James, G. L., Goldstein, J. L., Brown, M. S., Rawson, T. E., Somers, T. C., McDowell, R. S., Crowley, C. W., Lucas, B. K., Levinson, A. D., and Marsters, J. J. C. (1993) Science 260, 1937-1942
17. Kohl, N. E., Mosser, S. D., deSolmes, S. J., Giuliani, E. A., Pompliano, D. L., Graham, S. L., Smith, R. L., Scolnick, E. M., Oliff, A., and Gibbs, J. B. (1993) Science 260, 1934-1937
18. Cox, A. D., Garcia, A. M., Westwick, J. K., Kowalczyk, J. J., Lewis, M. D., Brenner, D. A., and Der, C. J. (1994) J. Biol. Chem. 269, 19203-19206
19. Bishop, W. R., Bond, R., Petrin, J., Wang, L., Patton, R., Doll, R., Njoroge, G., Catino, J., Schwartz, J., Windsor, W., Syto, R., Schwartz, J., Carr, D., James, L., and Kirschmeier, P. (1995) J. Biol. Chem. 270, 30611-30618
20. Suzuki, N., Del Villar, K., and Tamanoi, F. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 10499-10504
21. Lebowitz, P. F., Sakamuro, D., and Prendergast, G. C. (1997) Cancer Res. 57, 708-713
22. Barrington, R. E., Subler, M. A., Rands, E., Omer, C. A., Miller, P. J., Hundley, J. E., Koester, S. K. Troyer, D. A., Bearss, D. J., Conner, M. W., Gibbs, J. B., Hamilton, K., Koblan, K. S., Mosser, S. D., O'Neill, T. J., Schaber, M. D., Senderak, E. T., Windle, J. J., Oliff, A., and Kohl, N. E. (1998) Mol. Cell. Biol. 18, 85-92
23. Suzuki, N., Urano, J., and Tamanoi, F. (1998) Proc. Natl. Acad. Sci. U. S. A. 96, 15356-15361
24. Sepp-Lorenzino, L., Ma, Z., Rands, E., Kohl, N. E., Gibbs, J. B., Oliff, A., and Rosen, N. (1995) Cancer Res. 55, 5302-5309
25. Kohl, N. E., Wilson, F. R., Mosser, S. D., Giuliani, E., deSolms, S. J., Conner, M. W., Anthony, N. J., Holtz, W. J., Gomez, R. P., Lee, T.-J., Smith, R. L., Graham, S. L., Hartmen, G. D., Gibbs, J. B., and Oliff, A. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 9141-9145
26. Kohl, N. E., Omer, C. A., Conner, M. W., Anthony, N. J., Davide, J. P., deSolms, S. J., Giuliani, E. A., Gomez, R. P., Graham, S. L., Hamilton, K, Handt, L. K., Hartman, G. D., Koblan, K. S., Kral, A. M., Miller, P. J., Mosser, S. D., O'Neill, T. J., Rands, E., Schaber, M. D., Gibbs, J. B., and Oliff, A. (1995) Nat. Med. 1, 792-797
27. Sun, J., Qian, Y., Hamilton, A. D., and Sebti, S. (1995) Cancer Res. 55, 4243-4247
28. Barinaga, M. (1997) Science 278, 1036-1039
29. Prendergast, G. C., Davide, J. P., deSolms, S. J., Giuliani, E. A., Graham, S. L., Gibbs, J. B., Oliff, A., and Kohl, N. E. (1994) Mol. Cell. Biol. 14, 4193-4202
30. Vogt, A., Sun, J., Qian, Y., Hamilton, A. D., and Sebti, S. M. (1997) J. Biol. Chem. 272, 27224-27229
31. Whyte, D. B., Kirschmeier, P., Hockenberry, T. N., Nunez-Oliva, I., James, L., Catino, J. J., Bishop, W. R., and Pai, J. K. (1997) J. Biol. Chem. 272, 14459-14464
32. Nagasu, T., Yoshimatsu, K., Rowell, C., Lewis, M. D., and Garcia, A. M. (1995) Cancer Res. 55, 5310-5314
33. Hunt, J. T., Lee, V. G., Leftheris, K., Seizinger, B., Carboni, J., Mabus, J., Ricca, C., Yan, N., and Manne, V. (1996) J. Med. Chem. 39, 353-358
34. Gibbs, J. B., Pompliano, D. L., Mosser, S. D., Rands, E., Lingham, R. B., Singh, S. B., Scolnick, E. M., Kohl, N. E., and Oliff, A. (1993) J. Biol. Chem. 268, 7617-7620
35. Hara, M., Akasaka, K., Akinaga, S., Okabe, M., Nakano, H., Gomez, R., Wood, D., Uh, M., and Tamanoi, F. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 2281-2285
36. Fujita, M., Otsuka, M., and Sugiura, Y. (1996) J. Med. Chem. 39, 503-507
37. Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., and Pease, L. R. (1989) Gene (Amst.) 77, 51-59
38. Finegold, A. A., Johnson, D. I., Farnsworth, C. C., Gelb, M. H., Judd, S. R., Glomset, J. A., and Tamanoi, F. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 4448-4452
39. Sherman, F. (1991) Methods Enzymol. 194, 3-21
40. Gietz, D., St. Jean, A., Woods, R. A., and Schiestl, R. H. (1992) Nucleic Acids Res. 20, 1425
41. Otsuka, M., Fujita, M., Sugiura, Y., Yamamoto, T., Inoue, J., Maekawa, T., and Ishii, S. (1997) Bioorg. Med. Chem. 5, 205-215