Mutational analysis of conserved residues of the β-subunit of human farnesyl:protein transferase

Journal of Biological Chemistry

Volumn 272, Issue 43, 1997, Pages 27319-27323

  Kral, Astrid M ^a,b   Diehl, Ronald E ^a   DeSolms, S Jane ^a   Williams, Theresa M ^a   Kohl, Nancy E ^a   Omer, Charles A ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN FARNESYLTRANSFERASE;

AMINO ACID SEQUENCE; ANALYTIC METHOD; ANCHORAGE INDEPENDENT GROWTH; ARTICLE; BETA CHAIN; CARBOXY TERMINAL SEQUENCE; CROSS LINKING; CRYSTAL STRUCTURE; ENZYME KINETICS; ENZYME SUBSTRATE; GENE MUTATION; GENETIC CONSERVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ARGININE; BASE SEQUENCE; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; FARNESYLTRANSTRANSFERASE; HISTIDINE; HUMANS; KINETICS; LYSINE; MACROMOLECULAR SUBSTANCES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RATS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TRYPTOPHAN;

EID: 0030846872     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.43.27319     Document Type: Article

References (42)

1. Reiss, Y., Goldstein, J. L., Seabra, M. C., Casey, P. J., and Brown, M. S. (1990) Cell 62, 81-88
2. Zhang, F. L., and Casey, P. J. (1996) Annu. Rev. Biochem. 65, 241-269
3. Moores, S. L., Schaber, M. D., Mosser, S. D., Rands, E., O'Hara, M. B., Garsky, V. M., Marshall, M. S., Pompliano, D. L., and Gibbs, J. B. (1991) J. Biol. Chem. 266, 14603-14610
4. Reiss, Y., Stradley, S. J., Gierasch, L. M., Brown, M. S., and Goldstein, J. L. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 732-736
5. Gibbs, J. B., Oliff, A., and Kohl, N. E. (1994) Cell 77, 175-178
6. Nagasu, T., Yoshimatsu, K., Rowill, C., Lewis, M. D., and Garcia, A. M. (1995) Cancer Res. 55, 5310-5314
7. Kohl, N. E., Mosser, S. D., deSolms, S. J., Giuliani, E. A., Pompliano, D. L., Graham, S. L., Smith, R. L., Scolnick, E. M., Oliff, A., and Gibbs, J. B. (1993) Science 260, 1934-1937
8. Sepp-Lorenzino, L., Ma, Z., Rands, E., Kohl, N. E., Gibbs, J. B., Oliff, A., and Rosen, N. (1995) Cancer Res. 55, 5302-5309
9. Kohl, N. E., Omer, C. A., Conner, M. W., Anthony, N. J., Davide, J. P., deSolms, S. J., Giuliani, E. A., Gomez, R. P., Graham, S. L., Hamilton, K., Handt, L. K., Hartman, G. D., Koblan, K. S., Kral, A. M., Miller, P. J., Mosser, S. D., O'Neill, T. J., Rands, E., Schaber, M. D., Gibbs, J. B., and Oliff, A. (1995) Nat. Genet. 1, 792-797
10. Pompliano, D. L., Schaber, M. D., Mosser, S. D., Omer, C. A., Shafer, J. A., and Gibbs, J. B. (1993) Biochemistry 32, 8341-8347
11. Furfine, E. S., Leban, J. J., Landavazo, A., Moomaw, J. F., and Casey, P. J. (1995) Biochemistry 34, 6857-6862
12. Reiss, Y., Brown, M. S., and Goldstein, J. L. (1992) J. Biol. Chem. 267, 6403-6408
13. Chen, W-J., Moomaw, J. F., Overton, L., Kost, T. A., and Casey, P. J. (1993) J. Biol. Chem. 268, 9675-9680
14. Huang, C.-C., Casey, P. J., and Fierke, C. A. (1997) J. Biol. Chem. 272, 20-23
15. Moomaw, J. F., and Casey, P. J. (1992) J. Biol. Chem. 267, 17438-17443
16. Seabra, M. C., Goldstein, J. L., Sudhof, T. C., and Brown, M. S. (1992) J. Biol. Chem. 267, 14497-14503
