-
1
-
-
0003998061
-
-
Lippincott-Raven Press, Philadelphia, PA
-
V. DeVita, S. Hellman and S. Rosenberg (Eds.), Cancer Principles and Practice of Oncology, 5th edn., Lippincott-Raven Press, Philadelphia, PA, 1997.
-
(1997)
Cancer Principles and Practice of Oncology, 5th Edn
-
-
DeVita, V.1
Hellman, S.2
Rosenberg, S.3
-
2
-
-
0028097472
-
Pharmaceutical research in molecular oncology
-
J.B. Gibbs, A. Oliff, Pharmaceutical research in molecular oncology, Cell 79 (1994) 193-198.
-
(1994)
Cell
, vol.79
, pp. 193-198
-
-
Gibbs, J.B.1
Oliff, A.2
-
3
-
-
0025838675
-
Regulators and effectors of ras proteins
-
G. Bollag, F. McCormick, Regulators and effectors of ras proteins, Annu. Rev. Cell Biol. 7 (1991) 601-632.
-
(1991)
Annu. Rev. Cell Biol.
, vol.7
, pp. 601-632
-
-
Bollag, G.1
McCormick, F.2
-
5
-
-
0002457485
-
Ras proto-oncogene activation in human malignancy
-
C.T. Garret and S. Sell (Eds.), Hummana, Totowa, NJ
-
G.J. Clark and C.J. Der, ras proto-oncogene activation in human malignancy, in: C.T. Garret and S. Sell (Eds.), Cellular Cancer Markers, Hummana, Totowa, NJ, 1995, pp. 17-52.
-
(1995)
Cellular Cancer Markers
, pp. 17-52
-
-
Clark, G.J.1
Der, C.J.2
-
6
-
-
0023631608
-
Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo
-
E. Sinn, W. Muller, P. Pattengale, I. Tepler, R. Wallace, P. Leder, Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo, Cell 49 (1987) 465-475.
-
(1987)
Cell
, vol.49
, pp. 465-475
-
-
Sinn, E.1
Muller, W.2
Pattengale, P.3
Tepler, I.4
Wallace, R.5
Leder, P.6
-
7
-
-
0025188145
-
Tumorigenesis and male sterility in transgenic mice expressing a MMTV/N-ras oncogene
-
R. Mangues, I. Seidman, A. Pellicer, J.W. Gordon, Tumorigenesis and male sterility in transgenic mice expressing a MMTV/N-ras oncogene, Oncogene 5 (1990) 1491-1497.
-
(1990)
Oncogene
, vol.5
, pp. 1491-1497
-
-
Mangues, R.1
Seidman, I.2
Pellicer, A.3
Gordon, J.W.4
-
8
-
-
0019193408
-
Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus
-
T.Y. Shih, A.G. Papageorge, P.E. Stokes, M.O. Weeks, E.M. Scolnick, Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus, Nature 287 (1980) 686-691.
-
(1980)
Nature
, vol.287
, pp. 686-691
-
-
Shih, T.Y.1
Papageorge, A.G.2
Stokes, P.E.3
Weeks, M.O.4
Scolnick, E.M.5
-
9
-
-
0027304731
-
Human Sos1: A guanine nucleotide exchange factor for Ras that binds to GRB2
-
P. Chardin, J.H. Camonis, N.W. Gale, L. van-Aelst, J. Schlessinger, M.H. Wigler, D. Bar-Sagi, Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2, Science 260 (1993) 1338-1343.
-
(1993)
Science
, vol.260
, pp. 1338-1343
-
-
Chardin, P.1
Camonis, J.H.2
Gale, N.W.3
Van-Aelst, L.4
Schlessinger, J.5
Wigler, M.H.6
Bar-Sagi, D.7
-
11
-
-
0030962347
-
The potential of farnesyltransferase inhibitors as cancer therapeutics
-
J.B. Gibbs, A. Oliff, The potential of farnesyltransferase inhibitors as cancer therapeutics, Annu. Rev. Pharmacol. Toxicol. 37 (1997) 143-166.
-
(1997)
Annu. Rev. Pharmacol. Toxicol.
, vol.37
, pp. 143-166
-
-
Gibbs, J.B.1
Oliff, A.2
-
12
-
-
0030749458
-
Farnesyltransferase inhibitors and cancer treatment: Targeting simply Ras?
-
A.D. Cox, C.J. Der, Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?, Biochim. Biophys. Acta 1333 (1997) F51-71.
