Aromatic carboxylic acids as farnesyl surrogates in farnesylpyrophosphate-based farnesyltransferase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 11, 1999, Pages 2391-2395

  Schlitzer, Martin ^a   Sattler, Isabel ^b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

Author keywords

Aspartates; Farnesylpyrophosphate analogues; Farnesyltransferase inhibitors; Ras

Indexed keywords

AROMATIC CARBOXYLIC ACID; ASPARTIC ACID DERIVATIVE; FARNESYL DIPHOSPHATE; PROTEIN FARNESYLTRANSFERASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; ASPARTIC ACID; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; INHIBITORY CONCENTRATION 50;

EID: 0033492218     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00191-1     Document Type: Article

References (16)

1. Casey P.J. J. Biol. Chem. 271:1996;5289.
2. Leonard D.M. J. Med. Chem. 40:1997;2971.
3. Graham S.L. Exp. Opin. Ther. Patents. 5:1995;1269.
4. Ayral-Kaloustian, S.; Skotnicki, J. S. Ann. Rep. Med. Chem. 1996, 31, 171.
5. Clarke S. Ann. Rev. Biochem. 61:1992;355.
6. Lerner E.C., Hamilton A.D., Sebti S.M. Anti-Cancer Drug Design. 12:1997;229.
7. Qian Y., Sebti S.M., Hamilton A.D. Biopolymers. 43:1997;25.
8. Sattler, I.; Tamanoi, F. In Regulation of the RAS Signaling Network; Maruta, H.; Burgess, A. W., Eds.; Springer: Heidelberg. 1996; pp 95-138.
9. Patel D.V., Schmidt R.J., Biller S.A., Gordon E.M., Robinson S.S., Manne V.J. Med. Chem. 38:1995;2906.
10. Jones, G. The Knoevenagel Condensation. In Organic Reactions, Vol. 15; Cope, A. C., Ed.; John Wiley & Sons, Inc.: New York, 1967. pp 204-599.
11. Abraham D.J., Kennedy P.E., Mehanna A.S., Patwa D.C., Williams F.L. J. Med. Chem. 27:1984;967.
12. Pompliano D.L., Gomez R.P., Anthony N.J. J. Am. Chem. Soc. 114:1992;7945.
13. Del Villar K., Mitsuzawa H., Yang W., Sattler I., Tamanoi F. J. Biol. Chem. 272:1997;680.
14. Aoyama T., Satoh T., Vonemoto M., Shibata J., Nonoshita K., Arai S., Kawakami K., Iwasawa Y., Sano H., Tanaka K., Monden Y., Kondera T., Arakawa H., Suzuki-Takahashi I., Kamei T., Tomimoto K. J. Med. Chem. 41:1998;143.
15. Schlitzer, M.; Sattler, I. Angew. Chem. 1999, 111, 2150; Angew. Chem., Int. Ed. 1999, 38, 2032.
16. Schlitzer, M.; Sattler, I. Angew. Chem. 1999, 111, 2150; Angew. Chem., Int. Ed. 1999, 38, 2032.