Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling

Biochemical and Biophysical Research Communications

Volumn 293, Issue 5, 2002, Pages 1364-1369

  Matsumoto, Misako ^a   Kikkawa, Satomi ^a   Kohase, Masayoshi ^c   Miyake, Kensuke ^b   Seya, Tsukasa ^a  

^a OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

Double stranded RNA; Human fibroblasts; Monoclonal antibody; Signal transduction; Toll like receptor; Type I interferon

Indexed keywords

BETA INTERFERON; DOUBLE STRANDED RNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MONOCLONAL ANTIBODY; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN; CELL SURFACE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXTRACELLULAR SPACE; GENETIC ANALYSIS; GENETIC TRANSFECTION; HOST CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; REPORTER GENE; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE; CELL MEMBRANE; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; DROSOPHILA PROTEINS; FIBROBLASTS; FLOW CYTOMETRY; GENES, REPORTER; GENETIC VECTORS; HUMANS; INTERFERON-BETA; LUCIFERASES; LUNG; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; NF-KAPPA B; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; RNA; RNA, DOUBLE-STRANDED; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTORS; TRANSFECTION;

VECTORS;

EID: 0036076593     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00380-7     Document Type: Article

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