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Volumn 269, Issue 1, 2016, Pages 60-75

Nucleic acid-sensing TLRs and autoimmunity: Novel insights from structural and cell biology

Author keywords

Autoimmunity; Nucleic acid sensing; TLR; UNC93B1

Indexed keywords

DEOXYRIBONUCLEASE; DEOXYRIBONUCLEASE I; DEOXYRIBONUCLEASE II; DEOXYRIBONUCLEASE III; DNA; INTERFERON; NUCLEASE; NUCLEIC ACID; RIBONUCLEASE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

EID: 84950109725     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12375     Document Type: Article
Times cited : (94)

References (176)
  • 1
    • 0024955886 scopus 로고
    • Approaching the asymptote? Evolution and revolution in immunology
    • Janeway CA. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 1989;54(Pt 1):1-13.
    • (1989) Cold Spring Harb Symp Quant Biol , vol.54 , pp. 1-13
    • Janeway, C.A.1
  • 2
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol 1994;12:991-1045.
    • (1994) Annu Rev Immunol , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 3
    • 58049202272 scopus 로고    scopus 로고
    • Innate immunity to virus infection
    • Takeuchi O, Akira S. Innate immunity to virus infection. Immunol Rev 2009;227:75-86.
    • (2009) Immunol Rev , vol.227 , pp. 75-86
    • Takeuchi, O.1    Akira, S.2
  • 4
    • 35748964708 scopus 로고    scopus 로고
    • Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity
    • Krieg AM, Vollmer J. Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity. Immunol Rev 2007;220:251-269.
    • (2007) Immunol Rev , vol.220 , pp. 251-269
    • Krieg, A.M.1    Vollmer, J.2
  • 6
    • 84896958063 scopus 로고    scopus 로고
    • Innate immune sensing and signaling of cytosolic nucleic acids
    • Wu J, Chen ZJ. Innate immune sensing and signaling of cytosolic nucleic acids. Annu Rev Immunol 2014;32:461-488.
    • (2014) Annu Rev Immunol , vol.32 , pp. 461-488
    • Wu, J.1    Chen, Z.J.2
  • 8
    • 5444262511 scopus 로고    scopus 로고
    • Toll-like receptor control of the adaptive immune responses
    • Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004;5:987-995.
    • (2004) Nat Immunol , vol.5 , pp. 987-995
    • Iwasaki, A.1    Medzhitov, R.2
  • 9
    • 20644433342 scopus 로고    scopus 로고
    • TLR11 activation of dendritic cells by a protozoan profilin-like protein
    • Yarovinsky F, et al. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science 2005;308:1626-1629.
    • (2005) Science , vol.308 , pp. 1626-1629
    • Yarovinsky, F.1
  • 10
    • 84872761427 scopus 로고    scopus 로고
    • Recognition of profilin by toll-like receptor 12 is critical for host resistance to Toxoplasma gondii
    • Koblansky AA, et al. Recognition of profilin by toll-like receptor 12 is critical for host resistance to Toxoplasma gondii. Immunity 2013;38:119-130.
    • (2013) Immunity , vol.38 , pp. 119-130
    • Koblansky, A.A.1
  • 11
    • 84886041693 scopus 로고    scopus 로고
    • Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin
    • Raetz M, et al. Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin. J Immunol 2013;191:4818-4827.
    • (2013) J Immunol , vol.191 , pp. 4818-4827
    • Raetz, M.1
  • 12
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001;413:732-738.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 13
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold SS. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004;303:1529-1531.
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1
  • 14
    • 1542317578 scopus 로고    scopus 로고
    • Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8
    • Heil F, et al. Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 2004;303:1526-1529.
    • (2004) Science , vol.303 , pp. 1526-1529
    • Heil, F.1
  • 15
    • 84865571191 scopus 로고    scopus 로고
    • TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification
    • Oldenburg M, et al. TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification. Science 2012;337:1111-1115.
    • (2012) Science , vol.337 , pp. 1111-1115
    • Oldenburg, M.1
  • 16
    • 84866159316 scopus 로고    scopus 로고
    • Cutting edge: TLR13 is a receptor for bacterial RNA
    • Hidmark A, von Saint Paul A, Dalpke AH. Cutting edge: TLR13 is a receptor for bacterial RNA. J Immunol 2012;189:2717-2721.
    • (2012) J Immunol , vol.189 , pp. 2717-2721
    • Hidmark, A.1    von Saint Paul, A.2    Dalpke, A.H.3
  • 17
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • Hemmi H, et al. A Toll-like receptor recognizes bacterial DNA. Nature 2000;408:740-745.
    • (2000) Nature , vol.408 , pp. 740-745
    • Hemmi, H.1
  • 18
    • 0035979192 scopus 로고    scopus 로고
    • Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
    • Bauer S, et al. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci USA 2001;98:9237-9242.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9237-9242
    • Bauer, S.1
  • 19
    • 0036008014 scopus 로고    scopus 로고
    • Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    • Hemmi H, et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 2002;3:196-200.
    • (2002) Nat Immunol , vol.3 , pp. 196-200
    • Hemmi, H.1
  • 20
    • 0036088492 scopus 로고    scopus 로고
    • Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
    • Jurk M, et al. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat Immunol 2002;3:499.
    • (2002) Nat Immunol , vol.3 , pp. 499
    • Jurk, M.1
  • 21
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
    • Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 2010;11:373-384.
    • (2010) Nat Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 22
    • 0022540321 scopus 로고
    • CpG-rich islands and the function of DNA methylation
    • Bird AP. CpG-rich islands and the function of DNA methylation. Nature 1986;321:209-213.
    • (1986) Nature , vol.321 , pp. 209-213
    • Bird, A.P.1
  • 23
    • 0025299347 scopus 로고    scopus 로고
    • The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model
    • Sved J, Bird A. The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model. Proc Natl Acad Sci USA 2015;87:4692-4696.
    • (2015) Proc Natl Acad Sci USA , vol.87 , pp. 4692-4696
    • Sved, J.1    Bird, A.2
  • 24
    • 0023936754 scopus 로고
    • Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity
    • Cornacchia E, Golbus J, Maybaum J, Strahler J, Hanash S, Richardson B. Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. J Immunol 1988;140:2197-2200.
    • (1988) J Immunol , vol.140 , pp. 2197-2200
    • Cornacchia, E.1    Golbus, J.2    Maybaum, J.3    Strahler, J.4    Hanash, S.5    Richardson, B.6
  • 25
    • 0030585155 scopus 로고    scopus 로고
    • When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA
    • Jacobs BL, Langland JO. When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA. Virology 1996;219:339-349.
    • (1996) Virology , vol.219 , pp. 339-349
    • Jacobs, B.L.1    Langland, J.O.2
  • 26
    • 26844467349 scopus 로고    scopus 로고
    • Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    • Barrat FJ. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med 2005;202:1131-1139.
    • (2005) J Exp Med , vol.202 , pp. 1131-1139
    • Barrat, F.J.1
  • 27
    • 29244450802 scopus 로고    scopus 로고
    • Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
    • Barton GM, Kagan JC, Medzhitov R. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol 2006;7:49-56.
    • (2006) Nat Immunol , vol.7 , pp. 49-56
    • Barton, G.M.1    Kagan, J.C.2    Medzhitov, R.3
  • 28
    • 84864713870 scopus 로고    scopus 로고
    • Ultraviolet radiation damages self noncoding RNA and is detected by TLR3
    • Bernard JJ, et al. Ultraviolet radiation damages self noncoding RNA and is detected by TLR3. Nat Med 2012;18:1286-1290.
