The human 2',5'-oligoadenylate synthetase family: Interferon-induced proteins with unique enzymatic properties

Journal of Interferon and Cytokine Research

Volumn 19, Issue 4, 1999, Pages 295-308

  Rebouillat, Dominique ^a   Hovanessian, Ara G ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; INTERFERON;

ANIMAL CELL; AUTOPHOSPHORYLATION; CATALYSIS; COMPLEX FORMATION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME REGULATION; GENE CLUSTER; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN INDUCTION; PROTEIN SYNTHESIS INHIBITION; REVIEW; VIRUS REPLICATION;

2',5'-OLIGOADENYLATE SYNTHETASE; AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; ENZYME INDUCTION; HUMANS; INTERFERONS; ISOENZYMES; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; RNA, DOUBLE-STRANDED;

ANIMALIA;

EID: 0032951754     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/107999099313992     Document Type: Review

References (108)

1. KERR, I.M., BROWN, R.E., and BALL, L.A. (1974). Increased sensitivity of cell-free protein synthesis to double-stranded RNA after interferon treatment. Nature 250, 57-59.
2. HOVANESSIAN, A.G. (1991). Interferon-induced and doublestranded RNA-activated enzymes: a specific protein kinase and 2′,5′-oligoadenylate synthetases. J. Interferon Res. 11, 199-205.
3. ROBERTS, W.K., CLEMENS, M.J., and KERR, I.M. (1976). Interferon-induced inhibition of protein synthesis in L-cell extracts: an ATP-dependent step in the activation of an inhibitor by double-stranded RNA. Proc. Natl. Acad. Sci. USA 73, 3136-3140.
4. LEBLEU, B., SEN, G.C., SHAILA, S., CABRER, B., and LENGYEL, P. (1976). Interferon, double-stranded RNA, and protein phosphorylation. Proc. Natl. Acad. Sci. USA 73, 3107-3111.
5. ZILBERSTEIN, A., FEDERMAN, P., SHULMAN, L., and REVEL, M. (1976). Specific phosphorylation in vitro of a protein associated with ribosomes of interferon-treated mouse L cells. FEBS Lett. 68, 119-124.
6. HOVANESSIAN, A.G., BROWN, R.E., and KERR, I.M. (1977). Synthesis of low molecular weight inhibitor of protein synthesis with enzyme from interferon-treated cells. Nature 268, 537-540.
7. KERR, I.M., BROWN, R.E., and HOVANESSIAN, A.G. (1977). Nature of inhibitor of cell-free protein synthesis formed in response to interferon and double-stranded RNA. Nature 268, 540-542.
8. KERR, I.M., and BROWN, R.E. (1978). pppA2′p5′A2′p5′A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells. Proc. Natl. Acad. Sci. USA 75, 256-260.
9. HOVANESSIAN, A.G. (1995). Protein kinasein RNA dependent, PKR. In: Protein Kinase Factsbook: Protein-Serine Kinases. G. Hardie, (ed.) London: Academic Press, pp. 314-316.
10. MEURS, E., CHONG, K., GALABRU, J., THOMAS, N.S., KERR, I.M., WILLIAMS, B.R., and HOVANESSIAN, A.G. (1990). Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. Cell 62, 379-390.
11. HOVANESSIAN, A.G. (1993). Interferon-induced dsRNA-activated protein kinase (PKR): antiproliferative, antiviral and antitumoral functions. Semin. Virol. 4, 237-245.
12. HOVANESSIAN, A.G., LAURENT, A.G., CHEBATH, J., GALABRU, J., ROBERT, N., and SVAB, J. (1987). Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies. EMBO J. 6, 1273-1280.
13. CHEBATH, J., BENECH, P., HOVANESSIAN, A.G., GALABRU, J., and REVEL, M. (1987). Four different forms of interferon-induced 2′,5′-oIigo(A) synthetase identified by immunoblotting in human cells. J. Biol. Chem. 262, 3852-3857.
14. BENECH, P., MERLIN, G., REVEL, M., and CHEBATH, J. (1985). 3′-End structure of the human (2′-5′) oligo A synthetase gene: prediction of two distinct proteins with cell type-specific expression. Nucleic Acids Res. 13, 1267-1281.
