메뉴 건너뛰기




Volumn 4, Issue , 2013, Pages

An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CALNEXIN; DNA; GREEN FLUORESCENT PROTEIN; HYDROGEN; INTERLEUKIN 12P40; LIPID A; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; LEUCINE-RICH REPEAT PROTEINS; MONOCLONAL ANTIBODY; PROTEIN; PROTEIN BINDING; LEUCINE RICH REPEAT PROTEINS;

EID: 84887504831     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms2949     Document Type: Article
Times cited : (72)

References (27)
  • 1
    • 33646183566 scopus 로고    scopus 로고
    • Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large
    • Beutler, B. et al. Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu. Rev. Immunol. 24, 353-389 (2006).
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 353-389
    • Beutler, B.1
  • 2
    • 33646147362 scopus 로고    scopus 로고
    • Toll-like receptor function and signaling
    • quiz 988
    • Kaisho, T. & Akira, S. Toll-like receptor function and signaling. J. Allergy Clin. Immunol. 117, 979-987 quiz 988 (2006).
    • (2006) J. Allergy Clin. Immunol. , vol.117 , pp. 979-987
    • Kaisho, T.1    Akira, S.2
  • 3
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
    • Kawai, T. & Akira, S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11, 373-384 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 4
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg, A. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20, 709-760 (2002).
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 709-760
    • Krieg, A.1
  • 5
    • 34247891509 scopus 로고    scopus 로고
    • Immunologically active autoantigens: The role of toll-like receptors in the development of chronic inflammatory disease
    • Marshak-Rothstein, A. & Rifkin, I. R. Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease. Annu. Rev. Immunol. 25, 419-441 (2007).
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 419-441
    • Marshak-Rothstein, A.1    Rifkin, I.R.2
  • 6
    • 29244450802 scopus 로고    scopus 로고
    • Intracellular localization of Tolllike receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
    • Barton, G. M., Kagan, J. C. & Medzhitov, R. Intracellular localization of Tolllike receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat. Immunol. 7, 49-56 (2006).
    • (2006) Nat. Immunol. , vol.7 , pp. 49-56
    • Barton, G.M.1    Kagan, J.C.2    Medzhitov, R.3
  • 7
    • 34948862264 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
    • Lande, R. et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 449, 564-569 (2007).
    • (2007) Nature , vol.449 , pp. 564-569
    • Lande, R.1
  • 8
    • 0037061453 scopus 로고    scopus 로고
    • Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
    • Leadbetter, E. A. et al. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416, 603-607 (2002).
    • (2002) Nature , vol.416 , pp. 603-607
    • Leadbetter, E.A.1
  • 9
    • 26844467349 scopus 로고    scopus 로고
    • Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    • Barrat, F. J. et al. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J. Exp. Med. 202, 1131-1139 (2005).
    • (2005) J. Exp. Med. , vol.202 , pp. 1131-1139
    • Barrat, F.J.1
  • 10
    • 69549135324 scopus 로고    scopus 로고
    • Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8
    • Ganguly, D. et al. Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. J. Exp. Med. 206, 1983-1994 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 1983-1994
    • Ganguly, D.1
  • 11
    • 40749098665 scopus 로고    scopus 로고
    • UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes
    • Kim, Y. M., Brinkmann, M. M., Paquet, M. E. & Ploegh, H. L. UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature 452, 234-238 (2008).
    • (2008) Nature , vol.452 , pp. 234-238
    • Kim, Y.M.1    Brinkmann, M.M.2    Paquet, M.E.3    Ploegh, H.L.4
  • 12
    • 10744219675 scopus 로고    scopus 로고
    • TLR9 signals after translocating from the ER to CpG DNA in the lysosome
    • Latz, E. et al. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat. Immunol. 5, 190-198 (2004).
    • (2004) Nat. Immunol. , vol.5 , pp. 190-198
    • Latz, E.1
  • 13
    • 81955161805 scopus 로고    scopus 로고
    • Transmembrane mutations in Toll-like receptor 9 bypass the requirement for ectodomain proteolysis and induce fatal inflammation
    • Mouchess, M. L. et al. Transmembrane mutations in Toll-like receptor 9 bypass the requirement for ectodomain proteolysis and induce fatal inflammation. Immunity 35, 721-732 (2011).
    • (2011) Immunity , vol.35 , pp. 721-732