    • (2012) Nat Med , vol.18 , pp. 1286-1290
    • Bernard, J.J.1
  • 29
    • 42349090335 scopus 로고    scopus 로고
    • Structural basis of toll-like receptor 3 signaling with double-stranded RNA
    • Liu L, et al. Structural basis of toll-like receptor 3 signaling with double-stranded RNA. Science 2008;320:379-381.
    • (2008) Science , vol.320 , pp. 379-381
    • Liu, L.1
  • 30
    • 84875425019 scopus 로고    scopus 로고
    • Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
    • Tanji H, Ohto U, Shibata T, Miyake K, Shimizu T. Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands. Science 2013;339:1426-1429.
    • (2013) Science , vol.339 , pp. 1426-1429
    • Tanji, H.1    Ohto, U.2    Shibata, T.3    Miyake, K.4    Shimizu, T.5
  • 31
    • 84926395729 scopus 로고    scopus 로고
    • Toll-like receptor 8 senses degradation products of single-stranded RNA
    • Tanji H, et al. Toll-like receptor 8 senses degradation products of single-stranded RNA. Nat Struct Mol Biol 2015;22:109-115.
    • (2015) Nat Struct Mol Biol , vol.22 , pp. 109-115
    • Tanji, H.1
  • 32
    • 84928791608 scopus 로고    scopus 로고
    • Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
    • Ohto U, et al. Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9. Nature 2015;520:702-705.
    • (2015) Nature , vol.520 , pp. 702-705
    • Ohto, U.1
  • 34
    • 12344290452 scopus 로고    scopus 로고
    • Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA
    • Yoshida H, Okabe Y, Kawane K, Fukuyama H, Nagata S. Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA. Nat Immunol 2005;6:49-56.
    • (2005) Nat Immunol , vol.6 , pp. 49-56
    • Yoshida, H.1    Okabe, Y.2    Kawane, K.3    Fukuyama, H.4    Nagata, S.5
  • 35
    • 33750465224 scopus 로고    scopus 로고
    • Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages
    • Kawane K, et al. Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature 2006;443:998-1002.
    • (2006) Nature , vol.443 , pp. 998-1002
    • Kawane, K.1
  • 36
    • 49549100511 scopus 로고    scopus 로고
    • Trex1 prevents cell-intrinsic initiation of autoimmunity
    • Stetson DB, Ko JS, Heidmann T, Medzhitov R. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 2008;134:587-598.
    • (2008) Cell , vol.134 , pp. 587-598
    • Stetson, D.B.1    Ko, J.S.2    Heidmann, T.3    Medzhitov, R.4
  • 37
    • 84907996785 scopus 로고    scopus 로고
    • Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy
    • Lan YY, Londoño D, Bouley R, Rooney MS, Hacohen N. Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy. Cell Rep 2014;9:180-192.
    • (2014) Cell Rep , vol.9 , pp. 180-192
    • Lan, Y.Y.1    Londoño, D.2    Bouley, R.3    Rooney, M.S.4    Hacohen, N.5
  • 38
    • 0034939627 scopus 로고    scopus 로고
    • Mutation of DNASE1 in people with systemic lupus erythematosus
    • Yasutomo K, et al. Mutation of DNASE1 in people with systemic lupus erythematosus. Nat Genet 2001;28:313-314.
    • (2001) Nat Genet , vol.28 , pp. 313-314
    • Yasutomo, K.1
  • 39
    • 35349019691 scopus 로고    scopus 로고
    • Clinical and molecular phenotype of Aicardi-Goutieres syndrome
    • Rice G, et al. Clinical and molecular phenotype of Aicardi-Goutieres syndrome. Am J Hum Genet 2007;81:713-725.
    • (2007) Am J Hum Genet , vol.81 , pp. 713-725
    • Rice, G.1
  • 40
    • 34948862264 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
    • Lande R, et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 2007;449:564-569.
    • (2007) Nature , vol.449 , pp. 564-569
    • Lande, R.1
  • 41
    • 81955161805 scopus 로고    scopus 로고
    • Transmembrane mutations in Toll-like receptor 9 bypass the requirement for ectodomain proteolysis and induce fatal inflammation
    • Mouchess ML, et al. Transmembrane mutations in Toll-like receptor 9 bypass the requirement for ectodomain proteolysis and induce fatal inflammation. Immunity 2011;35:721-732.
    • (2011) Immunity , vol.35 , pp. 721-732
    • Mouchess, M.L.1
  • 42
    • 57349191215 scopus 로고    scopus 로고
    • The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor
    • Ewald SE, et al. The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature 2008;456:658-662.
    • (2008) Nature , vol.456 , pp. 658-662
    • Ewald, S.E.1
  • 43
    • 0032525023 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species
    • Yi AK, Tuetken R, Redford T, Waldschmidt M, Kirsch J, Krieg AM. CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species. J Immunol 1998;160:4755-4761.
    • (1998) J Immunol , vol.160 , pp. 4755-4761
    • Yi, A.K.1    Tuetken, R.2    Redford, T.3    Waldschmidt, M.4    Kirsch, J.5    Krieg, A.M.6
  • 44
    • 0032476602 scopus 로고    scopus 로고
    • CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
    • Häcker H, et al. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J 1998;17:6230-6240.
    • (1998) EMBO J , vol.17 , pp. 6230-6240
    • Häcker, H.1
  • 45
    • 0038651180 scopus 로고    scopus 로고
    • Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7
    • Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci USA 2003;100:6646-6651.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6646-6651
    • Lee, J.1
  • 46
    • 0242391997 scopus 로고    scopus 로고
    • The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily
    • Heil F, et al. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol 2003;33:2987-2997.
    • (2003) Eur J Immunol , vol.33 , pp. 2987-2997
    • Heil, F.1
  • 47
    • 31344476404 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH
    • de Bouteiller O, et al. Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH. J Biol Chem 2005;280:38133-38145.
    • (2005) J Biol Chem , vol.280 , pp. 38133-38145
    • de Bouteiller, O.1
  • 48
    • 79955046267 scopus 로고    scopus 로고
    • Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines
    • Kuznik A, Bencina M, Svajger U, Jeras M, Rozman B, Jerala R. Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines. J Immunol 2011;186:4794-4804.
    • (2011) J Immunol , vol.186 , pp. 4794-4804
    • Kuznik, A.1    Bencina, M.2    Svajger, U.3    Jeras, M.4    Rozman, B.5    Jerala, R.6
  • 49
    • 38349115933 scopus 로고    scopus 로고
    • The TLR3 signaling complex forms by cooperative receptor dimerization
    • Leonard JN, et al. The TLR3 signaling complex forms by cooperative receptor dimerization. Proc Natl Acad Sci USA 2008;105:258-263.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 258-263
    • Leonard, J.N.1
  • 50
    • 4644330955 scopus 로고    scopus 로고
    • Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner
    • Rutz M, et al. Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. Eur J Immunol 2004;34:2541-2550.
    • (2004) Eur J Immunol , vol.34 , pp. 2541-2550
    • Rutz, M.1
  • 51
    • 0032696406 scopus 로고    scopus 로고
    • Lack of immune stimulation by immobilized CpG-oligodeoxynucleotide
    • Manzel L, Macfarlane DE. Lack of immune stimulation by immobilized CpG-oligodeoxynucleotide. Antisense Nucleic Acid Drug Dev 1999;9:459-464.
    • (1999) Antisense Nucleic Acid Drug Dev , vol.9 , pp. 459-464
    • Manzel, L.1    Macfarlane, D.E.2
  • 52
    • 0036318851 scopus 로고    scopus 로고
    • Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments
    • Ahmad-Nejad P, Häcker H, Rutz M, Bauer S, Vabulas RM, Wagner H. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur J Immunol 2002;32:1958-1968.