15. MARIÉ, I., and HOVANESSIAN, A.G. (1992). The 69-kDa 25A synthetase is composed of two homologous and adjacent functional domains. J. Biol. Chem. 267, 9933-9939.
16. REBOUILLAT, D., HOVNANIAN, A., MARIÉ, I., and HOVANESSIAN, A.G. (1999). The 100-kDa 2′-5′-oligoadenylate synthetase catalyzing preferential the synthesis of dimeric pppA2′p5′A molecules is composed of three homologous domains. J. Biol. Chem 274, 1557-1565.
17. CLEMENS, M.J., and WILLIAMS, B.R. (1978). Inhibition of cell-free protein synthesis by pppA2′p5A2′p5′A: a novel oligonucleotide synthesized by interferon-treated L cell extracts. Cell 13, 565-572.
18. BAGLIONI, C. MINKS, M.A., and MARONEY, P.A. (1978). Interferon action may be mediated by activation of a nuclease by pppA2′p5′A2′p5′A2′p5′A. Nature 273, 684-687.
19. ZHOU, A., HASSEL, B.A., and SILVERMAN, R.H. (1993). Ex- pression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action. Cell 72, 753-765.
20. SEN, G.C., and LENGYEL, P. (1992). The interferon system. A bird's eye view of its biochemistry. J. Biol. Chem. 267, 5017-5020.
21. KERR, I.M. (1987). The 2-5A system: a personal view. J. Interferon Res. 7, 505-510.
22. SAMUEL, C.E. (1991). Antiviral actions of interferon. Interferonregulated cellular proteins and their surprisingly selective antiviral activities. Virology 183, 1-11.
23. r protein kinase. Semin. Virol. 4, 259-268.
24. WILLIAMS, B.R.G. (1995). The role of the dsRNA-activated protein kinase, PKR, in signal transduction. Semin. Virol. 6, 191-202.
25. LEE, S.B., and ESTEBAN, M. (1994). The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis. Virology 199, 491-496.
26. DER, S.D., YANG, Y.L., WEISSMANN, C., and WILLIAMS, B.R. (1997). A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis. Proc. Natl. Acad. Sci. USA 94, 3279-3283.
27. CLEMENS, M.J., and ELIA, A. (1997). The double-stranded RNA-dependent protein kinase PKR: structure and function [Review]. J. Interferon Cytokine Res. 17, 503-524.
28. STARK, G.R., DOWER, W.J., SCHIMKE, R.T., BROWN, R.E., and KERR, I.M. (1979). 2-5A synthetase: assay, distribution and variation with growth or hormone status. Nature 278, 471-473.
29. KRUST, B., RIVIÈRE, Y., and HOVANESSIAN, A.G. (1982). p 67 kinase in different tissues and plasma of control and interferon-treated mice. Virology 120, 240-246.
30. HOVANESSIAN, A.G., and KERR, I.M. (1979). The (2′-5′) oligoadenylate (pppA2′-5′A2-5′A) synthetase and protein kinase(s) from interferon-treated cells. Eur. J. Biol. Chem. 93, 515-526.
31. WITT, P.L., MARIE, I., ROBERT, N., IRIZARRY, A., BORDEN, E.C., and HOVANESSIAN, A.G. (1993). Isoforms p69 and p100 of 2′,5′-oligoadenylate synthetase induced differentially by interferons in vivo and in vitro. J. Interferon Res. 13, 17-23.
32. JACOBS, B.L., and LANGLAND, J.O. (1996). When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA. Virology 219, 339-349.
33. MARIÉ, I., SVAB, J., and HOVANESSIAN, A.G. (1990). The binding of the 69- and 100-kD forms of 2′,5′-oligoadenylate synthetase to different polynucleotides. J. Interferon Res. 10, 571-578.
34. MAITRA, R.K., McMILLAN, N.A., DESAI, S., McSWIGGEN, J., HOVANESSIAN, A.G., SEN. G., WILLIAMS, B.R., and SILVERMAN, R.H. (1994). HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes. Virology 204, 823-827.
35. WILLIAMS, B.R., GOLGHER, R.R. BROWN, R.E., GILBERT, C.S., and KERR, I.M. (1979). Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells. Nature 282, 582-586.
