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Volumn 170, Issue 9, 2003, Pages 4465-4474

Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CD40 LIGAND; COMPLEMENTARY DNA; CYTOKINE; INTERFERON; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 8; OLIGONUCLEOTIDE; RNA; STAT1 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 0037407691     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.9.4465     Document Type: Article
Times cited : (296)

References (53)
  • 3
    • 0035003538 scopus 로고    scopus 로고
    • Toll meets bacterial CpG-DNA
    • Wagner, H. 2001. Toll meets bacterial CpG-DNA. Immunity 14:499.
    • (2001) Immunity , vol.14 , pp. 499
    • Wagner, H.1
  • 4
    • 0036160406 scopus 로고    scopus 로고
    • Interactions between bacterial CpG-DNA and TLR9 bridge innate and adaptive immunity
    • Wagner, H. 2002. Interactions between bacterial CpG-DNA and TLR9 bridge innate and adaptive immunity. Curr. Opin. Microbiol. 5:62.
    • (2002) Curr. Opin. Microbiol. , vol.5 , pp. 62
    • Wagner, H.1
  • 5
    • 0035903288 scopus 로고    scopus 로고
    • Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens
    • Kadowaki, N., S. Ho, S. Antonenko, R. W. Malefyt, R. A. Kastelein, F. Bazan, and Y. J. Liu. 2001. Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens. J. Exp. Med. 194:863.
    • (2001) J. Exp. Med. , vol.194 , pp. 863
    • Kadowaki, N.1    Ho, S.2    Antonenko, S.3    Malefyt, R.W.4    Kastelein, R.A.5    Bazan, F.6    Liu, Y.J.7
  • 6
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung, V., S. Rothenfusser, S. Britsch, A. Krug, B. Jahrsdorfer, T. Giese, S. Endres, and G. Hartmann. 2002. Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 168:4531.
    • (2002) J. Immunol. , vol.168 , pp. 4531
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3    Krug, A.4    Jahrsdorfer, B.5    Giese, T.6    Endres, S.7    Hartmann, G.8
  • 7
    • 0345120862 scopus 로고    scopus 로고
    • Oligode-oxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-γ production in cells from allergic individuals and inhibit IgE synthesis in vitro
    • Bohle, B., B. Jahn-Schmid, D. Maurer, D. Kraft, and C. Ebner. 1999. Oligode-oxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-γ production in cells from allergic individuals and inhibit IgE synthesis in vitro. Eur. J. Immunol. 29:2344.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 2344
    • Bohle, B.1    Jahn-Schmid, B.2    Maurer, D.3    Kraft, D.4    Ebner, C.5
  • 8
    • 0034650517 scopus 로고    scopus 로고
    • Mechanism and function of a newly identified CpG DNA motif in human primary B cells
    • Hartmann, G., and A. M. Krieg. 2000. Mechanism and function of a newly identified CpG DNA motif in human primary B cells. J. Immunol. 164:944.
    • (2000) J. Immunol. , vol.164 , pp. 944
    • Hartmann, G.1    Krieg, A.M.2
  • 9
    • 0034777579 scopus 로고    scopus 로고
    • Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12
    • Krug, A., A. Towarowski, S. Britsch, S. Rothenfusser, V. Hornung, R. Bals, T. Giese, H. Engelmann, S. Endres, A. M. Krieg, and G. Hartmann. 2001. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur. J. Immunol. 31:3026.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 3026
    • Krug, A.1    Towarowski, A.2    Britsch, S.3    Rothenfusser, S.4    Hornung, V.5    Bals, R.6    Giese, T.7    Engelmann, H.8    Endres, S.9    Krieg, A.M.10    Hartmann, G.11
  • 15
    • 0033779762 scopus 로고    scopus 로고
    • The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides
    • Weiner, G. J. 2000. The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides. J. Leukocyte Biol. 68:455.
    • (2000) J. Leukocyte Biol. , vol.68 , pp. 455
    • Weiner, G.J.1
  • 16
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg, A. M. 2002. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20:709.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 709
    • Krieg, A.M.1
  • 19
    • 0027323998 scopus 로고
    • Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium
    • O'Doherty, U., R. M. Steinman, M. Peng, P. U. Cameron, S. Gezelter, I. Kopeloff, W. J. Swiggard, M. Pope, and N. Bhardwaj. 1993. Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium. J. Exp. Med. 178:1067.
