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Volumn 1423, Issue 3, 1999, Pages

Farnesyltransferase inhibitors: Targeting the molecular basis of cancer

Author keywords

Cancer; D rug; Farnesyltransferase; Geranylgeranyltransferase; Inhibitor; Oncogene; Ras; Therapy

Indexed keywords

DIMETHYLALLYLTRANSFERASE; FARNESYL TRANS TRANSFERASE; GERANYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN;

EID: 0033620684     PISSN: 0304419X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-419X(99)00007-4     Document Type: Article
Times cited : (136)

References (63)
  • 2
    • 0028097472 scopus 로고
    • Pharmaceutical research in molecular oncology
    • J.B. Gibbs, A. Oliff, Pharmaceutical research in molecular oncology, Cell 79 (1994) 193-198.
    • (1994) Cell , vol.79 , pp. 193-198
    • Gibbs, J.B.1    Oliff, A.2
  • 3
    • 0025838675 scopus 로고
    • Regulators and effectors of ras proteins
    • G. Bollag, F. McCormick, Regulators and effectors of ras proteins, Annu. Rev. Cell Biol. 7 (1991) 601-632.
    • (1991) Annu. Rev. Cell Biol. , vol.7 , pp. 601-632
    • Bollag, G.1    McCormick, F.2
  • 5
    • 0002457485 scopus 로고
    • Ras proto-oncogene activation in human malignancy
    • C.T. Garret and S. Sell (Eds.), Hummana, Totowa, NJ
    • G.J. Clark and C.J. Der, ras proto-oncogene activation in human malignancy, in: C.T. Garret and S. Sell (Eds.), Cellular Cancer Markers, Hummana, Totowa, NJ, 1995, pp. 17-52.
    • (1995) Cellular Cancer Markers , pp. 17-52
    • Clark, G.J.1    Der, C.J.2
  • 6
    • 0023631608 scopus 로고
    • Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo
    • E. Sinn, W. Muller, P. Pattengale, I. Tepler, R. Wallace, P. Leder, Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo, Cell 49 (1987) 465-475.
    • (1987) Cell , vol.49 , pp. 465-475
    • Sinn, E.1    Muller, W.2    Pattengale, P.3    Tepler, I.4    Wallace, R.5    Leder, P.6
  • 7
    • 0025188145 scopus 로고
    • Tumorigenesis and male sterility in transgenic mice expressing a MMTV/N-ras oncogene
    • R. Mangues, I. Seidman, A. Pellicer, J.W. Gordon, Tumorigenesis and male sterility in transgenic mice expressing a MMTV/N-ras oncogene, Oncogene 5 (1990) 1491-1497.
    • (1990) Oncogene , vol.5 , pp. 1491-1497
    • Mangues, R.1    Seidman, I.2    Pellicer, A.3    Gordon, J.W.4
  • 8
    • 0019193408 scopus 로고
    • Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus
    • T.Y. Shih, A.G. Papageorge, P.E. Stokes, M.O. Weeks, E.M. Scolnick, Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus, Nature 287 (1980) 686-691.
    • (1980) Nature , vol.287 , pp. 686-691
    • Shih, T.Y.1    Papageorge, A.G.2    Stokes, P.E.3    Weeks, M.O.4    Scolnick, E.M.5
  • 11
    • 0030962347 scopus 로고    scopus 로고
    • The potential of farnesyltransferase inhibitors as cancer therapeutics
    • J.B. Gibbs, A. Oliff, The potential of farnesyltransferase inhibitors as cancer therapeutics, Annu. Rev. Pharmacol. Toxicol. 37 (1997) 143-166.
    • (1997) Annu. Rev. Pharmacol. Toxicol. , vol.37 , pp. 143-166
    • Gibbs, J.B.1    Oliff, A.2
  • 12
    • 0030749458 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors and cancer treatment: Targeting simply Ras?
    • A.D. Cox, C.J. Der, Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?, Biochim. Biophys. Acta 1333 (1997) F51-71.
    • (1997) Biochim. Biophys. Acta , vol.1333 , pp. 51-71
    • Cox, A.D.1    Der, C.J.2
  • 13
    • 0018875887 scopus 로고
    • Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry
    • M.C. Willingham, I. Pastan, T.Y. Shih, E.M. Scolnick, Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry, Cell 19 (1980) 1005-1014.