36. NILSEN, T.W., MARONEY, P.A., and BAGLIONI, C. (1982). Inhibition of protein synthesis in reovirus-infected HeLa cells with elevated levels of interferon-induced protein kinase activity. J. Biol. Chem. 257, 14593-14596.
37. LAURENCE, L., ROUX, D., CAILLA, H., RIVIERE, Y., MARCOVISTZ, R., and HOVANESSIAN, A. (1985). Comparison of the effects of rabies virus infection and of combined Interferon and poly(I).poly(C) treatment on the levels of 2′,5′-adenyladenosine oligonucleotides in different organs of mice. Virology 143, 290-299.
38. GRIBAUDO, G., LEMBO, D., CAVALLO, G., LANDOLFO, S., and LENGYEL, P. (1991). Interferon action: binding of viral RNA to the 40-kilodalton 2′-5′-oligoadenylate synthetase in interferon-treated HcLa cells infected with encephalomyocarditis virus. J. Virol. 65, 1748-1757.
39. WILLIAMS, B.R.G., and SILVERMAN, R.H. (1985) The 2-5A System. New York: Alan R. Liss, Inc.
40. WILLIAMS, B.R., and KERR, I.M. (1978). Inhibition of protein synthesis by 2′-5′ linked adenine oligonucleotides in intact cells. Nature 276, 88-90.
41. HOVANESSIAN, A.G., and WOOD, J.N. (1980). Anticellular and antiviral effects of pppA(2′p5′A)n. Virology 101, 81-90.
42. CHEBATH, J. BENECH, P., REVEL, M., and VIGNERON, M. (1987). Constitutive expression of (2′-5′) oligo A synthetase confers resistance to picornavirus infection. Nature 330, 587-588.
43. COCCIA, E.M., ROMEO, G., NISSIM, A., MARZIALI, G., ALBERTINI, R., AFFABRIS, E., BATTISTINI, A., FIORUCCI, G., ORSATTI, R., ROSSI, G.B., et al. (1990). A full-length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication. Virology 179, 228-233.
44. MARIÉ, I., REBOUILLAT, D., and HOVANESSIAN, A.G. (1999). Both domains of the human interferon-induced 69 kDa 2′,5′ oligoadenylate synthetase are required for catalytic activity. Eur. J. Biochem. In press.
45. + cells against human immunodeficiency virus (HIV) infection after stable transfection with HIV LTR-2′,5′-oligoadenylate synthetase hybrid gene. FASEB J. 4, 3124-3130.
46. SCHRODER, H.C., SUHADOLNIK, R.J., PFLEIDERER, W., CHARUBELA, R., and MULLER, W.E.G. (1992). (2′-5′)Oligoadenylate and intracellular immunity against retrovirus infection. Int. J. Biochem 1, 55-63.
47. HASSEL, B.A., ZHOU, A., SOTOMAYOR, C., MARAN, A., and SILVERMAN, R.H. (1993). A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon. EMBO J. 12, 3297-3304.
48. LAURENCE, L., MARI, J., ROUX, D., and CAILLA, H. (1984). Immunological evidence for the in vivo occurrence of (2′-5′) adenylyladenosine oligonucleotides in eukaryotes and prokaryotes. Proc. Natl. Acad. Sci. USA 81, 2322-2326.
49. RYSIECKI, G., GEWERT, D.R., and WILLIAMS, B.R. (1989). Constitutive expression of a 2′,5′-oligoadenylate synthetase cDNA results in increased antiviral activity and growth suppression. J. Interferon Res. 9, 649-657.
50. KIMCHI, A., SHURE, R, and REVEL, M. (1981). Anti-mitogenic function of interferon-induced (2′5′) oligo adenylate and growth related variations in enzymes that synthesize and degrade this oligonucleotide. Eur. J. Biochem. 114, 5-10.
51. KIMCHI, A., SHURE, H., LAPIDOT, Y., RAPOPORT, S., PANET, A., and REVEL, M. (1981). Antimitogenic effects of interferon and (2′-5′)-oligoadenylate in synchronized 3T3 fibroblasts. FEBS Lett. 134, 212-216.
