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Volumn 133, Issue , 2017, Pages 121-169

Nucleic Acid Immunity

Author keywords

ADAR1; Antiviral immunity; cGAMP; cGAS; CpG DNA; CRISPR Cas; DNase; Immune sensing of nucleic acids; Innate immunity; OAS; Oligonucleotide; RIG I; RNAi; RNase H; RNase L; SAMHD1; Sting; TLR3; TLR7; TLR8; TLR9; Trex1

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; ABSENT IN MELANOMA 2 PROTEIN; ADENOSINE DEAMINASE; ADENOSINE DEAMINASE ACTING ON RNA 1; CYCLIC GMP AMP SYNTHASE; DEOXYRIBONUCLEASE; DEOXYRIBONUCLEASE I; DEOXYRIBONUCLEASE II; IFIT1 PROTEIN; IFIT5 PROTEIN; INTERFERON INDUCED HELICASE C DOMAIN CONTAINING PROTEIN 1; LGP2 PROTEIN; NUCLEAR PROTEIN; NUCLEIC ACID; PROTEIN KINASE; PROTEIN KINASE RNA ACTIVATED; RETINOIC ACID INDUCIBLE PROTEIN I; RIBONUCLEASE H; RNA BINDING PROTEIN; SMALL INTERFERING RNA; STERILE ALPHA MOTIF AND HISTIDINE ASPARTATE DOMAIN CONTAINING PROTEIN 1; SYNTHETASE; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TREX1 PROTEIN; UNCLASSIFIED DRUG; PATTERN RECOGNITION RECEPTOR; RETROPOSON;

EID: 85008401038     PISSN: 00652776     EISSN: 15578445     Source Type: Book Series    
DOI: 10.1016/bs.ai.2016.11.001     Document Type: Chapter
Times cited : (203)

References (256)
  • 1
    • 84874671928 scopus 로고    scopus 로고
    • Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins
    • Abbas, Y.M., Pichlmair, A., Gorna, M.W., Superti-Furga, G., Nagar, B., Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature 494 (2013), 60–64.
    • (2013) Nature , vol.494 , pp. 60-64
    • Abbas, Y.M.1    Pichlmair, A.2    Gorna, M.W.3    Superti-Furga, G.4    Nagar, B.5
  • 2
    • 84868569570 scopus 로고    scopus 로고
    • RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids
    • Abdullah, Z., Schlee, M., Roth, S., Mraheil, M.A., Barchet, W., Bottcher, J., et al. RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids. The EMBO Journal 31 (2012), 4153–4164.
    • (2012) The EMBO Journal , vol.31 , pp. 4153-4164
    • Abdullah, Z.1    Schlee, M.2    Roth, S.3    Mraheil, M.A.4    Barchet, W.5    Bottcher, J.6
  • 3
    • 70349459734 scopus 로고    scopus 로고
    • RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate
    • Ablasser, A., Bauernfeind, F., Hartmann, G., Latz, E., Fitzgerald, K.A., Hornung, V., RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nature Immunology 10 (2009), 1065–1072.
    • (2009) Nature Immunology , vol.10 , pp. 1065-1072
    • Ablasser, A.1    Bauernfeind, F.2    Hartmann, G.3    Latz, E.4    Fitzgerald, K.A.5    Hornung, V.6
  • 4
    • 84879385334 scopus 로고    scopus 로고
    • cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING
    • Ablasser, A., Goldeck, M., Cavlar, T., Deimling, T., Witte, G., Rohl, I., et al. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature 498 (2013), 380–384.
    • (2013) Nature , vol.498 , pp. 380-384
    • Ablasser, A.1    Goldeck, M.2    Cavlar, T.3    Deimling, T.4    Witte, G.5    Rohl, I.6
  • 6
    • 84888637695 scopus 로고    scopus 로고
    • Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
    • Ablasser, A., Schmid-Burgk, J.L., Hemmerling, I., Horvath, G.L., Schmidt, T., Latz, E., et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature 503 (2013), 530–534.
    • (2013) Nature , vol.503 , pp. 530-534
    • Ablasser, A.1    Schmid-Burgk, J.L.2    Hemmerling, I.3    Horvath, G.L.4    Schmidt, T.5    Latz, E.6
  • 8
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • Alexopoulou, L., Holt, A.C., Medzhitov, R., Flavell, R.A., Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413 (2001), 732–738.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 9
    • 82255192363 scopus 로고    scopus 로고
    • Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus
    • Al-Mayouf, S.M., Sunker, A., Abdwani, R., Abrawi, S.A., Almurshedi, F., Alhashmi, N., et al. Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus. Nature Genetics 43 (2011), 1186–1188.
    • (2011) Nature Genetics , vol.43 , pp. 1186-1188
    • Al-Mayouf, S.M.1    Sunker, A.2    Abdwani, R.3    Abrawi, S.A.4    Almurshedi, F.5    Alhashmi, N.6
  • 10
    • 77953275701 scopus 로고    scopus 로고
    • Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides
    • Avalos, A.M., Latz, E., Mousseau, B., Christensen, S.R., Shlomchik, M.J., Lund, F., et al. Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides. Journal of Immunology 183 (2009), 6262–6268.
    • (2009) Journal of Immunology , vol.183 , pp. 6262-6268
    • Avalos, A.M.1    Latz, E.2    Mousseau, B.3    Christensen, S.R.4    Shlomchik, M.J.5    Lund, F.6
  • 11
    • 0017847367 scopus 로고
    • Interferon action may be mediated by activation of a nuclease by pppA2'p5'A2'p5'A
    • Baglioni, C., Minks, M.A., Maroney, P.A., Interferon action may be mediated by activation of a nuclease by pppA2'p5'A2'p5'A. Nature 273 (1978), 684–687.
    • (1978) Nature , vol.273 , pp. 684-687
    • Baglioni, C.1    Minks, M.A.2    Maroney, P.A.3
  • 14
    • 84893637182 scopus 로고    scopus 로고
    • STING-dependent cytosolic DNA sensing pathways
    • Barber, G.N., STING-dependent cytosolic DNA sensing pathways. Trends in Immunology 35 (2014), 88–93.
    • (2014) Trends in Immunology , vol.35 , pp. 88-93
    • Barber, G.N.1
  • 15
    • 34047118522 scopus 로고    scopus 로고
    • CRISPR provides acquired resistance against viruses in prokaryotes
    • Barrangou, R., Fremaux, C., Deveau, H., Richards, M., Boyaval, P., Moineau, S., et al. CRISPR provides acquired resistance against viruses in prokaryotes. Science 315 (2007), 1709–1712.
    • (2007) Science , vol.315 , pp. 1709-1712
    • Barrangou, R.1    Fremaux, C.2    Deveau, H.3    Richards, M.4    Boyaval, P.5    Moineau, S.6
  • 16
    • 0023666074 scopus 로고
    • A developmentally regulated activity that unwinds RNA duplexes
    • Bass, B.L., Weintraub, H., A developmentally regulated activity that unwinds RNA duplexes. Cell 48 (1987), 607–613.
    • (1987) Cell , vol.48 , pp. 607-613
    • Bass, B.L.1    Weintraub, H.2
  • 17
    • 0024233053 scopus 로고
    • An unwinding activity that covalently modifies its double-stranded RNA substrate
    • Bass, B.L., Weintraub, H., An unwinding activity that covalently modifies its double-stranded RNA substrate. Cell 55 (1988), 1089–1098.
    • (1988) Cell , vol.55 , pp. 1089-1098
    • Bass, B.L.1    Weintraub, H.2
  • 18
    • 84872717154 scopus 로고    scopus 로고
    • Toll-like receptor 9 processing: The key event in Toll-like receptor 9 activation?
    • Bauer, S., Toll-like receptor 9 processing: The key event in Toll-like receptor 9 activation?. Immunology Letters 149 (2013), 85–87.
    • (2013) Immunology Letters , vol.149 , pp. 85-87
    • Bauer, S.1
  • 19
    • 84921478452 scopus 로고    scopus 로고
    • Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice
    • Baum, R., Sharma, S., Carpenter, S., Li, Q.Z., Busto, P., Fitzgerald, K.A., et al. Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice. Journal of Immunology 194 (2015), 873–877.
    • (2015) Journal of Immunology , vol.194 , pp. 873-877
    • Baum, R.1    Sharma, S.2    Carpenter, S.3    Li, Q.Z.4    Busto, P.5    Fitzgerald, K.A.6
  • 20
    • 80455174404 scopus 로고    scopus 로고
    • An autoimmune disease prevented by anti-retroviral drugs
    • Beck-Engeser, G.B., Eilat, D., Wabl, M., An autoimmune disease prevented by anti-retroviral drugs. Retrovirology, 8, 2011, 91.
    • (2011) Retrovirology , vol.8 , pp. 91
    • Beck-Engeser, G.B.1    Eilat, D.2    Wabl, M.3
  • 21
    • 84883277795 scopus 로고    scopus 로고
    • Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response
    • Behrendt, R., Schumann, T., Gerbaulet, A., Nguyen, L.A., Schubert, N., Alexopoulou, D., et al. Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response. Cell Reports 4 (2013), 689–696.
    • (2013) Cell Reports , vol.4 , pp. 689-696
    • Behrendt, R.1    Schumann, T.2    Gerbaulet, A.3    Nguyen, L.A.4    Schubert, N.5    Alexopoulou, D.6
  • 22
    • 84874959500 scopus 로고    scopus 로고
    • Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction
    • Beloglazova, N., Flick, R., Tchigvintsev, A., Brown, G., Popovic, A., Nocek, B., et al. Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction. The Journal of Biological Chemistry 288 (2013), 8101–8110.
    • (2013) The Journal of Biological Chemistry , vol.288 , pp. 8101-8110
    • Beloglazova, N.1    Flick, R.2    Tchigvintsev, A.3    Brown, G.4    Popovic, A.5    Nocek, B.6
  • 23
    • 19344370167 scopus 로고    scopus 로고
    • Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing
    • Bennasser, Y., Le, S.Y., Benkirane, M., Jeang, K.T., Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing. Immunity 22 (2005), 607–619.
    • (2005) Immunity , vol.22 , pp. 607-619
    • Bennasser, Y.1    Le, S.Y.2    Benkirane, M.3    Jeang, K.T.4
  • 24
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein, E., Caudy, A.A., Hammond, S.M., Hannon, G.J., Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409 (2001), 363–366.
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 26
    • 68849096790 scopus 로고    scopus 로고
    • Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells
    • Besch, R., Poeck, H., Hohenauer, T., Senft, D., Hacker, G., Berking, C., et al. Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells. The Journal of Clinical Investigation 119 (2009), 2399–2411.
    • (2009) The Journal of Clinical Investigation , vol.119 , pp. 2399-2411
    • Besch, R.1    Poeck, H.2    Hohenauer, T.3    Senft, D.4    Hacker, G.5    Berking, C.6
  • 28
    • 84949725975 scopus 로고    scopus 로고
    • LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling
    • Bruns, A.M., Horvath, C.M., LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling. Cytokine 74 (2015), 198–206.
    • (2015) Cytokine , vol.74 , pp. 198-206
    • Bruns, A.M.1    Horvath, C.M.2
  • 29
    • 84926104091 scopus 로고    scopus 로고
    • The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly
    • Bruns, A.M., Leser, G.P., Lamb, R.A., Horvath, C.M., The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly. Molecular Cell 55 (2014), 771–781.
    • (2014) Molecular Cell , vol.55 , pp. 771-781
    • Bruns, A.M.1    Leser, G.P.2    Lamb, R.A.3    Horvath, C.M.4
  • 30
    • 84934435982 scopus 로고    scopus 로고
    • Swiss army knives: Non-canonical functions of nuclear Drosha and Dicer
    • Burger, K., Gullerova, M., Swiss army knives: Non-canonical functions of nuclear Drosha and Dicer. Nature Reviews. Molecular Cell Biology 16 (2015), 417–430.