    • (1980) Cell , vol.19 , pp. 1005-1014
    • Willingham, M.C.1    Pastan, I.2    Shih, T.Y.3    Scolnick, E.M.4
  • 14
    • 0021528719 scopus 로고
    • Harvey murine sarcoma virus p21 ras protein: Biological and biochemical significance of the cysteine nearest the carboxy terminus
    • B.M. Willumsen, K. Norris, A.G. Papageorge, N.L. Hubbert, D.R. Lowy, Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus, EMBO J. 3 (1984) 2581-2585.
    • (1984) EMBO J. , vol.3 , pp. 2581-2585
    • Willumsen, B.M.1    Norris, K.2    Papageorge, A.G.3    Hubbert, N.L.4    Lowy, D.R.5
  • 15
    • 0026747866 scopus 로고
    • Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity
    • K. Kato, A.D. Cox, M.M. Hisaka, S.M. Graham, J.E. Buss, C.J. Der, Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity, Proc. Natl. Acad. Sci. USA 89 (1992) 6403-6407.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 6403-6407
    • Kato, K.1    Cox, A.D.2    Hisaka, M.M.3    Graham, S.M.4    Buss, J.E.5    Der, C.J.6
  • 16
    • 0025194466 scopus 로고
    • Inhibition of purified p21ras farnesyl:Protein transferase by Cys-AAX tetrapeptides
    • Y. Reiss, J.L. Goldstein, M.C. Seabra, P.J. Casey, M.S. Brown, Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides, Cell 62 (1990) 81-88.
    • (1990) Cell , vol.62 , pp. 81-88
    • Reiss, Y.1    Goldstein, J.L.2    Seabra, M.C.3    Casey, P.J.4    Brown, M.S.5
  • 18
    • 0025871919 scopus 로고
    • cDNA cloning and expression of the peptide-binding beta subunit of rat p21ras farnesyltransferase, the counterpart of yeast DPR1/RAM1
    • W.J. Chen, D.A. Andres, J.L. Goldstein, D.W. Russell, M.S. Brown, cDNA cloning and expression of the peptide-binding beta subunit of rat p21ras farnesyltransferase, the counterpart of yeast DPR1/RAM1, Cell 66 (1991) 327-341.
    • (1991) Cell , vol.66 , pp. 327-341
    • Chen, W.J.1    Andres, D.A.2    Goldstein, J.L.3    Russell, D.W.4    Brown, M.S.5
  • 19
    • 0027289625 scopus 로고
    • Characterization of recombinant human farnesyl-protein transferase: Cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases
    • C.A. Omer, A.M. Kral, R.E. Diehl, G.C. Prendergast, S. Powers, C.M. Allen, J.B. Gibbs, N.E. Kohl, Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases, Biochemistry 32 (1993) 5167-5176.
    • (1993) Biochemistry , vol.32 , pp. 5167-5176
    • Omer, C.A.1    Kral, A.M.2    Diehl, R.E.3    Prendergast, G.C.4    Powers, S.5    Allen, C.M.6    Gibbs, J.B.7    Kohl, N.E.8
  • 21
    • 0029664317 scopus 로고    scopus 로고
    • Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells
    • G. James, J.L. Goldstein, M.S. Brown, Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells, Proc. Natl. Acad. Sci. USA 93 (1996) 4454-4458.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4454-4458
    • James, G.1    Goldstein, J.L.2    Brown, M.S.3
  • 23
    • 0030943198 scopus 로고    scopus 로고
    • Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I
    • F.L. Zhang, P. Kirschmeier, D. Carr, L. James, R.W. Bond, L. Wang, R. Patton, W.T. Windsor, R. Syto, R. Zhang, W.R. Bishop, Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I, J. Biol. Chem. 272 (1997) 10232-10239.
    • (1997) J. Biol. Chem. , vol.272 , pp. 10232-10239
    • Zhang, F.L.1    Kirschmeier, P.2    Carr, D.3    James, L.4    Bond, R.W.5    Wang, L.6    Patton, R.7    Windsor, W.T.8    Syto, R.9    Zhang, R.10    Bishop, W.R.11
  • 24
    • 0032546264 scopus 로고    scopus 로고
    • Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts
    • J. Sun, Y. Qian, A.D. Hamilton, S.M. Sebti, Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts, Oncogene 16 (1998) 1467-1473.