    • (1993) J. Exp. Med. , vol.178 , pp. 1067
    • O'Doherty, U.1    Steinman, R.M.2    Peng, M.3    Cameron, P.U.4    Gezelter, S.5    Kopeloff, I.6    Swiggard, W.J.7    Pope, M.8    Bhardwaj, N.9
  • 20
    • 0028048051 scopus 로고
    • Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature
    • O'Doherty, U., M. Peng, S. Gezelter, W. J. Swiggard, M. Betjes, N. Bhardwaj, and R. M. Steinman. 1994. Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. Immunology 82:487.
    • (1994) Immunology , vol.82 , pp. 487
    • O'Doherty, U.1    Peng, M.2    Gezelter, S.3    Swiggard, W.J.4    Betjes, M.5    Bhardwaj, N.6    Steinman, R.M.7
  • 21
    • 0033966367 scopus 로고    scopus 로고
    • Distinct signals control the hematopoiesis of lymphoid-related dendritic cells
    • Galy, A., I. Christopherson, G. Ferlazzo, G. Liu, H. Spits, and K. Georgopoulos. 2000. Distinct signals control the hematopoiesis of lymphoid-related dendritic cells. Blood 95:128.
    • (2000) Blood , vol.95 , pp. 128
    • Galy, A.1    Christopherson, I.2    Ferlazzo, G.3    Liu, G.4    Spits, H.5    Georgopoulos, K.6
  • 24
    • 0027788005 scopus 로고
    • Human natural interferon-α producing cells
    • Fitzgerald-Bocarsly, P. 1993. Human natural interferon-α producing cells. Pharmacol. Ther. 60:39.
    • (1993) Pharmacol. Ther. , vol.60 , pp. 39
    • Fitzgerald-Bocarsly, P.1
  • 26
    • 0037013830 scopus 로고    scopus 로고
    • Interferon-α and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets
    • Ito, T., R. Amakawa, T. Kaisho, H. Hemmi, K. Tajima, K. Uehira, Y. Ozaki, H. Tomizawa, S. Akira, and S. Fukuhara. 2002. Interferon-α and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets. J. Exp. Med. 195:1507.
    • (2002) J. Exp. Med. , vol.195 , pp. 1507
    • Ito, T.1    Amakawa, R.2    Kaisho, T.3    Hemmi, H.4    Tajima, K.5    Uehira, K.6    Ozaki, Y.7    Tomizawa, H.8    Akira, S.9    Fukuhara, S.10
  • 27
    • 0035905409 scopus 로고    scopus 로고
    • A pivotal role for the natural interferonα-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus
    • Ronnblom, L., and G. V. Alm. 2001. A pivotal role for the natural interferonα-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus. J. Exp. Med. 194:F59.
    • (2001) J. Exp. Med. , vol.194
    • Ronnblom, L.1    Alm, G.V.2
  • 32
    • 0023899859 scopus 로고
    • Differential and cell type specific expression of murine α-interferon genes is regulated on the transcriptional level
    • Bisat, F., N. B. Raj, and P. M. Pitha. 1988. Differential and cell type specific expression of murine α-interferon genes is regulated on the transcriptional level. Nucleic Acids Res. 16:6067.
    • (1988) Nucleic Acids Res. , vol.16 , pp. 6067
    • Bisat, F.1    Raj, N.B.2    Pitha, P.M.3
  • 33
    • 0034602156 scopus 로고    scopus 로고
    • Multiple regulatory domains control IRF-7 activity in response to virus infection
    • Lin, R., Y. Mamane, and J. Hiscott. 2000. Multiple regulatory domains control IRF-7 activity in response to virus infection. J. Biol. Chem. 275:34320.
