5′-Triphosphate RNA is the ligand for RIG-I

Science

Volumn 314, Issue 5801, 2006, Pages 994-997

  Hornung, Veit ^a   Ellegast, Jana ^a   Kim, Sarah ^a   Brzózka, Krzysztof ^a   Jung, Andreas ^b   Kato, Hiroki ^b   Poeck, Hendrik ^a   Akira, Shizuo ^b   Conzelmann, Karl Klaus ^a   Schlee, Martin ^c   Endres, Stefan ^a   Hartmann, Gunther ^c  

^a UNIVERSITY OF MUNICH   (Germany)

^b OSAKA UNIVERSITY   (Japan)

^c UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CYTOLOGY; MOLECULAR BIOLOGY; PROTEINS; VIRUSES;

CYTOPLASM; EUKARYOTES; INTERFERON; MOLECULAR SIGNATURE;

RNA;

5' TRIPHOSPHATE RNA; ALPHA INTERFERON; LIGAND; PROTEIN; PROTEIN RIG I; RNA; UNCLASSIFIED DRUG; VIRUS RNA; BACTERIOPHAGE T7 RNA POLYMERASE; BETA INTERFERON; CAPPED RNA; DDX58 PROTEIN, HUMAN; DEAD BOX PROTEIN; DNA DIRECTED RNA POLYMERASE; DOUBLE STRANDED RNA; OLIGORIBONUCLEOTIDE; PHOSPHATE; VIRUS PROTEIN;

CYTOPLASM; LIGAND; PHOSPHATE (ORGANIC); RNA; VIRUS;

ARTICLE; CONTROLLED STUDY; CYTOPLASM; EUKARYOTE; HUMAN; HUMAN CELL; NONHUMAN; PICORNAVIRUS; PRIORITY JOURNAL; PROTEIN RNA BINDING; RNA ANALYSIS; RNA PROCESSING; RNA STRUCTURE; RNA VIRUS; VIRUS DETECTION; VIRUS INFECTION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL LINE; CHEMISTRY; CYTOSOL; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; METABOLISM; MONOCYTE; MOUSE; PHOSPHORYLATION; PHYSIOLOGY; RABIES VIRUS; VIROLOGY; VIRUS REPLICATION;

EUKARYOTA; RNA VIRUSES;

ANIMALS; CELL LINE; CELLS, CULTURED; CYTOSOL; DEAD-BOX RNA HELICASES; DNA-DIRECTED RNA POLYMERASES; HUMANS; INTERFERON-ALPHA; INTERFERON-BETA; LIGANDS; MICE; MONOCYTES; OLIGORIBONUCLEOTIDES; PHOSPHATES; PHOSPHORYLATION; RABIES VIRUS; RNA; RNA CAPS; RNA, DOUBLE-STRANDED; RNA, VIRAL; TRANSCRIPTION, GENETIC; TRANSFECTION; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 33750976374     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1132505     Document Type: Article

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20. This study was supported by grants from the Bundesministerium für Bildung und Forschung (Biofuture 0311896) and the Deutsche Forschungsgemeinschaft (HA 2780/4-1 and Sonderforschungsbereich 571) to G.H., a grant from the Sonderforschungsbereich 455 to K.C., two grants from the Förderprogramm für Forschung und Lehre (489 to V.H. and 2004/33 to S.K.), and by the Graduiertenkolleg 1202 of the Deutsche Forschungsgemeinschaft. This work is part of the thesis of J.E. and S.K. at the University of Munich. We thank 5. Rothenfusser for critically reading the manuscript.