    • (1998) Oncogene , vol.16 , pp. 1467-1473
    • Sun, J.1    Qian, Y.2    Hamilton, A.D.3    Sebti, S.M.4
  • 25
    • 0026659959 scopus 로고
    • Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein
    • A.D. Cox, M.M. Hisaka, J.E. Buss, C.J. Der, Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein, Mol. Cell Biol. 12 (1992) 2606-2615.
    • (1992) Mol. Cell Biol. , vol.12 , pp. 2606-2615
    • Cox, A.D.1    Hisaka, M.M.2    Buss, J.E.3    Der, C.J.4
  • 26
    • 0344768003 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors: Agents for the treatment of human cancer
    • R.G. Landes
    • K.S. Koblan and N.E. Kohl, Farnesyltransferase inhibitors: agents for the treatment of human cancer, in: G Proteins, Cytoskeleton and Cancer, R.G. Landes, 1998.
    • (1998) G Proteins, Cytoskeleton and Cancer
    • Koblan, K.S.1    Kohl, N.E.2
  • 27
    • 0030733653 scopus 로고    scopus 로고
    • Inhibition of growth and invasive activity of human pancreatic cancer cells by a farnesyltransferase inhibitor, manumycin
    • O. Kainuma, T. Asano, M. Hasegawa, T. Kenmochi, T. Nakagohri, Y. Tokoro, K. Isono, Inhibition of growth and invasive activity of human pancreatic cancer cells by a farnesyltransferase inhibitor, manumycin, Pancreas 15 (1997) 379-383.
    • (1997) Pancreas , vol.15 , pp. 379-383
    • Kainuma, O.1    Asano, T.2    Hasegawa, M.3    Kenmochi, T.4    Nakagohri, T.5    Tokoro, Y.6    Isono, K.7
  • 31
    • 0029586503 scopus 로고
    • Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells
    • W.R. Bishop, R. Bond, J. Petrin, L. Wang, R. Patton, R. Doll, G. Njoroge, J. Catino, J. Schwartz, W. Windsor et al., Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells, J. Biol. Chem. 270 (1995) 30611-30618.
    • (1995) J. Biol. Chem. , vol.270 , pp. 30611-30618
    • Bishop, W.R.1    Bond, R.2    Petrin, J.3    Wang, L.4    Patton, R.5    Doll, R.6    Njoroge, G.7    Catino, J.8    Schwartz, J.9    Windsor, W.10
  • 36
    • 0030909826 scopus 로고    scopus 로고
    • Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution
    • H.W. Park, S.R. Boduluri, J.F. Moomaw, P.J. Casey, L.S. Beese, Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution, Science 275 (1997) 1800-1804.
    • (1997) Science , vol.275 , pp. 1800-1804
    • Park, H.W.1    Boduluri, S.R.2    Moomaw, J.F.3    Casey, P.J.4    Beese, L.S.5
  • 37
    • 0032474284 scopus 로고    scopus 로고
    • Protein farnesyltransferase: Structure and implications for substrate binding
    • P. Dunten, U. Kammlott, R. Crowther, D. Weber, R. Palermo, J. Birktoft, Protein farnesyltransferase: structure and implications for substrate binding, Biochemistry. 37 (1998) 7907-7912.
    • (1998) Biochemistry , vol.37 , pp. 7907-7912
    • Dunten, P.1    Kammlott, U.2    Crowther, R.3    Weber, D.4    Palermo, R.5    Birktoft, J.6
  • 38
    • 0032493317 scopus 로고    scopus 로고
    • Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate
    • S.B. Long, P.J. Casey, L.S. Beese, Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate, Biochemistry. 37 (1998) 9612-9618.
    • (1998) Biochemistry , vol.37 , pp. 9612-9618
    • Long, S.B.1    Casey, P.J.2    Beese, L.S.3
  • 41
    • 0027998986 scopus 로고
    • The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation
    • A.D. Cox, A.M. Garcia, J.K. Westwick, J.J. Kowalczyk, M.D. Lewis, D.A. Brenner, C.J. Der, The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation, J. Biol. Chem. 269 (1994) 19203-19206.