-
(1997)
Biochim. Biophys. Acta
, vol.1333
, pp. 51-71
-
-
Cox, A.D.1
Der, C.J.2
-
13
-
-
0018875887
-
Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry
-
M.C. Willingham, I. Pastan, T.Y. Shih, E.M. Scolnick, Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry, Cell 19 (1980) 1005-1014.
-
(1980)
Cell
, vol.19
, pp. 1005-1014
-
-
Willingham, M.C.1
Pastan, I.2
Shih, T.Y.3
Scolnick, E.M.4
-
14
-
-
0021528719
-
Harvey murine sarcoma virus p21 ras protein: Biological and biochemical significance of the cysteine nearest the carboxy terminus
-
B.M. Willumsen, K. Norris, A.G. Papageorge, N.L. Hubbert, D.R. Lowy, Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus, EMBO J. 3 (1984) 2581-2585.
-
(1984)
EMBO J.
, vol.3
, pp. 2581-2585
-
-
Willumsen, B.M.1
Norris, K.2
Papageorge, A.G.3
Hubbert, N.L.4
Lowy, D.R.5
-
15
-
-
0026747866
-
Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity
-
K. Kato, A.D. Cox, M.M. Hisaka, S.M. Graham, J.E. Buss, C.J. Der, Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity, Proc. Natl. Acad. Sci. USA 89 (1992) 6403-6407.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 6403-6407
-
-
Kato, K.1
Cox, A.D.2
Hisaka, M.M.3
Graham, S.M.4
Buss, J.E.5
Der, C.J.6
-
16
-
-
0025194466
-
Inhibition of purified p21ras farnesyl:Protein transferase by Cys-AAX tetrapeptides
-
Y. Reiss, J.L. Goldstein, M.C. Seabra, P.J. Casey, M.S. Brown, Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides, Cell 62 (1990) 81-88.
-
(1990)
Cell
, vol.62
, pp. 81-88
-
-
Reiss, Y.1
Goldstein, J.L.2
Seabra, M.C.3
Casey, P.J.4
Brown, M.S.5
-
17
-
-
0027413551
-
Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo
-
J.B. Gibbs, D.L. Pompliano, S.D. Mosser, E. Rands, R.B. Lingham, S.B. Singh, E.M. Scolnick, N.B. Kohl, A. Oliff, Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo, J. Biol. Chem. 268 (1993) 7617-7620.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 7617-7620
-
-
Gibbs, J.B.1
Pompliano, D.L.2
Mosser, S.D.3
Rands, E.4
Lingham, R.B.5
Singh, S.B.6
Scolnick, E.M.7
Kohl, N.B.8
Oliff, A.9
-
18
-
-
0025871919
-
cDNA cloning and expression of the peptide-binding beta subunit of rat p21ras farnesyltransferase, the counterpart of yeast DPR1/RAM1
-
W.J. Chen, D.A. Andres, J.L. Goldstein, D.W. Russell, M.S. Brown, cDNA cloning and expression of the peptide-binding beta subunit of rat p21ras farnesyltransferase, the counterpart of yeast DPR1/RAM1, Cell 66 (1991) 327-341.
-
(1991)
Cell
, vol.66
, pp. 327-341
-
-
Chen, W.J.1
Andres, D.A.2
Goldstein, J.L.3
Russell, D.W.4
Brown, M.S.5
-
19
-
-
0027289625
-
Characterization of recombinant human farnesyl-protein transferase: Cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases
-
C.A. Omer, A.M. Kral, R.E. Diehl, G.C. Prendergast, S. Powers, C.M. Allen, J.B. Gibbs, N.E. Kohl, Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases, Biochemistry 32 (1993) 5167-5176.
