Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice

Journal of Immunology

Volumn 194, Issue 3, 2015, Pages 873-877

  Baum, Rebecca ^a   Sharma, Shruti ^a   Carpenter, Susan ^b   Li, Quan Zhen ^c   Busto, Patricia ^a   Fitzgerald, Katherine A ^a   Marshak Rothstein, Ann ^a   Gravallese, Ellen M ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSENT IN MELANOMA 2 PROTEIN; ADAPTOR PROTEIN; AUTOANTIBODY; INFLAMMASOME; REGULATOR PROTEIN; STIMULATOR OF INTERFERON GENE PROTEIN; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; AIM2 PROTEIN, MOUSE; AUTACOID; AUTOANTIGEN; CYTOKINE; DEOXYRIBONUCLEASE; DEOXYRIBONUCLEASE II; DNA BINDING PROTEIN; TOLL LIKE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTHRITIS; ARTICLE; ATTENUATION; AUTOIMMUNITY; CONTROLLED STUDY; EMBRYO; FEMALE; INNATE IMMUNITY; MALE; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; THICKNESS; ANIMAL; ARTHRITIS, EXPERIMENTAL; BIOSYNTHESIS; CLUSTER ANALYSIS; DEFICIENCY; DISEASE MODEL; GENE EXPRESSION PROFILING; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PHENOTYPE;

ANIMALS; ANTIBODY FORMATION; ARTHRITIS, EXPERIMENTAL; AUTOANTIBODIES; AUTOANTIGENS; CLUSTER ANALYSIS; CYTOKINES; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; FEMALE; GENE EXPRESSION PROFILING; IMMUNITY, INNATE; INFLAMMATION MEDIATORS; MALE; MICE; MICE, KNOCKOUT; PHENOTYPE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 84921478452     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1402573     Document Type: Article

References (18)

1. Baccala, R., K. Hoebe, D. H. Kono, B. Beutler, and A. N. Theofilopoulos. 2007. TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nat. Med. 13: 543-551.
2. Liu, Y., A. A. Jesus, B. Marrero, D. Yang, S. E. Ramsey, G. A. Montealegre Sanchez, K. Tenbrock, H. Wittkowski, O. Y. Jones, H. S. Kuehn, et al. 2014. Activated STING in a vascular and pulmonary syndrome. N. Engl. J. Med. 371: 507-518.
3. Yoshida, H., Y. Okabe, K. Kawane, H. Fukuyama, and S. Nagata. 2005. Lethal anemia caused by interferon-β produced in mouse embryos carrying undigested DNA. Nat. Immunol. 6: 49-56.
4. Kawane, K., M. Ohtani, K. Miwa, T. Kizawa, Y. Kanbara, Y. Yoshioka, H. Yoshikawa, and S. Nagata. 2006. Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature 443: 998-1002.
5. Kawane, K., H. Tanaka, Y. Kitahara, S. Shimaoka, and S. Nagata. 2010. Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation. Proc. Natl. Acad. Sci. USA 107: 19432-19437.
6. Ahn, J., D. Gutman, S. Saijo, and G. N. Barber. 2012. STING manifests self DNA-dependent inflammatory disease. Proc. Natl. Acad. Sci. USA 109: 19386-19391.
7. Rathinam, V. A., S. K. Vanaja, and K. A. Fitzgerald. 2012. Regulation of inflammasome signaling. Nat. Immunol. 13: 333-342.
8. Ishikawa, H., Z. Ma, and G. N. Barber. 2009. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461: 788-792.
9. Rathinam, V. A., Z. Jiang, S. N. Waggoner, S. Sharma, L. E. Cole, L. Waggoner, S. K. Vanaja, B. G. Monks, S. Ganesan, E. Latz, et al. 2010. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat. Immunol. 11: 395-402.
10. Pettit, A. R., H. Ji, D. von Stechow, R. Müller, S. R. Goldring, Y. Choi, C. Benoist, and E. M. Gravallese. 2001. TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am. J. Pathol. 159: 1689-1699.
11. Korganow, A. S., H. Ji, S. Mangialaio, V. Duchatelle, R. Pelanda, T. Martin, C. Degott, H. Kikutani, K. Rajewsky, J. L. Pasquali, et al. 1999. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity 10: 451-461.
12. Walsh, N. C., S. Reinwald, C. A. Manning, K. W. Condon, K. Iwata, D. B. Burr, and E. M. Gravallese. 2009. Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis. J. Bone Miner. Res. 24: 1572-1585.
13. Li, Q. Z., J. Zhou, A. E. Wandstrat, F. Carr-Johnson, V. Branch, D. R. Karp, C. Mohan, E. K. Wakeland, and N. J. Olsen. 2007. Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes. Clin. Exp. Immunol. 147: 60-70.
14. Sedimbi, S. K., T. Hägglöf, and M. C. Karlsson. 2013. IL-18 in inflammatory and autoimmune disease. Cell. Mol. Life Sci. 70: 4795-4808.
15. Wu, C., C. Orozco, J. Boyer, M. Leglise, J. Goodale, S. Batalov, C. L. Hodge, J. Haase, J. Janes, J. W. Huss, III, and A. I. Su. 2009. BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol. 10: R130.
16. Mangialaio, S., H. Ji, A. S. Korganow, V. Kouskoff, C. Benoist, and D. Mathis. 1999. The arthritogenic T cell receptor and its ligand in a model of spontaneous arthritis. Arthritis Rheum. 42: 2517-2523.
17. Stetson, D. B., J. S. Ko, T. Heidmann, and R. Medzhitov. 2008. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 134: 587-598.
18. Crow, Y. J., B. E. Hayward, R. Parmar, P. Robins, A. Leitch, M. Ali, D. N. Black, H. van Bokhoven, H. G. Brunner, B. C. Hamel, et al. 2006. Mutations in the gene encoding the 39-59 DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus. Nat. Genet. 38: 917-920.