    • (2015) Nature Reviews. Molecular Cell Biology , vol.16 , pp. 417-430
    • Burger, K.1    Gullerova, M.2
  • 32
    • 84899131835 scopus 로고    scopus 로고
    • The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling
    • Cai, X., Chiu, Y.H., Chen, Z.J., The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling. Molecular Cell 54 (2014), 289–296.
    • (2014) Molecular Cell , vol.54 , pp. 289-296
    • Cai, X.1    Chiu, Y.H.2    Chen, Z.J.3
  • 34
    • 61349102407 scopus 로고    scopus 로고
    • Ribonuclease H: The enzymes in eukaryotes
    • Cerritelli, S.M., Crouch, R.J., Ribonuclease H: The enzymes in eukaryotes. The FEBS Journal 276 (2009), 1494–1505.
    • (2009) The FEBS Journal , vol.276 , pp. 1494-1505
    • Cerritelli, S.M.1    Crouch, R.J.2
  • 36
    • 58549086990 scopus 로고    scopus 로고
    • Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex
    • Chon, H., Vassilev, A., DePamphilis, M.L., Zhao, Y., Zhang, J., Burgers, P.M., et al. Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex. Nucleic Acids Research 37 (2009), 96–110.
    • (2009) Nucleic Acids Research , vol.37 , pp. 96-110
    • Chon, H.1    Vassilev, A.2    DePamphilis, M.L.3    Zhao, Y.4    Zhang, J.5    Burgers, P.M.6
  • 37
    • 0033257795 scopus 로고    scopus 로고
    • JNK2 and IKKbeta are required for activating the innate response to viral infection
    • Chu, W.M., Ostertag, D., Li, Z.W., Chang, L., Chen, Y., Hu, Y., et al. JNK2 and IKKbeta are required for activating the innate response to viral infection. Immunity 11 (1999), 721–731.
    • (1999) Immunity , vol.11 , pp. 721-731
    • Chu, W.M.1    Ostertag, D.2    Li, Z.W.3    Chang, L.4    Chen, Y.5    Hu, Y.6
  • 38
    • 80255141860 scopus 로고    scopus 로고
    • The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling
    • Civril, F., Bennett, M., Moldt, M., Deimling, T., Witte, G., Schiesser, S., et al. The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling. EMBO Reports 12 (2011), 1127–1134.
    • (2011) EMBO Reports , vol.12 , pp. 1127-1134
    • Civril, F.1    Bennett, M.2    Moldt, M.3    Deimling, T.4    Witte, G.5    Schiesser, S.6
  • 40
    • 0017948303 scopus 로고
    • Inhibition of cell-free protein synthesis by pppA2'p5'A2'p5'A: A novel oligonucleotide synthesized by interferon-treated L cell extracts
    • Clemens, M.J., Williams, B.R., Inhibition of cell-free protein synthesis by pppA2'p5'A2'p5'A: A novel oligonucleotide synthesized by interferon-treated L cell extracts. Cell 13 (1978), 565–572.
    • (1978) Cell , vol.13 , pp. 565-572
    • Clemens, M.J.1    Williams, B.R.2
  • 41
    • 70149090387 scopus 로고    scopus 로고
    • Higher activation of TLR9 in plasmacytoid dendritic cells by microbial DNA compared with self-DNA based on CpG-specific recognition of phosphodiester DNA
    • Coch, C., Busch, N., Wimmenauer, V., Hartmann, E., Janke, M., Abdel-Mottaleb, M.M., et al. Higher activation of TLR9 in plasmacytoid dendritic cells by microbial DNA compared with self-DNA based on CpG-specific recognition of phosphodiester DNA. Journal of Leukocyte Biology 86 (2009), 663–670.
    • (2009) Journal of Leukocyte Biology , vol.86 , pp. 663-670
    • Coch, C.1    Busch, N.2    Wimmenauer, V.3    Hartmann, E.4    Janke, M.5    Abdel-Mottaleb, M.M.6
  • 42
    • 33746581694 scopus 로고    scopus 로고
    • Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus
    • Crow, Y.J., Hayward, B.E., Parmar, R., Robins, P., Leitch, A., Ali, M., et al. Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus. Nature Genetics 38 (2006), 917–920.
    • (2006) Nature Genetics , vol.38 , pp. 917-920
    • Crow, Y.J.1    Hayward, B.E.2    Parmar, R.3    Robins, P.4    Leitch, A.5    Ali, M.6
  • 43
    • 77950400643 scopus 로고    scopus 로고
    • Aicardi-Goutieres syndrome and related phenotypes: Linking nucleic acid metabolism with autoimmunity
    • Crow, Y.J., Rehwinkel, J., Aicardi-Goutieres syndrome and related phenotypes: Linking nucleic acid metabolism with autoimmunity. Human Molecular Genetics 18 (2009), R130–R136.
    • (2009) Human Molecular Genetics , vol.18 , pp. R130-R136
    • Crow, Y.J.1    Rehwinkel, J.2
  • 44
    • 78549284909 scopus 로고    scopus 로고
    • 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members
    • Daffis, S., Szretter, K.J., Schriewer, J., Li, J., Youn, S., Errett, J., et al. 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members. Nature 468 (2010), 452–456.
    • (2010) Nature , vol.468 , pp. 452-456
    • Daffis, S.1    Szretter, K.J.2    Schriewer, J.3    Li, J.4    Youn, S.5    Errett, J.6
  • 46
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold, S.S., Kaisho, T., Hemmi, H., Akira, S., Reis e Sousa, C., Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303 (2004), 1529–1531.
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis e Sousa, C.5
  • 49
    • 84940704663 scopus 로고    scopus 로고
    • Targeted activation of melanoma differentiation-associated protein 5 (MDA5) for immunotherapy of pancreatic carcinoma
    • Duewell, P., Beller, E., Kirchleitner, S.V., Adunka, T., Bourhis, H., Siveke, J., et al. Targeted activation of melanoma differentiation-associated protein 5 (MDA5) for immunotherapy of pancreatic carcinoma. Oncoimmunology, 4, 2015, e1029698.
    • (2015) Oncoimmunology , vol.4
    • Duewell, P.1    Beller, E.2    Kirchleitner, S.V.3    Adunka, T.4    Bourhis, H.5    Siveke, J.6
  • 50
    • 85027949213 scopus 로고    scopus 로고
    • RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8(+) T cells
    • Duewell, P., Steger, A., Lohr, H., Bourhis, H., Hoelz, H., Kirchleitner, S.V., et al. RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8(+) T cells. Cell Death and Differentiation 21 (2014), 1825–1837.
    • (2014) Cell Death and Differentiation , vol.21 , pp. 1825-1837
    • Duewell, P.1    Steger, A.2    Lohr, H.3    Bourhis, H.4    Hoelz, H.5    Kirchleitner, S.V.6
  • 51
    • 84893354769 scopus 로고    scopus 로고
    • A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosis
    • El Maadidi, S., Faletti, L., Berg, B., Wenzl, C., Wieland, K., Chen, Z.J., et al. A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosis. Journal of Immunology 192 (2014), 1171–1183.
    • (2014) Journal of Immunology , vol.192 , pp. 1171-1183
    • El Maadidi, S.1    Faletti, L.2    Berg, B.3    Wenzl, C.4    Wieland, K.5    Chen, Z.J.6
  • 52
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22-nucleotide RNAs
    • Elbashir, S.M., Lendeckel, W., Tuschl, T., RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes & Development 15 (2001), 188–200.
    • (2001) Genes & Development , vol.15 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 53
    • 84875464528 scopus 로고    scopus 로고
    • Therapeutic efficacy of bifunctional siRNA combining TGF-beta1 silencing with RIG-I activation in pancreatic cancer
    • Ellermeier, J., Wei, J., Duewell, P., Hoves, S., Stieg, M.R., Adunka, T., et al. Therapeutic efficacy of bifunctional siRNA combining TGF-beta1 silencing with RIG-I activation in pancreatic cancer. Cancer Research 73 (2013), 1709–1720.
    • (2013) Cancer Research , vol.73 , pp. 1709-1720
    • Ellermeier, J.1    Wei, J.2    Duewell, P.3    Hoves, S.4    Stieg, M.R.5    Adunka, T.6
  • 54
    • 0344009629 scopus 로고    scopus 로고
    • DNase II: Genes, enzymes and function
    • Evans, C.J., Aguilera, R.J., DNase II: Genes, enzymes and function. Gene 322 (2003), 1–15.
    • (2003) Gene , vol.322 , pp. 1-15
    • Evans, C.J.1    Aguilera, R.J.2
  • 55
    • 57349191215 scopus 로고    scopus 로고
    • The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor
    • Ewald, S.E., Lee, B.L., Lau, L., Wickliffe, K.E., Shi, G.P., Chapman, H.A., et al. The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature 456 (2008), 658–662.
    • (2008) Nature , vol.456 , pp. 658-662
    • Ewald, S.E.1    Lee, B.L.2    Lau, L.3    Wickliffe, K.E.4    Shi, G.P.5    Chapman, H.A.6
  • 56
    • 84937762040 scopus 로고    scopus 로고
    • RIG-I-dependent antiviral immunity is effective against an RNA virus encoding a potent suppressor of RNAi
    • Fan, X., Dong, S., Li, Y., Ding, S.W., Wang, M., RIG-I-dependent antiviral immunity is effective against an RNA virus encoding a potent suppressor of RNAi. Biochemical and Biophysical Research Communications 460 (2015), 1035–1040.
    • (2015) Biochemical and Biophysical Research Communications , vol.460 , pp. 1035-1040
    • Fan, X.1    Dong, S.2    Li, Y.3    Ding, S.W.4    Wang, M.5
  • 59
    • 63649145255 scopus 로고    scopus 로고
    • AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    • Fernandes-Alnemri, T., Yu, J.W., Datta, P., Wu, J., Alnemri, E.S., AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458 (2009), 509–513.
    • (2009) Nature , vol.458 , pp. 509-513
    • Fernandes-Alnemri, T.1    Yu, J.W.2    Datta, P.3    Wu, J.4    Alnemri, E.S.5
  • 60
    • 84887865235 scopus 로고    scopus 로고
    • A retrotransposon-driven dicer isoform directs endogenous small interfering RNA production in mouse oocytes
    • Flemr, M., Malik, R., Franke, V., Nejepinska, J., Sedlacek, R., Vlahovicek, K., et al. A retrotransposon-driven dicer isoform directs endogenous small interfering RNA production in mouse oocytes. Cell 155 (2013), 807–816.
    • (2013) Cell , vol.155 , pp. 807-816
    • Flemr, M.1    Malik, R.2    Franke, V.3    Nejepinska, J.4    Sedlacek, R.5    Vlahovicek, K.6
  • 61
    • 44649137559 scopus 로고    scopus 로고
    • Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses
    • Forsbach, A., Nemorin, J.G., Montino, C., Muller, C., Samulowitz, U., Vicari, A.P., et al. Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses. Journal of Immunology 180 (2008), 3729–3738.
    • (2008) Journal of Immunology , vol.180 , pp. 3729-3738
    • Forsbach, A.1    Nemorin, J.G.2    Montino, C.3    Muller, C.4    Samulowitz, U.5    Vicari, A.P.6
  • 62
    • 84856301080 scopus 로고    scopus 로고
    • Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease
    • Gall, A., Treuting, P., Elkon, K.B., Loo, Y.M., Gale, M. Jr., Barber, G.N., et al. Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity 36 (2012), 120–131.
    • (2012) Immunity , vol.36 , pp. 120-131
    • Gall, A.1    Treuting, P.2    Elkon, K.B.3    Loo, Y.M.4    Gale, M.5    Barber, G.N.6
  • 65
    • 84878309796 scopus 로고    scopus 로고
    • Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase
    • Gao, P., Ascano, M., Wu, Y., Barchet, W., Gaffney, B.L., Zillinger, T., et al. Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell 153 (2013), 1094–1107.
