-
1
-
-
0028331587
-
Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic
-
Gibbs, J., Oliff, A., and Kohl, N. E. Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic. Cell, 77: 175-178, 1994.
-
(1994)
Cell
, vol.77
, pp. 175-178
-
-
Gibbs, J.1
Oliff, A.2
Kohl, N.E.3
-
2
-
-
0030962347
-
The potential of farnesyltransferase inhibitors as cancer chemotherapeutics
-
Gibbs, J. B., and Oliff, A. The potential of farnesyltransferase inhibitors as cancer chemotherapeutics. Annu. Rev. Pharmacol. Toxicol., 37: 143-166, 1997.
-
(1997)
Annu. Rev. Pharmacol. Toxicol.
, vol.37
, pp. 143-166
-
-
Gibbs, J.B.1
Oliff, A.2
-
3
-
-
0030865773
-
Ras farnesyltransferase: A new therapeutic target
-
Leonard, D. M. Ras farnesyltransferase: a new therapeutic target. J. Med. Chem., 40: 2971-2990, 1997.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 2971-2990
-
-
Leonard, D.M.1
-
4
-
-
0030749464
-
Inhibition of Ras prenylation: A novel approach to cancer chemotherapy
-
Sebti, S. M., and Hamilton, A. D. Inhibition of Ras prenylation: a novel approach to cancer chemotherapy. Pharmacol. Ther., 74: 103-114, 1997.
-
(1997)
Pharmacol. Ther.
, vol.74
, pp. 103-114
-
-
Sebti, S.M.1
Hamilton, A.D.2
-
5
-
-
0030749458
-
Farnesyltransferase inhibitors and cancer treatment: Targeting simply Ras?
-
Cox, A. D., and Der, C. J,. Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras? Biochim. Biophys. Acta, 1333: F51-71, 1997.
-
(1997)
Biochim. Biophys. Acta
, vol.1333
-
-
Cox, A.D.1
Der, C.J.2
-
6
-
-
0032541625
-
Non-Ras targets for farnesyltransferase inhibitors: Focus on Rho
-
Lebowitz, P. F., and Prendergast, G. C. Non-Ras targets for farnesyltransferase inhibitors: focus on Rho. Oncogene, 17: 1439-1447, 1998.
-
(1998)
Oncogene
, vol.17
, pp. 1439-1447
-
-
Lebowitz, P.F.1
Prendergast, G.C.2
-
7
-
-
0032981812
-
Targeting farnesyltransferase: Is Ras relevant?
-
Prendergast, G. C., and Du, W. Targeting farnesyltransferase: is Ras relevant? Drug Resist. Updates, 2: 81-84, 1999.
-
(1999)
Drug Resist. Updates
, vol.2
, pp. 81-84
-
-
Prendergast, G.C.1
Du, W.2
-
8
-
-
0029966304
-
Protein prenyltransferases
-
Casey, P. J., and Seabra, M. C. Protein prenyltransferases. J. Biol. Chem., 271: 5289-5292, 1996.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 5289-5292
-
-
Casey, P.J.1
Seabra, M.C.2
-
9
-
-
0029898894
-
Protein prenylation: Molecular mechanisms and functional consequences
-
Zhang, F. L., and Casey, P. J. Protein prenylation: molecular mechanisms and functional consequences. Annu. Rev. Biochem., 65: 241-269, 1996.
-
(1996)
Annu. Rev. Biochem.
, vol.65
, pp. 241-269
-
-
Zhang, F.L.1
Casey, P.J.2
-
10
-
-
0026659959
-
Specific isoprenoid modification is required for function of normal, but not oncogenic. Ras function
-
Cox, A. D., Hisaka, M. M., Buss, J. E., and Der, C. J., Specific isoprenoid modification is required for function of normal, but not oncogenic. Ras function. Mol. Cell. Biol., 12: 2606-2615, 1992.
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 2606-2615
-
-
Cox, A.D.1
Hisaka, M.M.2
Buss, J.E.3
Der, C.J.4
-
11
-
-
0030916369
-
Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB
-
Lebowitz, P., Casey, P. J., Prendergast, G. C. and Thissen, J. Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB. J. Biol. Chem., 272: 15591-15594, 1997.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 15591-15594
-
-
Lebowitz, P.1
Casey, P.J.2
Prendergast, G.C.3
Thissen, J.4
-
12
-
-
0026747866
-
Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity
-
Kato, K., Cox, A. D., Hisaka, M. M., Graham, S. M., Buss, J. E., and Der, C. J. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. Proc. Nati. Acad. Sci. USA, 89: 6403-6407, 1992.