    • (2002) Eur J Immunol , vol.32 , pp. 1958-1968
    • Ahmad-Nejad, P.1    Häcker, H.2    Rutz, M.3    Bauer, S.4    Vabulas, R.M.5    Wagner, H.6
  • 53
    • 10744219675 scopus 로고    scopus 로고
    • TLR9 signals after translocating from the ER to CpG DNA in the lysosome
    • Latz E, et al. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol 2004;5:190-198.
    • (2004) Nat Immunol , vol.5 , pp. 190-198
    • Latz, E.1
  • 54
    • 32244432768 scopus 로고    scopus 로고
    • Double-stranded RNA-mediated TLR3 activation is enhanced by CD14
    • Lee H-K, Dunzendorfer S, Soldau K, Tobias PS. Double-stranded RNA-mediated TLR3 activation is enhanced by CD14. Immunity 2006;24:153-163.
    • (2006) Immunity , vol.24 , pp. 153-163
    • Lee, H.-K.1    Dunzendorfer, S.2    Soldau, K.3    Tobias, P.S.4
  • 55
    • 49049103420 scopus 로고    scopus 로고
    • Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi
    • Bartholomeu DC, et al. Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi. J Immunol 2008;181:1333-1344.
    • (2008) J Immunol , vol.181 , pp. 1333-1344
    • Bartholomeu, D.C.1
  • 56
    • 78650638271 scopus 로고    scopus 로고
    • TLR9 is actively recruited to Aspergillus fumigatus phagosomes and requires the N-terminal proteolytic cleavage domain for proper intracellular trafficking
    • Kasperkovitz PV, Cardenas ML, Vyas JM. TLR9 is actively recruited to Aspergillus fumigatus phagosomes and requires the N-terminal proteolytic cleavage domain for proper intracellular trafficking. J Immunol 2010;185:7614-7622.
    • (2010) J Immunol , vol.185 , pp. 7614-7622
    • Kasperkovitz, P.V.1    Cardenas, M.L.2    Vyas, J.M.3
  • 57
    • 33947134377 scopus 로고    scopus 로고
    • Autophagy-dependent viral recognition by plasmacytoid dendritic cells
    • Lee HK, Lund JM, Ramanathan B, Mizushima N, Iwasaki A. Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 2007;315:1398-1401.
    • (2007) Science , vol.315 , pp. 1398-1401
    • Lee, H.K.1    Lund, J.M.2    Ramanathan, B.3    Mizushima, N.4    Iwasaki, A.5
  • 58
    • 84870861513 scopus 로고    scopus 로고
    • Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes
    • Henault J, et al. Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes. Immunity 2012;37:986-997.
    • (2012) Immunity , vol.37 , pp. 986-997
    • Henault, J.1
  • 59
    • 44649161194 scopus 로고    scopus 로고
    • The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigens
    • Chaturvedi A, Dorward D, Pierce SK. The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigens. Immunity 2008;28:799-809.
    • (2008) Immunity , vol.28 , pp. 799-809
    • Chaturvedi, A.1    Dorward, D.2    Pierce, S.K.3
  • 60
    • 17844380477 scopus 로고    scopus 로고
    • Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
    • Honda K, et al. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 2005;434:1035-1040.
    • (2005) Nature , vol.434 , pp. 1035-1040
    • Honda, K.1
  • 61
    • 33746884630 scopus 로고    scopus 로고
    • Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
    • Guiducci C. Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. J Exp Med 2006;203:1999-2008.
    • (2006) J Exp Med , vol.203 , pp. 1999-2008
    • Guiducci, C.1
  • 62
    • 77956689533 scopus 로고    scopus 로고
    • Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3
    • Sasai M, Linehan MM, Iwasaki A. Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3. Science 2010;329:1530-1534.
    • (2010) Science , vol.329 , pp. 1530-1534
    • Sasai, M.1    Linehan, M.M.2    Iwasaki, A.3
  • 63
    • 84936781864 scopus 로고    scopus 로고
    • DNase II-dependent DNA digestion is required for DNA sensing by TLR9
    • Chan MP, et al. DNase II-dependent DNA digestion is required for DNA sensing by TLR9. Nat Commun 2014;6:5853.
    • (2014) Nat Commun , vol.6 , pp. 5853
    • Chan, M.P.1
  • 65
    • 30544451546 scopus 로고    scopus 로고
    • Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
    • Häcker H, et al. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature 2005;439:204-207.
    • (2005) Nature , vol.439 , pp. 204-207
    • Häcker, H.1
  • 66
    • 78649877815 scopus 로고    scopus 로고
    • Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells
    • Blasius AL, et al. Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells. Proc Natl Acad Sci USA 2010;107:19973-19978.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 19973-19978
    • Blasius, A.L.1
  • 67
    • 79956300649 scopus 로고    scopus 로고
    • Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
    • Kawai T, Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 2011;34:637-650.
    • (2011) Immunity , vol.34 , pp. 637-650
    • Kawai, T.1    Akira, S.2
  • 69
    • 33745859044 scopus 로고    scopus 로고
    • Mechanisms of pathogen entry through the endosomal compartments
    • Gruenberg J, van der Goot FG. Mechanisms of pathogen entry through the endosomal compartments. Nat Rev Mol Cell Biol 2006;7:495-504.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 495-504
    • Gruenberg, J.1    van der Goot, F.G.2
  • 70
    • 79955743119 scopus 로고    scopus 로고
    • Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase
    • Ewald SE, Engel A, Lee J, Wang M, Bogyo M, Barton GM. Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase. J Exp Med 2011;208:643-651.
    • (2011) J Exp Med , vol.208 , pp. 643-651
    • Ewald, S.E.1    Engel, A.2    Lee, J.3    Wang, M.4    Bogyo, M.5    Barton, G.M.6
  • 71
    • 84861861142 scopus 로고    scopus 로고
    • Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling
    • Garcia-Cattaneo A, et al. Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling. Proc Natl Acad Sci USA 2012;109:9053-9058.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 9053-9058
    • Garcia-Cattaneo, A.1
  • 72
    • 84866558003 scopus 로고    scopus 로고
    • Proteolytic processing regulates Toll-like receptor 3 stability and endosomal localization
    • Qi R, Singh D, Kao CC. Proteolytic processing regulates Toll-like receptor 3 stability and endosomal localization. J Biol Chem 2012;287:32617-32629.
    • (2012) J Biol Chem , vol.287 , pp. 32617-32629
    • Qi, R.1    Singh, D.2    Kao, C.C.3
  • 73
    • 84885766791 scopus 로고    scopus 로고
    • Processing of human Toll-like receptor 7by furin-like proprotein convertases is required for its accumulation and activity in endosomes
    • Hipp MM, et al. Processing of human Toll-like receptor 7by furin-like proprotein convertases is required for its accumulation and activity in endosomes. Immunity 2013;39:711-721.
    • (2013) Immunity , vol.39 , pp. 711-721
    • Hipp, M.M.1
  • 74
    • 84910153079 scopus 로고    scopus 로고
    • Endosomal localization of TLR8 confers distinctive proteolytic processing on human myeloid cells
    • Ishii N, Funami K, Tatematsu M, Seya T, Matsumoto M. Endosomal localization of TLR8 confers distinctive proteolytic processing on human myeloid cells. J Immunol 2014;193:5118-5128.
    • (2014) J Immunol , vol.193 , pp. 5118-5128
    • Ishii, N.1    Funami, K.2    Tatematsu, M.3    Seya, T.4    Matsumoto, M.5
  • 75
    • 56349114913 scopus 로고    scopus 로고
    • Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9
    • Park B, Brinkmann MM, Spooner E, Lee CC, Kim Y-M, Ploegh HL. Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9. Nat Immunol 2008;9:1407-1414.
