Oxidative damage of dna confers resistance to cytosolic nuclease trex1 degradation and potentiates STING-dependent immune sensing

Immunity

Volumn 39, Issue 3, 2013, Pages 482-495

  Gehrke, Nadine ^a   Mertens, Christina ^a   Zillinger, Thomas ^a   Wenzel, Jörg ^b   Bald, Tobias ^b   Zahn, Sabine ^b   Tüting, Thomas ^b   Hartmann, Gunther ^a   Barchet, Winfried ^a  

^a Institute of Clinical Chemistry and Clinical Pharmacology   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CPG OLIGODEOXYNUCLEOTIDE; DNA; EXONUCLEASE; EXONUCLEASE 1; GENOMIC DNA; INTERFERON; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; ARTICLE; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; DNA MODIFICATION; ENDOSOME; HUMAN; HUMAN CELL; LUPUS ERYTHEMATOSUS; MOUSE; MYELOID DENDRITIC CELL; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RESPIRATORY BURST; SIGNAL TRANSDUCTION; SKIN DEFECT; ULTRAVIOLET IRRADIATION;

ANIMALS; CELLS, CULTURED; DNA; DNA DAMAGE; DNA REPAIR; EXODEOXYRIBONUCLEASES; GUANOSINE; HUMANS; INTERFERON TYPE I; LUPUS ERYTHEMATOSUS, SYSTEMIC; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; NEUTROPHILS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOSPHOPROTEINS; REACTIVE OXYGEN SPECIES;

EID: 84884333427     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2013.08.004     Document Type: Article

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