Tricyclic farnesyl protein transferase inhibitors: Crystallographic and calorimetric studies of structure-activity relationships

Journal of Medicinal Chemistry

Volumn 42, Issue 12, 1999, Pages 2125-2135

  Strickland, Corey L ^a   Weber, Patricia C ^a   Windsor, William T ^a   Wu, Zhen ^a   Le, Hung V ^a   Albanese, Margaret M ^a   Alvarez, Carmen S ^a   Cesarz, David ^a   Del Rosario, Joycelyn ^a   Deskus, Jeffrey ^a   Mallams, Alan K ^a   Njoroge, F George ^a   Piwinski, John J ^a   Remiszewski, Stacy ^a   Rossman, Randall R ^a   Taveras, Arthur G ^a   Vibulbhan, Bancha ^a   Doll, Ronald J ^a   Girijavallabhan, Viyyoor M ^a   Ganguly, Ashit K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (8 CHLORO 5,6 DIHYDRO 11H BENZO[5,6]CYCLOHEPTA[1,2 B]PYRIDIN 11 YLIDENE) 1 (4 PYRIDYLACETYL)PIPERIDINE; 4 [2 [4 [3,10 DIBROMO 8 CHLORO 6,11 DIHYDRO 5H BENZO(5,6) CYCLOHEPTA[1,2 B]PYRIDIN 11 YL] 1 PIPERIDINYL] 2 OXOETHYL] 1 PIPERIDINECARBOXAMIDE; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CALORIMETRY; CANCER CHEMOTHERAPY; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENTHALPY; ENTROPY; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS;

ALKYL AND ARYL TRANSFERASES; ANTINEOPLASTIC AGENTS; BINDING SITES; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; CYCLIC N-OXIDES; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS, 3-RING; HYDROGEN BONDING; MODELS, MOLECULAR; PIPERIDINES; PROTEIN ISOPRENYLATION; PYRIDINES; THERMODYNAMICS;

EID: 0033578085     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990030g     Document Type: Article

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