-
(1993)
Biochemistry
, vol.32
, pp. 5167-5176
-
-
Omer, C.A.1
Kral, A.M.2
Diehl, R.E.3
Prendergast, G.C.4
Powers, S.5
Allen, C.M.6
Gibbs, J.B.7
Kohl, N.E.8
-
20
-
-
0026353346
-
Sequence dependence of protein isoprenylation
-
S.L. Moores, M.D. Schaber, S.D. Mosser, E. Rands, M.B. O'Hara, V.M. Garsky, M.S. Marshall, D.L. Pompliano, J.B. Gibbs, Sequence dependence of protein isoprenylation, J. Biol. Chem. 266 (1991) 14603-14610.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 14603-14610
-
-
Moores, S.L.1
Schaber, M.D.2
Mosser, S.D.3
Rands, E.4
O'Hara, M.B.5
Garsky, V.M.6
Marshall, M.S.7
Pompliano, D.L.8
Gibbs, J.B.9
-
21
-
-
0029664317
-
Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells
-
G. James, J.L. Goldstein, M.S. Brown, Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells, Proc. Natl. Acad. Sci. USA 93 (1996) 4454-4458.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 4454-4458
-
-
James, G.1
Goldstein, J.L.2
Brown, M.S.3
-
22
-
-
0030923192
-
K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors
-
D.B. Whyte, P. Kirschmeier, T.N. Hockenberry, I. Nunez-Oliva, L. James, J.J. Catino, W.R. Bishop, J.K. Pai, K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors, J. Biol. Chem. 30 (1997) 14459-14464.
-
(1997)
J. Biol. Chem.
, vol.30
, pp. 14459-14464
-
-
Whyte, D.B.1
Kirschmeier, P.2
Hockenberry, T.N.3
Nunez-Oliva, I.4
James, L.5
Catino, J.J.6
Bishop, W.R.7
Pai, J.K.8
-
23
-
-
0030943198
-
Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I
-
F.L. Zhang, P. Kirschmeier, D. Carr, L. James, R.W. Bond, L. Wang, R. Patton, W.T. Windsor, R. Syto, R. Zhang, W.R. Bishop, Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I, J. Biol. Chem. 272 (1997) 10232-10239.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 10232-10239
-
-
Zhang, F.L.1
Kirschmeier, P.2
Carr, D.3
James, L.4
Bond, R.W.5
Wang, L.6
Patton, R.7
Windsor, W.T.8
Syto, R.9
Zhang, R.10
Bishop, W.R.11
-
24
-
-
0032546264
-
Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts
-
J. Sun, Y. Qian, A.D. Hamilton, S.M. Sebti, Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts, Oncogene 16 (1998) 1467-1473.
-
(1998)
Oncogene
, vol.16
, pp. 1467-1473
-
-
Sun, J.1
Qian, Y.2
Hamilton, A.D.3
Sebti, S.M.4
-
25
-
-
0026659959
-
Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein
-
A.D. Cox, M.M. Hisaka, J.E. Buss, C.J. Der, Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein, Mol. Cell Biol. 12 (1992) 2606-2615.
-
(1992)
Mol. Cell Biol.
, vol.12
, pp. 2606-2615
-
-
Cox, A.D.1
Hisaka, M.M.2
Buss, J.E.3
Der, C.J.4
-
26
-
-
0344768003
-
Farnesyltransferase inhibitors: Agents for the treatment of human cancer
-
R.G. Landes
-
K.S. Koblan and N.E. Kohl, Farnesyltransferase inhibitors: agents for the treatment of human cancer, in: G Proteins, Cytoskeleton and Cancer, R.G. Landes, 1998.
-
(1998)
G Proteins, Cytoskeleton and Cancer
-
-
Koblan, K.S.1
Kohl, N.E.2
-
27
-
-
0030733653
-
Inhibition of growth and invasive activity of human pancreatic cancer cells by a farnesyltransferase inhibitor, manumycin
-
O. Kainuma, T. Asano, M. Hasegawa, T. Kenmochi, T. Nakagohri, Y. Tokoro, K. Isono, Inhibition of growth and invasive activity of human pancreatic cancer cells by a farnesyltransferase inhibitor, manumycin, Pancreas 15 (1997) 379-383.
-
(1997)
Pancreas
, vol.15
, pp. 379-383
-
-
Kainuma, O.1
Asano, T.2
Hasegawa, M.3
Kenmochi, T.4
Nakagohri, T.5
Tokoro, Y.6
Isono, K.7
-
28
-
-
0027519572
-
Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protein transferase
-
R.B. Lingham, K.C. Silverman, G.F. Bills, C. Cascales, M. Sanchez, R.G. Jenkins, S.E. Gartner, I. Martin, M.T. Diez, F. Pelaez, Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protein transferase, Appl. Microbiol. Biotechnol. 40 (1993) 370-374.
-
(1993)
Appl. Microbiol. Biotechnol.