    • (2013) Cell , vol.153 , pp. 1094-1107
    • Gao, P.1    Ascano, M.2    Wu, Y.3    Barchet, W.4    Gaffney, B.L.5    Zillinger, T.6
  • 66
    • 84882815198 scopus 로고    scopus 로고
    • Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA
    • Gao, P., Ascano, M., Zillinger, T., Wang, W., Dai, P., Serganov, A.A., et al. Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell 154 (2013), 748–762.
    • (2013) Cell , vol.154 , pp. 748-762
    • Gao, P.1    Ascano, M.2    Zillinger, T.3    Wang, W.4    Dai, P.5    Serganov, A.A.6
  • 70
    • 84884333427 scopus 로고    scopus 로고
    • Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing
    • Gehrke, N., Mertens, C., Zillinger, T., Wenzel, J., Bald, T., Zahn, S., et al. Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing. Immunity 39 (2013), 482–495.
    • (2013) Immunity , vol.39 , pp. 482-495
    • Gehrke, N.1    Mertens, C.2    Zillinger, T.3    Wenzel, J.4    Bald, T.5    Zahn, S.6
  • 71
    • 84871412468 scopus 로고    scopus 로고
    • SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4 + T-lymphocytes cannot be upregulated by interferons
    • Gelais, C. St., de Silva, S., Amie, S.M., Coleman, C.M., Hoy, H., Hollenbaugh, J.A., et al. SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4 + T-lymphocytes cannot be upregulated by interferons. Retrovirology, 9, 2012, 105.
    • (2012) Retrovirology , vol.9 , pp. 105
    • Gelais, C.1    de Silva, S.2    Amie, S.M.3    Coleman, C.M.4    Hoy, H.5    Hollenbaugh, J.A.6
  • 73
    • 84877962587 scopus 로고    scopus 로고
    • Targeting the cytosolic innate immune receptors RIG-I and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma
    • Glas, M., Coch, C., Trageser, D., Dassler, J., Simon, M., Koch, P., et al. Targeting the cytosolic innate immune receptors RIG-I and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma. Stem Cells 31 (2013), 1064–1074.
    • (2013) Stem Cells , vol.31 , pp. 1064-1074
    • Glas, M.1    Coch, C.2    Trageser, D.3    Dassler, J.4    Simon, M.5    Koch, P.6
  • 75
  • 76
    • 84908192059 scopus 로고    scopus 로고
    • Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates
    • Goubau, D., Schlee, M., Deddouche, S., Pruijssers, A.J., Zillinger, T., Goldeck, M., et al. Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates. Nature 514 (2014), 372–375.
    • (2014) Nature , vol.514 , pp. 372-375
    • Goubau, D.1    Schlee, M.2    Deddouche, S.3    Pruijssers, A.J.4    Zillinger, T.5    Goldeck, M.6
  • 78
    • 84940121945 scopus 로고    scopus 로고
    • Cutting edge: cGAS is required for lethal autoimmune disease in the Trex1-deficient mouse model of aicardi-goutieres syndrome
    • Gray, E.E., Treuting, P.M., Woodward, J.J., Stetson, D.B., Cutting edge: cGAS is required for lethal autoimmune disease in the Trex1-deficient mouse model of aicardi-goutieres syndrome. Journal of Immunology 195 (2015), 1939–1943.
    • (2015) Journal of Immunology , vol.195 , pp. 1939-1943
    • Gray, E.E.1    Treuting, P.M.2    Woodward, J.J.3    Stetson, D.B.4
  • 80
    • 84887295537 scopus 로고    scopus 로고
    • Sequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA
    • Habjan, M., Hubel, P., Lacerda, L., Benda, C., Holze, C., Eberl, C.H., et al. Sequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA. PLoS Pathogens, 9, 2013, e1003663.
    • (2013) PLoS Pathogens , vol.9
    • Habjan, M.1    Hubel, P.2    Lacerda, L.3    Benda, C.4    Holze, C.5    Eberl, C.H.6
  • 82
    • 84896045262 scopus 로고    scopus 로고
    • Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response
    • Han, Y., Donovan, J., Rath, S., Whitney, G., Chitrakar, A., Korennykh, A., Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response. Science 343 (2014), 1244–1248.
    • (2014) Science , vol.343 , pp. 1244-1248
    • Han, Y.1    Donovan, J.2    Rath, S.3    Whitney, G.4    Chitrakar, A.5    Korennykh, A.6
  • 83
    • 84939942920 scopus 로고    scopus 로고
    • APOBECs and virus restriction
    • Harris, R.S., Dudley, J.P., APOBECs and virus restriction. Virology 479–480 (2015), 131–145.
    • (2015) Virology , vol.479-480 , pp. 131-145
    • Harris, R.S.1    Dudley, J.P.2
  • 84
    • 33846799474 scopus 로고    scopus 로고
    • Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo
    • Hartman, Z.C., Kiang, A., Everett, R.S., Serra, D., Yang, X.Y., Clay, T.M., et al. Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo. Journal of Virology 81 (2007), 1796–1812.
    • (2007) Journal of Virology , vol.81 , pp. 1796-1812
    • Hartman, Z.C.1    Kiang, A.2    Everett, R.S.3    Serra, D.4    Yang, X.Y.5    Clay, T.M.6
  • 85
    • 0038236749 scopus 로고    scopus 로고
    • Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells
    • Hartmann, G., Battiany, J., Poeck, H., Wagner, M., Kerkmann, M., Lubenow, N., et al. Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells. European Journal of Immunology 33 (2003), 1633–1641.
    • (2003) European Journal of Immunology , vol.33 , pp. 1633-1641
    • Hartmann, G.1    Battiany, J.2    Poeck, H.3    Wagner, M.4    Kerkmann, M.5    Lubenow, N.6
  • 86
    • 0033027749 scopus 로고    scopus 로고
    • CpG DNA and LPS induce distinct patterns of activation in human monocytes
    • Hartmann, G., Krieg, A.M., CpG DNA and LPS induce distinct patterns of activation in human monocytes. Gene Therapy 6 (1999), 893–903.
    • (1999) Gene Therapy , vol.6 , pp. 893-903
    • Hartmann, G.1    Krieg, A.M.2
  • 87
    • 0034650517 scopus 로고    scopus 로고
    • Mechanism and function of a newly identified CpG DNA motif in human primary B cells
    • Hartmann, G., Krieg, A.M., Mechanism and function of a newly identified CpG DNA motif in human primary B cells. Journal of Immunology 164 (2000), 944–953.
    • (2000) Journal of Immunology , vol.164 , pp. 944-953
    • Hartmann, G.1    Krieg, A.M.2
  • 88
    • 0034142182 scopus 로고    scopus 로고
    • Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo
    • Hartmann, G., Weeratna, R.D., Ballas, Z.K., Payette, P., Blackwell, S., Suparto, I., et al. Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo. Journal of Immunology 164 (2000), 1617–1624.
    • (2000) Journal of Immunology , vol.164 , pp. 1617-1624
    • Hartmann, G.1    Weeratna, R.D.2    Ballas, Z.K.3    Payette, P.4    Blackwell, S.5    Suparto, I.6
  • 90
    • 84876872146 scopus 로고    scopus 로고
    • The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages
    • He, Y., Franchi, L., Nunez, G., The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages. European Journal of Immunology 43 (2013), 1147–1152.
    • (2013) European Journal of Immunology , vol.43 , pp. 1147-1152
    • He, Y.1    Franchi, L.2    Nunez, G.3
  • 91
    • 0036785631 scopus 로고    scopus 로고
    • Peritumoral CpG DNA elicits a coordinated response of CD8 T cells and innate effectors to cure established tumors in a murine colon carcinoma model
    • Heckelsmiller, K., Rall, K., Beck, S., Schlamp, A., Seiderer, J., Jahrsdorfer, B., et al. Peritumoral CpG DNA elicits a coordinated response of CD8 T cells and innate effectors to cure established tumors in a murine colon carcinoma model. Journal of Immunology 169 (2002), 3892–3899.
    • (2002) Journal of Immunology , vol.169 , pp. 3892-3899
    • Heckelsmiller, K.1    Rall, K.2    Beck, S.3    Schlamp, A.4    Seiderer, J.5    Jahrsdorfer, B.6
  • 92
    • 1542317578 scopus 로고    scopus 로고
    • Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    • Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303 (2004), 1526–1529.
    • (2004) Science , vol.303 , pp. 1526-1529
    • Heil, F.1    Hemmi, H.2    Hochrein, H.3    Ampenberger, F.4    Kirschning, C.5    Akira, S.6
  • 94
    • 84941954118 scopus 로고    scopus 로고
    • Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA
    • Herzner, A.M., Hagmann, C.A., Goldeck, M., Wolter, S., Kubler, K., Wittmann, S., et al. Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA. Nature Immunology 16 (2015), 1025–1033.
    • (2015) Nature Immunology , vol.16 , pp. 1025-1033
    • Herzner, A.M.1    Hagmann, C.A.2    Goldeck, M.3    Wolter, S.4    Kubler, K.5    Wittmann, S.6
  • 95
    • 84962585468 scopus 로고    scopus 로고
    • Cutting edge: The RIG-I ligand 3pRNA potently improves CTL cross-priming and facilitates antiviral vaccination
    • Hochheiser, K., Klein, M., Gottschalk, C., Hoss, F., Scheu, S., Coch, C., et al. Cutting edge: The RIG-I ligand 3pRNA potently improves CTL cross-priming and facilitates antiviral vaccination. Journal of Immunology 196 (2016), 2439–2443.
    • (2016) Journal of Immunology , vol.196 , pp. 2439-2443
    • Hochheiser, K.1    Klein, M.2    Gottschalk, C.3    Hoss, F.4    Scheu, S.5    Coch, C.6
  • 98
    • 63649133278 scopus 로고    scopus 로고
    • AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
    • Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D.R., et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458 (2009), 514–518.
    • (2009) Nature , vol.458 , pp. 514-518
    • Hornung, V.1    Ablasser, A.2    Charrel-Dennis, M.3    Bauernfeind, F.4    Horvath, G.5    Caffrey, D.R.6
  • 100
    • 20144389695 scopus 로고    scopus 로고
    • Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7
    • Hornung, V., Guenthner-Biller, M., Bourquin, C., Ablasser, A., Schlee, M., Uematsu, S., et al. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nature Medicine 11 (2005), 263–270.
    • (2005) Nature Medicine , vol.11 , pp. 263-270
    • Hornung, V.1    Guenthner-Biller, M.2    Bourquin, C.3    Ablasser, A.4    Schlee, M.5    Uematsu, S.6
  • 101
    • 84905123345 scopus 로고    scopus 로고
    • OAS proteins and cGAS: Unifying concepts in sensing and responding to cytosolic nucleic acids
    • Hornung, V., Hartmann, R., Ablasser, A., Hopfner, K.P., OAS proteins and cGAS: Unifying concepts in sensing and responding to cytosolic nucleic acids. Nature Reviews. Immunology 14 (2014), 521–528.
    • (2014) Nature Reviews. Immunology , vol.14 , pp. 521-528
    • Hornung, V.1    Hartmann, R.2    Ablasser, A.3    Hopfner, K.P.4
  • 103
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1–10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung, V., Rothenfusser, S., Britsch, S., Krug, A., Jahrsdorfer, B., Giese, T., et al. Quantitative expression of toll-like receptor 1–10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. Journal of Immunology 168 (2002), 4531–4537.
    • (2002) Journal of Immunology , vol.168 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3    Krug, A.4    Jahrsdorfer, B.5    Giese, T.6
  • 104
    • 0037786682 scopus 로고    scopus 로고
    • A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein
    • Hoss, M., Robins, P., Naven, T.J., Pappin, D.J., Sgouros, J., Lindahl, T., A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein. The EMBO Journal 18 (1999), 3868–3875.