-
(1992)
Proc. Nati. Acad. Sci. USA
, vol.89
, pp. 6403-6407
-
-
Kato, K.1
Cox, A.D.2
Hisaka, M.M.3
Graham, S.M.4
Buss, J.E.5
Der, C.J.6
-
13
-
-
0031983131
-
A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis
-
Barrington, R. E., Subler, M. A., Rands, E., Omer, C. A., Miller, P. J., Hundley, J. E., Koester, S. K., Troyer, D. A., Bearss, D. J., Conner, M. W., Gibbs, J. B., Hamilton, K., Koblan, K. S., Mosser, S. D., O'Neill, T. J., Schaber, M. D., Senderak, E. T., Windle, J. J., Oliff, A., and Kohl, N. E. A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Mol. Cell. Biol., 18: 85-92, 1998.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 85-92
-
-
Barrington, R.E.1
Subler, M.A.2
Rands, E.3
Omer, C.A.4
Miller, P.J.5
Hundley, J.E.6
Koester, S.K.7
Troyer, D.A.8
Bearss, D.J.9
Conner, M.W.10
Gibbs, J.B.11
Hamilton, K.12
Koblan, K.S.13
Mosser, S.D.14
O'Neill, T.J.15
Schaber, M.D.16
Senderak, E.T.17
Windle, J.J.18
Oliff, A.19
Kohl, N.E.20
more..
-
14
-
-
0027323459
-
Benzodiazepine peptidomimetics: Potent inhibitors of Ras farnesylation in animal cells
-
Washington DC
-
James, G. L., Goldstein, J. L., Brown, M. S., Rawson, T. E., Somers, T. C., McDowell, R. S., Crowley, C. W., Lucas, B. K., Levinson, A. D., and Marsters, J. C. Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells. Science (Washington DC), 260: 1937-1942, 1993.
-
(1993)
Science
, vol.260
, pp. 1937-1942
-
-
James, G.L.1
Goldstein, J.L.2
Brown, M.S.3
Rawson, T.E.4
Somers, T.C.5
McDowell, R.S.6
Crowley, C.W.7
Lucas, B.K.8
Levinson, A.D.9
Marsters, J.C.10
-
15
-
-
0027248872
-
Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor
-
Washington DC
-
Kohl, N. E., Mosser, S. D., deSolms, S. J., Giuliani, E. A., Pompliano, D. L., Graham, S. L., Smith, R. L., Scolnick, E. M., Oliff, A., and Gibbs, J. B. Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. Science (Washington DC), 260: 1934-1937, 1993.
-
(1993)
Science
, vol.260
, pp. 1934-1937
-
-
Kohl, N.E.1
Mosser, S.D.2
DeSolms, S.J.3
Giuliani, E.A.4
Pompliano, D.L.5
Graham, S.L.6
Smith, R.L.7
Scolnick, E.M.8
Oliff, A.9
Gibbs, J.B.10
-
16
-
-
0029150669
-
Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice
-
Kohl, N. E., Omer, C. A., Conner, M. W., Anthony, N. J., Davide, J. P., deSolms, S. J., Giuliani, E. A., Gomez, R. P., Graham, S. L., Hamilton, K., Handt, L. K., Hartman, G. D., Koblan, K. S., Kral, A. M., Miller, P. J., Mosser, S. D., O'Neill, T. J., Rands, E., Schaber, M. D., Gibbs, J. B., and Oliff, A. Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nat. Med., 1: 792-797, 1995.
-
(1995)
Nat. Med.
, vol.1
, pp. 792-797
-
-
Kohl, N.E.1
Omer, C.A.2
Conner, M.W.3
Anthony, N.J.4
Davide, J.P.5
DeSolms, S.J.6
Giuliani, E.A.7
Gomez, R.P.8
Graham, S.L.9
Hamilton, K.10
Handt, L.K.11
Hartman, G.D.12
Koblan, K.S.13
Kral, A.M.14
Miller, P.J.15
Mosser, S.D.16
O'Neill, T.J.17
Rands, E.18
Schaber, M.D.19
Gibbs, J.B.20
Oliff, A.21
more..
