Evidence for a catalytic role of zinc in protein farnesyltransferase: Spectroscopy of Co2+-farnesyltransferase indicates metal coordination of the substrate thiolate

Journal of Biological Chemistry

Volumn 272, Issue 1, 1997, Pages 20-23

  Huang, Chih Chin ^a   Casey, Patrick J ^a   Fierke, Carol A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COBALT; PROTEIN FARNESYLTRANSFERASE; ZINC;

ARTICLE; CATALYSIS; ENERGY TRANSFER; ENZYME CHEMISTRY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; REACTION ANALYSIS;

ALKYL AND ARYL TRANSFERASES; ANIMALS; APOPROTEINS; BINDING SITES; CATALYSIS; COBALT; CYSTEINE; FARNESYLTRANSTRANSFERASE; RATS; RECOMBINANT PROTEINS; SPECTRUM ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFERASES; ZINC;

EID: 0031017064     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.1.20     Document Type: Article

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