Cutting edge: CGAS is required for lethal autoimmune disease in the Trex1-deficient mouse model of Aicardi-Goutières syndrome

Journal of Immunology

Volumn 195, Issue 5, 2015, Pages 1939-1943

  Gray, Elizabeth E ^a   Treuting, Piper M ^a   Woodward, Joshua J ^a   Stetson, Daniel B ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CYCLIC GMP AMP SYNTHASE; INTERFERON; SYNTHETASE; UNCLASSIFIED DRUG; BETA INTERFERON; CYCLIC GUANOSINE MONOPHOSPHATE-ADENOSINE MONOPHOSPHATE; CYCLIC NUCLEOTIDE; EXODEOXYRIBONUCLEASE; MB21D1 PROTEIN, MOUSE; NUCLEOTIDYLTRANSFERASE; PHOSPHOPROTEIN; THREE PRIME REPAIR EXONUCLEASE 1;

AICARDI GOUTIERES SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNITY; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; INTERFERON PRODUCTION; LETHALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; ANIMAL EMBRYO; BLOOD; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; FIBROBLAST; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOBLOTTING; IMMUNOLOGY; INFLAMMATION; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; NERVOUS SYSTEM MALFORMATION; NEUROLOGIC DISEASE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; AUTOANTIBODIES; AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; EXODEOXYRIBONUCLEASES; FIBROBLASTS; GENE EXPRESSION; HUMANS; IMMUNOBLOTTING; INFLAMMATION; INTERFERON-BETA; INTERFERONS; MACROPHAGES; MICE, INBRED C57BL; MICE, KNOCKOUT; NERVOUS SYSTEM MALFORMATIONS; NUCLEOTIDES, CYCLIC; NUCLEOTIDYLTRANSFERASES; PHOSPHOPROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84940121945     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1500969     Document Type: Article

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