Species-Specific Recognition of Single-Stranded RNA via Till-like Receptor 7 and 8

Science

Volumn 303, Issue 5663, 2004, Pages 1526-1529

  Heil, Florian ^a   Hemmi, Hiroaki ^b   Hochrein, Hubertus ^a   Ampenberger, Franziska ^a   Kirschning, Carsten ^a   Akira, Shizuo ^b,c   Lipford, Grayson ^d   Wagner, Hermann ^a   Bauer, Stefan ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b OSAKA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; PROTEINS; VIRUSES;

IMMUNE RECEPTORS; VIRAL INFECTIONS;

RNA;

CYTOKINE; DOUBLE STRANDED RNA; GUANOSINE; LIGAND; OLIGONUCLEOTIDE; RNA; SINGLE STRANDED RNA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; UNCLASSIFIED DRUG; URIDINE;

IMMUNE RESPONSE; RNA;

ANIMAL CELL; ARTICLE; CYTOKINE RELEASE; DENDRITIC CELL; GENETIC COMPLEMENTATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNITY; IMMUNOCOMPETENT CELL; IMMUNOSTIMULATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS INFECTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, DIFFERENTIATION; BASE SEQUENCE; CYTOKINES; DENDRITIC CELLS; FATTY ACIDS, MONOUNSATURATED; GENETIC COMPLEMENTATION TEST; GUANOSINE; HIV-1; HUMANS; INTERFERON-ALPHA; LEUKOCYTES, MONONUCLEAR; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MYELOID DIFFERENTIATION FACTOR 88; OLIGORIBONUCLEOTIDES; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; RNA, VIRAL; SPECIES SPECIFICITY; THIONUCLEOTIDES; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8; TOLL-LIKE RECEPTORS; TRANSFECTION; URIDINE;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MURINAE;

EID: 1542317578     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1093620     Document Type: Article

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26. We would like to thank P. Yu and G. Köllisch for critically reading the manuscript and C. Wagner for excellent technical assistance. Supported by BMBF grant 0311675/Coley Pharmaceuticals GmbH, SFB 456 and 576, Deutsche Forschungsgemeinschaft grant BA 1618/2-2, and Klinische Forschergruppe "Molekulare und klinische Allergotoxikologie," TU Munich.