, vol.40
, pp. 370-374
-
-
Lingham, R.B.1
Silverman, K.C.2
Bills, G.F.3
Cascales, C.4
Sanchez, M.5
Jenkins, R.G.6
Gartner, S.E.7
Martin, I.8
Diez, M.T.9
Pelaez, F.10
-
29
-
-
0031820282
-
J-104,871, a novel farnesyltransferase inhibitor, blocks Ras farnesylation in vivo in a farnesyl pyrophosphate-competitive manner
-
M. Yonemoto, T. Satoh, H. Arakawa, I. Suzuki-Takahashi, Y. Monden, T. Kodera, K. Tanaka, T. Aoyama, Y. Iwasawa, T. Kamei, S. Nishimura, K. Tomimoto, J-104,871, a novel farnesyltransferase inhibitor, blocks Ras farnesylation in vivo in a farnesyl pyrophosphate-competitive manner, Mol. Pharmacol. 54 (1998) 1-7.
-
(1998)
Mol. Pharmacol.
, vol.54
, pp. 1-7
-
-
Yonemoto, M.1
Satoh, T.2
Arakawa, H.3
Suzuki-Takahashi, I.4
Monden, Y.5
Kodera, T.6
Tanaka, K.7
Aoyama, T.8
Iwasawa, Y.9
Kamei, T.10
Nishimura, S.11
Tomimoto, K.12
-
30
-
-
15144355763
-
Potent and selective non-cysteine-containing inhibitors of protein farnesyltransferase
-
D.J. Augeri, S.J. O'Connor, D. Janowick, B. Szczepankiewicz, G. Sullivan, J. Larsen, D. Kalvin, J. Cohen, E. Devine, H. Zhang, S. Cherian, B. Saeed, S.-C. Ng, S. Rosenberg, Potent and selective non-cysteine-containing inhibitors of protein farnesyltransferase, J. Med. Chem. 41 (1998) 4288-4300.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 4288-4300
-
-
Augeri, D.J.1
O'Connor, S.J.2
Janowick, D.3
Szczepankiewicz, B.4
Sullivan, G.5
Larsen, J.6
Kalvin, D.7
Cohen, J.8
Devine, E.9
Zhang, H.10
Cherian, S.11
Saeed, B.12
Ng, S.-C.13
Rosenberg, S.14
-
31
-
-
0029586503
-
Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells
-
W.R. Bishop, R. Bond, J. Petrin, L. Wang, R. Patton, R. Doll, G. Njoroge, J. Catino, J. Schwartz, W. Windsor et al., Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells, J. Biol. Chem. 270 (1995) 30611-30618.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 30611-30618
-
-
Bishop, W.R.1
Bond, R.2
Petrin, J.3
Wang, L.4
Patton, R.5
Doll, R.6
Njoroge, G.7
Catino, J.8
Schwartz, J.9
Windsor, W.10
-
32
-
-
0028211246
-
Pseudopeptide inhibitors of Ras farnesyl-protein transferase
-
S.L. Graham, S.J. deSolms, E.A. Giuliani, N.E. Kohl, S.D. Mosser, A. Oliff, D.L. Pompliano, E. Rands, M.J. Breslin, A.A. Deana, V.M. Garsky, T.H. Scholz, J.B. Gibbs, R.L. Smith, Pseudopeptide inhibitors of Ras farnesyl-protein transferase, J. Med. Chem. 37 (1994) 725-732.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 725-732
-
-
Graham, S.L.1
DeSolms, S.J.2
Giuliani, E.A.3
Kohl, N.E.4
Mosser, S.D.5
Oliff, A.6
Pompliano, D.L.7
Rands, E.8
Breslin, M.J.9
Deana, A.A.10
Garsky, V.M.11
Scholz, T.H.12
Gibbs, J.B.13
Smith, R.L.14
-
33
-
-
0029986149
-
2-Substituted piperazines as constrained amino acids. Application to the synthesis of potent, non-carboxylic acid inhibitors of farnesyltransferase
-
T.M. Williams, T.M. Ciccarone, S.C. MacTough, R.L. Bock, M.W. Conner, J.P. Davide, K. Hamilton, K.S. Koblan, N.E. Kohl, A.M. Kral, S.D. Mosser, C.A. Omer, D.L. Pompliano, E. Rands, M.D. Schaber, D. Shah, F.R. Wilson, J.B. Gibbs, S.L. Graham, G.D. Hartman, A. Oliff, R.L. Smith, 2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non-carboxylic acid inhibitors of farnesyltransferase, J. Med. Chem. 39 (1996) 1345-1348.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 1345-1348
-
-
Williams, T.M.1
Ciccarone, T.M.2
MacTough, S.C.3
Bock, R.L.4
Conner, M.W.5
Davide, J.P.6
Hamilton, K.7
Koblan, K.S.8
Kohl, N.E.9
Kral, A.M.10
Mosser, S.D.11
Omer, C.A.12
Pompliano, D.L.13
Rands, E.14
Schaber, M.D.15
Shah, D.16
Wilson, F.R.17
Gibbs, J.B.18
Graham, S.L.19
Hartman, G.D.20
Oliff, A.21
Smith, R.L.22
more..