    • (2008) Nat Immunol , vol.9 , pp. 1407-1414
    • Park, B.1    Brinkmann, M.M.2    Spooner, E.3    Lee, C.C.4    Kim, Y.-M.5    Ploegh, H.L.6
  • 76
    • 70449477746 scopus 로고    scopus 로고
    • Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells
    • Sepulveda FE, et al. Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells. Immunity 2009;31:737-748.
    • (2009) Immunity , vol.31 , pp. 737-748
    • Sepulveda, F.E.1
  • 77
    • 38649126557 scopus 로고    scopus 로고
    • Cathepsins are required for Toll-like receptor 9 responses
    • Matsumoto F, et al. Cathepsins are required for Toll-like receptor 9 responses. Biochem Biophys Res Commun 2008;367:693-699.
    • (2008) Biochem Biophys Res Commun , vol.367 , pp. 693-699
    • Matsumoto, F.1
  • 78
    • 84887504831 scopus 로고    scopus 로고
    • An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing
    • Onji M, et al. An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing. Nat Commun 2013;4:1949.
    • (2013) Nat Commun , vol.4 , pp. 1949
    • Onji, M.1
  • 79
    • 67649232601 scopus 로고    scopus 로고
    • Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation
    • Peter ME, Kubarenko AV, Weber ANR, Dalpke AH. Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation. J Immunol 2009;182:7690-7697.
    • (2009) J Immunol , vol.182 , pp. 7690-7697
    • Peter, M.E.1    Kubarenko, A.V.2    Weber, A.N.R.3    Dalpke, A.H.4
  • 80
    • 84907212781 scopus 로고    scopus 로고
    • Negative self-regulation of TLR9 signaling by its N-terminal proteolytic cleavage product
    • Lee S, Kang D, Ra EA, Lee TA, Ploegh HL, Park B. Negative self-regulation of TLR9 signaling by its N-terminal proteolytic cleavage product. J Immunol 2014;193:3726-3735.
    • (2014) J Immunol , vol.193 , pp. 3726-3735
    • Lee, S.1    Kang, D.2    Ra, E.A.3    Lee, T.A.4    Ploegh, H.L.5    Park, B.6
  • 81
    • 84910113455 scopus 로고    scopus 로고
    • Roles of the cleaved N-terminal TLR3 fragment and cell surface TLR3 in double-stranded RNA sensing
    • Murakami Y, et al. Roles of the cleaved N-terminal TLR3 fragment and cell surface TLR3 in double-stranded RNA sensing. J Immunol 2014;193:5208-5217.
    • (2014) J Immunol , vol.193 , pp. 5208-5217
    • Murakami, Y.1
  • 82
    • 84880260267 scopus 로고    scopus 로고
    • Essential role for Toll-like receptor 7 (TLR7)-unique cysteines in an intramolecular disulfide bond, proteolytic cleavage and RNA sensing
    • Kanno A, et al. Essential role for Toll-like receptor 7 (TLR7)-unique cysteines in an intramolecular disulfide bond, proteolytic cleavage and RNA sensing. Int Immunol 2013;25:413-422.
    • (2013) Int Immunol , vol.25 , pp. 413-422
    • Kanno, A.1
  • 83
    • 84929649112 scopus 로고    scopus 로고
    • The processed amino-terminal fragment of human TLR7 acts as a chaperone to direct human TLR7 into endosomes
    • Hipp MM, Shepherd D, Booth S, Waithe D, Reis e Sousa C, Cerundolo V. The processed amino-terminal fragment of human TLR7 acts as a chaperone to direct human TLR7 into endosomes. J Immunol 2015;194:5417-5425.
    • (2015) J Immunol , vol.194 , pp. 5417-5425
    • Hipp, M.M.1    Shepherd, D.2    Booth, S.3    Waithe, D.4    Reis e Sousa, C.5    Cerundolo, V.6
  • 84
    • 84872178810 scopus 로고    scopus 로고
    • Cleaved/associated TLR3 represents the primary form of the signaling receptor
    • Toscano F, et al. Cleaved/associated TLR3 represents the primary form of the signaling receptor. J Immunol 2013;190:764-773.
    • (2013) J Immunol , vol.190 , pp. 764-773
    • Toscano, F.1
  • 85
    • 23044445303 scopus 로고    scopus 로고
    • Crystal structure of human toll-like receptor 3 (TLR3) ectodomain
    • Choe J, Kelker MS, Wilson IA. Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science 2005;309:581-585.
    • (2005) Science , vol.309 , pp. 581-585
    • Choe, J.1    Kelker, M.S.2    Wilson, I.A.3
  • 86
    • 23344431978 scopus 로고    scopus 로고
    • The molecular structure of the Toll-like receptor 3 ligand-binding domain
    • Bell JK, et al. The molecular structure of the Toll-like receptor 3 ligand-binding domain. Proc Natl Acad Sci USA 2005;102:10976-10980.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 10976-10980
    • Bell, J.K.1
  • 87
    • 34250698370 scopus 로고    scopus 로고
    • Ligand-induced conformational changes allosterically activate Toll-like receptor 9
    • Latz E, et al. Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat Immunol 2007;8:772-779.
    • (2007) Nat Immunol , vol.8 , pp. 772-779
    • Latz, E.1
  • 88
    • 84922552164 scopus 로고    scopus 로고
    • Cutting edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands
    • Pawaria S, et al. Cutting edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands. J Immunol 2015;194:1403-1407.
    • (2015) J Immunol , vol.194 , pp. 1403-1407
    • Pawaria, S.1
  • 89
    • 20244367698 scopus 로고    scopus 로고
    • Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-alpha induction by CpG-A in plasmacytoid dendritic cells
    • Kerkmann M, et al. Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-alpha induction by CpG-A in plasmacytoid dendritic cells. J Biol Chem 2005;280:8086-8093.
    • (2005) J Biol Chem , vol.280 , pp. 8086-8093
    • Kerkmann, M.1
  • 90
    • 9144238063 scopus 로고    scopus 로고
    • Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities
    • Vollmer J, et al. Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities. Eur J Immunol 2004;34:251-262.
    • (2004) Eur J Immunol , vol.34 , pp. 251-262
    • Vollmer, J.1
  • 92
    • 84872171591 scopus 로고    scopus 로고
    • Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice
    • Avalos AM, et al. Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice. J Immunol 2013;190:695-702.
    • (2013) J Immunol , vol.190 , pp. 695-702
    • Avalos, A.M.1
  • 93
    • 84922437081 scopus 로고    scopus 로고
    • Mucolipin 1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes
    • Li X, Saitoh SI, Shibata T, Tanimura N, Fukui R, Miyake K. Mucolipin 1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes. Int Immunol 2015;27:83-94.
    • (2015) Int Immunol , vol.27 , pp. 83-94
    • Li, X.1    Saitoh, S.I.2    Shibata, T.3    Tanimura, N.4    Fukui, R.5    Miyake, K.6
  • 94
    • 82555187209 scopus 로고    scopus 로고
    • UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling
    • Itoh H, et al. UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling. PLoS ONE 2011;6:e28500.
    • (2011) PLoS ONE , vol.6 , pp. e28500
    • Itoh, H.1
  • 95
    • 0036076593 scopus 로고    scopus 로고
    • Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling
    • Matsumoto M, Kikkawa S, Kohase M, Miyake K, Seya T. Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem Biophys Res Commun 2002;293:1364-1369.
