Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity

Molecular Cell

Volumn 53, Issue 2, 2014, Pages 221-234

  Huang, Hao ^a,b   Zeqiraj, Elton ^a,b   Dong, Beihua ^c   Jha, Babal Kant ^c   Duffy, Nicole M ^a   Orlicky, Stephen ^a   Thevakumaran, Neroshan ^a,b   Talukdar, Manisha ^a,b   Pillon, Monica C ^d   Ceccarelli, Derek F ^a   Wan, Leo C K ^a,b   Juang, Yu Chi ^a   Mao, Daniel Y L ^a,e   Gaughan, Christina ^c   Brinton, Margo A ^f   Perelygin, Andrey A ^f   Kourinov, Igor ^g   Guarné, Alba ^d   Silverman, Robert H ^c   Sicheri, Frank ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c LERNER RESEARCH INSTITUTE   (United States)

^d MCMASTER UNIVERSITY   (Canada)

^e RYERSON UNIVERSITY   (Canada)

^f GEORGIA STATE UNIVERSITY   (United States)

^g ARGONNE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ANKYRIN; DIMER; INTERFERON; RIBONUCLEASE L;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR RECOGNITION; MUTAGENESIS; NUCLEOTIDE BINDING SITE; PROTEIN DOMAIN; PROTEIN INTERACTION; SMALL ANGLE SCATTERING; VIRUS INFECTION; X RAY CRYSTALLOGRAPHY;

ADENINE NUCLEOTIDES; ADENOSINE DIPHOSPHATE; ADENYLYL IMIDODIPHOSPHATE; ANIMALS; ANKYRIN REPEAT; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ENCEPHALOMYOCARDITIS VIRUS; ENDORIBONUCLEASES; HELA CELLS; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OLIGORIBONUCLEOTIDES; PICORNAVIRIDAE; PROTEIN STRUCTURE, TERTIARY; SCATTERING, RADIATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUS SCROFA;

EID: 84892890442     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2013.12.025     Document Type: Article

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