Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase

Journal of Medicinal Chemistry

Volumn 39, Issue 2, 1996, Pages 353-358

  Hunt, John T ^a   Lee, Ving G ^a   Leftheris, Katerina ^a   Seizinger, Bernd ^a   Carboni, Joan ^a   Mabus, John ^a   Ricca, Carol ^a   Yan, Ning ^a   Manne, Veeraswamy ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; FARNESYL TRANS TRANSFERASE; N [[1,2,3,4 TETRAHYDRO 2 [N [2 (1H IMIDAZOL 4 YL)ETHYL]VALYL] 3 ISOQUINOLINYL]CARBONYL]METHIONINE; PRODRUG; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER GROWTH; CARCINOGENESIS; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; GROWTH INHIBITION; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

3T3 CELLS; ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; ANIMALS; FARNESYLTRANSTRANSFERASE; MICE; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; TRANSFERASES;

EID: 0030034763     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9507284     Document Type: Article

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