    • (2002) Biochem Biophys Res Commun , vol.293 , pp. 1364-1369
    • Matsumoto, M.1    Kikkawa, S.2    Kohase, M.3    Miyake, K.4    Seya, T.5
  • 96
    • 0041331693 scopus 로고    scopus 로고
    • Subcellular localization of Toll-like receptor 3 in human dendritic cells
    • Matsumoto M, et al. Subcellular localization of Toll-like receptor 3 in human dendritic cells. J Immunol 2003;171:3154-3162.
    • (2003) J Immunol , vol.171 , pp. 3154-3162
    • Matsumoto, M.1
  • 97
    • 4344620814 scopus 로고    scopus 로고
    • The cytoplasmic "linker region" in Toll-like receptor 3 controls receptor localization and signaling
    • Funami K. The cytoplasmic "linker region" in Toll-like receptor 3 controls receptor localization and signaling. Int Immunol 2004;16:1143-1154.
    • (2004) Int Immunol , vol.16 , pp. 1143-1154
    • Funami, K.1
  • 98
    • 33746545577 scopus 로고    scopus 로고
    • Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling
    • Johnsen IB, et al. Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. EMBO J 2006;25:3335-3346.
    • (2006) EMBO J , vol.25 , pp. 3335-3346
    • Johnsen, I.B.1
  • 99
    • 2442565738 scopus 로고    scopus 로고
    • Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors
    • Nishiya T, DeFranco AL. Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J Biol Chem 2004;279:19008-19017.
    • (2004) J Biol Chem , vol.279 , pp. 19008-19017
    • Nishiya, T.1    DeFranco, A.L.2
  • 100
    • 84929640671 scopus 로고    scopus 로고
    • Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases
    • Kanno A, et al. Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases. Nat Commun 2015;6:6119.
    • (2015) Nat Commun , vol.6 , pp. 6119
    • Kanno, A.1
  • 102
    • 33747408269 scopus 로고    scopus 로고
    • Expression and function of Toll-like receptor 9 in severely injured patients prone to sepsis
    • Baiyee EE, et al. Expression and function of Toll-like receptor 9 in severely injured patients prone to sepsis. Clin Exp Immunol 2006;145:456-462.
    • (2006) Clin Exp Immunol , vol.145 , pp. 456-462
    • Baiyee, E.E.1
  • 103
    • 9244246298 scopus 로고    scopus 로고
    • Toll-like receptor 9 can be expressed at the cell surface of distinct populations of tonsils and human peripheral blood mononuclear cells
    • Eaton-Bassiri A, et al. Toll-like receptor 9 can be expressed at the cell surface of distinct populations of tonsils and human peripheral blood mononuclear cells. Infect Immun 2004;72:7202-7211.
    • (2004) Infect Immun , vol.72 , pp. 7202-7211
    • Eaton-Bassiri, A.1
  • 104
    • 10344228773 scopus 로고    scopus 로고
    • Human monocytes infected with Yersinia pestis express cell surface TLR9 and differentiate into dendritic cells
    • Saikh KU, Kissner TL, Sultana A, Ruthel G, Ulrich RG. Human monocytes infected with Yersinia pestis express cell surface TLR9 and differentiate into dendritic cells. J Immunol 2004;173:7426-7434.
    • (2004) J Immunol , vol.173 , pp. 7426-7434
    • Saikh, K.U.1    Kissner, T.L.2    Sultana, A.3    Ruthel, G.4    Ulrich, R.G.5
  • 105
    • 84881536267 scopus 로고    scopus 로고
    • Primary blood neutrophils express a functional cell surface Toll-like receptor 9
    • Lindau D, et al. Primary blood neutrophils express a functional cell surface Toll-like receptor 9. Eur J Immunol 2013;43:2101-2113.
    • (2013) Eur J Immunol , vol.43 , pp. 2101-2113
    • Lindau, D.1
  • 106
    • 33751551466 scopus 로고    scopus 로고
    • Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells
    • Lee J, et al. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat Cell Biol 2006;8:1327-1336.
    • (2006) Nat Cell Biol , vol.8 , pp. 1327-1336
    • Lee, J.1
  • 107
    • 2542510727 scopus 로고    scopus 로고
    • Expression and subcellular distribution of toll-like receptors TLR4, TLR5 and TLR9 on the gastric epithelium in Helicobacter pylori infection
    • Schmausser B, et al. Expression and subcellular distribution of toll-like receptors TLR4, TLR5 and TLR9 on the gastric epithelium in Helicobacter pylori infection. Clin Exp Immunol 2004;136:521-526.
    • (2004) Clin Exp Immunol , vol.136 , pp. 521-526
    • Schmausser, B.1
  • 108
    • 84875518435 scopus 로고    scopus 로고
    • TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neurons
    • Shintani Y, et al. TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neurons. Proc Natl Acad Sci USA 2013;110:5109-5114.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 5109-5114
    • Shintani, Y.1
  • 109
    • 0027333415 scopus 로고
    • Signal-dependent membrane protein trafficking in the endocytic pathway
    • Trowbridge IS, Collawn JF, Hopkins CR. Signal-dependent membrane protein trafficking in the endocytic pathway. Annu Rev Cell Biol 1993;9:129-161.
    • (1993) Annu Rev Cell Biol , vol.9 , pp. 129-161
    • Trowbridge, I.S.1    Collawn, J.F.2    Hopkins, C.R.3
  • 110
    • 84881559292 scopus 로고    scopus 로고
    • UNC93B1 mediates differential trafficking of endosomal TLRs
    • Lee BL, et al. UNC93B1 mediates differential trafficking of endosomal TLRs. Elife 2013;2:e00291.
    • (2013) Elife , vol.2 , pp. e00291
    • Lee, B.L.1
  • 111
    • 31344466165 scopus 로고    scopus 로고
    • The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
    • Tabeta K, et al. The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol 2006;7:156-164.
    • (2006) Nat Immunol , vol.7 , pp. 156-164
    • Tabeta, K.1
  • 112
    • 40749098665 scopus 로고    scopus 로고
    • UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes
    • Kim Y-M, Brinkmann MM, Paquet M-E, Ploegh HL. UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature 2008;452:234-238.
    • (2008) Nature , vol.452 , pp. 234-238
    • Kim, Y.-M.1    Brinkmann, M.M.2    Paquet, M.-E.3    Ploegh, H.L.4
  • 113
    • 34247484007 scopus 로고    scopus 로고
    • The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
    • Brinkmann MM, Spooner E, Hoebe K, Beutler B, Ploegh HL, Kim Y-M. The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol 2007;177:265-275.
    • (2007) J Cell Biol , vol.177 , pp. 265-275
    • Brinkmann, M.M.1    Spooner, E.2    Hoebe, K.3    Beutler, B.4    Ploegh, H.L.5    Kim, Y.-M.6
  • 114
    • 33750016788 scopus 로고    scopus 로고
    • Herpes simplex virus encephalitis in human UNC-93B deficiency
    • Casrouge A, et al. Herpes simplex virus encephalitis in human UNC-93B deficiency. Science 2006;314:308-312.
    • (2006) Science , vol.314 , pp. 308-312
    • Casrouge, A.1
  • 115
    • 84870292016 scopus 로고    scopus 로고
    • Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells
    • Lafaille FG, et al. Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells. Nature 2012;491:769-773.
    • (2012) Nature , vol.491 , pp. 769-773
    • Lafaille, F.G.1
  • 116
    • 84907195510 scopus 로고    scopus 로고
    • Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms
    • Pelka K, et al. Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms. J Immunol 2014;193:3257-3261.
    • (2014) J Immunol , vol.193 , pp. 3257-3261
    • Pelka, K.1
  • 117
    • 67449136127 scopus 로고    scopus 로고
    • Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing
    • Fukui R, et al. Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing. J Exp Med 2009;206:1339-1350.