-
17
-
-
0028603395
-
Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice
-
Kohl, N. E., Redner, F., Mosser, S., Guiliani, E. A., deSolms, S. J., Conner, M. W., Anthony, N. J., Holtz, W. J., Gomez, R. P., Lee, T-J., Smith, R. L., Graham, S. L., Hartman, G. D., Gibbs, J., and Oliff, A. Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice. Proc. Natl. Acad. Sci. USA, 91: 9141-9145, 1994.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 9141-9145
-
-
Kohl, N.E.1
Redner, F.2
Mosser, S.3
Guiliani, E.A.4
DeSolms, S.J.5
Conner, M.W.6
Anthony, N.J.7
Holtz, W.J.8
Gomez, R.P.9
Lee, T.-J.10
Smith, R.L.11
Graham, S.L.12
Hartman, G.D.13
Gibbs, J.14
Oliff, A.15
-
18
-
-
0032521211
-
Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice
-
Mangues, R., Corral, T., Kohl, N. E., Symmans, W. F., Lu, S., Malumbres, M., Gibbs, J. B., Oliff, A., and Pellicer, A. Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice. Cancer Res., 58: 1253-1259, 1998.
-
(1998)
Cancer Res.
, vol.58
, pp. 1253-1259
-
-
Mangues, R.1
Corral, T.2
Kohl, N.E.3
Symmans, W.F.4
Lu, S.5
Malumbres, M.6
Gibbs, J.B.7
Oliff, A.8
Pellicer, A.9
-
19
-
-
0029000897
-
Bisubstrate inhibitors of farnesyltransferase: A novel class of specific inhibitors of ras transformed cells
-
Manne, V., Yan, N., Carboni, J. M., Tuomari, A. V., Ricca, C. S., Brown, J. G., Andahazy, M. L., Schmidt, R. J., Patel, D., Zahler, R., Weinmann, R., Der, C. J., Cox, A. D., Hunt, J. T., Gordon, E. M., Barbacid, M., and Seizinger, B. R. Bisubstrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras transformed cells. Oncogene, 10: 1763-1779, 1995.
-
(1995)
Oncogene
, vol.10
, pp. 1763-1779
-
-
Manne, V.1
Yan, N.2
Carboni, J.M.3
Tuomari, A.V.4
Ricca, C.S.5
Brown, J.G.6
Andahazy, M.L.7
Schmidt, R.J.8
Patel, D.9
Zahler, R.10
Weinmann, R.11
Der, C.J.12
Cox, A.D.13
Hunt, J.T.14
Gordon, E.M.15
Barbacid, M.16
Seizinger, B.R.17
-
20
-
-
0028869067
-
Inhibition of human tumor xenograft growth by treatment with the farnesyltransferase inhibitor B956
-
Nagasu, T., Yoshimatsu, K., Rowell, C., Lewis, M. D., and Garcia, A. M. Inhibition of human tumor xenograft growth by treatment with the farnesyltransferase inhibitor B956. Cancer Res., 55: 5310-5314, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 5310-5314
-
-
Nagasu, T.1
Yoshimatsu, K.2
Rowell, C.3
Lewis, M.D.4
Garcia, A.M.5
-
21
-
-
0028318136
-
Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton
-
Prendergast, G. C., Davide, J. P., deSolms, S. J., Giuliani, E., Graham, S., Gibbs, J. B., Oliff, A., and Kohl, N. E. Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton. Mol. Cell. Biol., 14: 4193-4202, 1994.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 4193-4202
-
-
Prendergast, G.C.1
Davide, J.P.2
DeSolms, S.J.3
Giuliani, E.4
Graham, S.5
Gibbs, J.B.6
Oliff, A.7
Kohl, N.E.8
-
22
-
-
0028835253
-
A peptidomimetic inhibitor of farnesyl:Protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines
-
Sepp-Lorenzino, L., Ma, Z., Rands, E., Kohl, N. E., Gibbs, J. B., Oliff, A., and Rosen, N. A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res., 55: 5302-5309, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 5302-5309
-
-
Sepp-Lorenzino, L.1
Ma, Z.2
Rands, E.3
Kohl, N.E.4
Gibbs, J.B.5
Oliff, A.6
Rosen, N.7
-
23
-
-
0029023145
-
Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion
-
Sun, J., Qian, Y., Hamilton, A. D., and Sebti, S. M. Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion. Cancer Res., 55: 4243-4247, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 4243-4247
-
-
Sun, J.1
Qian, Y.2
Hamilton, A.D.3
Sebti, S.M.4
-
24
-
-
0033016719
-
Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB
-
Du, W., Lebowitz, P., and Prendergast, G. C. Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB. Mol. Cell. Biol., 19: 1831-1840, 1999.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 1831-1840
-
-
Du, W.1
Lebowitz, P.2
Prendergast, G.C.3
-
25
-
-
0032939619
-
Rho GTPases are overexpressed in human tumors
-
Fritz, G., Just, I., and Kaina, B. Rho GTPases are overexpressed in human tumors. Int. J. Cancer, 81: 682-687, 1999.