    • (1999) The EMBO Journal , vol.18 , pp. 3868-3875
    • Hoss, M.1    Robins, P.2    Naven, T.J.3    Pappin, D.J.4    Sgouros, J.5    Lindahl, T.6
  • 105
    • 0017372188 scopus 로고
    • Synthesis of low molecular weight inhibitor of protein synthesis with enzyme from interferon-treated cells
    • Hovanessian, A.G., Brown, R.E., Kerr, I.M., Synthesis of low molecular weight inhibitor of protein synthesis with enzyme from interferon-treated cells. Nature 268 (1977), 537–540.
    • (1977) Nature , vol.268 , pp. 537-540
    • Hovanessian, A.G.1    Brown, R.E.2    Kerr, I.M.3
  • 106
    • 79959858243 scopus 로고    scopus 로고
    • Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
    • Hrecka, K., Hao, C., Gierszewska, M., Swanson, S.K., Kesik-Brodacka, M., Srivastava, S., et al. Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature 474 (2011), 658–661.
    • (2011) Nature , vol.474 , pp. 658-661
    • Hrecka, K.1    Hao, C.2    Gierszewska, M.3    Swanson, S.K.4    Kesik-Brodacka, M.5    Srivastava, S.6
  • 107
    • 84892890442 scopus 로고    scopus 로고
    • Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity
    • Huang, H., Zeqiraj, E., Dong, B., Jha, B.K., Duffy, N.M., Orlicky, S., et al. Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity. Molecular Cell 53 (2014), 221–234.
    • (2014) Molecular Cell , vol.53 , pp. 221-234
    • Huang, H.1    Zeqiraj, E.2    Dong, B.3    Jha, B.K.4    Duffy, N.M.5    Orlicky, S.6
  • 108
    • 84929374105 scopus 로고    scopus 로고
    • Innate immune restriction and antagonism of viral RNA lacking 2-O methylation
    • Hyde, J.L., Diamond, M.S., Innate immune restriction and antagonism of viral RNA lacking 2-O methylation. Virology 479–480 (2015), 66–74.
    • (2015) Virology , vol.479-480 , pp. 66-74
    • Hyde, J.L.1    Diamond, M.S.2
  • 109
    • 70449142319 scopus 로고
    • Particle counts and infectivity titrations for animal viruses
    • Isaacs, A., Particle counts and infectivity titrations for animal viruses. Advances in Virus Research 4 (1957), 111–158.
    • (1957) Advances in Virus Research , vol.4 , pp. 111-158
    • Isaacs, A.1
  • 110
    • 0343185886 scopus 로고
    • Foreign nucleic acids as the stimulus to make interferon
    • Isaacs, A., Cox, R.A., Rotem, Z., Foreign nucleic acids as the stimulus to make interferon. Lancet 2 (1963), 113–116.
    • (1963) Lancet , vol.2 , pp. 113-116
    • Isaacs, A.1    Cox, R.A.2    Rotem, Z.3
  • 111
    • 84945541165 scopus 로고    scopus 로고
    • The functions of MicroRNAs: mRNA decay and translational repression
    • Iwakawa, H.O., Tomari, Y., The functions of MicroRNAs: mRNA decay and translational repression. Trends in Cell Biology 25 (2015), 651–665.
    • (2015) Trends in Cell Biology , vol.25 , pp. 651-665
    • Iwakawa, H.O.1    Tomari, Y.2
  • 112
    • 84938515167 scopus 로고    scopus 로고
    • AIM2 drives joint inflammation in a self-DNA triggered model of chronic polyarthritis
    • Jakobs, C., Perner, S., Hornung, V., AIM2 drives joint inflammation in a self-DNA triggered model of chronic polyarthritis. PloS One, 10, 2015, e0131702.
    • (2015) PloS One , vol.10
    • Jakobs, C.1    Perner, S.2    Hornung, V.3
  • 115
    • 81555204380 scopus 로고    scopus 로고
    • Structural basis of RNA recognition and activation by innate immune receptor RIG-I
    • Jiang, F., Ramanathan, A., Miller, M.T., Tang, G.Q., Gale, M. Jr., Patel, S.S., et al. Structural basis of RNA recognition and activation by innate immune receptor RIG-I. Nature 479 (2011), 423–427.
    • (2011) Nature , vol.479 , pp. 423-427
    • Jiang, F.1    Ramanathan, A.2    Miller, M.T.3    Tang, G.Q.4    Gale, M.5    Patel, S.S.6
  • 116
    • 84859986329 scopus 로고    scopus 로고
    • Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor
    • Jin, T., Perry, A., Jiang, J., Smith, P., Curry, J.A., Unterholzner, L., et al. Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity 36 (2012), 561–571.
    • (2012) Immunity , vol.36 , pp. 561-571
    • Jin, T.1    Perry, A.2    Jiang, J.3    Smith, P.4    Curry, J.A.5    Unterholzner, L.6
  • 117
    • 84863115824 scopus 로고    scopus 로고
    • The 2'-O-methylation status of a single guanosine controls transfer RNA-mediated Toll-like receptor 7 activation or inhibition
    • Jockel, S., Nees, G., Sommer, R., Zhao, Y., Cherkasov, D., Hori, H., et al. The 2'-O-methylation status of a single guanosine controls transfer RNA-mediated Toll-like receptor 7 activation or inhibition. The Journal of Experimental Medicine 209 (2012), 235–241.
    • (2012) The Journal of Experimental Medicine , vol.209 , pp. 235-241
    • Jockel, S.1    Nees, G.2    Sommer, R.3    Zhao, Y.4    Cherkasov, D.5    Hori, H.6
  • 118
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • Judge, A.D., Sood, V., Shaw, J.R., Fang, D., McClintock, K., MacLachlan, I., Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nature Biotechnology 23 (2005), 457–462.
    • (2005) Nature Biotechnology , vol.23 , pp. 457-462
    • Judge, A.D.1    Sood, V.2    Shaw, J.R.3    Fang, D.4    McClintock, K.5    MacLachlan, I.6
  • 119
    • 84940451580 scopus 로고    scopus 로고
    • Translating nucleic acid-sensing pathways into therapies
    • Junt, T., Barchet, W., Translating nucleic acid-sensing pathways into therapies. Nature Reviews. Immunology 15 (2015), 529–544.
    • (2015) Nature Reviews. Immunology , vol.15 , pp. 529-544
    • Junt, T.1    Barchet, W.2
  • 120
    • 23844464444 scopus 로고    scopus 로고
    • Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA
    • Kariko, K., Buckstein, M., Ni, H., Weissman, D., Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23 (2005), 165–175.
    • (2005) Immunity , vol.23 , pp. 165-175
    • Kariko, K.1    Buckstein, M.2    Ni, H.3    Weissman, D.4
  • 121
    • 84945945130 scopus 로고    scopus 로고
    • RIG-I-like receptors and autoimmune diseases
    • Kato, H., Fujita, T., RIG-I-like receptors and autoimmune diseases. Current Opinion in Immunology 37 (2015), 40–45.
    • (2015) Current Opinion in Immunology , vol.37 , pp. 40-45
    • Kato, H.1    Fujita, T.2
  • 122
    • 22544455673 scopus 로고    scopus 로고
    • Cell type-specific involvement of RIG-I in antiviral response
    • Kato, H., Sato, S., Yoneyama, M., Yamamoto, M., Uematsu, S., Matsui, K., et al. Cell type-specific involvement of RIG-I in antiviral response. Immunity 23 (2005), 19–28.
    • (2005) Immunity , vol.23 , pp. 19-28
    • Kato, H.1    Sato, S.2    Yoneyama, M.3    Yamamoto, M.4    Uematsu, S.5    Matsui, K.6
  • 123
    • 33750465224 scopus 로고    scopus 로고
    • Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages
    • Kawane, K., Ohtani, M., Miwa, K., Kizawa, T., Kanbara, Y., Yoshioka, Y., et al. Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature 443 (2006), 998–1002.
    • (2006) Nature , vol.443 , pp. 998-1002
    • Kawane, K.1    Ohtani, M.2    Miwa, K.3    Kizawa, T.4    Kanbara, Y.5    Yoshioka, Y.6
  • 124
    • 20244367698 scopus 로고    scopus 로고
    • Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-alpha induction by CpG-A in plasmacytoid dendritic cells
    • Kerkmann, M., Costa, L.T., Richter, C., Rothenfusser, S., Battiany, J., Hornung, V., et al. Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-alpha induction by CpG-A in plasmacytoid dendritic cells. The Journal of Biological Chemistry 280 (2005), 8086–8093.
    • (2005) The Journal of Biological Chemistry , vol.280 , pp. 8086-8093
    • Kerkmann, M.1    Costa, L.T.2    Richter, C.3    Rothenfusser, S.4    Battiany, J.5    Hornung, V.6
  • 125
    • 0037407691 scopus 로고    scopus 로고
    • Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells
    • Kerkmann, M., Rothenfusser, S., Hornung, V., Towarowski, A., Wagner, M., Sarris, A., et al. Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells. Journal of Immunology 170 (2003), 4465–4474.
    • (2003) Journal of Immunology , vol.170 , pp. 4465-4474
    • Kerkmann, M.1    Rothenfusser, S.2    Hornung, V.3    Towarowski, A.4    Wagner, M.5    Sarris, A.6
  • 127
    • 84862654149 scopus 로고    scopus 로고
    • Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages
    • Kim, B., Nguyen, L.A., Daddacha, W., Hollenbaugh, J.A., Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages. The Journal of Biological Chemistry 287 (2012), 21570–21574.
    • (2012) The Journal of Biological Chemistry , vol.287 , pp. 21570-21574
    • Kim, B.1    Nguyen, L.A.2    Daddacha, W.3    Hollenbaugh, J.A.4
  • 130
    • 84883488816 scopus 로고    scopus 로고
    • Defining the functional determinants for RNA surveillance by RIG-I
    • Kohlway, A., Luo, D., Rawling, D.C., Ding, S.C., Pyle, A.M., Defining the functional determinants for RNA surveillance by RIG-I. EMBO Reports 14 (2013), 772–779.
    • (2013) EMBO Reports , vol.14 , pp. 772-779
    • Kohlway, A.1    Luo, D.2    Rawling, D.C.3    Ding, S.C.4    Pyle, A.M.5
  • 131
    • 80054703126 scopus 로고    scopus 로고
    • Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA
    • Kowalinski, E., Lunardi, T., McCarthy, A.A., Louber, J., Brunel, J., Grigorov, B., et al. Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA. Cell 147 (2011), 423–435.
    • (2011) Cell , vol.147 , pp. 423-435
    • Kowalinski, E.1    Lunardi, T.2    McCarthy, A.A.3    Louber, J.4    Brunel, J.5    Grigorov, B.6
  • 133
    • 0037377990 scopus 로고    scopus 로고
    • CpG-A oligonucleotides induce a monocyte-derived dendritic cell-like phenotype that preferentially activates CD8 T cells
    • Krug, A., Rothenfusser, S., Selinger, S., Bock, C., Kerkmann, M., Battiany, J., et al. CpG-A oligonucleotides induce a monocyte-derived dendritic cell-like phenotype that preferentially activates CD8 T cells. Journal of Immunology 170 (2003), 3468–3477.
    • (2003) Journal of Immunology , vol.170 , pp. 3468-3477
    • Krug, A.1    Rothenfusser, S.2    Selinger, S.3    Bock, C.4    Kerkmann, M.5    Battiany, J.6
  • 134
    • 77954372029 scopus 로고    scopus 로고
    • Targeted activation of RNA helicase retinoic acid-inducible gene-I induces proimmunogenic apoptosis of human ovarian cancer cells
    • Kubler, K., Gehrke, N., Riemann, S., Bohnert, V., Zillinger, T., Hartmann, E., et al. Targeted activation of RNA helicase retinoic acid-inducible gene-I induces proimmunogenic apoptosis of human ovarian cancer cells. Cancer Research 70 (2010), 5293–5304.