    • (1994) J. Biol. Chem. , vol.269 , pp. 19203-19206
    • Cox, A.D.1    Garcia, A.M.2    Westwick, J.K.3    Kowalczyk, J.J.4    Lewis, M.D.5    Brenner, D.A.6    Der, C.J.7
  • 42
    • 0028318136 scopus 로고
    • Farnesyl transferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton
    • G.C. Prendergast, J.P. Davide, S.J. deSolms, E.A. Giuliani, S.L. Graham, J.B. Gibbs, A. Oliff, N.E. Kohl, Farnesyl transferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton, Mol. Cell. Biol. 14 (1994) 4193-4202.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4193-4202
    • Prendergast, G.C.1    Davide, J.P.2    DeSolms, S.J.3    Giuliani, E.A.4    Graham, S.L.5    Gibbs, J.B.6    Oliff, A.7    Kohl, N.E.8
  • 43
    • 0028892646 scopus 로고
    • Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity
    • P.F. Lebowitz, J.P. Davide, G.C. Prendergast, Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity, Mol. Cell Biol. 15 (1995) 6613-6622.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 6613-6622
    • Lebowitz, P.F.1    Davide, J.P.2    Prendergast, G.C.3
  • 44
    • 0028835253 scopus 로고
    • A peptidomimetic inhibitor of farnesyl:Protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines
    • L. Sepp-Lorenzino, Z. Ma, E. Rands, N.E. Kohl, J.B. Gibbs, A. Oliff, N. Rosen, A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines, Cancer Res. 55 (1995) 5302-5309.
    • (1995) Cancer Res. , vol.55 , pp. 5302-5309
    • Sepp-Lorenzino, L.1    Ma, Z.2    Rands, E.3    Kohl, N.E.4    Gibbs, J.B.5    Oliff, A.6    Rosen, N.7
  • 45
    • 0031004491 scopus 로고    scopus 로고
    • GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells
    • K. Miquel, A. Pradines, J. Sun, Y. Qian, A.D. Hamilton, S.M. Sebti, G. Favre, GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells, Cancer Res. 57 (1997) 1846-1850.
    • (1997) Cancer Res. , vol.57 , pp. 1846-1850
    • Miquel, K.1    Pradines, A.2    Sun, J.3    Qian, Y.4    Hamilton, A.D.5    Sebti, S.M.6    Favre, G.7
  • 46
    • 0032493641 scopus 로고    scopus 로고
    • A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells
    • L. Sepp-Lorenzino, N. Rosen, A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells, J. Biol. Chem. 273 (1998) 20243-20251.
    • (1998) J. Biol. Chem. , vol.273 , pp. 20243-20251
    • Sepp-Lorenzino, L.1    Rosen, N.2
  • 47
    • 0031050738 scopus 로고    scopus 로고
    • Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment
    • P.F. Lebowitz, D. Sakamuro, G.C. Prendergast, Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment, Cancer Res. 57 (1997) 708-713.
    • (1997) Cancer Res. , vol.57 , pp. 708-713
    • Lebowitz, P.F.1    Sakamuro, D.2    Prendergast, G.C.3
  • 48
    • 0029830845 scopus 로고    scopus 로고
    • Growth inhibition of human pancreatic cancer by farnesyl transferase inhibitor
    • O. Kainuma, T. Asano, M. Hasegawa, K. Isono, Growth inhibition of human pancreatic cancer by farnesyl transferase inhibitor, Gan To Kagaku Ryoho. 23 (1996) 1657-1659.
    • (1996) Gan To Kagaku Ryoho. , vol.23 , pp. 1657-1659
    • Kainuma, O.1    Asano, T.2    Hasegawa, M.3    Isono, K.4
  • 49
    • 0031914004 scopus 로고    scopus 로고
    • Selective cytotoxicity of farnesylamine to pancreatic carcinoma cells and Ki-ras-transformed fibroblasts
    • H. Ura, T. Obara, R. Shudo, A. Itoh, S. Tanno, T. Fujii, N. Nishino, Y. Kohgo, Selective cytotoxicity of farnesylamine to pancreatic carcinoma cells and Ki-ras-transformed fibroblasts, Mol. Carcinog. 21 (1998) 93-99.
    • (1998) Mol. Carcinog. , vol.21 , pp. 93-99
    • Ura, H.1    Obara, T.2    Shudo, R.3    Itoh, A.4    Tanno, S.5    Fujii, T.6    Nishino, N.7    Kohgo, Y.8
  • 51
    • 14344254868 scopus 로고    scopus 로고
    • Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice
    • M. Liu, M.S. Bryant, J. Chen, S. Lee, B. Yaremko, P. Lipari, M. Malkowski, E. Ferrari, L. Nielsen, N. Prioli et al., Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice, Cancer Res. 58 (1998) 4947-4956.
