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Volumn 83, Issue 2, 1999, Pages 283-287

Inhibition of human tumor cell growth in vitro and in vivo by a specific inhibitor of human farnesyltransferase: BIM-46068

Author keywords

[No Author keywords available]

Indexed keywords

BIM 46050; BIM 46068; DAUNORUBICIN; DOXORUBICIN; ETOPOSIDE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 0032859475     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19991008)83:2<283::AID-IJC22>3.0.CO;2-6     Document Type: Article
Times cited : (21)

References (20)
  • 1
    • 0029921232 scopus 로고    scopus 로고
    • The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts
    • BERNHARD, E.J., KAO, G., COX, A.D., SEBTI, S.M., HAMILTON, A.D., MUSCHEL, R.J. and MCKENNA, W.G., The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts. Cancer Res., 56, 1727-1730 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 1727-1730
    • Bernhard, E.J.1    Kao, G.2    Cox, A.D.3    Sebti, S.M.4    Hamilton, A.D.5    Muschel, R.J.6    Mckenna, W.G.7
  • 3
    • 0033016719 scopus 로고    scopus 로고
    • Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB
    • DU, W., LEBOWITZ, P.F. and PRENDERGAST, G.C., Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB. Mol. cell. Biol., 19, 1831-1840 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1831-1840
    • Du, W.1    Lebowitz, P.F.2    Prendergast, G.C.3
  • 6
    • 0029664317 scopus 로고    scopus 로고
    • Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells
    • JAMES, G., GOLDSTEIN, J.L. and BROWN, M.S., Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells. Proc. nat. Acad. Sci. (Wash.), 93, 4454-4458 (1996).
    • (1996) Proc. Nat. Acad. Sci. (Wash.) , vol.93 , pp. 4454-4458
    • James, G.1    Goldstein, J.L.2    Brown, M.S.3
  • 9
    • 0033521860 scopus 로고    scopus 로고
    • Growth inhibition of human pancreatic cancer cell lines by anti-sense oligonucleotides specific to mutated K-ras genes
    • KITA, K., SAITO, S., MORIOKA, C.Y. and WATANABE, A., Growth inhibition of human pancreatic cancer cell lines by anti-sense oligonucleotides specific to mutated K-ras genes. Int. J. Cancer, 80, 553-558 (1999).
    • (1999) Int. J. Cancer , vol.80 , pp. 553-558
    • Kita, K.1    Saito, S.2    Morioka, C.Y.3    Watanabe, A.4
  • 10
    • 0030952552 scopus 로고    scopus 로고
    • Inhibition of the prenylation of K-Ras, but not H-or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines
    • LERNER, E.G., ZHANG, T.T., KNOWLES, D.B., QIAN, Y., HAMILTON, A.D. and SEBTI, S.M., Inhibition of the prenylation of K-Ras, but not H-or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines. Oncogene, 15, 1283-1288 (1997).
    • (1997) Oncogene , vol.15 , pp. 1283-1288
    • Lerner, E.G.1    Zhang, T.T.2    Knowles, D.B.3    Qian, Y.4    Hamilton, A.D.5    Sebti, S.M.6
  • 11
    • 0030179370 scopus 로고    scopus 로고
    • Tumor inhibitory activity of anti-ras ribozymes delivered by retroviral gene transfer
    • LI, M., LONIAL, H., CITARELLA, R., LINDH, D., COLINA, L. and KRAMER, R., Tumor inhibitory activity of anti-ras ribozymes delivered by retroviral gene transfer. Cancer Gene Ther., 3, 221-229 (1996).
    • (1996) Cancer Gene Ther. , vol.3 , pp. 221-229
    • Li, M.1    Lonial, H.2    Citarella, R.3    Lindh, D.4    Colina, L.5    Kramer, R.6
  • 12
    • 14344254868 scopus 로고    scopus 로고
    • Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice
    • LIU, M. and 24 OTHERS, Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res., 58, 4947-4956 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 4947-4956
    • Liu, M.1
  • 15
    • 0028869067 scopus 로고
    • Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956
    • NAGASU, T., YOSHIMATSU, K., ROWELL, C., LEWIS, M.D. and GARCIA, A.M., Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956. Cancer Res., 55, 5310-5314 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 5310-5314
    • Nagasu, T.1    Yoshimatsu, K.2    Rowell, C.3    Lewis, M.D.4    Garcia, A.M.5
  • 16
    • 0030829794 scopus 로고    scopus 로고
    • Inhibitors of prenyl transferases
    • SEBTI, S. and HAMILTON, A.D., Inhibitors of prenyl transferases. Curr. Opin. Oncol., 9, 557-561 (1997).
    • (1997) Curr. Opin. Oncol. , vol.9 , pp. 557-561
    • Sebti, S.1    Hamilton, A.D.2
  • 17
    • 0028835253 scopus 로고
    • A peptidomimetic inhibitor of farnesyl:Protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines
    • SEPP-LORENZINO, L., MA, Z., RANDS, E., KOHL, N.E., GIBBS, J.B., OLIFF, A. and ROSEN, N., A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res., 55, 5302-5309 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 5302-5309
    • Sepp-Lorenzino, L.1    Ma, Z.2    Rands, E.3    Kohl, N.E.4    Gibbs, J.B.5    Oliff, A.6    Rosen, N.7
  • 18
    • 0032546264 scopus 로고    scopus 로고
    • Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts
    • SUN, J., QIAN, Y., HAMILTON, A.D. and SEBTI, S.M., Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts. Oncogene, 16, 1467-1473 (1998).
    • (1998) Oncogene , vol.16 , pp. 1467-1473
    • Sun, J.1    Qian, Y.2    Hamilton, A.D.3    Sebti, S.M.4
  • 20
    • 0030046472 scopus 로고    scopus 로고
    • Lovastatin inhibits the stimulation of mitogen-activated protein kinase by insulin in HIRcB fibroblasts
    • XU, X.Q., MCGUIRE, T.F., BLASKOVICH, M.A., SEBTI, S.M. and ROMERO, G., Lovastatin inhibits the stimulation of mitogen-activated protein kinase by insulin in HIRcB fibroblasts. Arch. Biochem. Biophys., 326, 233-237 (1996).
    • (1996) Arch. Biochem. Biophys. , vol.326 , pp. 233-237
    • Xu, X.Q.1    Mcguire, T.F.2    Blaskovich, M.A.3    Sebti, S.M.4    Romero, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.