    • (2010) Cancer Research , vol.70 , pp. 5293-5304
    • Kubler, K.1    Gehrke, N.2    Riemann, S.3    Bohnert, V.4    Zillinger, T.5    Hartmann, E.6
  • 136
    • 84970925335 scopus 로고    scopus 로고
    • IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity
    • Kumar, S., Ingle, H., Mishra, S., Mahla, R.S., Kumar, A., Kawai, T., et al. IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity. Cell Death & Disease, 6, 2015, e1758.
    • (2015) Cell Death & Disease , vol.6
    • Kumar, S.1    Ingle, H.2    Mishra, S.3    Mahla, R.S.4    Kumar, A.5    Kawai, T.6
  • 137
    • 79959843617 scopus 로고    scopus 로고
    • SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
    • Laguette, N., Sobhian, B., Casartelli, N., Ringeard, M., Chable-Bessia, C., Segeral, E., et al. SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature 474 (2011), 654–657.
    • (2011) Nature , vol.474 , pp. 654-657
    • Laguette, N.1    Sobhian, B.2    Casartelli, N.3    Ringeard, M.4    Chable-Bessia, C.5    Segeral, E.6
  • 138
    • 84862777555 scopus 로고    scopus 로고
    • SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates
    • Lahouassa, H., Daddacha, W., Hofmann, H., Ayinde, D., Logue, E.C., Dragin, L., et al. SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. Nature Immunology 13 (2012), 223–228.
    • (2012) Nature Immunology , vol.13 , pp. 223-228
    • Lahouassa, H.1    Daddacha, W.2    Hofmann, H.3    Ayinde, D.4    Logue, E.C.5    Dragin, L.6
  • 139
    • 84907996785 scopus 로고    scopus 로고
    • Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy
    • Lan, Y.Y., Londono, D., Bouley, R., Rooney, M.S., Hacohen, N., Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy. Cell Reports 9 (2014), 180–192.
    • (2014) Cell Reports , vol.9 , pp. 180-192
    • Lan, Y.Y.1    Londono, D.2    Bouley, R.3    Rooney, M.S.4    Hacohen, N.5
  • 140
    • 84955250204 scopus 로고    scopus 로고
    • ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA
    • Lassig, C., Matheisl, S., Sparrer, K.M., de Oliveira Mann, C.C., Moldt, M., Patel, J.R., et al. ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA. eLife, 4, 2015, e10859.
    • (2015) eLife , vol.4 , pp. e10859
    • Lassig, C.1    Matheisl, S.2    Sparrer, K.M.3    de Oliveira Mann, C.C.4    Moldt, M.5    Patel, J.R.6
  • 143
    • 0141843656 scopus 로고    scopus 로고
    • The nuclear RNase III Drosha initiates microRNA processing
    • Lee, Y., Ahn, C., Han, J., Choi, H., Kim, J., Yim, J., et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 425 (2003), 415–419.
    • (2003) Nature , vol.425 , pp. 415-419
    • Lee, Y.1    Ahn, C.2    Han, J.3    Choi, H.4    Kim, J.5    Yim, J.6
  • 144
    • 34247842779 scopus 로고    scopus 로고
    • A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus
    • Lee-Kirsch, M.A., Chowdhury, D., Harvey, S., Gong, M., Senenko, L., Engel, K., et al. A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus. Journal of Molecular Medicine 85 (2007), 531–537.
    • (2007) Journal of Molecular Medicine , vol.85 , pp. 531-537
    • Lee-Kirsch, M.A.1    Chowdhury, D.2    Harvey, S.3    Gong, M.4    Senenko, L.5    Engel, K.6
  • 145
    • 34548327158 scopus 로고    scopus 로고
    • Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus
    • Lee-Kirsch, M.A., Gong, M., Chowdhury, D., Senenko, L., Engel, K., Lee, Y.A., et al. Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nature Genetics 39 (2007), 1065–1067.
    • (2007) Nature Genetics , vol.39 , pp. 1065-1067
    • Lee-Kirsch, M.A.1    Gong, M.2    Chowdhury, D.3    Senenko, L.4    Engel, K.5    Lee, Y.A.6
  • 146
    • 0017890248 scopus 로고
    • Regulation of protein synthesis: Activation by double-stranded RNA of a protein kinase that phosphorylates eukaryotic initiation factor 2
    • Levin, D., London, I.M., Regulation of protein synthesis: Activation by double-stranded RNA of a protein kinase that phosphorylates eukaryotic initiation factor 2. Proceedings of the National Academy of Sciences of the United States of America 75 (1978), 1121–1125.
    • (1978) Proceedings of the National Academy of Sciences of the United States of America , vol.75 , pp. 1121-1125
    • Levin, D.1    London, I.M.2
  • 148
    • 84885635441 scopus 로고    scopus 로고
    • RNA interference functions as an antiviral immunity mechanism in mammals
    • Li, Y., Lu, J., Han, Y., Fan, X., Ding, S.W., RNA interference functions as an antiviral immunity mechanism in mammals. Science 342 (2013), 231–234.
    • (2013) Science , vol.342 , pp. 231-234
    • Li, Y.1    Lu, J.2    Han, Y.3    Fan, X.4    Ding, S.W.5
  • 149
    • 0034330682 scopus 로고    scopus 로고
    • Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells
    • Li, N., Zhang, W., Cao, X., Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells. Immunology Letters 74 (2000), 221–224.
    • (2000) Immunology Letters , vol.74 , pp. 221-224
    • Li, N.1    Zhang, W.2    Cao, X.3
  • 150
    • 84941100160 scopus 로고    scopus 로고
    • RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself
    • Liddicoat, B.J., Piskol, R., Chalk, A.M., Ramaswami, G., Higuchi, M., Hartner, J.C., et al. RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself. Science 349 (2015), 1115–1120.
    • (2015) Science , vol.349 , pp. 1115-1120
    • Liddicoat, B.J.1    Piskol, R.2    Chalk, A.M.3    Ramaswami, G.4    Higuchi, M.5    Hartner, J.C.6
  • 152
    • 42349090335 scopus 로고    scopus 로고
    • Structural basis of toll-like receptor 3 signaling with double-stranded RNA
    • Liu, L., Botos, I., Wang, Y., Leonard, J.N., Shiloach, J., Segal, D.M., et al. Structural basis of toll-like receptor 3 signaling with double-stranded RNA. Science 320 (2008), 379–381.
    • (2008) Science , vol.320 , pp. 379-381
    • Liu, L.1    Botos, I.2    Wang, Y.3    Leonard, J.N.4    Shiloach, J.5    Segal, D.M.6
  • 153
    • 8644247492 scopus 로고    scopus 로고
    • Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and MicroRNA biogenesis
    • Lu, S., Cullen, B.R., Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and MicroRNA biogenesis. Journal of Virology 78 (2004), 12868–12876.
    • (2004) Journal of Virology , vol.78 , pp. 12868-12876
    • Lu, S.1    Cullen, B.R.2
  • 154
    • 84895923768 scopus 로고    scopus 로고
    • Crystal structure of the F27G AIM2 PYD mutant and similarities of its self-association to DED/DED interactions
    • Lu, A., Kabaleeswaran, V., Fu, T., Magupalli, V.G., Wu, H., Crystal structure of the F27G AIM2 PYD mutant and similarities of its self-association to DED/DED interactions. Journal of Molecular Biology 426 (2014), 1420–1427.
    • (2014) Journal of Molecular Biology , vol.426 , pp. 1420-1427
    • Lu, A.1    Kabaleeswaran, V.2    Fu, T.3    Magupalli, V.G.4    Wu, H.5
  • 155
    • 84951838786 scopus 로고    scopus 로고
    • Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2
    • Lu, A., Li, Y., Yin, Q., Ruan, J., Yu, X., Egelman, E., et al. Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2. Cell Discovery, 1, 2015, 15013.
    • (2015) Cell Discovery , vol.1 , pp. 15013
    • Lu, A.1    Li, Y.2    Yin, Q.3    Ruan, J.4    Yu, X.5    Egelman, E.6
  • 156
    • 84896332642 scopus 로고    scopus 로고
    • Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes
    • Lu, A., Magupalli, V.G., Ruan, J., Yin, Q., Atianand, M.K., Vos, M.R., et al. Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell 156 (2014), 1193–1206.
    • (2014) Cell , vol.156 , pp. 1193-1206
    • Lu, A.1    Magupalli, V.G.2    Ruan, J.3    Yin, Q.4    Atianand, M.K.5    Vos, M.R.6
  • 157
    • 84865511926 scopus 로고    scopus 로고
    • Novel role of PKR in inflammasome activation and HMGB1 release
    • Lu, B., Nakamura, T., Inouye, K., Li, J., Tang, Y., Lundback, P., et al. Novel role of PKR in inflammasome activation and HMGB1 release. Nature 488 (2012), 670–674.
    • (2012) Nature , vol.488 , pp. 670-674
    • Lu, B.1    Nakamura, T.2    Inouye, K.3    Li, J.4    Tang, Y.5    Lundback, P.6
  • 159
    • 0001538170 scopus 로고
    • A nonhereditary, host-induced variation of bacterial viruses
    • Luria, S.E., Human, M.L., A nonhereditary, host-induced variation of bacterial viruses. Journal of Bacteriology 64 (1952), 557–569.
    • (1952) Journal of Bacteriology , vol.64 , pp. 557-569
    • Luria, S.E.1    Human, M.L.2
  • 163
    • 79953166075 scopus 로고    scopus 로고
    • Short double-stranded RNAs with an overhanging 5' ppp-nucleotide, as found in arenavirus genomes, act as RIG-I decoys
    • Marq, J.B., Hausmann, S., Veillard, N., Kolakofsky, D., Garcin, D., Short double-stranded RNAs with an overhanging 5' ppp-nucleotide, as found in arenavirus genomes, act as RIG-I decoys. The Journal of Biological Chemistry 286 (2010), 6108–6116.
    • (2010) The Journal of Biological Chemistry , vol.286 , pp. 6108-6116
    • Marq, J.B.1    Hausmann, S.2    Veillard, N.3    Kolakofsky, D.4    Garcin, D.5
  • 164
    • 77953308262 scopus 로고    scopus 로고
    • Unpaired 5' ppp-nucleotides, as found in arenavirus double-stranded RNA panhandles, are not recognized by RIG-I
    • Marq, J.B., Kolakofsky, D., Garcin, D., Unpaired 5' ppp-nucleotides, as found in arenavirus double-stranded RNA panhandles, are not recognized by RIG-I. The Journal of Biological Chemistry 285 (2010), 18208–18216.
    • (2010) The Journal of Biological Chemistry , vol.285 , pp. 18208-18216
    • Marq, J.B.1    Kolakofsky, D.2    Garcin, D.3
  • 165
    • 77249170201 scopus 로고    scopus 로고
    • CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea
    • Marraffini, L.A., Sontheimer, E.J., CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea. Nature Reviews. Genetics 11 (2010), 181–190.
    • (2010) Nature Reviews. Genetics , vol.11 , pp. 181-190
    • Marraffini, L.A.1    Sontheimer, E.J.2
  • 166
    • 33748448304 scopus 로고    scopus 로고
    • Tolling for autoimmunity-prime time for 7
    • Marshak-Rothstein, A., Tolling for autoimmunity-prime time for 7. Immunity 25 (2006), 397–399.
    • (2006) Immunity , vol.25 , pp. 397-399
    • Marshak-Rothstein, A.1
  • 167
    • 0036076593 scopus 로고    scopus 로고
    • Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling
    • Matsumoto, M., Kikkawa, S., Kohase, M., Miyake, K., Seya, T., Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochemical and Biophysical Research Communications 293 (2002), 1364–1369.
