Substrate binding is required for release of product from mammalian protein farnesyltransferase

Journal of Biological Chemistry

Volumn 272, Issue 15, 1997, Pages 9989-9993

  Tschantz, William R ^a   Furfine, Eric S ^b   Casey, Patrick J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN FARNESYLTRANSFERASE;

ANIMAL CELL; ARTICLE; BINDING KINETICS; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; NONHUMAN; PRIORITY JOURNAL; RAT;

ALKYL AND ARYL TRANSFERASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DITHIOTHREITOL; KINETICS; LIPOPROTEINS; MODELS, MOLECULAR; POLYISOPRENYL PHOSPHATES; PROTEIN ISOPRENYLATION; RAS PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFERASES;

ANIMALIA; MAMMALIA;

EID: 0030999833     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.15.9989     Document Type: Article

References (34)

1. Clarke, S. (1992) Annu. Rev. Biochem. 61, 355-386
2. Zhang, F. L., and Casey, P. J. (1996) Annu. Rev. Biochem. 65, 241-269
3. Glomset, J. A., and Farnsworth, C. C. (1994) Annu. Rev. Cell Biol. 10, 181-205
4. Gibbs, J. B., Oliff, A., and Kohl, N. E. (1994) Cell 77, 175-178
5. Kohl, N. E., Mosser, S. D., deSolms, S. J., Giuliani, E. A., Pompliano, D. L., Graham, S. L., Smith, R. L., Scolnick, E. M., Oliff, A., and Gibbs, J. B. (1993) Science 260, 1934-1937
6. James, G. L., Goldstein, J. L., Brown, M. S., Rawson, T. E., Somers, T. C., McDowell, R. S., Crowley, C. W., Lucas, B. K., Levinson, A. D., and Marsters, J. C., Jr. (1993) Science 260, 1937-1942
7. Kohl, N. E., Omer, C. A., Conner, M. W., Anthony, N. J., Davide, J. P., deSolms, S. J., Giuliani, E. A., Gomez, R. P., Graham, S. L., Hamilton, K., Handt, L. K., Hartman, G. D., Koblan, K. S., Kral, A. M., Miller, P. J., Mosser, S. D., O'Neill, T. J., Rands, E., Schaber, M. D., Gibbs, J. B., and Oliff, A. (1995) Nat. Med. 1, 792-797
8. Reiss, Y., Goldstein, J. L., Seabra, M. C., Casey, P. J., and Brown, M. S. (1990) Cell 62, 81-88
9. Moores, S. L., Schaber, M. D., Mosser, S. D., Rands, E., O'Hara, M. B., Garsky, V. M., Marshall, M. S., Pompliano, D. L., and Gibbs, J. B. (1991) J. Biol. Chem. 266, 14603-14610
10. Chen, W.-J., Andres, D. A., Goldstein, J. L., Russell, D. W., and Brown, M. S. (1991) Cell 66, 327-334
11. Chen, W.-J., Andres, D. A., Goldstein, J. L., and Brown, M. S. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 11368-11372
12. Kohl, N. E., Diehl, R. E., Schaber, M. D., Rands, E., Soderman, D. D., He, B., Moores, S. L., Pompliano, D. L., Ferro-Novick, S., Powers, S., Thomas, K. A., and Gibbs, J. B. (1991) J. Biol. Chem. 266, 18884-18888
13. Chen, W.-J., Moomaw, J. F., Overton, L., Kost, T. A., and Casey, P. J. (1993) J. Biol. Chem. 268, 9675-9680
14. Omer, C. A., Kral, A. M., Diehl, R. E., Prendergast, G. C., Powers, S., Allen, C. M., Gibbs, J. B., and Kohl, N. E. (1993) Biochemistry 32, 5167-5176
15. Ying, W., Sepp-Lorenzino, L., Cai, K., Aloise, P., and Coleman, P. S. (1994) J. Biol. Chem. 269, 470-477
16. Reiss, Y., Brown, M. S., and Goldstein, J. L. (1992) J. Biol. Chem. 267, 6403-6408
17. Bukhtiyarov, Y. E., Omer, C. A., and Allen, C. M. (1995) J. Biol. Chem. 270, 19035-19040
18. Pellicena, P., Scholten, J. D., Zimmerman, K., Creswell, M., Huang, C. C., and Miller, W. T. (1996) Biochemistry 35, 13494-13500
19. Huang, C.-C., Casey, P. J., and Fierke, C. A. (1997) J. Biol. Chem. 272, 20-23
20. Pompliano, D. L., Rands, E., Schaber, M. D., Mosser, S. D., Anthony, N. J., and Gibbs, J. B. (1992) Biochemistry 31, 3800-3807
21. Reiss, Y., Seabra, M. C., Armstrong, S. A., Slaughter, C. A., Goldstein, J. L., and Brown, M. S. (1991) J. Biol. Chem. 266, 10672-10677
22. Furfine, E. S., Leban, J. J., Landavazo, A., Moomaw, J. F., and Casey, P. J. (1995) Biochemistry 34, 6857-6862
23. Pompliano, D. L., Schaber, M. D., Mosser, S. D., Omer, C. A., Shafer, J. A., and Gibbs, J. B. (1993) Biochemistry 32, 8341-8347
24. Thissen, J. A., and Casey, P. J. (1993) J. Biol. Chem. 268, 13780-13783
25. James, G. L., Goldstein, J. L., and Brown, M. S. (1995) J. Biol. Chem. 270, 6221-6226
26. Brown, M. J., Milano, P. D., Lever, D. C., Epstein, W. W., and Poulter, C. D. (1991) J. Am. Chem. Soc. 113, 3176-3177
27. Northup, J. K., Sternweis, P. C., Smigel, M. D., Schleifer, L. S., Ross, E. M., and Gilman, A. G. (1980) Proc. Natl. Acad. Sci. U. S. A. 77, 6516-6520
28. Hummel, J. P., and Dreyer, W. J. (1962) Biochim. Biophys. Acta 63, 530-532
29. Penefsky, H. S. (1979) Methods Enzymol. 56, 527-530
30. Zhang, F. L., and Casey, P. J. (1996) Biochem. J. 320, 925-932
31. Fu, H.-W., Moomaw, J. F., Moomaw, C. R., and Casey, P. J. (1996) J. Biol. Chem. 271, 28541-28548
32. Seabra, M. C. (1996) J. Biol. Chem. 271, 14398-14404
33. Casey, P. J., and Seabra, M. C. (1996) J. Biol. Chem. 271, 5289-5292
34. Rando, R. R. (1996) Biochim. Biophys. Acta 1300, 5-16