    • (2000) J. Biol. Chem. , vol.275 , pp. 34320
    • Lin, R.1    Mamane, Y.2    Hiscott, J.3
  • 35
    • 0032538891 scopus 로고    scopus 로고
    • Differential viral induction of distinct interferon-α genes by positive feedback through interferon regulatory factor-7
    • Marie, I., J. E. Durbin, and D. E. Levy. 1998. Differential viral induction of distinct interferon-α genes by positive feedback through interferon regulatory factor-7. EMBO J. 17:6660.
    • (1998) EMBO J. , vol.17 , pp. 6660
    • Marie, I.1    Durbin, J.E.2    Levy, D.E.3
  • 36
    • 0032434924 scopus 로고    scopus 로고
    • Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7
    • Sato, M., N. Hata, M. Asagiri, T. Nakaya, T. Taniguchi, and N. Tanaka. 1998. Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7. FEBS Lett. 441:106.
    • (1998) FEBS Lett. , vol.441 , pp. 106
    • Sato, M.1    Hata, N.2    Asagiri, M.3    Nakaya, T.4    Taniguchi, T.5    Tanaka, N.6
  • 37
    • 0035968246 scopus 로고    scopus 로고
    • Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon-a genes
    • Barnes, B. J., P. A. Moore, and P. M. Pitha. 2001. Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon-a genes. J. Biol. Chem. 276:23382.
    • (2001) J. Biol. Chem. , vol.276 , pp. 23382
    • Barnes, B.J.1    Moore, P.A.2    Pitha, P.M.3
  • 38
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • Darnell, J. E., Jr. 1997. STATs and gene regulation. Science 277:1630.
    • (1997) Science , vol.277 , pp. 1630
    • Darnell J.E., Jr.1
  • 39
    • 0029618697 scopus 로고
    • Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes
    • Au, W. C., P. A. Moore, W. Lowther, Y. T. Juang, and P. M. Pitha. 1995. Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. Proc. Natl. Acad. Sci. USA 92:11657.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 11657
    • Au, W.C.1    Moore, P.A.2    Lowther, W.3    Juang, Y.T.4    Pitha, P.M.5
  • 40
    • 0035284744 scopus 로고    scopus 로고
    • Differential regulation of human blood dendritic cell subsets by IFNs
    • Ito, T., R. Amakawa, M. Inaba, S. Ikehara, K. Inaba, and S. Fukuhara. 2001. Differential regulation of human blood dendritic cell subsets by IFNs. J. Immunol. 166:2961.
    • (2001) J. Immunol. , vol.166 , pp. 2961
    • Ito, T.1    Amakawa, R.2    Inaba, M.3    Ikehara, S.4    Inaba, K.5    Fukuhara, S.6
  • 41
    • 0036376644 scopus 로고    scopus 로고
    • Type I interferon production by plasmacytoid dendritic cells and monocytes is triggered by viruses, but the level of production is controlled by distinct cytokines
    • Gary-Gouy, H., P. Lebon, and A. H. Dalloul. 2002. Type I interferon production by plasmacytoid dendritic cells and monocytes is triggered by viruses, but the level of production is controlled by distinct cytokines. J. Interferon Cytokine Res. 22:653.
    • (2002) J. Interferon Cytokine Res. , vol.22 , pp. 653
    • Gary-Gouy, H.1    Lebon, P.2    Dalloul, A.H.3
  • 42
    • 0037128177 scopus 로고    scopus 로고
    • Virus-induced interferon-α production by a dendritic cell subset in the absence of feedback signaling in vivo
    • Barchet, W., M. Cella, B. Odermatt, C. Asselin-Paturel, M. Colonna, and U. Kalinke. 2002. Virus-induced interferon-α production by a dendritic cell subset in the absence of feedback signaling in vivo. J. Exp. Med. 195:507.