    • (2009) J Exp Med , vol.206 , pp. 1339-1350
    • Fukui, R.1
  • 118
    • 79960470158 scopus 로고    scopus 로고
    • Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking
    • Fukui R, et al. Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking. Immunity 2011;35:69-81.
    • (2011) Immunity , vol.35 , pp. 69-81
    • Fukui, R.1
  • 119
    • 33748472865 scopus 로고    scopus 로고
    • Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
    • Christensen SR, Shupe J, Nickerson K, Kashgarian M, Flavell RA, Shlomchik MJ. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 2006;25:417-428.
    • (2006) Immunity , vol.25 , pp. 417-428
    • Christensen, S.R.1    Shupe, J.2    Nickerson, K.3    Kashgarian, M.4    Flavell, R.A.5    Shlomchik, M.J.6
  • 120
    • 84900491298 scopus 로고    scopus 로고
    • UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 5
    • Huh JW, et al. UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 5. Proc Natl Acad Sci USA 2014;111:7072-7077.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 7072-7077
    • Huh, J.W.1
  • 121
    • 84877797731 scopus 로고    scopus 로고
    • Acidic amino acid residues in the juxtamembrane region of the nucleotide-sensing TLRs are important for UNC93B1 binding and signaling
    • Kim J, et al. Acidic amino acid residues in the juxtamembrane region of the nucleotide-sensing TLRs are important for UNC93B1 binding and signaling. J Immunol 2013;190:5287-5295.
    • (2013) J Immunol , vol.190 , pp. 5287-5295
    • Kim, J.1
  • 122
    • 84872077258 scopus 로고    scopus 로고
    • The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists
    • Pohar J, Pirher N, Bencina M, Mancek-Keber M, Jerala R. The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists. J Biol Chem 2013;288:442-454.
    • (2013) J Biol Chem , vol.288 , pp. 442-454
    • Pohar, J.1    Pirher, N.2    Bencina, M.3    Mancek-Keber, M.4    Jerala, R.5
  • 124
    • 53849119555 scopus 로고    scopus 로고
    • Ins and outs of major facilitator superfamily antiporters
    • Law CJ, Maloney PC, Wang D-N. Ins and outs of major facilitator superfamily antiporters. Annu Rev Microbiol 2008;62:289-305.
    • (2008) Annu Rev Microbiol , vol.62 , pp. 289-305
    • Law, C.J.1    Maloney, P.C.2    Wang, D.-N.3
  • 125
    • 84886667895 scopus 로고    scopus 로고
    • No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice
    • Deguine J, Lee BL, Newman ZR, Barton GM. No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice. Nat Immunol 2013;14:1101-1102.
    • (2013) Nat Immunol , vol.14 , pp. 1101-1102
    • Deguine, J.1    Lee, B.L.2    Newman, Z.R.3    Barton, G.M.4
  • 126
    • 33750369226 scopus 로고    scopus 로고
    • Toll-like receptors in systemic autoimmune disease
    • Marshak-Rothstein A. Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol 2006;6:823-835.
    • (2006) Nat Rev Immunol , vol.6 , pp. 823-835
    • Marshak-Rothstein, A.1
  • 127
    • 80052180597 scopus 로고    scopus 로고
    • dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity
    • Wang Y, Swiecki M, McCartney SA, Colonna M. dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity. Immunol Rev 2011;243:74-90.
    • (2011) Immunol Rev , vol.243 , pp. 74-90
    • Wang, Y.1    Swiecki, M.2    McCartney, S.A.3    Colonna, M.4
  • 128
    • 84896320691 scopus 로고    scopus 로고
    • TLRs to cytokines: mechanistic insights from the imiquimod mouse model of psoriasis
    • Flutter B, Nestle FO. TLRs to cytokines: mechanistic insights from the imiquimod mouse model of psoriasis. Eur J Immunol 2013;43:3138-3146.
    • (2013) Eur J Immunol , vol.43 , pp. 3138-3146
    • Flutter, B.1    Nestle, F.O.2
  • 129
    • 84872053925 scopus 로고    scopus 로고
    • Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes
    • Diana J, et al. Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes. Nat Med 2012;19:65-73.
    • (2012) Nat Med , vol.19 , pp. 65-73
    • Diana, J.1
  • 130
    • 0036241068 scopus 로고    scopus 로고
    • Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis
    • Rachmilewitz D, et al. Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis. Gastroenterology 2002;122:1428-1441.
    • (2002) Gastroenterology , vol.122 , pp. 1428-1441
    • Rachmilewitz, D.1
  • 131
    • 14644403009 scopus 로고    scopus 로고
    • Toll-like receptor 9-induced type I IFN protects mice from experimental colitis
    • Katakura K, Lee J, Rachmilewitz D, Li G, Eckmann L, Raz E. Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. J Clin Invest 2005;115:695-702.
    • (2005) J Clin Invest , vol.115 , pp. 695-702
    • Katakura, K.1    Lee, J.2    Rachmilewitz, D.3    Li, G.4    Eckmann, L.5    Raz, E.6
  • 132
    • 53349164200 scopus 로고    scopus 로고
    • Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses
    • Hall JA, et al. Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity 2008;29:637-649.
    • (2008) Immunity , vol.29 , pp. 637-649
    • Hall, J.A.1
  • 133
    • 55349142293 scopus 로고    scopus 로고
    • IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans
    • Isnardi I, et al. IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans. Immunity 2008;29:746-757.
    • (2008) Immunity , vol.29 , pp. 746-757
    • Isnardi, I.1
  • 134
    • 79953061608 scopus 로고    scopus 로고
    • Human TLRs and IL-1Rs in host defense: natural insights from evolutionary, epidemiological, and clinical genetics
    • Casanova J-L, Abel L, Quintana-Murci L. Human TLRs and IL-1Rs in host defense: natural insights from evolutionary, epidemiological, and clinical genetics. Annu Rev Immunol 2011;29:447-491.
    • (2011) Annu Rev Immunol , vol.29 , pp. 447-491
    • Casanova, J.-L.1    Abel, L.2    Quintana-Murci, L.3
  • 135
    • 77957008935 scopus 로고    scopus 로고
    • Association of TLR9 gene polymorphisms with lupus nephritis in a Chinese Han population
    • Zhou X-J, Lv J-C, Cheng W-R, Yu L, Zhao M-H, Zhang H. Association of TLR9 gene polymorphisms with lupus nephritis in a Chinese Han population. Clin Exp Rheumatol 2010;28:397-400.
    • (2010) Clin Exp Rheumatol , vol.28 , pp. 397-400
    • Zhou, X.-J.1    Lv, J.-C.2    Cheng, W.-R.3    Yu, L.4    Zhao, M.-H.5    Zhang, H.6
  • 136
    • 84865473936 scopus 로고    scopus 로고
    • Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways
    • Vaughn SE, Kottyan LC, Munroe ME, Harley JB. Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways. J Leukoc Biol 2012;92:577-591.
    • (2012) J Leukoc Biol , vol.92 , pp. 577-591
    • Vaughn, S.E.1    Kottyan, L.C.2    Munroe, M.E.3    Harley, J.B.4
  • 137
    • 84875937513 scopus 로고    scopus 로고
    • Genetic susceptibility to SLE: recent progress from GWAS
    • Cui Y, Sheng Y, Zhang X. Genetic susceptibility to SLE: recent progress from GWAS. J Autoimmun 2013;41:25-33.
    • (2013) J Autoimmun , vol.41 , pp. 25-33
    • Cui, Y.1    Sheng, Y.2    Zhang, X.3
  • 138
    • 84892976361 scopus 로고    scopus 로고
    • Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population
    • Wang C-M, et al. Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population. Sci Rep 2014;4:3792.