-
(1999)
Int. J. Cancer
, vol.81
, pp. 682-687
-
-
Fritz, G.1
Just, I.2
Kaina, B.3
-
26
-
-
0032935495
-
An essential part for Rho-associated kinase in the transcellular invasion of tumor cells
-
Itoh, K., Yoshioka, K., Akedo, H., Uegata, M., Ishizaki, T., and Narumiya, S. An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nat. Med., 5: 221-225, 1999.
-
(1999)
Nat. Med.
, vol.5
, pp. 221-225
-
-
Itoh, K.1
Yoshioka, K.2
Akedo, H.3
Uegata, M.4
Ishizaki, T.5
Narumiya, S.6
-
27
-
-
0032609051
-
Rho-like GTPases: Their role in cell adhesion and invasion
-
Michiels, F., and Collard, J. G. Rho-like GTPases: their role in cell adhesion and invasion. Biochem. Soc. Symp., 65: 125-146, 1999.
-
(1999)
Biochem. Soc. Symp.
, vol.65
, pp. 125-146
-
-
Michiels, F.1
Collard, J.G.2
-
28
-
-
0031974721
-
Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas
-
Suwa, H., Ohshio, G., Imamura, T., Watanabe, G., Arii, S., Imamura, M., Narumiya; S., Hiai, H., and Fukumoto, M. Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas. Br. J. Cancer, 77: 147-152, 1998.
-
(1998)
Br. J. Cancer
, vol.77
, pp. 147-152
-
-
Suwa, H.1
Ohshio, G.2
Imamura, T.3
Watanabe, G.4
Arii, S.5
Imamura, M.6
Narumiya, S.7
Hiai, H.8
Fukumoto, M.9
-
29
-
-
0033561508
-
Overexpression of small GTP-binding protein RhoA promotes invasion of tumor cells
-
Yoshioka, K., Hakamori, S., and Itoh, K. Overexpression of small GTP-binding protein RhoA promotes invasion of tumor cells. Cancer Res., 59: 2004-2010, 1999.
-
(1999)
Cancer Res.
, vol.59
, pp. 2004-2010
-
-
Yoshioka, K.1
Hakamori, S.2
Itoh, K.3
-
30
-
-
0026640530
-
Post-translational modification of p21rho proteins
-
Adamson, P., Marshall, C. J., Hall, A., and Tilbrook, P. A. Post-translational modification of p21rho proteins. J. Biol. Chem., 267: 20033-20038, 1992.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 20033-20038
-
-
Adamson, P.1
Marshall, C.J.2
Hall, A.3
Tilbrook, P.A.4
-
31
-
-
0028892646
-
Evidence that farnesyl transferase inhibitors suppress Ras transformation by interfering with Rho activity
-
Lebowitz, P. F., Davide, J. P., and Prendergast, G. C. Evidence that farnesyl transferase inhibitors suppress Ras transformation by interfering with Rho activity. Mol. Cell. Biol., 15: 6613-6622, 1995.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 6613-6622
-
-
Lebowitz, P.F.1
Davide, J.P.2
Prendergast, G.C.3
-
32
-
-
0029973558
-
Transcriptional activation of the syndecan-1 promoter by the Wilms' tumor protein WT1
-
Cook, D. M., Hinkes, M. T., Bernfield, M., and Rauscher, F. J. Transcriptional activation of the syndecan-1 promoter by the Wilms' tumor protein WT1. Oncogene, 13: 1789-1799, 1996.
