HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

Nature

Volumn 480, Issue 7377, 2011, Pages 379-382

  Goldstone, David C ^a   Ennis Adeniran, Valerie ^a   Hedden, Joseph J ^a   Groom, Harriet C T ^a   Rice, Gillian I ^b   Christodoulou, Evangelos ^a   Walker, Philip A ^a   Kelly, Geoff ^a   Haire, Lesley F ^a   Yap, Melvyn W ^a   De Carvalho, Luiz Pedro S ^a   Stoye, Jonathan P ^a   Crow, Yanick J ^b   Taylor, Ian A ^a   Webb, Michelle ^b  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYADENOSINE TRIPHOSPHATE; DEOXYGUANOSINE TRIPHOSPHATE; PHOSPHATASE; SAMHD1 ENZYME; UNCLASSIFIED DRUG;

CRYSTAL STRUCTURE; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS; INHIBITION; MITOCHONDRIAL DNA; PROTEIN;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; DNA SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROLYSIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION; VIRUS INHIBITION; VIRUS REPLICATION;

ALLOSTERIC REGULATION; BIOCATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DENDRITIC CELLS; DEOXYADENINE NUCLEOTIDES; DEOXYCYTOSINE NUCLEOTIDES; DEOXYGUANINE NUCLEOTIDES; HIV-1; HUMANS; HYDROLYSIS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MONOMERIC GTP-BINDING PROTEINS; MYELOID CELLS; NUCLEOSIDE-TRIPHOSPHATASE; PROTEIN STRUCTURE, TERTIARY; REVERSE TRANSCRIPTION; THYMINE NUCLEOTIDES; VIRAL REGULATORY AND ACCESSORY PROTEINS; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1; MURINAE;

EID: 83555164881     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10623     Document Type: Article

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