52. FERBUS, D., TESTA, U., TITEUX, M., LOUACHE, F., and THANG, M.N. (1985). Induction of (2′-5′) oligoadenylate synthetase activity during granulocyte and monocyte differentiation. Mol. Cell. Biochem. 67, 125-133.
53. KRAUSE, D., SILVERMAN, R.H., JACOBSEN, H., LEISY, S.A., DIEEFENBACH, C.W., and FRIEDMAN, R.M. (1985). Regulation of ppp(A2′p)nA-dependent RNase levels during interferon treatment and cell differentiation. Eur. J. Biochem. 146, 611-618.
54. SALZBERG, S., HYMAN, T., TURM, H., KINAR, Y., SCHWARTZ, Y., NIR, U., LEJBKOWICZ, F., and HUBERMAN, E. (1997). Ectopic expression of 2-5a synthetase in myeloid cells induces growth arrest and facilitates the appearance of a myeloid differentiation marker. Cancer Res. 57, 2732-2740.
55. CASTELLI, J.C., MASSEL, B.A., WOOD, K.A., LI, X.L., AMEMIYA, K., DALAKAS, M.C., TORRENCE, P.F., and YOULE, R.J. (1997). A study of the interferon antiviral mechanism: apoptosis activation by the 2-5A system. J. Exp. Med. 186, 967-972.
56. CASTELLI, J.C., MASSEL, B.A., MARAN, A., PARANJAPE, J., HEWITT, J.A., LI, X.L., HSU, Y.T., SILVERMAN, R.H., and YOULE, R.J. (1998). The role of 2′-5′ oligoadenylate-activated ribonuclease 1 in apoptosis. Cell Death Differ 5, 313-320.
57. ZHOU, A., PARANJAPE, J., NAIK, S., DONG, B., CHANG, A., TRAPP, B., FAIRCHILD, R., COLMENARES, C., and SILVERMAN, R.H. (1997). Interferon action and apoptosis are defective in mice devoid of 2′,5′-oIigoadenylate-dependent RNase L. EMBO J. 16, 6355-6363.
58. MEURS, E.F., WATANABE, Y., KADEREIT, S., BARBER, G.N., KATZE, M.G., CHONG, K., WILLIAMS, B.R., and HOVANESSIAN, A.G. (1992). Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth. J. Virol. 66, 5804-5814.
59. HOVANESSIAN, A.G., WOOD, J., MEURS, E., and MONTAGNIER, L. (1979). Increased nuclease activity in cells treated with pppA2′p5′A2′p5′ A. Proc. Natl. Acad. Sci. USA 76, 3261-3265.
60. SCHMIDT, A., CHERNAJOVSKY, Y., SHULMAN, L., FEDERMAN, P., BERISSI, H., and REVEL, M. (1979). An interferon-induced phosphodiesterase degrading (2′-5′) oligoisoadenylate and the C-C-A terminus of tRNA. Proc. Natl. Acad. Sci. USA 76, 4788-4792.
61. BISBAL, C., MARTTNAND, C., SILHOL. M., LEBLEU, B., and SALEHZADA, T. (1995). Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway. J. Biol. Chem. 270, 13308-13317.
62. SCHRODER, H.C., WENGER, R., KUCHINO, Y., and MULLER, W.E. (1989). Modulation of nuclear matrix-associated 2′,5′-oligoadenylate metabolism and ribonuclease L activity in H9 cells by human immunodeficiency virus. J. Biol. Chem. 264, 5669-5673.
63. BALL, L.A., and WHITE, C.N. (1979). Nuclease activation by double-stranded RNA and by 2′,5′-oligoadenylate in extracts of interferon-treated chick cells. Virology 93, 348-356.
64. JUSTESEN, J., FERBUS, D., and THANG, M.N. (1980). Elongation mechanism and substrate specificity of 2′,5′-ofigoadenylate synthetase. Proc. Natl. Acad. Sci. USA 77, 4618-4622.
65. +, ADP-ribose and adenosine(5′)tetraphospho(5′) adenosine. Eur. J. Biochem. 122, 601-608.
66. JUSTESEN, J., WORM-LEONHARD, H., FERBUS, D., and PETERSEN, H.U. (1985). The interferon-induced enzyme 2-5A synthetase adenylates tRNA. Biochimie 67, 651-655.
