Kinetic analysis of zinc ligand mutants of mammalian protein farnesyltransferase

Biochemistry

Volumn 37, Issue 13, 1998, Pages 4465-4472

  Fu, Hua Wen ^a   Beese, Lorena S ^a   Casey, Patrick J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; METAL ION; MUTANT PROTEIN; PROTEIN FARNESYLTRANSFERASE; SQUALENE SYNTHASE; ZINC;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME MECHANISM; LIGAND BINDING; MAMMAL; METAL BINDING; NONHUMAN; PRENYLATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ASPARAGINE; CATALYSIS; ESCHERICHIA COLI; FARNESYLTRANSTRANSFERASE; HISTIDINE; KINETICS; LIGANDS; MUTAGENESIS, SITE-DIRECTED; MUTATION; RATS; RECOMBINANT PROTEINS; ZINC;

MAMMALIA;

EID: 0000854040     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi972511c     Document Type: Article

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