    • (2002) Biochemical and Biophysical Research Communications , vol.293 , pp. 1364-1369
    • Matsumoto, M.1    Kikkawa, S.2    Kohase, M.3    Miyake, K.4    Seya, T.5
  • 168
    • 84867763154 scopus 로고    scopus 로고
    • Protein kinase PKR amplification of interferon beta induction occurs through initiation factor eIF-2alpha-mediated translational control
    • McAllister, C.S., Taghavi, N., Samuel, C.E., Protein kinase PKR amplification of interferon beta induction occurs through initiation factor eIF-2alpha-mediated translational control. The Journal of Biological Chemistry 287 (2012), 36384–36392.
    • (2012) The Journal of Biological Chemistry , vol.287 , pp. 36384-36392
    • McAllister, C.S.1    Taghavi, N.2    Samuel, C.E.3
  • 171
    • 3242672339 scopus 로고    scopus 로고
    • Gene-targeted mice lacking the Trex1 (DNase III) 3'- > 5' DNA exonuclease develop inflammatory myocarditis
    • Morita, M., Stamp, G., Robins, P., Dulic, A., Rosewell, I., Hrivnak, G., et al. Gene-targeted mice lacking the Trex1 (DNase III) 3'- > 5' DNA exonuclease develop inflammatory myocarditis. Molecular and Cellular Biology 24 (2004), 6719–6727.
    • (2004) Molecular and Cellular Biology , vol.24 , pp. 6719-6727
    • Morita, M.1    Stamp, G.2    Robins, P.3    Dulic, A.4    Rosewell, I.5    Hrivnak, G.6
  • 174
    • 58849147558 scopus 로고    scopus 로고
    • Murine serum nucleases—Contrasting effects of plasmin and heparin on the activities of DNase1 and DNase1-like 3 (DNase1l3)
    • Napirei, M., Ludwig, S., Mezrhab, J., Klockl, T., Mannherz, H.G., Murine serum nucleases—Contrasting effects of plasmin and heparin on the activities of DNase1 and DNase1-like 3 (DNase1l3). The FEBS Journal 276 (2009), 1059–1073.
    • (2009) The FEBS Journal , vol.276 , pp. 1059-1073
    • Napirei, M.1    Ludwig, S.2    Mezrhab, J.3    Klockl, T.4    Mannherz, H.G.5
  • 175
    • 0016412560 scopus 로고
    • Restriction endonucleases in the analysis and restructuring of DNA molecules
    • Nathans, D., Smith, H.O., Restriction endonucleases in the analysis and restructuring of DNA molecules. Annual Review of Biochemistry 44 (1975), 273–293.
    • (1975) Annual Review of Biochemistry , vol.44 , pp. 273-293
    • Nathans, D.1    Smith, H.O.2
  • 176
    • 84955695193 scopus 로고    scopus 로고
    • A-to-I editing of coding and non-coding RNAs by ADARs
    • Nishikura, K., A-to-I editing of coding and non-coding RNAs by ADARs. Nature Reviews. Molecular Cell Biology 17 (2016), 83–96.
    • (2016) Nature Reviews. Molecular Cell Biology , vol.17 , pp. 83-96
    • Nishikura, K.1
  • 177
    • 84928791608 scopus 로고    scopus 로고
    • Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
    • Ohto, U., Shibata, T., Tanji, H., Ishida, H., Krayukhina, E., Uchiyama, S., et al. Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9. Nature 520 (2015), 702–705.
    • (2015) Nature , vol.520 , pp. 702-705
    • Ohto, U.1    Shibata, T.2    Tanji, H.3    Ishida, H.4    Krayukhina, E.5    Uchiyama, S.6
  • 178
    • 84860705893 scopus 로고    scopus 로고
    • Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
    • Oka, T., Hikoso, S., Yamaguchi, O., Taneike, M., Takeda, T., Tamai, T., et al. Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature 485 (2012), 251–255.
    • (2012) Nature , vol.485 , pp. 251-255
    • Oka, T.1    Hikoso, S.2    Yamaguchi, O.3    Taneike, M.4    Takeda, T.5    Tamai, T.6
  • 179
    • 84887504831 scopus 로고    scopus 로고
    • An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing
    • Onji, M., Kanno, A., Saitoh, S., Fukui, R., Motoi, Y., Shibata, T., et al. An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing. Nature Communications, 4, 2013, 1949.
    • (2013) Nature Communications , vol.4 , pp. 1949
    • Onji, M.1    Kanno, A.2    Saitoh, S.3    Fukui, R.4    Motoi, Y.5    Shibata, T.6
  • 180
    • 84876892072 scopus 로고    scopus 로고
    • ADAR1 forms a complex with dicer to promote microRNA processing and RNA-induced gene silencing
    • Ota, H., Sakurai, M., Gupta, R., Valente, L., Wulff, B.E., Ariyoshi, K., et al. ADAR1 forms a complex with dicer to promote microRNA processing and RNA-induced gene silencing. Cell 153 (2013), 575–589.
    • (2013) Cell , vol.153 , pp. 575-589
    • Ota, H.1    Sakurai, M.2    Gupta, R.3    Valente, L.4    Wulff, B.E.5    Ariyoshi, K.6
  • 181
    • 77649239548 scopus 로고    scopus 로고
    • Six RNA viruses and forty-one hosts: Viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems
    • Parameswaran, P., Sklan, E., Wilkins, C., Burgon, T., Samuel, M.A., Lu, R., et al. Six RNA viruses and forty-one hosts: Viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathogens, 6, 2010, e1000764.
    • (2010) PLoS Pathogens , vol.6
    • Parameswaran, P.1    Sklan, E.2    Wilkins, C.3    Burgon, T.4    Samuel, M.A.5    Lu, R.6
  • 182
    • 56349114913 scopus 로고    scopus 로고
    • Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9
    • Park, B., Brinkmann, M.M., Spooner, E., Lee, C.C., Kim, Y.M., Ploegh, H.L., Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9. Nature Immunology 9 (2008), 1407–1414.
    • (2008) Nature Immunology , vol.9 , pp. 1407-1414
    • Park, B.1    Brinkmann, M.M.2    Spooner, E.3    Lee, C.C.4    Kim, Y.M.5    Ploegh, H.L.6
  • 184
    • 84922552164 scopus 로고    scopus 로고
    • Cutting Edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands
    • Pawaria, S., Moody, K., Busto, P., Nundel, K., Choi, C.H., Ghayur, T., et al. Cutting Edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands. Journal of Immunology 194 (2015), 1403–1407.
    • (2015) Journal of Immunology , vol.194 , pp. 1403-1407
    • Pawaria, S.1    Moody, K.2    Busto, P.3    Nundel, K.4    Choi, C.H.5    Ghayur, T.6
  • 185
    • 84950109725 scopus 로고    scopus 로고
    • Nucleic acid-sensing TLRs and autoimmunity: Novel insights from structural and cell biology
    • Pelka, K., Shibata, T., Miyake, K., Latz, E., Nucleic acid-sensing TLRs and autoimmunity: Novel insights from structural and cell biology. Immunological Reviews 269 (2016), 60–75.
    • (2016) Immunological Reviews , vol.269 , pp. 60-75
    • Pelka, K.1    Shibata, T.2    Miyake, K.3    Latz, E.4
  • 186
    • 67649232601 scopus 로고    scopus 로고
    • Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation
    • Peter, M.E., Kubarenko, A.V., Weber, A.N., Dalpke, A.H., Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation. Journal of Immunology 182 (2009), 7690–7697.
    • (2009) Journal of Immunology , vol.182 , pp. 7690-7697
    • Peter, M.E.1    Kubarenko, A.V.2    Weber, A.N.3    Dalpke, A.H.4
  • 189
    • 33750984771 scopus 로고    scopus 로고
    • RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates
    • Pichlmair, A., Schulz, O., Tan, C.P., Naslund, T.I., Liljestrom, P., Weber, F., et al. RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates. Science 314 (2006), 997–1001.
    • (2006) Science , vol.314 , pp. 997-1001
    • Pichlmair, A.1    Schulz, O.2    Tan, C.P.3    Naslund, T.I.4    Liljestrom, P.5    Weber, F.6
  • 190
    • 70349728538 scopus 로고    scopus 로고
    • Activation of MDA5 requires higher-order RNA structures generated during virus infection
    • Pichlmair, A., Schulz, O., Tan, C.P., Rehwinkel, J., Kato, H., Takeuchi, O., et al. Activation of MDA5 requires higher-order RNA structures generated during virus infection. Journal of Virology 83 (2009), 10761–10769.
    • (2009) Journal of Virology , vol.83 , pp. 10761-10769
    • Pichlmair, A.1    Schulz, O.2    Tan, C.P.3    Rehwinkel, J.4    Kato, H.5    Takeuchi, O.6
  • 191
    • 74049126045 scopus 로고    scopus 로고
    • Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production
    • Poeck, H., Bscheider, M., Gross, O., Finger, K., Roth, S., Rebsamen, M., et al. Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Nature Immunology 11 (2010), 63–69.
    • (2010) Nature Immunology , vol.11 , pp. 63-69
    • Poeck, H.1    Bscheider, M.2    Gross, O.3    Finger, K.4    Roth, S.5    Rebsamen, M.6
  • 192
    • 84872077258 scopus 로고    scopus 로고
    • The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists
    • Pohar, J., Pirher, N., Bencina, M., Mancek-Keber, M., Jerala, R., The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists. The Journal of Biological Chemistry 288 (2013), 442–454.
    • (2013) The Journal of Biological Chemistry , vol.288 , pp. 442-454
    • Pohar, J.1    Pirher, N.2    Bencina, M.3    Mancek-Keber, M.4    Jerala, R.5
  • 193
    • 84961214693 scopus 로고    scopus 로고
    • RNase H2 catalytic core Aicardi-Goutieres syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice
    • Pokatayev, V., Hasin, N., Chon, H., Cerritelli, S.M., Sakhuja, K., Ward, J.M., et al. RNase H2 catalytic core Aicardi-Goutieres syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice. The Journal of Experimental Medicine 213 (2016), 329–336.
    • (2016) The Journal of Experimental Medicine , vol.213 , pp. 329-336
    • Pokatayev, V.1    Hasin, N.2    Chon, H.3    Cerritelli, S.M.4    Sakhuja, K.5    Ward, J.M.6
  • 194
    • 84876833883 scopus 로고    scopus 로고
    • Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells
    • Pothlichet, J., Meunier, I., Davis, B.K., Ting, J.P., Skamene, E., von Messling, V., et al. Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells. PLoS Pathogens, 9, 2013, e1003256.
    • (2013) PLoS Pathogens , vol.9
    • Pothlichet, J.1    Meunier, I.2    Davis, B.K.3    Ting, J.P.4    Skamene, E.5    von Messling, V.6
  • 195
    • 83755162644 scopus 로고    scopus 로고
    • Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase
    • Powell, R.D., Holland, P.J., Hollis, T., Perrino, F.W., Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase. The Journal of Biological Chemistry 286 (2011), 43596–43600.
    • (2011) The Journal of Biological Chemistry , vol.286 , pp. 43596-43600
    • Powell, R.D.1    Holland, P.J.2    Hollis, T.3    Perrino, F.W.4
  • 196
    • 84969522880 scopus 로고    scopus 로고
    • Genomic signatures of emerging viruses: A new era of systems epidemiology
    • Rasmussen, A.L., Katze, M.G., Genomic signatures of emerging viruses: A new era of systems epidemiology. Cell Host & Microbe 19 (2016), 611–618.
    • (2016) Cell Host & Microbe , vol.19 , pp. 611-618
    • Rasmussen, A.L.1    Katze, M.G.2
  • 199
    • 75749140581 scopus 로고    scopus 로고
    • RIG-I detects viral genomic RNA during negative-strand RNA virus infection
    • Rehwinkel, J., Tan, C.P., Goubau, D., Schulz, O., Pichlmair, A., Bier, K., et al. RIG-I detects viral genomic RNA during negative-strand RNA virus infection. Cell 140 (2010), 397–408.