67. MARIE, I., BLANCO, J., REBOUILLAT, D., and HOVANESSIAN, A.G. (1997). 69-kDa and 100-kDa isoforms of interferon-induced (2′-5′)oligoadenylate synthetase exhibit differential catalytic parameters. Eur. J. Biochem. 248, 558-566.
68. TURPAEV, K., HARTMANN, R., KISSELEV, L., and JUSTESEN, J. (1997). Ap(3)A and Ap(4)A are primers for oligoadenylate synthesis catalyzed by interferon-inducible 2-5A synthetase. FEBS Lett. 408, 177-181.
69. KUUSKSALU, A., SUBBI, J., PEHK, T., REINTAMM, T., MULLER, W., and KELVE, M. (1998). Identification of the reaction products of (2′-5′)oligoadenylate synthetase in the marine sponge. Eur. J. Biochem. 257, 420-426.
70. HOVANESSIAN, A.G., SVAB, J., MARIE, I., ROBERT, N., CHAMARET, S., and LAURENT, A.G. (1988). Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferontreated human cells. J. Biol. Chem. 263, 4945-4949.
71. YANG, K., SAMANTA, H., DOUGHERTY, J., JAYARAM. B., BROEZE, R., and LENGYEL, P. (1981). Interferons, doublestranded RNA, and RNA degradation. Isolation and characterization of homogeneous human (2′-5′)(A)n synthetase. J. Biol. Chem. 256, 9324-9328.
72. BENECH, P., MORY, Y., REVEL, M., and CHEBATH, J. (1985). Structure of two forms of the interferon-induced (2′-5′) oligo A synthetase of human cells based on cDNAs and gene sequences. EMBO J. 4, 2249-2256.
73. SAUNDERS, M.E., GEWERT, D.R., TUGWELL, M.E., McMAHON, M., and WILLIAMS, B.R. (1985). Human 2-5A synthetase: characterization of a novel cDNA and corresponding gene structure. EMBO J. 4, 1761-1768.
74. WATHELET, M., MOUTSCHEN, S., CRAVADOR, A., De WIT, L., DEFILIPPI, P., HUEZ, G., and CONTENT, J. (1986). Fulllength sequence and expression of the 42 kDa 2-5A synthetase induced by human interferon. FEBS Lett. 196, 113-120.
75. HOVNANIAN, A., REBOUILLAT, D., MATTEI, M.G., LEVY, E.R., MARIÉ, I., MONACO, A.P., and HOVANESSIAN, A.G. (1998). The human 2′-5′-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100, 69 and 40 kDa forms. Genomics 52, 267-277.
76. TRUVE, E., KELVE, M., AASPOLLU, A., SCHRODER, H.C., and MULLER, W.E. (1994). Homologies between different forms of 2-5A synthetases. Prog. Mol. Subcell. Biol. 14, 139-149.
77. HARTMANN, R. (1997). Molecular and Structural Biology. Thesis. Aarhus University. Accession No. AJ225090
78. YAMAMOTO, A., IWATA, A., KOH, Y., KAWAI, S., MURAYAMA, S., HAMADA, K., MAEKAWA, S., UEDA, S., and SOKAWA, Y. (1998). Two types of chicken 2′,5′-oligoadenylate synthetase mRNA derived from alleles at a single locus. Biochim. Biophys. Acta 1395, 181-191.
79. ICHII, Y., FUKUNAGA, R., SHIOJIRI, S., and SOKAWA, Y. (1986). Mouse 2-5A synthetase cDNA: nucleotide sequence and comparison to human 2-5A synthetase. Nucleic Acids Res. 14, 10117.
80. GHOSH, S.K. KUSARI, J., BANDYOPADHYAY, S.K., SAMANTA, H., KUMAR, R., and SEN, G.C. (1991). Cloning, sequencing, and expression of two murine 2′-5′-oligoadenylate synthetases. Structure-function relationships. J. Biol. Chem. 266, 15293-15299.