-
34
-
-
7344260158
-
N-Arylalkyl pseudopeptide inhibitors of farnesyltransferase
-
S.J. deSolms, E.A. Giuliani, S.L. Graham, K.S. Koblan, N.E. Kohl, S.D. Mosser, A.I. Oliff, D.L. Pompliano, E. Rands, T.H. Scholz, C.M. Wiscount, J.B. Gibbs, R.L. Smith, N-Arylalkyl pseudopeptide inhibitors of farnesyltransferase, J. Med. Chem. 41 (1998) 2651-2656.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 2651-2656
-
-
DeSolms, S.J.1
Giuliani, E.A.2
Graham, S.L.3
Koblan, K.S.4
Kohl, N.E.5
Mosser, S.D.6
Oliff, A.I.7
Pompliano, D.L.8
Rands, E.9
Scholz, T.H.10
Wiscount, C.M.11
Gibbs, J.B.12
Smith, R.L.13
-
35
-
-
0028936976
-
NMR studies of novel inhibitors bound to farnesyl-protein transferase
-
K.S. Koblan, J.C. Culberson, S.J. Desolms, E.A. Giuliani, S.D. Mosser, C.A. Omer, S.M. Pitzenberger, M.J. Bogusky, NMR studies of novel inhibitors bound to farnesyl-protein transferase, Protein Sci. 4 (1995) 681-688.
-
(1995)
Protein Sci.
, vol.4
, pp. 681-688
-
-
Koblan, K.S.1
Culberson, J.C.2
Desolms, S.J.3
Giuliani, E.A.4
Mosser, S.D.5
Omer, C.A.6
Pitzenberger, S.M.7
Bogusky, M.J.8
-
36
-
-
0030909826
-
Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution
-
H.W. Park, S.R. Boduluri, J.F. Moomaw, P.J. Casey, L.S. Beese, Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution, Science 275 (1997) 1800-1804.
-
(1997)
Science
, vol.275
, pp. 1800-1804
-
-
Park, H.W.1
Boduluri, S.R.2
Moomaw, J.F.3
Casey, P.J.4
Beese, L.S.5
-
37
-
-
0032474284
-
Protein farnesyltransferase: Structure and implications for substrate binding
-
P. Dunten, U. Kammlott, R. Crowther, D. Weber, R. Palermo, J. Birktoft, Protein farnesyltransferase: structure and implications for substrate binding, Biochemistry. 37 (1998) 7907-7912.
-
(1998)
Biochemistry
, vol.37
, pp. 7907-7912
-
-
Dunten, P.1
Kammlott, U.2
Crowther, R.3
Weber, D.4
Palermo, R.5
Birktoft, J.6
-
38
-
-
0032493317
-
Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate
-
S.B. Long, P.J. Casey, L.S. Beese, Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate, Biochemistry. 37 (1998) 9612-9618.
-
(1998)
Biochemistry
, vol.37
, pp. 9612-9618
-
-
Long, S.B.1
Casey, P.J.2
Beese, L.S.3
-
39
-
-
0027248872
-
Selective inhibition of ras-dependent cell transformation by a farnesyl-protein transferase inhibitor
-
N.E. Kohl, S.D. Mosser, S.J. deSolms, E.A. Guilian, S.L. Graham, R.L. Smith, E.M. Scolnick, A. Oliff, J.B. Gibbs, Selective inhibition of ras-dependent cell transformation by a farnesyl-protein transferase inhibitor, Science 260 (1993) 1934-1937.