-
(1996)
Oncogene
, vol.13
, pp. 1789-1799
-
-
Cook, D.M.1
Hinkes, M.T.2
Bernfield, M.3
Rauscher, F.J.4
-
33
-
-
0028385758
-
Versatile retroviral vectors for potential use in gene therapy
-
Hawley, R. G., Lieu, F. H., Fong, A. Z., and Hawley, T. S. Versatile retroviral vectors for potential use in gene therapy. Gene Ther., 1: 136-138, 1994.
-
(1994)
Gene Ther.
, vol.1
, pp. 136-138
-
-
Hawley, R.G.1
Lieu, F.H.2
Fong, A.Z.3
Hawley, T.S.4
-
34
-
-
0031896385
-
Analysis of cell-cycle profiles in transfected cells using a membrane-targeted GFP
-
Jiang, W., and Hunter, T. Analysis of cell-cycle profiles in transfected cells using a membrane-targeted GFP. Biotechniques, 24: 349-354, 1998.
-
(1998)
Biotechniques
, vol.24
, pp. 349-354
-
-
Jiang, W.1
Hunter, T.2
-
35
-
-
0023130372
-
Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing
-
Carmichael, J., DeGraff, W. G., Gazdar, A. F., Minna, J. D., and Mitchell, J. B. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res., 47: 936-942, 1987.
-
(1987)
Cancer Res.
, vol.47
, pp. 936-942
-
-
Carmichael, J.1
DeGraff, W.G.2
Gazdar, A.F.3
Minna, J.D.4
Mitchell, J.B.5
-
36
-
-
0030952552
-
Inhibition of the prenylation of K-Ras, but not H-or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase-1 inhibitor in human tumor cell lines
-
Lerner, E. C., Zhang, T. T., Knowles, D. B., Qian, Y. M., Hamilton, A. D., and Sebti, S. M. Inhibition of the prenylation of K-Ras, but not H-or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase-1 inhibitor in human tumor cell lines. Oncogene, 15: 1283-1288, 1997.
-
(1997)
Oncogene
, vol.15
, pp. 1283-1288
-
-
Lerner, E.C.1
Zhang, T.T.2
Knowles, D.B.3
Qian, Y.M.4
Hamilton, A.D.5
Sebti, S.M.6
-
37
-
-
0030968859
-
Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo
-
Rowell, C. A., Kowakzyk, J. J., Lewis, M. D., and Garcia, A. M. Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo. J. Biol. Chem., 272: 14093-14097, 1997.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 14093-14097
-
-
Rowell, C.A.1
Kowakzyk, J.J.2
Lewis, M.D.3
Garcia, A.M.4
-
38
-
-
0032546264
-
Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts
-
Sun, J., Qian, Y., Hamilton, A. D., and Sebti, S. M. Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts. Oncogene, 16: 1467-1473, 1998.
-
(1998)
Oncogene
, vol.16
, pp. 1467-1473
-
-
Sun, J.1
Qian, Y.2
Hamilton, A.D.3
Sebti, S.M.4
-
39
-
-
0030923192
-
K- and N-ras geranylgeranylated in cells treated with farnesyl protein transferase inhibitors
-
Whyte, D. B., Kirschmeier, P., Hockenberry, T. N., Nunez-Olivia, I., James, L., Catino J. J., Bishop, W. R., and Pai, J. K. K- and N-ras geranylgeranylated in cells treated with farnesyl protein transferase inhibitors. J. Biol. Chem., 272: 14459-14464, 1997.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 14459-14464
-
-
Whyte, D.B.1
Kirschmeier, P.2
Hockenberry, T.N.3
Nunez-Olivia, I.4
James, L.5
Catino, J.J.6
Bishop, W.R.7
Pai, J.K.8
-
42
-
-
0031004491
-
2-M enrichment in A549 cells
-
2-M enrichment in A549 cells. Cancer Res., 57: 1846-1850, 1997.
-
(1997)
Cancer Res.
, vol.57
, pp. 1846-1850
-
-
Miquel, K.1
Pradines, A.2
Sun, J.3
Qian, Y.4
Hamilton, A.D.5
Sebti, S.M.6
Favre, G.7
-
43
-
-
0032417689
-
Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells
-
Suzuki, N., Urano, J., and Tamanoi, F. Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells. Proc. Natl. Acad. Sci. USA, 95: 15356-15361, 1998.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 15356-15361
-
-
Suzuki, N.1
Urano, J.2
Tamanoi, F.3
-
44
-
-
0033198386
-
Activation of the P13′K-AKT pathway masks the proapoptotic effect of farnesyltransferase inhibitors
-
Du, W., Liu, A., and Prendergast, G. C. Activation of the P13′K-AKT pathway masks the proapoptotic effect of farnesyltransferase inhibitors. Cancer Res., 59:4208-4212, 1999.