81. MARIE, I., GALABRU, J., SVAB, J., and HOVANESSIAN, A.G. (1989). Preparation and characterization of polyclonal antibodies specific for the 69 and 100 k-dalton forms of human 2-5 A synthetase. Biochem. Biophys. Res. Commun. 160, 580-587.
82. DOUGHERTY, J.P., SAMANTA, H., FARRELL, P.J., and LENGYEL, P. (1980). Interferon, double-stranded RNA, and RNA degradation. Isolation of homogeneous pppA(2′p5′A)n-l synthetase from Ehrlich ascites tumor cells. J. Biol. Chem. 255, 3813-3816.
83. SAMANTA, H., DOUGHERTY, J.P., and LENGYEL, P. (1980). Synthesis of (2′-5′)(A)n from ATP. Characteristics of the reaction catalyzed by (2′-5′)(A)n synthetase purified from mouse Ehrlich ascites tumor cells treated with interferon. J. Biol. Chem. 255, 9807-9813.
84. ST. LAURENT, G., YOSHIE, O., FLOYD-SMITH, G., SAMANTA, H., SEHGAL, P.B., and LENGYEL, P. (1983). Interferon action: two (2′-5′)(A)n synthetases specified by distinct mRNAs in Ehrlich ascites tumor cells treated with interferon. Cell 33, 95-102.
85. MORY, Y., VAKS, B., and CHEBATH, J. (1989). Production of two human 2′,5′-oligoadenylate synthetase enzymes in Escherichia coli. J. Interferon Res. 9, 295-304.
86. MARIE, I., SVAB, J., ROBERT, N., GALABRU, J., and HOV- ANESSIAN, A.G. (1990). Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon. J. Biol. Chem. 265, 18601-18607.
87. KHANNA, K.K., AN, S.J., WU, J.M., LANDOLFO, S., and HOVANESSIAN, A.G. (1991). Absence of the 40-kDa form of (2′-5′)oligoadenylate synthetase and its corresponding mRNA from skin fibroblasts derived from Alzheimer disease patients. Proc. Natl. Acad. Sci. USA 88, 5852-5856.
88. DUBOIS, M.F., and HOVANESSIAN, A.G. (1990). Modified subcellular localization of interferon-induced p68 kinase during encephalomyocarditis virus infection. Virology 179, 591-598.
89. BESSE, S., REBOUILLAT, D., MARIE, I., PUVION-DUTILLEUL, F., and HOVANESSIAN, A.G. (1998). Ultrastructural localization of interferon-inducible double-stranded RNA-activated enzymes in human cells. Exp. Cell Res. 239, 379-392.
90. KON, N., and SUHADOLNIK, R.J. (1996). Identification of the ATP binding domain of recombinant human 40-kDa 2′,5′oligoadenylate synthetase by photoaffinity labeling with 8-azido[alpha-32P]ATP. J. Biol. Chem. 271, 19983-19990.
91. BANDYOPADHYAY, S., GHOSH, A., SARKAR, S.N., and SEN, G.C. (1998). Production and purification of recombinant 2′5′ oligoadenylate synthetase and its mutants using the baculovirus system. Biochemistry 37, 3824-3830.
92. SARKAR, S.N., and SEN, G.C. (1998). Production, purification, and characterization of recombinant 2′p,5′-oligoadenylate synthetases. Methods 15, 233-242.
93. GHOSH, A., SARKAR, S.N., GUO, W.D., BANDYOPADHYAY, S., and SEN, G.C. (1997). Enzymatic activity of 2′,5′oligoadenylate synthetase is impaired by specific mutations that affect oligomerization of the protein. J. Biol. Chem. 272, 33220-33226.
94. GHOSH, A., SARKAR. S.N., BANDYOPADHYAY, S., and SEN, G.C. (1997). Oligomerization of the 2-5(A) synthetase proteins is essential for their enzyme activity. J. Interferon Cytokine Res. 17(Suppl. 2), s51.
95. MIELE, M.B., LIU, D.K., and KAN, N.C. (1991). Fractionation and characterization of 2′,5′-oligoadenylates by polyacrylamide gel electrophoresis: an alternative method for assaying 2′,5′oligoadenylate synthetase. J. Interferon Res. 11, 33-40.