    • (2010) Cell , vol.140 , pp. 397-408
    • Rehwinkel, J.1    Tan, C.P.2    Goubau, D.3    Schulz, O.4    Pichlmair, A.5    Bier, K.6
  • 200
    • 67649861901 scopus 로고    scopus 로고
    • Mutations involved in Aicardi-Goutieres syndrome implicate SAMHD1 as regulator of the innate immune response
    • Rice, G.I., Bond, J., Asipu, A., Brunette, R.L., Manfield, I.W., Carr, I.M., et al. Mutations involved in Aicardi-Goutieres syndrome implicate SAMHD1 as regulator of the innate immune response. Nature Genetics 41 (2009), 829–832.
    • (2009) Nature Genetics , vol.41 , pp. 829-832
    • Rice, G.I.1    Bond, J.2    Asipu, A.3    Brunette, R.L.4    Manfield, I.W.5    Carr, I.M.6
  • 201
    • 84868207785 scopus 로고    scopus 로고
    • Mutations in ADAR1 cause Aicardi-Goutieres syndrome associated with a type I interferon signature
    • Rice, G.I., Kasher, P.R., Forte, G.M., Mannion, N.M., Greenwood, S.M., Szynkiewicz, M., et al. Mutations in ADAR1 cause Aicardi-Goutieres syndrome associated with a type I interferon signature. Nature Genetics 44 (2012), 1243–1248.
    • (2012) Nature Genetics , vol.44 , pp. 1243-1248
    • Rice, G.I.1    Kasher, P.R.2    Forte, G.M.3    Mannion, N.M.4    Greenwood, S.M.5    Szynkiewicz, M.6
  • 203
    • 34548334617 scopus 로고    scopus 로고
    • C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy
    • Richards, A., van den Maagdenberg, A.M., Jen, J.C., Kavanagh, D., Bertram, P., Spitzer, D., et al. C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy. Nature Genetics 39 (2007), 1068–1070.
    • (2007) Nature Genetics , vol.39 , pp. 1068-1070
    • Richards, A.1    van den Maagdenberg, A.M.2    Jen, J.C.3    Kavanagh, D.4    Bertram, P.5    Spitzer, D.6
  • 205
    • 60749104535 scopus 로고    scopus 로고
    • HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
    • Roberts, T.L., Idris, A., Dunn, J.A., Kelly, G.M., Burnton, C.M., Hodgson, S., et al. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science 323 (2009), 1057–1060.
    • (2009) Science , vol.323 , pp. 1057-1060
    • Roberts, T.L.1    Idris, A.2    Dunn, J.A.3    Kelly, G.M.4    Burnton, C.M.5    Hodgson, S.6
  • 206
    • 26844503987 scopus 로고    scopus 로고
    • The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I
    • Rothenfusser, S., Goutagny, N., DiPerna, G., Gong, M., Monks, B.G., Schoenemeyer, A., et al. The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. Journal of Immunology 175 (2005), 5260–5268.
    • (2005) Journal of Immunology , vol.175 , pp. 5260-5268
    • Rothenfusser, S.1    Goutagny, N.2    DiPerna, G.3    Gong, M.4    Monks, B.G.5    Schoenemeyer, A.6
  • 207
    • 12144290582 scopus 로고    scopus 로고
    • CpG-A and CpG-B oligonucleotides differentially enhance human peptide-specific primary and memory CD8 + T-cell responses in vitro
    • Rothenfusser, S., Hornung, V., Ayyoub, M., Britsch, S., Towarowski, A., Krug, A., et al. CpG-A and CpG-B oligonucleotides differentially enhance human peptide-specific primary and memory CD8 + T-cell responses in vitro. Blood 103 (2004), 2162–2169.
    • (2004) Blood , vol.103 , pp. 2162-2169
    • Rothenfusser, S.1    Hornung, V.2    Ayyoub, M.3    Britsch, S.4    Towarowski, A.5    Krug, A.6
  • 208
    • 84905732218 scopus 로고    scopus 로고
    • The ribonuclease activity of SAMHD1 is required for HIV-1 restriction
    • Ryoo, J., Choi, J., Oh, C., Kim, S., Seo, M., Kim, S.Y., et al. The ribonuclease activity of SAMHD1 is required for HIV-1 restriction. Nature Medicine 20 (2014), 936–941.
    • (2014) Nature Medicine , vol.20 , pp. 936-941
    • Ryoo, J.1    Choi, J.2    Oh, C.3    Kim, S.4    Seo, M.5    Kim, S.Y.6
  • 211
    • 68049089651 scopus 로고    scopus 로고
    • Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus
    • Schlee, M., Roth, A., Hornung, V., Hagmann, C.A., Wimmenauer, V., Barchet, W., et al. Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity 31 (2009), 25–34.
    • (2009) Immunity , vol.31 , pp. 25-34
    • Schlee, M.1    Roth, A.2    Hornung, V.3    Hagmann, C.A.4    Wimmenauer, V.5    Barchet, W.6
  • 212
    • 84870716729 scopus 로고    scopus 로고
    • Noncoding flavivirus RNA displays RNA interference suppressor activity in insect and Mammalian cells
    • Schnettler, E., Sterken, M.G., Leung, J.Y., Metz, S.W., Geertsema, C., Goldbach, R.W., et al. Noncoding flavivirus RNA displays RNA interference suppressor activity in insect and Mammalian cells. Journal of Virology 86 (2012), 13486–13500.
    • (2012) Journal of Virology , vol.86 , pp. 13486-13500
    • Schnettler, E.1    Sterken, M.G.2    Leung, J.Y.3    Metz, S.W.4    Geertsema, C.5    Goldbach, R.W.6
  • 213
    • 84886943543 scopus 로고    scopus 로고
    • Breaking tumor-induced immunosuppression with 5'-triphosphate siRNA silencing TGFbeta and activating RIG-I
    • Schnurr, M., Duewell, P., Breaking tumor-induced immunosuppression with 5'-triphosphate siRNA silencing TGFbeta and activating RIG-I. Oncoimmunology, 2, 2013, e24170.
    • (2013) Oncoimmunology , vol.2
    • Schnurr, M.1    Duewell, P.2
  • 214
    • 84984993012 scopus 로고    scopus 로고
    • Induction of immunogenic cell death by targeting RIG-I-like helicases in pancreatic cancer
    • Schnurr, M., Duewell, P., Induction of immunogenic cell death by targeting RIG-I-like helicases in pancreatic cancer. Oncoimmunology, 3, 2014, e955687.
    • (2014) Oncoimmunology , vol.3
    • Schnurr, M.1    Duewell, P.2
  • 215
    • 79955542915 scopus 로고    scopus 로고
    • A diverse range of gene products are effectors of the type I interferon antiviral response
    • Schoggins, J.W., Wilson, S.J., Panis, M., Murphy, M.Y., Jones, C.T., Bieniasz, P., et al. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 472 (2011), 481–485.
    • (2011) Nature , vol.472 , pp. 481-485
    • Schoggins, J.W.1    Wilson, S.J.2    Panis, M.3    Murphy, M.Y.4    Jones, C.T.5    Bieniasz, P.6
  • 216
    • 84937706124 scopus 로고    scopus 로고
    • A conserved histidine in the RNA sensor RIG-I controls immune tolerance to N1-2'O-methylated self RNA
    • Schuberth-Wagner, C., Ludwig, J., Bruder, A.K., Herzner, A.M., Zillinger, T., Goldeck, M., et al. A conserved histidine in the RNA sensor RIG-I controls immune tolerance to N1-2'O-methylated self RNA. Immunity 43 (2015), 41–51.
    • (2015) Immunity , vol.43 , pp. 41-51
    • Schuberth-Wagner, C.1    Ludwig, J.2    Bruder, A.K.3    Herzner, A.M.4    Zillinger, T.5    Goldeck, M.6
  • 217
    • 0018177012 scopus 로고
    • Interferon, double-stranded RNA, and protein phosphorylation. Characteristics of a double-stranded RNA-activated protein kinase system partially purified from interferon treated Ehrlich ascites tumor cells
    • Sen, G.C., Taira, H., Lengyel, P., Interferon, double-stranded RNA, and protein phosphorylation. Characteristics of a double-stranded RNA-activated protein kinase system partially purified from interferon treated Ehrlich ascites tumor cells. The Journal of Biological Chemistry 253 (1978), 5915–5921.
    • (1978) The Journal of Biological Chemistry , vol.253 , pp. 5915-5921
    • Sen, G.C.1    Taira, H.2    Lengyel, P.3
  • 218
    • 84885995929 scopus 로고    scopus 로고
    • Reciprocal inhibition between intracellular antiviral signaling and the RNAi machinery in mammalian cells
    • Seo, G.J., Kincaid, R.P., Phanaksri, T., Burke, J.M., Pare, J.M., Cox, J.E., et al. Reciprocal inhibition between intracellular antiviral signaling and the RNAi machinery in mammalian cells. Cell Host & Microbe 14 (2013), 435–445.
    • (2013) Cell Host & Microbe , vol.14 , pp. 435-445
    • Seo, G.J.1    Kincaid, R.P.2    Phanaksri, T.3    Burke, J.M.4    Pare, J.M.5    Cox, J.E.6
  • 219
    • 36348987303 scopus 로고    scopus 로고
    • Viral encounters with 2',5'-oligoadenylate synthetase and RNase L during the interferon antiviral response
    • Silverman, R.H., Viral encounters with 2',5'-oligoadenylate synthetase and RNase L during the interferon antiviral response. Journal of Virology 81 (2007), 12720–12729.
    • (2007) Journal of Virology , vol.81 , pp. 12720-12729
    • Silverman, R.H.1
  • 220
    • 84929907228 scopus 로고    scopus 로고
    • Intrinsic host restrictions to HIV-1 and mechanisms of viral escape
    • Simon, V., Bloch, N., Landau, N.R., Intrinsic host restrictions to HIV-1 and mechanisms of viral escape. Nature Immunology 16 (2015), 546–553.
    • (2015) Nature Immunology , vol.16 , pp. 546-553
    • Simon, V.1    Bloch, N.2    Landau, N.R.3
  • 221
    • 33646544416 scopus 로고    scopus 로고
    • Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: A central role for 2'-hydroxyl uridines in immune responses
    • Sioud, M., Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: A central role for 2'-hydroxyl uridines in immune responses. European Journal of Immunology 36 (2006), 1222–1230.
    • (2006) European Journal of Immunology , vol.36 , pp. 1222-1230
    • Sioud, M.1
  • 222
    • 0014682495 scopus 로고
    • Enzyme from calf thymus degrading the RNA moiety of DNA-RNA hybrids: Effect on DNA-dependent RNA polymerase
    • Stein, H., Hausen, P., Enzyme from calf thymus degrading the RNA moiety of DNA-RNA hybrids: Effect on DNA-dependent RNA polymerase. Science 166 (1969), 393–395.
    • (1969) Science , vol.166 , pp. 393-395
    • Stein, H.1    Hausen, P.2
  • 223
    • 49549100511 scopus 로고    scopus 로고
    • Trex1 prevents cell-intrinsic initiation of autoimmunity
    • Stetson, D.B., Ko, J.S., Heidmann, T., Medzhitov, R., Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 134 (2008), 587–598.
    • (2008) Cell , vol.134 , pp. 587-598
    • Stetson, D.B.1    Ko, J.S.2    Heidmann, T.3    Medzhitov, R.4
  • 224
    • 84904211721 scopus 로고    scopus 로고
    • Renaissance of mammalian endogenous RNAi
    • Svoboda, P., Renaissance of mammalian endogenous RNAi. FEBS Letters 588 (2014), 2550–2556.
