SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons

Retrovirology

Volumn 9, Issue , 2012, Pages

  St Gelais, Corine ^a   de Silva, Suresh ^a   Amie, Sarah M ^b   Coleman, Christopher M ^a   Hoy, Heather ^a   Hollenbaugh, Joseph A ^b   Kim, Baek ^b   Wu, Li ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Dendritic cells; HIV 1 restriction; Interferon; Intracellular dNTPs; SAMHD1

Indexed keywords

CELL PROTEIN; DEOXYRIBONUCLEOSIDE TRIPHOSPHATE; GAMMA INTERFERON; INTERFERON; MESSENGER RNA; SAM DOMAIN AND HD DOMAIN CONTAINING PROTEIN 1; UNCLASSIFIED DRUG; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; SAMHD1 PROTEIN, HUMAN; VIRAL PROTEIN; VPX PROTEIN, SIMIAN IMMUNODEFICIENCY VIRUS;

ARTICLE; CD4+ T LYMPHOCYTE; CELL STRAIN HEK293; CONTROLLED STUDY; DENDRITIC CELL; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INTRACELLULAR SIGNALING; MOLECULAR DYNAMICS; PRIMARY CELL CULTURE; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION; SAM DOMAIN AND HD DOMAIN CONTAINING PROTEIN 1 GENE; UPREGULATION; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; HELA CELL LINE; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; PHYSIOLOGY; VIROLOGY; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

CD4-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; GENE EXPRESSION REGULATION; HEK293 CELLS; HELA CELLS; HIV-1; HUMANS; INTERFERONS; MONOMERIC GTP-BINDING PROTEINS; PROTEOLYSIS; REVERSE TRANSCRIPTION; RNA, MESSENGER; VIRAL REGULATORY AND ACCESSORY PROTEINS; VIRUS REPLICATION;

EID: 84871412468     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-9-105     Document Type: Article

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