    • Mouchess, M.L.1
  • 14
    • 57349191215 scopus 로고    scopus 로고
    • The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor
    • Ewald, S. E. et al. The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature 456, 658-662 (2008).
    • (2008) Nature , vol.456 , pp. 658-662
    • Ewald, S.E.1
  • 15
    • 56349114913 scopus 로고    scopus 로고
    • Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9
    • Park, B. et al. Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9. Nat. Immunol. 9, 1407-1414 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 1407-1414
    • Park, B.1
  • 16
    • 79955743119 scopus 로고    scopus 로고
    • Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase
    • Ewald, S. E. et al. Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase. J. Exp. Med. 208, 643-651 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 643-651
    • Ewald, S.E.1
  • 17
    • 70449477746 scopus 로고    scopus 로고
    • Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells
    • Sepulveda, F. E. et al. Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells. Immunity 31, 737-748 (2009).
    • (2009) Immunity , vol.31 , pp. 737-748
    • Sepulveda, F.E.1
  • 18
    • 36549072863 scopus 로고    scopus 로고
    • A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses
    • Takahashi, K. et al. A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses. J. Exp. Med. 204, 2963-2976 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 2963-2976
    • Takahashi, K.1
  • 19
    • 31344466165 scopus 로고    scopus 로고
    • The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
    • Tabeta, K. et al. The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat. Immunol. 7, 156-164 (2006).
    • (2006) Nat. Immunol. , vol.7 , pp. 156-164
    • Tabeta, K.1
  • 20
    • 33751551466 scopus 로고    scopus 로고
    • Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells
    • Lee, J. et al. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat. Cell. Biol. 8, 1327-1336 (2006).
    • (2006) Nat. Cell. Biol. , vol.8 , pp. 1327-1336
    • Lee, J.1
  • 21
    • 67449136127 scopus 로고    scopus 로고
    • Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA-but against RNA-sensing
    • Fukui, R. et al. Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA-but against RNA-sensing. J. Exp. Med. 206, 1339-1350 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 1339-1350
    • Fukui, R.1
  • 22
    • 79953890803 scopus 로고    scopus 로고
    • The structural biology of Toll-like receptors
    • Botos, I., Segal, D. M. & Davies, D. R. The structural biology of Toll-like receptors. Structure. 19, 447-459 (2011).
    • (2011) Structure. , vol.19 , pp. 447-459
    • Botos, I.1    Segal, D.M.2    Davies, D.R.3
  • 23
    • 67649232601 scopus 로고    scopus 로고
    • Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNAmediated receptor activation
    • Peter, M. E., Kubarenko, A. V., Weber, A. N. & Dalpke, A. H. Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNAmediated receptor activation. J. Immunol. 182, 7690-7697 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 7690-7697
    • Peter, M.E.1    Kubarenko, A.V.2    Weber, A.N.3    Dalpke, A.H.4
  • 24
    • 17144404177 scopus 로고    scopus 로고
    • IRF-7 is the master regulator of type-I interferon-dependent immune responses
    • Honda, K. et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434, 772-777 (2005).
    • (2005) Nature , vol.434 , pp. 772-777
    • Honda, K.1
  • 25
    • 34250698370 scopus 로고    scopus 로고
    • Ligand-induced conformational changes allosterically activate Toll-like receptor 9
    • Latz, E. et al. Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat. Immunol. 8, 772-779 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 772-779
    • Latz, E.1
  • 26
    • 33746214788 scopus 로고    scopus 로고
    • A protein associated with Toll-like receptor 4 (PRAT4A) regulates cell surface expression of TLR4
    • Wakabayashi, Y. et al. A protein associated with Toll-like receptor 4 (PRAT4A) regulates cell surface expression of TLR4. J. Immunol. 177, 1772-1779 (2006).
    • (2006) J. Immunol. , vol.177 , pp. 1772-1779
    • Wakabayashi, Y.1
  • 27
    • 84867121105 scopus 로고    scopus 로고
    • PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells
    • Shibata, T. et al. PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells. Int. Immunol. 24, 613-623 (2012).
    • (2012) Int. Immunol. , vol.24 , pp. 613-623
    • Shibata, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.