-
(1993)
Science
, vol.260
, pp. 1934-1937
-
-
Kohl, N.E.1
Mosser, S.D.2
DeSolms, S.J.3
Guilian, E.A.4
Graham, S.L.5
Smith, R.L.6
Scolnick, E.M.7
Oliff, A.8
Gibbs, J.B.9
-
40
-
-
0027323459
-
Benzodiazepine peptidomimetics: Potent inhibitors of Ras farnesylation in animal cells
-
G.L. James, J.L. Goldstein, M.S. Brown, T.E. Rawson, T.C. Somers, R.S. McDowell, C.W. Crowley, B.K. Lucas, A.D. Levinson, J.C. Marsters Jr., Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells, Science. 260 (1993) 1937-1942.
-
(1993)
Science
, vol.260
, pp. 1937-1942
-
-
James, G.L.1
Goldstein, J.L.2
Brown, M.S.3
Rawson, T.E.4
Somers, T.C.5
McDowell, R.S.6
Crowley, C.W.7
Lucas, B.K.8
Levinson, A.D.9
Marsters J.C., Jr.10
-
41
-
-
0027998986
-
The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation
-
A.D. Cox, A.M. Garcia, J.K. Westwick, J.J. Kowalczyk, M.D. Lewis, D.A. Brenner, C.J. Der, The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation, J. Biol. Chem. 269 (1994) 19203-19206.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 19203-19206
-
-
Cox, A.D.1
Garcia, A.M.2
Westwick, J.K.3
Kowalczyk, J.J.4
Lewis, M.D.5
Brenner, D.A.6
Der, C.J.7
-
42
-
-
0028318136
-
Farnesyl transferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton
-
G.C. Prendergast, J.P. Davide, S.J. deSolms, E.A. Giuliani, S.L. Graham, J.B. Gibbs, A. Oliff, N.E. Kohl, Farnesyl transferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton, Mol. Cell. Biol. 14 (1994) 4193-4202.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 4193-4202
-
-
Prendergast, G.C.1
Davide, J.P.2
DeSolms, S.J.3
Giuliani, E.A.4
Graham, S.L.5
Gibbs, J.B.6
Oliff, A.7
Kohl, N.E.8
-
43
-
-
0028892646
-
Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity
-
P.F. Lebowitz, J.P. Davide, G.C. Prendergast, Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity, Mol. Cell Biol. 15 (1995) 6613-6622.
-
(1995)
Mol. Cell Biol.
, vol.15
, pp. 6613-6622
-
-
Lebowitz, P.F.1
Davide, J.P.2
Prendergast, G.C.3
-
44
-
-
0028835253
-
A peptidomimetic inhibitor of farnesyl:Protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines
-
L. Sepp-Lorenzino, Z. Ma, E. Rands, N.E. Kohl, J.B. Gibbs, A. Oliff, N. Rosen, A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines, Cancer Res. 55 (1995) 5302-5309.
-
(1995)
Cancer Res.
, vol.55
, pp. 5302-5309
-
-
Sepp-Lorenzino, L.1
Ma, Z.2
Rands, E.3
Kohl, N.E.4
Gibbs, J.B.5
Oliff, A.6
Rosen, N.7
-
45
-
-
0031004491
-
GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells
-
K. Miquel, A. Pradines, J. Sun, Y. Qian, A.D. Hamilton, S.M. Sebti, G. Favre, GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells, Cancer Res. 57 (1997) 1846-1850.
-
(1997)
Cancer Res.
, vol.57
, pp. 1846-1850
-
-
Miquel, K.1
Pradines, A.2
Sun, J.3
Qian, Y.4
Hamilton, A.D.5
Sebti, S.M.6
Favre, G.7
-
46
-
-
0032493641
-
A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells
-
L. Sepp-Lorenzino, N. Rosen, A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells, J. Biol. Chem. 273 (1998) 20243-20251.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 20243-20251
-
-
Sepp-Lorenzino, L.1
Rosen, N.2
-
47
-
-
0031050738
-
Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment
-
P.F. Lebowitz, D. Sakamuro, G.C. Prendergast, Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment, Cancer Res. 57 (1997) 708-713.
-
(1997)
Cancer Res.
, vol.57
, pp. 708-713
-
-
Lebowitz, P.F.1
Sakamuro, D.2
Prendergast, G.C.3
-
48
-
-
0029830845
-
Growth inhibition of human pancreatic cancer by farnesyl transferase inhibitor
-
O. Kainuma, T. Asano, M. Hasegawa, K. Isono, Growth inhibition of human pancreatic cancer by farnesyl transferase inhibitor, Gan To Kagaku Ryoho. 23 (1996) 1657-1659.