    • (2014) FEBS Letters , vol.588 , pp. 2550-2556
    • Svoboda, P.1
  • 225
  • 226
    • 26844459599 scopus 로고    scopus 로고
    • Wolbachia bacterial endosymbionts of filarial nematodes
    • Taylor, M.J., Bandi, C., Hoerauf, A., Wolbachia bacterial endosymbionts of filarial nematodes. Advances in Parasitology 60 (2005), 245–284.
    • (2005) Advances in Parasitology , vol.60 , pp. 245-284
    • Taylor, M.J.1    Bandi, C.2    Hoerauf, A.3
  • 227
    • 0026716253 scopus 로고
    • Mechanism of interferon action: cDNA structure, expression, and regulation of the interferon-induced, RNA-dependent P1/eIF-2 alpha protein kinase from human cells
    • Thomis, D.C., Doohan, J.P., Samuel, C.E., Mechanism of interferon action: cDNA structure, expression, and regulation of the interferon-induced, RNA-dependent P1/eIF-2 alpha protein kinase from human cells. Virology 188 (1992), 33–46.
    • (1992) Virology , vol.188 , pp. 33-46
    • Thomis, D.C.1    Doohan, J.P.2    Samuel, C.E.3
  • 228
    • 0026442274 scopus 로고
    • Mechanism of interferon action: Autoregulation of RNA-dependent P1/eIF-2 alpha protein kinase (PKR) expression in transfected mammalian cells
    • Thomis, D.C., Samuel, C.E., Mechanism of interferon action: Autoregulation of RNA-dependent P1/eIF-2 alpha protein kinase (PKR) expression in transfected mammalian cells. Proceedings of the National Academy of Sciences of the United States of America 89 (1992), 10837–10841.
    • (1992) Proceedings of the National Academy of Sciences of the United States of America , vol.89 , pp. 10837-10841
    • Thomis, D.C.1    Samuel, C.E.2
  • 231
    • 84874924160 scopus 로고    scopus 로고
    • Diverse functions of restriction-modification systems in addition to cellular defense
    • Vasu, K., Nagaraja, V., Diverse functions of restriction-modification systems in addition to cellular defense. Microbiology and Molecular Biology Reviews: MMBR 77 (2013), 53–72.
    • (2013) Microbiology and Molecular Biology Reviews: MMBR , vol.77 , pp. 53-72
    • Vasu, K.1    Nagaraja, V.2
  • 233
    • 28544449709 scopus 로고    scopus 로고
    • Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
    • Vollmer, J., Tluk, S., Schmitz, C., Hamm, S., Jurk, M., Forsbach, A., et al. Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. The Journal of Experimental Medicine 202 (2005), 1575–1585.
    • (2005) The Journal of Experimental Medicine , vol.202 , pp. 1575-1585
    • Vollmer, J.1    Tluk, S.2    Schmitz, C.3    Hamm, S.4    Jurk, M.5    Forsbach, A.6
  • 234
    • 0017385995 scopus 로고
    • Incorporation of phosphorothioate groups into fd and phi X174 DNA
    • Vosberg, H.P., Eckstein, F., Incorporation of phosphorothioate groups into fd and phi X174 DNA. Biochemistry 16 (1977), 3633–3640.
    • (1977) Biochemistry , vol.16 , pp. 3633-3640
    • Vosberg, H.P.1    Eckstein, F.2
  • 235
  • 236
    • 33645979325 scopus 로고    scopus 로고
    • RNA interference directs innate immunity against viruses in adult Drosophila
    • Wang, X.H., Aliyari, R., Li, W.X., Li, H.W., Kim, K., Carthew, R., et al. RNA interference directs innate immunity against viruses in adult Drosophila. Science 312 (2006), 452–454.
    • (2006) Science , vol.312 , pp. 452-454
    • Wang, X.H.1    Aliyari, R.2    Li, W.X.3    Li, H.W.4    Kim, K.5    Carthew, R.6
  • 237
    • 77954386541 scopus 로고    scopus 로고
    • Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I
    • Wang, Y., Ludwig, J., Schuberth, C., Goldeck, M., Schlee, M., Li, H., et al. Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I. Nature Structural & Molecular Biology 17 (2010), 781–787.
    • (2010) Nature Structural & Molecular Biology , vol.17 , pp. 781-787
    • Wang, Y.1    Ludwig, J.2    Schuberth, C.3    Goldeck, M.4    Schlee, M.5    Li, H.6
  • 238
    • 84974846075 scopus 로고    scopus 로고
    • Standing on three legs: Antiviral activities of RIG-I against influenza viruses
    • Weber-Gerlach, M., Weber, F., Standing on three legs: Antiviral activities of RIG-I against influenza viruses. Current Opinion in Immunology 42 (2016), 71–75.
    • (2016) Current Opinion in Immunology , vol.42 , pp. 71-75
    • Weber-Gerlach, M.1    Weber, F.2
  • 239
    • 0028081705 scopus 로고
    • Coley's toxins, tumor necrosis factor and cancer research: A historical perspective
    • Wiemann, B., Starnes, C.O., Coley's toxins, tumor necrosis factor and cancer research: A historical perspective. Pharmacology & Therapeutics 64 (1994), 529–564.
    • (1994) Pharmacology & Therapeutics , vol.64 , pp. 529-564
    • Wiemann, B.1    Starnes, C.O.2
  • 240
    • 84907924008 scopus 로고    scopus 로고
    • Cellular and biochemical mechanisms of the retroviral restriction factor SAMHD1
    • Wu, L., Cellular and biochemical mechanisms of the retroviral restriction factor SAMHD1. ISRN Biochemistry, 2013, 2013, 728392.
    • (2013) ISRN Biochemistry , vol.2013 , pp. 728392
    • Wu, L.1
  • 241
    • 84930934680 scopus 로고    scopus 로고
    • How RIG-I like receptors activate MAVS
    • Wu, B., Hur, S., How RIG-I like receptors activate MAVS. Current Opinion in Virology 12 (2015), 91–98.
    • (2015) Current Opinion in Virology , vol.12 , pp. 91-98
    • Wu, B.1    Hur, S.2
  • 242
    • 84873724533 scopus 로고    scopus 로고
    • Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
    • Wu, J., Sun, L., Chen, X., Du, F., Shi, H., Chen, C., et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339 (2012), 826–830.
    • (2012) Science , vol.339 , pp. 826-830
    • Wu, J.1    Sun, L.2    Chen, X.3    Du, F.4    Shi, H.5    Chen, C.6
  • 243
    • 0023689067 scopus 로고
    • In vitro augmentation of natural killer cell activity and production of interferon-alpha/beta and -gamma with deoxyribonucleic acid fraction from mycobacterium bovis BCG
    • Yamamoto, S., Kuramoto, E., Shimada, S., Tokunaga, T., In vitro augmentation of natural killer cell activity and production of interferon-alpha/beta and -gamma with deoxyribonucleic acid fraction from mycobacterium bovis BCG. Japanese Journal of Cancer Research: Gann 79 (1988), 866–873.
    • (1988) Japanese Journal of Cancer Research: Gann , vol.79 , pp. 866-873
    • Yamamoto, S.1    Kuramoto, E.2    Shimada, S.3    Tokunaga, T.4
  • 244
    • 0026625208 scopus 로고
    • Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity
    • Yamamoto, S., Yamamoto, T., Kataoka, T., Kuramoto, E., Yano, O., Tokunaga, T., Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity. Journal of Immunology 148 (1992), 4072–4076.
    • (1992) Journal of Immunology , vol.148 , pp. 4072-4076
    • Yamamoto, S.1    Yamamoto, T.2    Kataoka, T.3    Kuramoto, E.4    Yano, O.5    Tokunaga, T.6
  • 245
    • 0026464967 scopus 로고
    • DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth
    • Yamamoto, S., Yamamoto, T., Shimada, S., Kuramoto, E., Yano, O., Kataoka, T., et al. DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth. Microbiology and Immunology 36 (1992), 983–997.
    • (1992) Microbiology and Immunology , vol.36 , pp. 983-997
    • Yamamoto, S.1    Yamamoto, T.2    Shimada, S.3    Kuramoto, E.4    Yano, O.5    Kataoka, T.6
  • 246
    • 36248988008 scopus 로고    scopus 로고
    • Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease
    • Yang, Y.G., Lindahl, T., Barnes, D.E., Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell 131 (2007), 873–886.
    • (2007) Cell , vol.131 , pp. 873-886
    • Yang, Y.G.1    Lindahl, T.2    Barnes, D.E.3
  • 247
    • 0019805524 scopus 로고
    • Interferons, double-stranded RNA, and RNA degradation. Isolation and characterization of homogeneous human (2'-5')(a)n synthetase
    • Yang, K., Samanta, H., Dougherty, J., Jayaram, B., Broeze, R., Lengyel, P., Interferons, double-stranded RNA, and RNA degradation. Isolation and characterization of homogeneous human (2'-5')(a)n synthetase. The Journal of Biological Chemistry 256 (1981), 9324–9328.
    • (1981) The Journal of Biological Chemistry , vol.256 , pp. 9324-9328
    • Yang, K.1    Samanta, H.2    Dougherty, J.3    Jayaram, B.4    Broeze, R.5    Lengyel, P.6
  • 250
    • 23844438864 scopus 로고    scopus 로고
    • Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity
    • Yoneyama, M., Kikuchi, M., Matsumoto, K., Imaizumi, T., Miyagishi, M., Taira, K., et al. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. Journal of Immunology 175 (2005), 2851–2858.
    • (2005) Journal of Immunology , vol.175 , pp. 2851-2858
    • Yoneyama, M.1    Kikuchi, M.2    Matsumoto, K.3    Imaizumi, T.4    Miyagishi, M.5    Taira, K.6
  • 251
    • 12344290452 scopus 로고    scopus 로고
    • Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA
    • Yoshida, H., Okabe, Y., Kawane, K., Fukuyama, H., Nagata, S., Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA. Nature Immunology 6 (2005), 49–56.
    • (2005) Nature Immunology , vol.6 , pp. 49-56
    • Yoshida, H.1    Okabe, Y.2    Kawane, K.3    Fukuyama, H.4    Nagata, S.5
  • 252
    • 84869169968 scopus 로고    scopus 로고
    • Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors
    • Yu, P., Lubben, W., Slomka, H., Gebler, J., Konert, M., Cai, C., et al. Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors. Immunity 37 (2012), 867–879.
    • (2012) Immunity , vol.37 , pp. 867-879
    • Yu, P.1    Lubben, W.2    Slomka, H.3    Gebler, J.4    Konert, M.5    Cai, C.6
  • 253
    • 33645537549 scopus 로고    scopus 로고
    • RNAi is an antiviral immune response against a dsRNA virus in Drosophila melanogaster
    • Zambon, R.A., Vakharia, V.N., Wu, L.P., RNAi is an antiviral immune response against a dsRNA virus in Drosophila melanogaster. Cellular Microbiology 8 (2006), 880–889.
    • (2006) Cellular Microbiology , vol.8 , pp. 880-889
    • Zambon, R.A.1    Vakharia, V.N.2    Wu, L.P.3
  • 254
    • 84875792696 scopus 로고    scopus 로고
    • RNA-based mechanisms regulating host-virus interactions
    • Zhou, R., Rana, T.M., RNA-based mechanisms regulating host-virus interactions. Immunological Reviews 253 (2013), 97–111.
    • (2013) Immunological Reviews , vol.253 , pp. 97-111
    • Zhou, R.1    Rana, T.M.2
  • 255
    • 84902829130 scopus 로고    scopus 로고
    • Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor
    • Zhu, J., Zhang, Y., Ghosh, A., Cuevas, R.A., Forero, A., Dhar, J., et al. Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor. Immunity 40 (2014), 936–948.
    • (2014) Immunity , vol.40 , pp. 936-948
    • Zhu, J.1    Zhang, Y.2    Ghosh, A.3    Cuevas, R.A.4    Forero, A.5    Dhar, J.6


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