Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activation and G1-S transition in Ki-Ras-overexpressing transformed adrenocortical cells

FEBS Letters

Volumn 460, Issue 2, 1999, Pages 235-240

  Mazet, Jean Luc ^a   Padieu, Martine ^a   Osman, Hanan ^a   Maume, Gabrielle ^a   Mailliet, Patrick ^b   Dereu, Norbert ^b   Hamilton, Andrew D ^d   Lavelle, François ^b   Sebti, Saïd M ^c   Maume, Bernard F ^a  

^a UNIVERSITÉ DE BOURGOGNE   (France)

^b SANOFI   (France)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^d YALE UNIVERSITY   (United States)

Author keywords

Alternative pathway; Anti proliferative effect; Farnesyltransferase; Geranylgeranyltransferase; Kirsten Ras; Prenylation

Indexed keywords

GERANYLTRANSFERASE; GGTI 298; MEVINOLIN; MITOGEN ACTIVATED PROTEIN KINASE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RPR 13041; SIMVASTATIN; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ADRENAL CORTEX CELL; ANIMAL CELL; ARTICLE; BINDING SITE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOLYSIS; ENZYME ACTIVATION; GENE OVEREXPRESSION; NEWBORN; NONHUMAN; PRENYLATION; PRIORITY JOURNAL; RAT;

ADRENAL GLANDS; ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; BENZAMIDES; CELL DIVISION; CELL LINE, TRANSFORMED; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; FLOW CYTOMETRY; G1 PHASE; GENES, RAS; INDOLES; LOVASTATIN; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN ISOPRENYLATION; RAS PROTEINS; RATS; S PHASE; SIMVASTATIN; TIME FACTORS;

EID: 0032752610     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(99)01355-1     Document Type: Article

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