-
(1999)
Cancer Res.
, vol.59
, pp. 4208-4212
-
-
Du, W.1
Liu, A.2
Prendergast, G.C.3
-
45
-
-
0028958919
-
Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro
-
James, G. L., Goldstein, J. L., and Brown, M. S. Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro. J. Biol. Chem., 270: 6221-6226, 1995.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 6221-6226
-
-
James, G.L.1
Goldstein, J.L.2
Brown, M.S.3
-
46
-
-
0027409561
-
Identification of Ras farnesyltransferase inhibitors by microbial screening
-
Hara, M., Akasaka, K., Akinaga, S., Okabe, M., Nakano, H., Gomez, R., Wood, D., Uh, M., and Tamanoi, F. Identification of Ras farnesyltransferase inhibitors by microbial screening. Proc. Natl. Acad. Sci. USA, 90: 2281-2285, 1993.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 2281-2285
-
-
Hara, M.1
Akasaka, K.2
Akinaga, S.3
Okabe, M.4
Nakano, H.5
Gomez, R.6
Wood, D.7
Uh, M.8
Tamanoi, F.9
-
47
-
-
0029877708
-
Suppression of human pancreatic cancer growth in BALB/c nude mice by manumycin, a farnesyl:Protein transferase inhibitor
-
Ito, T., Kawata, S., Tamura, S., Igura, T., Nagase, T., Miyagawa, J. I., Yamazaki, E., Ishiguro, H., and Matasuzawa, Y. Suppression of human pancreatic cancer growth in BALB/c nude mice by manumycin, a farnesyl:protein transferase inhibitor. Jpn. J. Cancer Res., 87: 113-116, 1996.
-
(1996)
Jpn. J. Cancer Res.
, vol.87
, pp. 113-116
-
-
Ito, T.1
Kawata, S.2
Tamura, S.3
Igura, T.4
Nagase, T.5
Miyagawa, J.I.6
Yamazaki, E.7
Ishiguro, H.8
Matasuzawa, Y.9
-
48
-
-
0028964295
-
1 integrin receptor
-
1 integrin receptor. FEBS Lett., 363: 78-80, 1995.
-
(1995)
FEBS Lett.
, vol.363
, pp. 78-80
-
-
Aepfelbacher, M.1
-
49
-
-
0029731588
-
Focal adhesions, contractility, and signaling
-
Burridge, K., and Chrzanowska-Wodnicka, M. Focal adhesions, contractility, and signaling. Annu. Rev. Cell. Dev. Biol., 12: 463-518, 1996.
-
(1996)
Annu. Rev. Cell. Dev. Biol.
, vol.12
, pp. 463-518
-
-
Burridge, K.1
Chrzanowska-Wodnicka, M.2
-
50
-
-
0029562867
-
The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases
-
Hotchin, N. A., and Hall, A. The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J. Cell Biol., 131: 1857-1865, 1995.
-
(1995)
J. Cell Biol.
, vol.131
, pp. 1857-1865
-
-
Hotchin, N.A.1
Hall, A.2
-
51
-
-
0029855239
-
Regulation of the actin cytoskeleton, integrins and cell growth by the Rho family of small GTPases
-
Hotchin, N. A., and Hall, A. Regulation of the actin cytoskeleton, integrins and cell growth by the Rho family of small GTPases. Cancer Surv., 27: 311-322, 1996.
-
(1996)
Cancer Surv.
, vol.27
, pp. 311-322
-
-
Hotchin, N.A.1
Hall, A.2
-
52
-
-
17544377292
-
ADP-ribosylation of the G protein Rho inhibits integrin regulation of tumor cell growth
-
Udagawa, T., and McIntyre, B. W. ADP-ribosylation of the G protein Rho inhibits integrin regulation of tumor cell growth. J. Biol. Chem., 271: 12542-12548, 1996.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 12542-12548
-
-
Udagawa, T.1
McIntyre, B.W.2
|