Clavaric acid and steroidal analogues as Ras- and FPP-directed inhibitors of human farnesyl-protein transferase

Journal of Medicinal Chemistry

Volumn 41, Issue 23, 1998, Pages 4492-4501

  Lingham, Russell B ^a   Silverman, Keith C ^a   Jayasuriya, Hiranthi ^a   Kim, B Moon ^a   Amo, Suzanne E ^a   Wilson, Francine R ^a   Rew, Deborah J ^a   Schaber, Michael D ^a   Bergstrom, James D ^a   Koblan, Kenneth S ^a   Graham, Samuel L ^a   Kohl, Nancy E ^a   Gibbs, Jackson B ^a   Singh, Sheo B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

24,25 DIHYDROXY 2 (3 HYDROXY 3 METHYLGLUTARYL)LANOSTAN 3 ONE; CLAVARIC ACID; MEVINOLIN; PROTEIN FARNESYLTRANSFERASE; STEROID; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CELL TRANSFORMATION; CHOLESTEROL SYNTHESIS; COMPETITIVE INHIBITION; CYTOTOXICITY; DRUG ISOLATION; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; ENZYME INHIBITION; FUNGUS GROWTH; HYDROLYSIS; NONHUMAN; ONCOGENE RAS; SIGNAL TRANSDUCTION;

EID: 15444352578     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980356+     Document Type: Article

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