Synthesis of triphosphonated analogues of farnesyl pyrophosphate. Inhibitors of squalene synthase and protein:farnesyl transferase

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 18, 1997, Pages 2435-2440

  Overhand, Mark ^a   Pieterman, Elsbet ^b   Cohen, Louis H ^b   Valentijn, A Rob P M ^a   Van Der Marel, Gijs A ^a   Van Boom, Jacques H ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b TNO   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; SQUALENE SYNTHASE;

ARTICLE; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOCHEMISTRY;

EID: 0030796309     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00448-4     Document Type: Article

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32. p-p 2.3 Hz).
33. The other difarnesylated product proved to be a regioisomer of compound 6 which was obtained as mixture of 4 diastereoisomers in 10 % yield.
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37. 2O at 0 °C.
38. The in vitro assays were performed according to ref. 8c.