    • (2014) Sci Rep , vol.4 , pp. 3792
    • Wang, C.-M.1
  • 139
    • 84887245011 scopus 로고    scopus 로고
    • Association study of TLR-9 polymorphisms and systemic lupus erythematosus in northern Chinese Han population
    • Zhang J, Zhu Q, Meng F, Lei H, Zhao Y. Association study of TLR-9 polymorphisms and systemic lupus erythematosus in northern Chinese Han population. Gene 2014;533:385-388.
    • (2014) Gene , vol.533 , pp. 385-388
    • Zhang, J.1    Zhu, Q.2    Meng, F.3    Lei, H.4    Zhao, Y.5
  • 140
    • 84890913903 scopus 로고    scopus 로고
    • Polymorphisms within Toll-like receptors are associated with systemic lupus erythematosus in a cohort of Danish females
    • Laska MJ, et al. Polymorphisms within Toll-like receptors are associated with systemic lupus erythematosus in a cohort of Danish females. Rheumatology 2014;53:48-55.
    • (2014) Rheumatology , vol.53 , pp. 48-55
    • Laska, M.J.1
  • 141
    • 84886752677 scopus 로고    scopus 로고
    • Meta-analysis demonstrates association between TLR polymorphisms and rheumatoid arthritis
    • Lee YH, Bae SC, Song GG. Meta-analysis demonstrates association between TLR polymorphisms and rheumatoid arthritis. Genet Mol Res 2013;12:328-334.
    • (2013) Genet Mol Res , vol.12 , pp. 328-334
    • Lee, Y.H.1    Bae, S.C.2    Song, G.G.3
  • 142
    • 84907930948 scopus 로고    scopus 로고
    • A non-synonymous single-nucleotide polymorphism in the gene encoding Toll-like receptor 3 (TLR3) is associated with sero-negative rheumatoid arthritis (RA) in a Danish population
    • Laska MJ, et al. A non-synonymous single-nucleotide polymorphism in the gene encoding Toll-like receptor 3 (TLR3) is associated with sero-negative rheumatoid arthritis (RA) in a Danish population. BMC Res Notes 2014;7:716.
    • (2014) BMC Res Notes , vol.7 , pp. 716
    • Laska, M.J.1
  • 143
    • 84892605492 scopus 로고    scopus 로고
    • Toll-like receptor polymorphisms and rheumatoid arthritis: a systematic review
    • Lee YH, Bae S-C, Kim J-H, Song GG. Toll-like receptor polymorphisms and rheumatoid arthritis: a systematic review. Rheumatol Int 2013;34:111-116.
    • (2013) Rheumatol Int , vol.34 , pp. 111-116
    • Lee, Y.H.1    Bae, S.-C.2    Kim, J.-H.3    Song, G.G.4
  • 144
    • 77950243833 scopus 로고    scopus 로고
    • Multiple common variants for celiac disease influencing immune gene expression
    • Dubois PCA, et al. Multiple common variants for celiac disease influencing immune gene expression. Nat Genet 2010;42:295-302.
    • (2010) Nat Genet , vol.42 , pp. 295-302
    • Dubois, P.C.A.1
  • 145
    • 77957845606 scopus 로고    scopus 로고
    • TLR8 deficiency leads to autoimmunity in mice
    • Demaria O, et al. TLR8 deficiency leads to autoimmunity in mice. J Clin Invest 2010;120:3651-3662.
    • (2010) J Clin Invest , vol.120 , pp. 3651-3662
    • Demaria, O.1
  • 146
    • 84890840281 scopus 로고    scopus 로고
    • RNA recognition by human TLR8 can lead to autoimmune inflammation
    • Guiducci C, et al. RNA recognition by human TLR8 can lead to autoimmune inflammation. J Exp Med 2013;210:2903-2919.
    • (2013) J Exp Med , vol.210 , pp. 2903-2919
    • Guiducci, C.1
  • 147
    • 84893344016 scopus 로고    scopus 로고
    • TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice
    • Desnues B, et al. TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice. Proc Natl Acad Sci USA 2014;111:1497-1502.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 1497-1502
    • Desnues, B.1
  • 148
    • 84923169931 scopus 로고    scopus 로고
    • Suppression of systemic autoimmunity by the innate immune adaptor STING
    • Sharma S, et al. Suppression of systemic autoimmunity by the innate immune adaptor STING. Proc Natl Acad Sci USA 2015;112:E710-E717.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. E710-E717
    • Sharma, S.1
  • 149
    • 80755126865 scopus 로고    scopus 로고
    • Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
    • Li S, Wang L, Berman M, Kong Y-Y, Dorf ME. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity 2011;35:426-440.
    • (2011) Immunity , vol.35 , pp. 426-440
    • Li, S.1    Wang, L.2    Berman, M.3    Kong, Y.-Y.4    Dorf, M.E.5
  • 151
    • 84869794842 scopus 로고    scopus 로고
    • STING manifests self DNA-dependent inflammatory disease
    • Ahn J, Gutman D, Saijo S, Barber GN. STING manifests self DNA-dependent inflammatory disease. Proc Natl Acad Sci USA 2012;109:19386-19391.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 19386-19391
    • Ahn, J.1    Gutman, D.2    Saijo, S.3    Barber, G.N.4
  • 152
    • 69949157650 scopus 로고    scopus 로고
    • Homozygosity for DNASE2 single nucleotide polymorphisms in the 5′-regulatory region is associated with rheumatoid arthritis
    • Rossol M, et al. Homozygosity for DNASE2 single nucleotide polymorphisms in the 5′-regulatory region is associated with rheumatoid arthritis. Ann Rheum Dis 2009;68:1498-1503.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1498-1503
    • Rossol, M.1
  • 153
    • 84921478452 scopus 로고    scopus 로고
    • Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice
    • Baum R, et al. Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice. J Immunol 2015;194:873-877.
    • (2015) J Immunol , vol.194 , pp. 873-877
    • Baum, R.1
  • 154
    • 84938515167 scopus 로고    scopus 로고
    • AIM2 drives joint inflammation in a self-DNA triggered model of chronic polyarthritis
    • Jakobs C, Perner S, Hornung V. AIM2 drives joint inflammation in a self-DNA triggered model of chronic polyarthritis. PLoS ONE 2015;10:e0131702.
    • (2015) PLoS ONE , vol.10 , pp. e0131702
    • Jakobs, C.1    Perner, S.2    Hornung, V.3
  • 155
    • 84856301080 scopus 로고    scopus 로고
    • Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease
    • Gall A, et al. Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity 2012;36:120-131.
    • (2012) Immunity , vol.36 , pp. 120-131
    • Gall, A.1
  • 156
    • 84884333427 scopus 로고    scopus 로고
    • Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing
    • Gehrke N, et al. Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing. Immunity 2013;39:482-495.
    • (2013) Immunity , vol.39 , pp. 482-495
    • Gehrke, N.1
  • 157
    • 4844225631 scopus 로고    scopus 로고
    • Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice
    • Li J. Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice. Physiol Genomics 2004;18:261-272.
    • (2004) Physiol Genomics , vol.18 , pp. 261-272
    • Li, J.1
  • 158
    • 0028235917 scopus 로고
    • 8-Hydroxydeoxyguanosine. A marker of oxidative DNA damage in systemic lupus erythematosus
    • Lunec J, Herbert K, Blount S, Griffiths HR, Emery P. 8-Hydroxydeoxyguanosine. A marker of oxidative DNA damage in systemic lupus erythematosus. FEBS Lett 1994;348:131-138.
    • (1994) FEBS Lett , vol.348 , pp. 131-138
    • Lunec, J.1    Herbert, K.2    Blount, S.3    Griffiths, H.R.4    Emery, P.5
  • 159
    • 84881021395 scopus 로고    scopus 로고
    • Aicardi-Goutieres syndrome, a rare neurological disease in children: a new autoimmune disorder?
