Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-α induction in plasmacytoid dendritic cells

European Journal of Immunology

Volumn 33, Issue 6, 2003, Pages 1633-1641

  Hartmann, Gunther ^a   Battiany, Julia ^a   Poeck, Hendrick ^a   Wagner, Moritz ^a   Kerkmann, Miren ^a   Lubenow, Norbert ^b   Rothenfusser, Simon ^a   Endres, Stefan ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

B cell; CpG oligodeoxynucleotide; Innate immunity; Plasmacytoid dendritic cell; Type I IFN

Indexed keywords

ALPHA INTERFERON; CPG CONTAINING OLIGONUCLEOTIDE; OLIGONUCLEOTIDE; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE ACTIVATION; CELL SUBPOPULATION; CONTROLLED STUDY; CPG ISLAND; DENDRITIC CELL; DRUG DESIGN; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; IN VIVO STUDY; INTERFERON INDUCTION; NUCLEOTIDE SEQUENCE; PLASMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF;

ADJUVANTS, IMMUNOLOGIC; ADULT; AGED; ANTIGENS, CD; ANTIGENS, CD86; B-LYMPHOCYTES; BASE SEQUENCE; CPG ISLANDS; DENDRITIC CELLS; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; DRUG DESIGN; GENE EXPRESSION REGULATION; HUMANS; INTERFERON-ALPHA; LYMPHOCYTE ACTIVATION; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; OLIGODEOXYRIBONUCLEOTIDES; RECEPTORS, CELL SURFACE; STRUCTURE-ACTIVITY RELATIONSHIP; TOLL-LIKE RECEPTOR 9;

EID: 0038236749     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200323813     Document Type: Article

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