Selection of potent inhibitors of farnesyl-protein transferase from a synthetic tetrapeptide combinatorial library

Journal of Biological Chemistry

Volumn 271, Issue 49, 1996, Pages 31306-31311

  Wallace, Andrew ^a,c   Koblan, Kenneth S ^b   Hamilton, Kelly ^b   Marquis Omer, Dorothy J ^b   Miller, Patricia J ^b   Mosser, Scott D ^b   Omer, Charles A ^b   Schaber, Michael D ^b   Cortese, Riccardo ^a   Oliff, Allen ^b   Gibbs, Jackson B ^b   Pessi, Antonello ^a  

^a IRBM   (Italy)

^b MERCK RESEARCH LABORATORIES   (United States)

^c QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DEXTRO TRYPTOPHAN DEXTRO METHIONINE DEXTRO 4 CHLOROPHENYLALANINE LEVO GAMMA CARBOXYGLUTAMIC ACID; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SELECTIVITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL;

ALKYL AND ARYL TRANSFERASES; ANTINEOPLASTIC AGENTS; CIRCULAR DICHROISM; GENE LIBRARY; OLIGOPEPTIDES; TRANSFERASES;

ESCHERICHIA COLI;

EID: 10544220839     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.49.31306     Document Type: Article

References (26)

1. Gibbs, J. B. (1991) Cell 65, 1-4
2. Gibbs, J. B., Oliff, A., and Kohl, N. E. (1994) Cell 77, 175-178
3. Hamilton, A. D., and Sebti, S. M. (1995) Drug News Perspect. 8, 138-145
4. Glomset, J. A., and Farnsworth, C. C. (1994) Anna. Rev. Cell Biol. 10, 181-205
5. Casey, P. J., and Seabra, M. C. (1996) J. Biol. Chem. 271, 5289-5292
6. Garcia, A. M., Rowell, C., Ackermann, K., Kowalczyk, J. J., and Lewis, M. D. (1993) J. Biol. Chem. 268, 18415-18418
7. Kohl, N. E., Mosser, S. D., deSolms, S. J., Giuliani, E. A., Pompliano, D. L., Graham, S. L., Smith, R. L., Scolnick, E. M., Oliff, A., and Gibbs, J. B. (1993) Science 260, 1934-1937
8. James, G. L., Goldstein, J. L., Brown, M. S., Rawson, T. E., Somers, T. C., McDowell, R. S., Crowley, C. W., Lucas, B. K., Levinson, A. D., and Marsters, J. C. (1993) Science 260, 1937-1942
9. Nigam, M., Seong, C.-M., Quian, Y., Hamilton, A. D., and Sebti, S. M. (1993) J. Biol. Chem. 268, 20695-20698
10. Tamanoi, F. (1993) Trends Biochem. Sci. 18, 349-353
11. Gallop, M. A., Barrett, R. W., Dower, W. J., Fodor, S. P. A., and Gordon, E. M. (1994) J. Med. Chem. 37, 1233-1251
12. Dooley, C. T., Chung, N. N., Schiller, P. W., and Houghten, R. A. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 10811-10815
13. Houghten, R. A., Pinilla, C., Blondelle, S. E., Appel, J. R., Dooley, C. T., and Cuervo, J. H. (1991) Nature 354, 82-84
14. Wallace, A., Altamura, S., Toniatti, C., Vitelli, A., Bianchi, E., Delmastro, P., Ciliberto, G., and Pessi, A. (1994) Pept. Res. 7, 27-31
15. Bianchi, E., Folgori, A., Wallace, A., Nicotra, M., Acali, S., Phalipon, A., Barbato, G., Bazzo, R., Cortese, R., Felici, F., and Pessi, A. (1995) J. Mol. Biol. 247, 154-160
16. Omer, C. A., Diehl, R. E., and Kral, A. M. (1995) Methods Enzymol. 250, 3-12
17. Pompliano, D. L., Rands, E., Schaber, M. D., Mosser, S. D., Anthony, N. J., and Gibbs, J. B. (1992) Biochemistry 31, 3800-3807
18. Pinilla, C., Appel, J. R., Blanc, P., and Houghten, R. A. (1992) BioTechniques 13, 901-905
19. Eichler, J., and Houghten, R. A. (1993) Biochemistry 32, 11035-11041
20. Pinilla, C., Appel, J. R., and Houghten, R. A. (1994) Biochem. J. 301, 847-853
21. Furka, A., Sebestyen, F., Asgedom, M., and Dibo, G. (1991) Int. J. Pept. Protein Res. 37, 487-493
22. Lam, K., Salmon, S. E., Hersh, E. M., Hruby, V. J., Kazmiersky, W. M., and Knapp, R. J. (1991) Nature 354, 82-89
23. Pompliano, D. L., Schaber, M. D., Mosser, S. D., Omer, C. A., Shafer, J. A., and Gibbs, J. B. (1993) Biochemistry 32, 8341-8347
24. Furfine, E. S., Leban, J. J., Landavazo, A., Moomaw, J. F., and Casey, P. J. (1995) Biochemistry 34, 6857-6862
25. Dolence, J. M., Cassidy, P. B., Mathis, J. R., and Poulter, C. D. (1995) Biochemistry 34, 16687-16694
26. Singh, S. B., Zink, D. L., Liesch, J. M., Goetz, M. A., Jenkins, R. G., Nallin-Omstead, M., Silverman, K. C., Bills, G. F., Mosley, R. T., Gibbs, J. B., Albers-Schonberg, G., and Lingham, R. B. (1993) Tetrahedron 49, 5917-5926