ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA

eLife

Volumn 4, Issue NOVEMBER2015, 2015, Pages

  Lässig, Charlotte ^a   Matheisl, Sarah ^a   Sparrer, Konstantin M J ^a,e   Mann, Carina C de Oliveira ^a   Moldt, Manuela ^a   Patel, Jenish R ^b   Goldeck, Marion ^c   Hartmann, Gunther ^c   García Sastre, Adolfo ^b   Hornung, Veit ^c   Conzelmann, Karl Klaus ^a   Beckmann, Roland ^a,d   Hopfner, Karl Peter ^a,d  

^a UNIVERSITY OF MUNICH   (Germany)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY HOSPITAL BONN   (Germany)

^d Munich Center for Integrated Protein Science   (Germany)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BETA INTERFERON; BETA TUBULIN; COMPLEMENTARY DNA; DOUBLE STRANDED RNA; INTERFERON; RETINOIC ACID INDUCIBLE PROTEIN I; RIBOSOME RNA; RNA 18S; RNA 28S; VIRUS RNA; ADENOSINE TRIPHOSPHATE; DDX58 PROTEIN, HUMAN; DEAD BOX PROTEIN;

80S RIBOSOME; ADENOSINE TRIPHOSPHATASE HYDROLYSIS; ARTICLE; BIOCHEMICAL ANALYSIS; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; DOUBLE-STRANDED RNA VIRUS; FLUORESCENCE ANALYSIS; FLUORESCENCE ANISOTROPY ASSAY; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; HYDROLYSIS; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; IMMUNOSTIMULATION; INNATE IMMUNITY; LUCIFERASE ASSAY; MOLECULAR DOCKING; NONHUMAN; PROTEIN EXPRESSION; RIBOSOME; RNA ANALYSIS; RNA BINDING; RNA ISOLATION; SIGNAL TRANSDUCTION; SINGLETON MERTEN SYNDROME; SYSTEMIC DISEASE; THERMOSTABILITY; VIRUS MUTATION; CELL LINE; ENZYME SPECIFICITY; METABOLISM;

ADENOSINE TRIPHOSPHATE; CELL LINE; DEAD BOX PROTEIN 58; DEAD-BOX RNA HELICASES; HUMANS; HYDROLYSIS; RNA, VIRAL; SUBSTRATE SPECIFICITY;

EID: 84955250204     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.10859     Document Type: Article

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