17. Schmitt, D., Cullan, K., and Gruissem, W. (1996) Plant Physiol. 112, 767-777
18. Reiss, Y., Seabra, M. C., Armstrong, S. A., Slaughter, C. A., Goldstein, J. L., and Brown, M. S. (1991) J. Biol. Chem. 266, 10672-10677
19. Seabra, M. C., Reiss, Y., Casey, P. J., Brown, M. S., and Goldstein, J. L. (1991) Cell 65, 429-434
20. Zhang, F. L., Diehl, R. E., Kohl, N. E., Gibbs, J. B., Giros, B., Casey, P. J., and Omer, C. A. (1994) J. Biol. Chem. 269, 3175-3180
21. Armstrong, S. A., Seabra, M. C., Sudhof, T. C., Goldstein, J. L., and Brown, M. (1993) J. Biol. Chem. 268, 12221-12229
22. Omer, C. A., Kral, A. M., Diehl, R. E., Prendergast, G. C., Powers, S., Allen, C. M., Gibbs, J. B., and Kohl, N. E. (1993) Biochemistry 32, 5167-5176
23. Ying, W., Sepp-Lorenzino, L., Cai, K., Aloise, P., and Coleman, P. S. (1994) J. Biol. Chem. 269, 470-477
24. Bukhtiyarov, Y. E., Omer, C. A., and Allen, C. M. (1995) J. Biol. Chem. 270, 19035-19040
25. Yokoyama, K., McGeady, P., and Gelb, M. H. (1995) Biochemistry 34, 1344-1354
26. Park, J. T., Boduluri, S. R., Moomaw, J. F., Casey, P. J., and Beese, L. T. (1997) Science 275, 1800-1804
27. Eisenberg, S. P., Evans, R. J., Arend, W. P., Verderber, E., Brewer, M. T., Hannum, C. H., and Thompson, R. C. (1990) Nature 343, 341-346
28. Higuchi, R. (1990) in PCR Protocols: A Guide to Methods and Applications (Innis, M. A., Gelfand, D. H., Sninsky, J. J., and White, T. J., eds) pp. 177-183. Academic Press, San Diego
29. Omer, C. A., Diehl, R. E., and Kral, A. M. (1995) Methods Enzymol. 250, 3-12
30. Pompliano, D. L., Rands, E., Schaber, M. D., Mosser, S. D., Anthony, N. A., and Gibbs, J. B. (1992) Biochemistry 31, 3800-3807
31. Nelson, N. (1987) Anal. Biochem. 165, 287-293
32. Hoffman, R., and Cammeron, L. (1992) Anal. Biochem. 203, 70-75
33. Fu, H.-W., Moomaw, J. F., Moomaw, C. R., and Casey, P. J. (1996) J. Biol. Chem. 271, 28541-28548
34. Williams, T. M., Ciccarone, T. M., MacTough, S. L., Bock, R. L., Conner, M. W., Davide, J. P., Hamilton, K., Koblan, K. S., Kohl, N. E., Kral, A. M., Mosser, S. D., Omer, C. A., Pompliano, D. L., Rands, E., Schaber, M. D., Shah, D., Wilson, F. R., Gibbs, J. B., Graham, S. L., Hartman, G. D., Oliff, A. I., and Smith, R. L. (1996) J. Med. Chem. 39, 1345-1348
35. Koblan, K. S., Culberson, J. C., deSolms, S. J., Giuliani, E. A., Mosser, S. D., Omer, C. A., Pitzenberger, S. M., and Bogusky, M. J. (1995) Protein Sci. 4, 681-688
36. Cheng, Y. C., and Prusoff, W. H. (1973) Biochem. Pharm. 22, 3099-3108
37. Del Villar, K., Mitsuzawa, H., Yang, W., Sattler, I., and Tamanoi, F. (1997) J. Biol. Chem. 272, 680-687
38. Liu, S., Zhang, P., Ji, X., Johnson, W. W., Gilliland, G. L., and Armstrong, R. N. (1992) J. Biol. Chem. 267, 4296-4299
39. Ji, X., Zhang, P., Armstrong, R. N., and Gilliland, G. L. (1992) Biochemistry 31, 10169-10184
40. Goodman, L. E., Perou, C. M., Fujiyama, A., and Tamanoi, F. (1988) Yeast 4, 271-281
41. Ohya, Y., Goebl, M., Goodman, L. E., Petersen-Bjorn, S., Friesen, J. D., Tamanoi, F., and Anraku, Y. (1991) J. Biol. Chem. 266, 12356-12360
42. Higgins, D. G., and Sharp, P. M. (1988) Gene 15, 237-244