Structural basis of toll-like receptor 3 signaling with double-stranded RNA

Science

Volumn 320, Issue 5874, 2008, Pages 379-381

  Liu, Lin ^a   Botos, Istvan ^a   Wang, Yan ^b   Leonard, Joshua N ^b   Shiloach, Joseph ^a   Segal, David M ^b   Davies, David R ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3;

CYTOPLASM; RNA; SIGNALING;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; HERPES SIMPLEX ENCEPHALITIS; INFLAMMATION; LIGAND BINDING; MOLECULAR RECOGNITION; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; HUMANS; LIGANDS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; NF-KAPPA B; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RNA, DOUBLE-STRANDED; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 3;

EID: 42349090335     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1155406     Document Type: Article

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16. We thank D. Xia for assistance with data collection and F. Dyda for valuable discussions. This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases and the National Cancer Institute and by an NIH/FDA Intramural Biodefense Award from the National Institute of Allergy and Infectious Diseases. We acknowledge the valuable assistance of the Protein Expression laboratory, Science Applications International Corp., Frederick MD, in developing protein expression systems. Use of the Advanced Photon Source was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under contract W-31-109-Eng-38. The coordinates were deposited in the Protein DataBank, accession codes 3CIG (apo) and 3CIY (complex).