-
(1996)
Gan To Kagaku Ryoho.
, vol.23
, pp. 1657-1659
-
-
Kainuma, O.1
Asano, T.2
Hasegawa, M.3
Isono, K.4
-
49
-
-
0031914004
-
Selective cytotoxicity of farnesylamine to pancreatic carcinoma cells and Ki-ras-transformed fibroblasts
-
H. Ura, T. Obara, R. Shudo, A. Itoh, S. Tanno, T. Fujii, N. Nishino, Y. Kohgo, Selective cytotoxicity of farnesylamine to pancreatic carcinoma cells and Ki-ras-transformed fibroblasts, Mol. Carcinog. 21 (1998) 93-99.
-
(1998)
Mol. Carcinog.
, vol.21
, pp. 93-99
-
-
Ura, H.1
Obara, T.2
Shudo, R.3
Itoh, A.4
Tanno, S.5
Fujii, T.6
Nishino, N.7
Kohgo, Y.8
-
50
-
-
0028603395
-
Selective inhibition of ras-dependent tumors in nude mice by an inhibitor of farnesyltransferase
-
N.E. Kohl, F.R. Wilson, S.D. Mosser, E. Giuliani, S.J. deSolms, N.J. Anthony, W.J. Holtz, R.P. Gomez, T.-J. Lee, S.L. Graham, R.L. Smith, J.B. Gibbs, A. Oliff, Selective inhibition of ras-dependent tumors in nude mice by an inhibitor of farnesyltransferase, Proc. Natl. Acad. Sci. USA 91 (1994) 9141-9145.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 9141-9145
-
-
Kohl, N.E.1
Wilson, F.R.2
Mosser, S.D.3
Giuliani, E.4
DeSolms, S.J.5
Anthony, N.J.6
Holtz, W.J.7
Gomez, R.P.8
Lee, T.-J.9
Graham, S.L.10
Smith, R.L.11
Gibbs, J.B.12
Oliff, A.13
-
51
-
-
14344254868
-
Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice
-
M. Liu, M.S. Bryant, J. Chen, S. Lee, B. Yaremko, P. Lipari, M. Malkowski, E. Ferrari, L. Nielsen, N. Prioli et al., Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice, Cancer Res. 58 (1998) 4947-4956.
-
(1998)
Cancer Res.
, vol.58
, pp. 4947-4956
-
-
Liu, M.1
Bryant, M.S.2
Chen, J.3
Lee, S.4
Yaremko, B.5
Lipari, P.6
Malkowski, M.7
Ferrari, E.8
Nielsen, L.9
Prioli, N.10
-
52
-
-
0029150669
-
Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in Ras transgenic mice
-
N.E. Kohl, C.A. Omer, M.W. Conner, N.J. Anthony, J.P. Davide, S.J. DeSolms, E.A. Giuliani, R.P. Gomez, S.L. Graham et al., Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in Ras transgenic mice, Nat. Med. 1 (1995) 792-797.
-
(1995)
Nat. Med.
, vol.1
, pp. 792-797
-
-
Kohl, N.E.1
Omer, C.A.2
Conner, M.W.3
Anthony, N.J.4
Davide, J.P.5
DeSolms, S.J.6
Giuliani, E.A.7
Gomez, R.P.8
Graham, S.L.9
-
53
-
-
0032521211
-
Antitumor Effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice
-
R. Mangues, T. Corral, N.E. Kohl, W.F. Symmans, S. Lu, M. Malumbres, J.B. Gibbs, A. Oliff, A. Pellicer, Antitumor Effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice, Cancer Res. 58 (1998) 1253-1259.
-
(1998)
Cancer Res.
, vol.58
, pp. 1253-1259
-
-
Mangues, R.1
Corral, T.2
Kohl, N.E.3
Symmans, W.F.4
Lu, S.5
Malumbres, M.6
Gibbs, J.B.7
Oliff, A.8
Pellicer, A.9
-
54
-
-
0031983131
-
A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis
-
R.E. Barrington, M.A. Subler, E. Rands, C.A. Omer, P.J. Miller, I.E. Hundley et al., A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis, Mol. Cell Biol. 18 (1998) 85-92.
-
(1998)
Mol. Cell Biol.
