A new class of highly potent farnesyl diphosphate-competitive inhibitors of farnesyltransferase

Journal of Medicinal Chemistry

Volumn 41, Issue 2, 1998, Pages 143-147

  Aoyama, T ^a   Satoh, T ^a   Yonemoto, M ^a   Shibata, J ^a   Nonoshita, K ^a   Arai, S ^a   Kawakami, K ^a   Iwasawa, Y ^a   Sano, H ^a   Tanaka, K ^a   Monden, Y ^a   Kodera, T ^a   Arakawa, H ^a   Suzuki Takahashi, I ^a   Kamei, T ^a   Tomimoto, K ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 [N [5 (2 BENZOXAZOLYL) 1 METHYL 2 [3,4 (METHYLENEDIOXY)PHENYL] 4 PENTENYL] N (2 NAPHTHYLMETHYL)CARBAMOYL] 1,3 DIOXOLANE 2,2,4 TRICARBOXYLIC ACID; ANTINEOPLASTIC AGENT; J 104133; J 104135; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; SQUALENE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; DOSE RESPONSE; DRUG POTENCY; ENANTIOMER; ENZYME INHIBITION; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; ONCOGENE RAS; PRENYLATION; STEREOCHEMISTRY;

3T3 CELLS; ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; FEMALE; MICE; MICE, NUDE; MODELS, CHEMICAL; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; POLYISOPRENYL PHOSPHATES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031893481     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970540f     Document Type: Article

References (21)