Targeted inactivation of the isoprenyleysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells

Journal of Biological Chemistry

Volumn 275, Issue 23, 2000, Pages 17605-17610

  Bergo, Martin O ^a,d   Leung, Gordon K ^a,b   Ambroziak, Patricia ^a   Otto, James C ^c   Casey, Patrick J ^c   Young, Stephen G ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CARBOXYL GROUP; GEFARNATE; GERANYL ACETATE; GERANYLGERANIOL; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; ISOPRENE; METHYLTRANSFERASE; RAS PROTEIN; PHOTOPROTEIN; PROTEIN METHYLTRANSFERASE; PROTEIN P21; PROTEIN S ISOPRENYLCYSTEINE O METHYLTRANSFERASE; PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EMBRYO; GENE CONSTRUCT; GENE FUSION; GENE INACTIVATION; GENE TARGETING; GENETIC TRANSFECTION; ISOPRENYLATION; KNOCKOUT GENE; MAMMAL CELL; METHYLATION; MOUSE; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN TARGETING; STEM CELL; ANIMAL; CYTOLOGY; ENZYMOLOGY; GENETICS; HOMOZYGOTE; LIVER; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

ANIMALS; GREEN FLUORESCENT PROTEINS; HOMOZYGOTE; LIVER; LUMINESCENT PROTEINS; MICE; MICE, KNOCKOUT; PROTEIN METHYLTRANSFERASES; PROTO-ONCOGENE PROTEINS P21(RAS); RECOMBINANT FUSION PROTEINS; STEM CELLS;

EID: 0034625181     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C000079200     Document Type: Article

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