, vol.18
, pp. 85-92
-
-
Barrington, R.E.1
Subler, M.A.2
Rands, E.3
Omer, C.A.4
Miller, P.J.5
Hundley, I.E.6
-
55
-
-
0030916369
-
Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB
-
P.F. Lebowitz, P.J. Casey, G.C. Prendergast, J.A. Thissen, Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB, J. Biol. Chem. 272 (1997) 15591-15594.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 15591-15594
-
-
Lebowitz, P.F.1
Casey, P.J.2
Prendergast, G.C.3
Thissen, J.A.4
-
56
-
-
0028973293
-
Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes
-
E.C. Lerner, Y. Qian, M.A. Blaskovich, R.D. Fossum, A. Vogt, J. Sun, A.D. Cox, C.J. Der, A.D. Hamilton, S.M. Sebti, Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes, J. Biol. Chem. 270 (1995) 26802-26806.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 26802-26806
-
-
Lerner, E.C.1
Qian, Y.2
Blaskovich, M.A.3
Fossum, R.D.4
Vogt, A.5
Sun, J.6
Cox, A.D.7
Der, C.J.8
Hamilton, A.D.9
Sebti, S.M.10
-
57
-
-
0029087475
-
Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene
-
A. Goga, J. McLaughlin, D.E. Afar, D.C. Saffran, O.N. Witte, Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene, Cell 82 (1995) 981-988.
-
(1995)
Cell
, vol.82
, pp. 981-988
-
-
Goga, A.1
McLaughlin, J.2
Afar, D.E.3
Saffran, D.C.4
Witte, O.N.5
-
58
-
-
0028147448
-
Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway
-
L. Puil, J. Liu, G. Gish, G. Mbamalu, D. Bowtell, P.G. Pelicci, R. Arlinghaus, T. Pawson, Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway, EMBO J. 13 (1994) 764-773.
-
(1994)
EMBO J.
, vol.13
, pp. 764-773
-
-
Puil, L.1
Liu, J.2
Gish, G.3
Mbamalu, G.4
Bowtell, D.5
Pelicci, P.G.6
Arlinghaus, R.7
Pawson, T.8
-
59
-
-
0032539559
-
Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones
-
M.M. Moasser, L. Sepp-Lorenzino, N.E. Kohl, A. Oliff, A. Balog, D.-S. Su, S.J. Danishefsky, N. Rosen, Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones, Proc. Natl. Acad. Sci. USA 95 (1998) 1369-1374.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 1369-1374
-
-
Moasser, M.M.1
Sepp-Lorenzino, L.2
Kohl, N.E.3
Oliff, A.4
Balog, A.5
Su, D.-S.6
Danishefsky, S.J.7
Rosen, N.8
-
60
-
-
0029921232
-
The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts
-
E.J. Bernhard, G. Kao, A.D. Cox, S.M. Sebti, A.D. Hamilton, R.J. Muschel, W.G. McKenna, The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts, Cancer Res. 56 (1996) 1727-1730.
-
(1996)
Cancer Res.
, vol.56
, pp. 1727-1730
-
-
Bernhard, E.J.1
Kao, G.2
Cox, A.D.3
Sebti, S.M.4
Hamilton, A.D.5
Muschel, R.J.6
McKenna, W.G.7
-
61
-
-
0032522849
-
Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes
-
E.J. Bernhard, W.G. McKenna, A.D. Hamilton, S.M. Sebti, Y. Qian, J.M. Wu, R.J. Muschel, Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes, Cancer Res. 58 (1998) 1754-1761.
-
(1998)
Cancer Res.
, vol.58
, pp. 1754-1761
-
-
Bernhard, E.J.1
McKenna, W.G.2
Hamilton, A.D.3
Sebti, S.M.4
Qian, Y.5
Wu, J.M.6
Muschel, R.J.7
-
62
-
-
0345198543
-
Oral active, trihalobenzocycloheptapyridine farnesyl protein transferase inhibitor antitumor agents
-
March
-
F.G. Njoroge, A. Taveras, J. Kelly, S. Reminszewski, A.K. Mallams, R.J. Doll et al., Oral active, trihalobenzocycloheptapyridine farnesyl protein transferase inhibitor antitumor agents, Proceedings of the American Association for Cancer Research, 89th annual meeting 39:318, March 1998.
-
(1998)
Proceedings of the American Association for Cancer Research, 89th Annual Meeting
, vol.39
, pp. 318
-
-
Njoroge, F.G.1
Taveras, A.2
Kelly, J.3
Reminszewski, S.4
Mallams, A.K.5
Doll, R.J.6
|