    • (2002) J. Exp. Med. , vol.195 , pp. 507
    • Barchet, W.1    Cella, M.2    Odermatt, B.3    Asselin-Paturel, C.4    Colonna, M.5    Kalinke, U.6
  • 43
    • 0033529891 scopus 로고    scopus 로고
    • CpG DNA: A potent signal for growth, activation and maturation of human dendritic cells
    • Hartmann, G., G. Weiner, and A. M. Krieg. 1999. CpG DNA: a potent signal for growth, activation and maturation of human dendritic cells. Proc. Natl. Acad. Sci. USA 96:9305.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 9305
    • Hartmann, G.1    Weiner, G.2    Krieg, A.M.3
  • 44
    • 0029771599 scopus 로고    scopus 로고
    • Oligode-oxynucleotides enhance lipopolysaccharide-stimulated synthesis of tumor necrosis factor: Dependence on phosphorothioate modification and reversal by heparin
    • Hartmann, G., A. Krug, K. Waller-Fontaine, and S. Endres. 1996. Oligode-oxynucleotides enhance lipopolysaccharide-stimulated synthesis of tumor necrosis factor: dependence on phosphorothioate modification and reversal by heparin. Mol. Med. 2:429.
    • (1996) Mol. Med. , vol.2 , pp. 429
    • Hartmann, G.1    Krug, A.2    Waller-Fontaine, K.3    Endres, S.4
  • 46
    • 0027200178 scopus 로고
    • 2+-measurements with visible wavelength indicators in isolated cardiac myocytes
    • 2+-measurements with visible wavelength indicators in isolated cardiac myocytes. Cell Calcium 14:359.
    • (1993) Cell Calcium , vol.14 , pp. 359
    • Lipp, P.1    Niggli, E.2
  • 47
    • 0028082534 scopus 로고
    • Improved sensitivity in flow cytometric intracellular ionized calcium measurement using fluo-3/fura red fluorescence ratios
    • Novak, E. J., and P. S. Rabinovitch. 1994. Improved sensitivity in flow cytometric intracellular ionized calcium measurement using fluo-3/fura red fluorescence ratios. Cytometry 17:135.
    • (1994) Cytometry , vol.17 , pp. 135
    • Novak, E.J.1    Rabinovitch, P.S.2
  • 48
    • 0035865054 scopus 로고    scopus 로고
    • Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs
    • Verthelyi, D., K. Ishii, M. Gursel, F. Takeshita, and D. Klinman. 2001. Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs. J. Immunol. 166:2372.
    • (2001) J. Immunol. , vol.166 , pp. 2372
    • Verthelyi, D.1    Ishii, K.2    Gursel, M.3    Takeshita, F.4    Klinman, D.5
  • 49
    • 0035905321 scopus 로고    scopus 로고
    • BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon α/β induction
    • Dzionek, A., Y. Sohma, J. Nagafune, M. Cella, M. Colonna, F. Facchetti, G. Gunther, I. Johnston, A. Lanzavecchia, T. Nagasaka, et al. 2001. BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon α/β induction. J. Exp. Med. 194:1823.
    • (2001) J. Exp. Med. , vol.194 , pp. 1823
    • Dzionek, A.1    Sohma, Y.2    Nagafune, J.3    Cella, M.4    Colonna, M.5    Facchetti, F.6    Gunther, G.7    Johnston, I.8    Lanzavecchia, A.9    Nagasaka, T.10
  • 50
    • 0027325225 scopus 로고
    • Identification of a novel subunit of the type I interferon receptor localized to human chromosome 21
    • Colamonici, O. R., and P. Domanski. 1993. Identification of a novel subunit of the type I interferon receptor localized to human chromosome 21. J. Biol. Chem. 268:10895.
    • (1993) J. Biol. Chem. , vol.268 , pp. 10895
    • Colamonici, O.R.1    Domanski, P.2
  • 51
    • 0035887505 scopus 로고    scopus 로고
    • + cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells
    • + cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J. Exp. Med. 194:1171.
    • (2001) J. Exp. Med. , vol.194 , pp. 1171
    • Nakano, H.1    Yanagita, M.2    Gunn, M.D.3
  • 52
    • 0036534871 scopus 로고    scopus 로고
    • The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor
    • Gilliet, M., A. Boonstra, C. Paturel, S. Antonenko, X. L. Xu, G. Trinchieri, A. O'Garra, and Y. J. Liu. 2002. The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 195:953.
    • (2002) J. Exp. Med. , vol.195 , pp. 953
    • Gilliet, M.1    Boonstra, A.2    Paturel, C.3    Antonenko, S.4    Xu, X.L.5    Trinchieri, G.6    O'Garra, A.7    Liu, Y.J.8


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