(+)-4-[2-[4-(8-chloro-3,10-dibromo-6,11-dihydro-5H- benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1- piperidinecarboxamide (SCH-66336): A very potent farnesyl protein transferase inhibitor as a novel antitumor agent

Journal of Medicinal Chemistry

Volumn 41, Issue 24, 1998, Pages 4890-4902

  George Njoroge, F ^a   Taveras, Arthur G ^a   Kelly, Joseph ^a   Remiszewski, Stacy ^a   Mallams, Alan K ^a   Wolin, Ronald ^a   Afonso, Adriano ^a   Cooper, Alan B ^a   Rane, Dinananth F ^a   Liu, Yi Tsung ^a   Wong, Jesse ^a   Vibulbhan, Bancha ^a   Pinto, Patrick ^a   Deskus, Jeffrey ^a   Alvarez, Carmen S ^a   Del Rosario, Joycelyn ^a   Connolly, Michael ^a   Wang, James ^a   Desai, Jagdish ^a   Rossman, Randall R ^a   Robert Bishop, W ^a   Patton, Robert ^a   Wang, Lynn ^a   Kirschmeier, Paul ^a   Bryant, Mathew S ^a   Nomeir, Amin A ^a   Lin, C C ^a   Liu, Ming ^a   McPhail, Andrew T ^b   Doll, Ronald J ^a   Girijavallabhan, Viyyoor M ^a   Ganguly, Ashit K ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 [4 (8 CHLORO 3,10 DIBROMO 6,11 DIHYDRO 5H BENZO[5,6]CYCLOHEPTA[1,2 BETA]PYRIDIN YL) 1 PIPERIDINYL] 2 OXO ETHYL] 1 PIPERIDINECARBOXAMIDE; ANTINEOPLASTIC AGENT; LONAFARNIB; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; ENZYME INHIBITION; MOUSE; NONHUMAN; NUDE MOUSE; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; COS CELLS; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; MACACA FASCICULARIS; MICE; MICE, NUDE; PIPERIDINES; PROTEIN ISOPRENYLATION; PYRIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 7844233665     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980462b     Document Type: Article

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