96. LATHAM, K.E., COSENZA, S., REICHENBACH, N.L., MORDECHAI, E., ADELSON, M.E., KON, N., HORVATH, S.E., CHARUBALA, R., MIKHAILOV, S.N., PFEIDERER, W., and SUHADOLNIK, R.J. (1996). Inhibition of growth of estrogen receptor positive and estrogen receptor negative breast cancer cells in culture by AA-etherA, a stable 2-5A derivative. Oncogene 12, 827-837.
97. CASTORA, F.J., ERICKSON, C.E., KOVACS, T., LESIAK, K., and TORRENCE, P.F. (1991). 2′,5′-Oligoadenylates inhibit relaxation of supercoiled DNA by calf thymus DNA topoisomerase I. J. Interferon Res. 11, 143-149.
98. PAWLOTSKY, J.M., HOVANESSIAN, A.G., ROUDOT-THORAVAL, F., ROBERT, N., BOUVIER, M., BABANY, G., DUVAL, J., and DHUMEAUX, D. (1996). Effect of alpha interferon (IFN-alpha) on 2′-5′ oligoadenylate synthetase activity in peripheral blood mononuclear cells of patients with chronic hepatitis C: relationship to the antiviral effect of IFN-alpha. Antimicrob. Agents Chemother. 40, 320-324.
99. SPERLING, J., CHEBATH, J., ARAD-DANN, H., OFFEN, D., SPANN, P., LEHRER, R., GOLDBLATT, D., JOLLES. B., and SPERLING, R. (1991). Possible involvement of (2′5′)oligoadenylate synthetase activity in pre-mRNA splicing. Proc. Natl. Acad. Sci. USA 88, 10377-10381.
100. HOVNANIAN, A., REBOUILLAT, D., LEVY, E.R., MATTEI, M.G., and HOVANESSIAN, A.G. (1999). The human 2′,5′oligoadenylate synthetase-like gene (OASL) encoding the inter- feron-induced 56 kDa protein, maps to chromosome 12q24.2 at the proximity of the 2′,5′-OAS locus. Genomics. In press.
101. RUTHERFORD, M.N., KUMAR, A., NISSIM, A., CHEBATH, J., and WILLIAMS, B.R. (1991). The murine 2-5A synthetase locus: three distinct transcripts from two linked genes. Nucleic Acids Res. 19, 1917-1924.
102. WILLIAMS, B.R.G., SAUNDERS, M.E., and WILLIARD, H.F. (1986). Interferon-regulated human 2′5′ A synthetase gene maps to chromosome 12. Somat. Cell. Mol. Genet. 12, 403-408.
103. SHULMAN, L.M., BARKER, P.E., HART, J.T., MESSER PETERS, P.G., and RUDDLE, R.H. (1984). Assignment of low molecular weight human (2′5′A) synthetase to chromosome 11. Somat. Cell. Mol. Genet. 10, 247-257.
104. BENECH, P., VIGNERON, M., PERETZ, D., REVEL, M., and CHEBATH, J. (1987). Interferon-responsive regulatory elements in the promoter of the human 2′,5′-oligo(A) synthetase gene. Mol. Cell. Biol. 7, 4498-4504.
105. WANG, Q., and FLOYD-SMITH, G. (1997). The p69/71 2-5A synthetase promoter contains multiple regulatory elements required for interferon-alpha-induced expression. DNA Cell Biol. 16, 1385-1394.
106. REBOUILLAT, D., DAVID, G., and HOVANESSIAN, A.G. (1999). Characterization of the promoter region of the gene encoding the 100 kDa 2′,5′-Oligoadenylate synthetase. In preparation.
107. REBOUILLAT, D., MARIÉ. I., and HOVANESSIAN, A.G. (1998). Molecular cloning and characterization of two related and interferon-induced 56 and 30 kDa proteins highly homologous to the 2′-5′ oligoadenylate synthetase. Eur. J. Biochem. 257, 319-330.
108. HARTMANN, R., STEE OLSEN, H., WIDDER, S., JORGENSEN, R., and JUSTESEN, J. (1998). p59OASL. a 2(prime)5(prime) oligoadenylate synthetase like protein: a novel human gene related to the 2(prime)-5(prime) oligoadenylate synthetase family. Nucleic Acids Res. 26, 4121-4127.