Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 9, 1996, Pages 4454-4458

  James, Guy ^a   Goldstein, Joseph L ^a   Brown, Michael S ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Benzodiazepine 5B; Geranylgeranyl transferase I; L 739,749; Protein prenylation; Transformed cells

Indexed keywords

BENZODIAZEPINE DERIVATIVE; BZA 5B; ENZYME INHIBITOR; FARNESYL TRANS TRANSFERASE; HYBRID PROTEIN; MEVALONIC ACID; N [2 [2 (2 AMINO 3 MERCAPTOPROPYLAMINO) 3 METHYLPENTYLOXY] 3 PHENYLPROPIONYL]METHIONINE SULFONE METHYL ESTER; OLIGOPEPTIDE; RAS PROTEIN; TRANSFERASE; PROTEIN FARNESYLTRANSFERASE;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL LINE; CELL TRANSFORMATION; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSFECTION; METABOLISM; PROTEIN PROCESSING; RAT; AMINO TERMINAL SEQUENCE; ANIMAL CELL; CHIMERA; COMPETITIVE INHIBITION; ENZYME INHIBITION; GROWTH INHIBITION; NONHUMAN; ONCOGENE K RAS; PRENYLATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MODIFICATION;

ALKYL AND ARYL TRANSFERASES; ANIMALS; BENZODIAZEPINES; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; MEVALONIC ACID; OLIGOPEPTIDES; PROTEIN ISOPRENYLATION; RAS PROTEINS; RATS; RECOMBINANT FUSION PROTEINS; TRANSFECTION; TRANSFERASES;

EID: 0029664317     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.9.4454     Document Type: Article

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