    • (1998) Cancer Res. , vol.58 , pp. 4947-4956
    • Liu, M.1    Bryant, M.S.2    Chen, J.3    Lee, S.4    Yaremko, B.5    Lipari, P.6    Malkowski, M.7    Ferrari, E.8    Nielsen, L.9    Prioli, N.10
  • 53
    • 0032521211 scopus 로고    scopus 로고
    • Antitumor Effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice
    • R. Mangues, T. Corral, N.E. Kohl, W.F. Symmans, S. Lu, M. Malumbres, J.B. Gibbs, A. Oliff, A. Pellicer, Antitumor Effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice, Cancer Res. 58 (1998) 1253-1259.
    • (1998) Cancer Res. , vol.58 , pp. 1253-1259
    • Mangues, R.1    Corral, T.2    Kohl, N.E.3    Symmans, W.F.4    Lu, S.5    Malumbres, M.6    Gibbs, J.B.7    Oliff, A.8    Pellicer, A.9
  • 54
    • 0031983131 scopus 로고    scopus 로고
    • A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis
    • R.E. Barrington, M.A. Subler, E. Rands, C.A. Omer, P.J. Miller, I.E. Hundley et al., A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis, Mol. Cell Biol. 18 (1998) 85-92.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 85-92
    • Barrington, R.E.1    Subler, M.A.2    Rands, E.3    Omer, C.A.4    Miller, P.J.5    Hundley, I.E.6
  • 55
    • 0030916369 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB
    • P.F. Lebowitz, P.J. Casey, G.C. Prendergast, J.A. Thissen, Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB, J. Biol. Chem. 272 (1997) 15591-15594.
    • (1997) J. Biol. Chem. , vol.272 , pp. 15591-15594
    • Lebowitz, P.F.1    Casey, P.J.2    Prendergast, G.C.3    Thissen, J.A.4
  • 56
    • 0028973293 scopus 로고
    • Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes
    • E.C. Lerner, Y. Qian, M.A. Blaskovich, R.D. Fossum, A. Vogt, J. Sun, A.D. Cox, C.J. Der, A.D. Hamilton, S.M. Sebti, Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes, J. Biol. Chem. 270 (1995) 26802-26806.
    • (1995) J. Biol. Chem. , vol.270 , pp. 26802-26806
    • Lerner, E.C.1    Qian, Y.2    Blaskovich, M.A.3    Fossum, R.D.4    Vogt, A.5    Sun, J.6    Cox, A.D.7    Der, C.J.8    Hamilton, A.D.9    Sebti, S.M.10
  • 57
    • 0029087475 scopus 로고
    • Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene
    • A. Goga, J. McLaughlin, D.E. Afar, D.C. Saffran, O.N. Witte, Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene, Cell 82 (1995) 981-988.
    • (1995) Cell , vol.82 , pp. 981-988
    • Goga, A.1    McLaughlin, J.2    Afar, D.E.3    Saffran, D.C.4    Witte, O.N.5
  • 60
    • 0029921232 scopus 로고    scopus 로고
    • The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts
    • E.J. Bernhard, G. Kao, A.D. Cox, S.M. Sebti, A.D. Hamilton, R.J. Muschel, W.G. McKenna, The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts, Cancer Res. 56 (1996) 1727-1730.
    • (1996) Cancer Res. , vol.56 , pp. 1727-1730
    • Bernhard, E.J.1    Kao, G.2    Cox, A.D.3    Sebti, S.M.4    Hamilton, A.D.5    Muschel, R.J.6    McKenna, W.G.7
  • 61
    • 0032522849 scopus 로고    scopus 로고
    • Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes
    • E.J. Bernhard, W.G. McKenna, A.D. Hamilton, S.M. Sebti, Y. Qian, J.M. Wu, R.J. Muschel, Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes, Cancer Res. 58 (1998) 1754-1761.
    • (1998) Cancer Res. , vol.58 , pp. 1754-1761
    • Bernhard, E.J.1    McKenna, W.G.2    Hamilton, A.D.3    Sebti, S.M.4    Qian, Y.5    Wu, J.M.6    Muschel, R.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.