    • Fazzi E, et al. Aicardi-Goutieres syndrome, a rare neurological disease in children: a new autoimmune disorder?. Autoimmun Rev 2013;12:506-509.
    • (2013) Autoimmun Rev , vol.12 , pp. 506-509
    • Fazzi, E.1
  • 160
    • 84906230645 scopus 로고    scopus 로고
    • The SKIV2L RNA exosome limits activation of the RIG-I-like receptors
    • Eckard SC, et al. The SKIV2L RNA exosome limits activation of the RIG-I-like receptors. Nat Immunol 2014;15:839-845.
    • (2014) Nat Immunol , vol.15 , pp. 839-845
    • Eckard, S.C.1
  • 161
    • 34249677845 scopus 로고    scopus 로고
    • Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
    • Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 2007;13:552-559.
    • (2007) Nat Med , vol.13 , pp. 552-559
    • Kanzler, H.1    Barrat, F.J.2    Hessel, E.M.3    Coffman, R.L.4
  • 162
    • 47249092785 scopus 로고    scopus 로고
    • Development of TLR inhibitors for the treatment of autoimmune diseases
    • Barrat FJ, Coffman RL. Development of TLR inhibitors for the treatment of autoimmune diseases. Immunol Rev 2008;223:271-283.
    • (2008) Immunol Rev , vol.223 , pp. 271-283
    • Barrat, F.J.1    Coffman, R.L.2
  • 163
    • 84865032889 scopus 로고    scopus 로고
    • New developments in Toll-like receptor targeted therapeutics
    • Connolly DJ, O'Neill LA. New developments in Toll-like receptor targeted therapeutics. Curr Opin Pharmacol 2012;12:510-518.
    • (2012) Curr Opin Pharmacol , vol.12 , pp. 510-518
    • Connolly, D.J.1    O'Neill, L.A.2
  • 165
    • 34249915031 scopus 로고    scopus 로고
    • Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus
    • Pawar RD, Ramanjaneyulu A, Kulkarni OP, Lech M, Segerer S, Anders HJ. Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus. J Am Soc Nephrol 2007;18:1721-1731.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1721-1731
    • Pawar, R.D.1    Ramanjaneyulu, A.2    Kulkarni, O.P.3    Lech, M.4    Segerer, S.5    Anders, H.J.6
  • 166
    • 84885464688 scopus 로고    scopus 로고
    • A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice
    • Zhu F-G, et al. A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice. Autoimmunity 2013;46:419-428.
    • (2013) Autoimmunity , vol.46 , pp. 419-428
    • Zhu, F.-G.1
  • 167
    • 84879410185 scopus 로고    scopus 로고
    • A Toll-like receptor 7, 8, and 9 antagonist inhibits Th1 and Th17 responses and inflammasome activation in a model of IL-23-induced psoriasis
    • Jiang W, et al. A Toll-like receptor 7, 8, and 9 antagonist inhibits Th1 and Th17 responses and inflammasome activation in a model of IL-23-induced psoriasis. J Invest Dermatol 2013;133:1777-1784.
    • (2013) J Invest Dermatol , vol.133 , pp. 1777-1784
    • Jiang, W.1
  • 168
    • 84865386355 scopus 로고    scopus 로고
    • Human Toll-like receptor 8 can be cool too: implications for foreign RNA sensing
    • Sarvestani ST, Williams BRG, Gantier MP. Human Toll-like receptor 8 can be cool too: implications for foreign RNA sensing. J Interferon Cytokine Res 2012;32:350-361.
    • (2012) J Interferon Cytokine Res , vol.32 , pp. 350-361
    • Sarvestani, S.T.1    Williams, B.R.G.2    Gantier, M.P.3
  • 169
    • 48549097394 scopus 로고    scopus 로고
    • Accessing the therapeutic potential of immunostimulatory nucleic acids
    • Barchet W, Wimmenauer V, Schlee M, Hartmann G. Accessing the therapeutic potential of immunostimulatory nucleic acids. Curr Opin Immunol 2008;20:389-395.
    • (2008) Curr Opin Immunol , vol.20 , pp. 389-395
    • Barchet, W.1    Wimmenauer, V.2    Schlee, M.3    Hartmann, G.4
  • 170
    • 84950123402 scopus 로고    scopus 로고
    • Dynavax Regains Full Rights to Investigational TLR7/9 Inhibitor DV1179 Following Expiration of Collaboration with GSK.
    • Dynavax. Dynavax Regains Full Rights to Investigational TLR7/9 Inhibitor DV1179 Following Expiration of Collaboration with GSK. 2014:1.
    • (2014) , pp. 1
    • Dynavax1
  • 171
    • 84950136609 scopus 로고    scopus 로고
    • Idera Pharmaceuticals Announces Positive Top-line Data in Phase 2 Trial of IMO-8400.
    • Idera Pharmaceuticals. Idera Pharmaceuticals Announces Positive Top-line Data in Phase 2 Trial of IMO-8400. 2014:1-3.
    • (2014) , pp. 1-3
  • 172
    • 84950154407 scopus 로고    scopus 로고
    • Idera Pharmaceuticals. Idera Pharmaceuticals Announces Positive Top-line Results from Phase 2 Trial of IMO-3100 in Patients with Moderate-to-Severe Plaque Psoriasis. :-
    • Idera Pharmaceuticals. Idera Pharmaceuticals Announces Positive Top-line Results from Phase 2 Trial of IMO-3100 in Patients with Moderate-to-Severe Plaque Psoriasis. 2012:1-4.
    • (2012) , pp. 1-4
  • 173
    • 84876412015 scopus 로고    scopus 로고
    • Topical treatment with the Toll-like receptor agonist DIMS0150 has potential for lasting relief of symptoms in patients with chronic active ulcerative colitis by restoring glucocorticoid sensitivity
    • Musch E, et al. Topical treatment with the Toll-like receptor agonist DIMS0150 has potential for lasting relief of symptoms in patients with chronic active ulcerative colitis by restoring glucocorticoid sensitivity. Inflamm Bowel Dis 2013;19:283-292.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 283-292
    • Musch, E.1
  • 174
    • 84950118361 scopus 로고    scopus 로고
    • ® in the Treatment of Moderate to Severe Ulcerative Colitis. :-
    • ® in the Treatment of Moderate to Severe Ulcerative Colitis. 2014:1-2.
    • (2014) , pp. 1-2
  • 175
    • 2342520028 scopus 로고    scopus 로고
    • The human antimicrobial peptide LL-37 transfers extracellular DNA plasmid to the nuclear compartment of mammalian cells via lipid rafts and proteoglycan-dependent endocytosis
    • Sandgren S, et al. The human antimicrobial peptide LL-37 transfers extracellular DNA plasmid to the nuclear compartment of mammalian cells via lipid rafts and proteoglycan-dependent endocytosis. J Biol Chem 2004;279:17951-17956.
    • (2004) J Biol Chem , vol.279 , pp. 17951-17956
    • Sandgren, S.1
  • 176
    • 0022468419 scopus 로고
    • Transport of macrophage Fc receptors and Fc receptor-bound ligands to lysosomes
    • Ukkonen P, Lewis V, Marsh M, Helenius A, Mellman I. Transport of macrophage Fc receptors and Fc receptor-bound ligands to lysosomes. J Exp Med 1986;163:952-971.
    • (1986) J Exp Med , vol.163 , pp. 952-971
    • Ukkonen, P.1    Lewis, V.2    Marsh, M.3    Helenius, A.4    Mellman, I.5


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