Farnesyl protein transferase: Identification of K164α and Y300β as catalytic residues by mutagenesis and kinetic studies

Biochemistry

Volumn 38, Issue 35, 1999, Pages 11239-11249

  Wu, Zhen ^a   Demma, Mark ^a   Strickland, Corey L ^a   Radisky, Evette S ^b   Poulter, C Dale ^b   Le, Hung V ^a   Windsor, William T ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; PROTEIN FARNESYLTRANSFERASE; RAS PROTEIN; REGULATOR PROTEIN; ZINC;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME MECHANISM; ONCOGENE RAS; PRENYLATION; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

FELIS CATUS;

EID: 0033621051     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990583t     Document Type: Article

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